{"id":"https://openalex.org/W1997921079","doi":"https://doi.org/10.1016/0168-3659(96)01464-2","title":"Controlled delivery of antibodies against leukocyte adhesion molecules from polymer matrices","display_name":"Controlled delivery of antibodies against leukocyte adhesion molecules from polymer matrices","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W1997921079","doi":"https://doi.org/10.1016/0168-3659(96)01464-2","mag":"1997921079"},"language":"en","primary_location":{"id":"doi:10.1016/0168-3659(96)01464-2","doi":"https://doi.org/10.1016/0168-3659(96)01464-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0168-3659(96)01464-2","pdf_url":"https://www.sciencedirect.com/science/article/pii/0168365996014642/pdf","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/0168365996014642/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058077037","display_name":"Maria R. Parkhurst","orcid":"https://orcid.org/0000-0001-7231-5069","observed_orcids":["https://orcid.org/0000-0001-7231-5069"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria R. Parkhurst","raw_affiliation_strings":["Department of Chemical Engineering, The Johns Hopkins University, 3401 N. Charles Street, Room 42 New Engineering Building, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Johns Hopkins University, 3401 N. Charles Street, Room 42 New Engineering Building, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012106344","display_name":"W. Mark Saltzman","orcid":"https://orcid.org/0000-0002-2163-549X","observed_orcids":["https://orcid.org/0000-0002-2163-549X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W.Mark Saltzman","raw_affiliation_strings":["Department of Chemical Engineering, The Johns Hopkins University, 3401 N. Charles Street, Room 42 New Engineering Building, Baltimore, MD 21218, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, The Johns Hopkins University, 3401 N. Charles Street, Room 42 New Engineering Building, Baltimore, MD 21218, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012106344"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":{"value":4440,"currency":"USD","value_usd":4440},"fwci":0.0,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.10970334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"42","issue":"3","first_page":"273","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12642","display_name":"Polymer-Based Agricultural Enhancements","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.800000011920929},{"id":"https://openalex.org/keywords/leukocyte-adhesion-molecules","display_name":"leukocyte adhesion molecules","score":0.9369999766349792},{"id":"https://openalex.org/keywords/controlled-drug-delivery","display_name":"controlled drug delivery","score":0.6919999718666077},{"id":"https://openalex.org/keywords/ethylene-vinyl-acetate-copolymer","display_name":"ethylene-vinyl acetate copolymer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mac-1","display_name":"Mac-1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mucosal-epithelium","display_name":"mucosal epithelium","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vaginal-drug-delivery","display_name":"vaginal drug delivery","score":0.6830000281333923},{"id":"https://openalex.org/keywords/t84-cells","display_name":"T84 cells","score":0.8569999933242798}],"concepts":[{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.7622533440589905},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.7528013586997986},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.54542475938797},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.53611820936203},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4958551824092865},{"id":"https://openalex.org/C2909375385","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Intercellular Adhesion Molecule-1","level":3,"score":0.48852264881134033},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.43310320377349854},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4274858832359314},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41527512669563293},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35467272996902466},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33702152967453003},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3185240924358368},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2536488175392151},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22818487882614136},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/0168-3659(96)01464-2","doi":"https://doi.org/10.1016/0168-3659(96)01464-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0168-3659(96)01464-2","pdf_url":"https://www.sciencedirect.com/science/article/pii/0168365996014642/pdf","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/0168-3659(96)01464-2","doi":"https://doi.org/10.1016/0168-3659(96)01464-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0168-3659(96)01464-2","pdf_url":"https://www.sciencedirect.com/science/article/pii/0168365996014642/pdf","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997921079.pdf","grobid_xml":"https://content.openalex.org/works/W1997921079.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W39184334","https://openalex.org/W1486262144","https://openalex.org/W1530566145","https://openalex.org/W1530621577","https://openalex.org/W1538000667","https://openalex.org/W1570191167","https://openalex.org/W1594700207","https://openalex.org/W1963847339","https://openalex.org/W1964264035","https://openalex.org/W1966286149","https://openalex.org/W1967597481","https://openalex.org/W1970509478","https://openalex.org/W1985136380","https://openalex.org/W1988589152","https://openalex.org/W1999141010","https://openalex.org/W2003648230","https://openalex.org/W2020457853","https://openalex.org/W2025482164","https://openalex.org/W2029561253","https://openalex.org/W2031418756","https://openalex.org/W2041040594","https://openalex.org/W2042360672","https://openalex.org/W2057359558","https://openalex.org/W2059005571","https://openalex.org/W2061284344","https://openalex.org/W2065072784","https://openalex.org/W2068536158","https://openalex.org/W2072126017","https://openalex.org/W2099435753","https://openalex.org/W2101858999","https://openalex.org/W2113182319","https://openalex.org/W2118531513","https://openalex.org/W2146087750","https://openalex.org/W2150217066","https://openalex.org/W2320473591","https://openalex.org/W2414310521","https://openalex.org/W2417863742","https://openalex.org/W2466812878","https://openalex.org/W2749610831","https://openalex.org/W3150346501","https://openalex.org/W4285719527","https://openalex.org/W6631859838"],"related_works":["https://openalex.org/W2002786300","https://openalex.org/W2146087750","https://openalex.org/W2029561253","https://openalex.org/W1996463097","https://openalex.org/W7098340554","https://openalex.org/W2480347278","https://openalex.org/W2331136297","https://openalex.org/W2164282645","https://openalex.org/W2049041819","https://openalex.org/W1900392249"],"abstract_inverted_index":{"The":[0],"interaction":[1],"between":[2],"infected":[3],"leukocytes":[4],"and":[5,47,141],"mucosal":[6,75],"epithelia":[7],"is":[8,59],"likely":[9],"to":[10,26,72,92,123],"play":[11],"a":[12,63,97,187,197],"critical":[13],"role":[14],"in":[15,104,150],"the":[16,28,85,93,105,116,166],"sexual":[17],"transmission":[18,29],"of":[19,30,50,56,69,88,96,99,107,169,177,199],"certain":[20],"diseases.":[21],"It":[22],"may":[23],"be":[24],"possible":[25],"prevent":[27],"intracellular":[31],"pathogens":[32],"by":[33,126],"inhibiting":[34],"leukocyte-epithelial":[35,51],"interactions.":[36],"Monoclonal":[37],"antibodies":[38],"(MAbs)":[39],"against":[40,109,115,132,193],"leukocyte":[41,90,111,134],"adhesion":[42,91,118,194],"receptors":[43,135,195],"can":[44],"provide":[45,186],"specific":[46],"potent":[48],"inhibition":[49],"interactions,":[52],"but":[53],"systemic":[54],"delivery":[55,68],"such":[57],"MAbs":[58,71,108,114,131,159,192],"not":[60],"desirable;":[61],"therefore,":[62],"new":[64,188],"method":[65],"for":[66,160,180,190],"local":[67],"anti-adhesion":[70],"an":[73],"exposed":[74],"surface":[76,95,112],"was":[77,102],"developed":[78],"using":[79,191],"polymeric":[80],"controlled-release":[81,184],"devices.":[82,147],"To":[83],"evaluate":[84],"prophylactic":[86],"potential":[87],"MAbs,":[89],"apical":[94],"monolayer":[98],"T84":[100,124],"cells":[101,125],"examined":[103],"presence":[106],"human":[110],"proteins.":[113],"MAC-1":[117],"receptor":[119],"inhibited":[120],"neutrophil":[121],"attachment":[122],"as":[127,129,196],"much":[128],"97%.":[130],"murine":[133],"were":[136],"produced":[137,174],"from":[138],"several":[139,181],"hybridomas":[140],"incorporated":[142],"into":[143,165],"poly(ethylene-co-vinyl":[144],"acetate)":[145],"(EVAc)":[146],"During":[148],"incubation":[149],"buffered":[151],"saline,":[152],"small":[153],"polymer":[154,172],"discs":[155],"continuously":[156],"released":[157],"active":[158],"10":[161],"days.":[162,182],"After":[163],"insertion":[164],"vaginal":[167],"canals":[168],"mice,":[170],"these":[171],"disks":[173],"high":[175],"levels":[176],"anti-MAC-1":[178],"MAb":[179],"Polymeric":[183],"devices":[185],"technique":[189],"means":[198],"long-term,":[200],"localized":[201],"sexually":[202],"transmitted":[203],"disease":[204],"(STD)":[205],"prophylaxis.":[206]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}