{"id":"https://openalex.org/W1997918706","doi":"https://doi.org/10.1016/j.cardfail.2014.07.018","title":"Plasma Galectin-3 and Heart Failure Outcomes in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)","display_name":"Plasma Galectin-3 and Heart Failure Outcomes in MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)","publication_year":2014,"publication_date":"2014-08-06","ids":{"openalex":"https://openalex.org/W1997918706","doi":"https://doi.org/10.1016/j.cardfail.2014.07.018","mag":"1997918706","pmid":"https://pubmed.ncbi.nlm.nih.gov/25106783"},"language":"en","primary_location":{"id":"doi:10.1016/j.cardfail.2014.07.018","doi":"https://doi.org/10.1016/j.cardfail.2014.07.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2014.07.018","pdf_url":"http://www.onlinejcf.com/article/S1071916414006952/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.onlinejcf.com/article/S1071916414006952/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038469190","display_name":"Craig Stolen","orcid":"https://orcid.org/0000-0002-5725-463X","observed_orcids":["https://orcid.org/0000-0002-5725-463X"]},"institutions":[{"id":"https://openalex.org/I2948663404","display_name":"Boston Scientific (United States)","ror":"https://ror.org/0385es521","country_code":"US","type":"company","lineage":["https://openalex.org/I2948663404"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig M. Stolen","raw_affiliation_strings":["Boston Scientific Corporation, St Paul, Minnesota. Electronic address: craig.stolen@bsci.com","Boston Scientific Corporation, St Paul, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Scientific Corporation, St Paul, Minnesota. Electronic address: craig.stolen@bsci.com","institution_ids":["https://openalex.org/I2948663404"]},{"raw_affiliation_string":"Boston Scientific Corporation, St Paul, Minnesota","institution_ids":["https://openalex.org/I2948663404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010200052","display_name":"Aram S. Adourian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210125757","display_name":"BG Medicine (United States)","ror":"https://ror.org/02x1cd136","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aram Adourian","raw_affiliation_strings":["BG Medicine, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BG Medicine, Waltham, Massachusetts","institution_ids":["https://openalex.org/I4210125757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022012412","display_name":"Timothy E. Meyer","orcid":"https://orcid.org/0000-0002-1223-9030","observed_orcids":["https://orcid.org/0000-0002-1223-9030"]},"institutions":[{"id":"https://openalex.org/I2948663404","display_name":"Boston Scientific (United States)","ror":"https://ror.org/0385es521","country_code":"US","type":"company","lineage":["https://openalex.org/I2948663404"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy E. Meyer","raw_affiliation_strings":["Boston Scientific Corporation, St Paul, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Scientific Corporation, St Paul, Minnesota","institution_ids":["https://openalex.org/I2948663404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110414172","display_name":"Kenneth M. Ste\u00edn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948663404","display_name":"Boston Scientific (United States)","ror":"https://ror.org/0385es521","country_code":"US","type":"company","lineage":["https://openalex.org/I2948663404"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth M. Stein","raw_affiliation_strings":["Boston Scientific Corporation, St Paul, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston Scientific Corporation, St Paul, Minnesota","institution_ids":["https://openalex.org/I2948663404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054830306","display_name":"Scott David Solomon","orcid":"https://orcid.org/0000-0003-3698-9597","observed_orcids":["https://orcid.org/0000-0003-3698-9597"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott D. Solomon","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5038469190"],"corresponding_institution_ids":["https://openalex.org/I2948663404"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":{"value":3970,"currency":"USD","value_usd":3970},"fwci":4.7973,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.95596194,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"11","first_page":"793","last_page":"799"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.4562999904155731,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.4562999904155731,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.3732999861240387,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.029400000348687172,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":1.0},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cardiac-resynchronization-therapy","display_name":"cardiac resynchronization therapy","score":0.9670000076293945},{"id":"https://openalex.org/keywords/implantable-cardioverter-defibrillator","display_name":"implantable cardioverter-defibrillator","score":0.8830000162124634},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.550000011920929},{"id":"https://openalex.org/keywords/treatment-response-heterogeneity","display_name":"treatment response heterogeneity","score":0.7059999704360962},{"id":"https://openalex.org/keywords/fibrogenesis","display_name":"fibrogenesis","score":0.6119999885559082},{"id":"https://openalex.org/keywords/heart-failure-outcomes","display_name":"heart failure outcomes","score":0.4790000021457672},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9509349465370178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7950524091720581},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.7729895114898682},{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.7722523212432861},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7703463435173035},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.760384202003479},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6261545419692993},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.5891666412353516},{"id":"https://openalex.org/C2777093960","wikidata":"https://www.wikidata.org/wiki/Q594446","display_name":"Implantable cardioverter-defibrillator","level":2,"score":0.5826635956764221},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5648913979530334},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.5059427618980408},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4685918688774109},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4217546284198761},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.08650052547454834}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017147","descriptor_name":"Defibrillators, Implantable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D058406","descriptor_name":"Cardiac Resynchronization Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cardfail.2014.07.018","doi":"https://doi.org/10.1016/j.cardfail.2014.07.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2014.07.018","pdf_url":"http://www.onlinejcf.com/article/S1071916414006952/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},{"id":"pmid:25106783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25106783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiac failure","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.cardfail.2014.07.018","doi":"https://doi.org/10.1016/j.cardfail.2014.07.018","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cardfail.2014.07.018","pdf_url":"http://www.onlinejcf.com/article/S1071916414006952/pdf","source":{"id":"https://openalex.org/S67869649","display_name":"Journal of Cardiac Failure","issn_l":"1071-9164","issn":["1071-9164","1532-8414"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiac Failure","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310567","display_name":"Boston Scientific Corporation","ror":"https://ror.org/0385es521"},{"id":"https://openalex.org/F4320315693","display_name":"BG Medicine","ror":"https://ror.org/02x1cd136"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997918706.pdf","grobid_xml":"https://content.openalex.org/works/W1997918706.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W110569400","https://openalex.org/W1943554866","https://openalex.org/W1965328698","https://openalex.org/W1986750147","https://openalex.org/W1986985376","https://openalex.org/W2014189665","https://openalex.org/W2015404118","https://openalex.org/W2018049609","https://openalex.org/W2020332328","https://openalex.org/W2035667813","https://openalex.org/W2050865773","https://openalex.org/W2053101511","https://openalex.org/W2067973515","https://openalex.org/W2074958057","https://openalex.org/W2075361978","https://openalex.org/W2090048170","https://openalex.org/W2098787760","https://openalex.org/W2106421416","https://openalex.org/W2123248199","https://openalex.org/W2126617892","https://openalex.org/W2130907431","https://openalex.org/W2132715587","https://openalex.org/W2134265214","https://openalex.org/W2134996862","https://openalex.org/W2135164569","https://openalex.org/W2138605772","https://openalex.org/W2141895646","https://openalex.org/W2143795945","https://openalex.org/W2144426613","https://openalex.org/W2146521529","https://openalex.org/W2148719028","https://openalex.org/W2161321429","https://openalex.org/W2166805849","https://openalex.org/W2169401348","https://openalex.org/W2172116519","https://openalex.org/W2181968881","https://openalex.org/W2328176404","https://openalex.org/W3175417087"],"related_works":["https://openalex.org/W2280885112","https://openalex.org/W4231406337","https://openalex.org/W2504241385","https://openalex.org/W4220989910","https://openalex.org/W2898787333","https://openalex.org/W2050227484","https://openalex.org/W2425022234","https://openalex.org/W3209580219","https://openalex.org/W2003581952","https://openalex.org/W4396617697"],"abstract_inverted_index":{"BACKGROUND:":[0],"Elevated":[1,201],"circulating":[2],"levels":[3,117,241],"of":[4,10,83,103,122,134,181,210,223],"the":[5,36,78,97,119,123,135,182,237],"protein":[6],"galectin-3,":[7],"a":[8,129,160,243],"mediator":[9],"fibrogenesis,":[11],"have":[12],"previously":[13],"been":[14],"associated":[15,127,158],"with":[16,114,128,151,159,216,227,233,236],"adverse":[17,211],"outcomes":[18,43],"in":[19,44,66,77,118,132,163,214],"heart":[20],"failure":[21],"(HF)":[22],"patients":[23,46,75,113,150,215,235],"and":[24,41,90],"appear":[25],"to":[26,29,48,176,205],"modify":[27],"response":[28,84],"certain":[30],"pharmacologic":[31],"therapies.":[32],"This":[33],"study":[34],"investigated":[35],"relationship":[37],"between":[38,87],"galectin-3":[39,62,89,116,154,171,202,229,240],"level":[40,172,230],"clinical":[42],"HF":[45,105,212,234],"randomized":[47],"implantable":[49],"cardioverter":[50],"defibrillator":[51],"(ICD-only)":[52],"or":[53,94,107],"cardiac":[54],"resynchronization":[55],"therapy":[56],"(CRT-D).":[57],"METHODS":[58],"AND":[59],"RESULTS:":[60],"Plasma":[61],"concentrations":[63],"were":[64],"measured":[65],"654":[67],"New":[68],"York":[69],"Heart":[70],"Association":[71],"functional":[72],"class":[73],"I/II":[74],"participating":[76],"MADIT-CRT":[79,99],"trial.":[80],"A":[81,220],"heterogeneity":[82],"was":[85,126,157,174,203,231],"detected":[86],"pre-implantation":[88,228],"randomization":[91,225],"group":[92,226],"(CRT-D":[93],"ICD-only)":[95],"on":[96],"primary":[98,136,183],"trial":[100],"end":[101,137,184],"point":[102,138,185],"nonfatal":[104],"event":[106],"death":[108],"(P":[109],"=":[110,198],".045).":[111],"Among":[112],"baseline":[115,153,239],"top":[120],"quartile":[121],"distribution,":[124],"CRT-D":[125,156],"65%":[130],"reduction":[131],"risk":[133,164],"(hazard":[139],"ratio":[140],"[HR]":[141],"0.35,":[142],"95%":[143,167,194],"confidence":[144],"interval":[145],"[CI]":[146],"0.19-0.67),":[147],"whereas":[148],"among":[149],"lower":[152],"values":[155],"25%":[161],"decrease":[162],"(HR":[165],"0.75,":[166],"CI.":[168],"0.51-1.11).":[169],"Baseline":[170],"also":[173],"observed":[175],"be":[177,206],"an":[178,207],"independent":[179,208],"predictor":[180,209],"(multivariable":[186],"adjusted":[187],"HR":[188],"per":[189],"log":[190],"unit":[191],"increase:":[192],"1.55;":[193],"CI":[195],"1.01-2.38;":[196],"P":[197],".043).":[199],"CONCLUSIONS:":[200],"found":[204],"outcome":[213],"mildly":[217],"symptomatic":[218],"HF.":[219],"significant":[221],"interaction":[222],"device":[224],"detected,":[232],"highest":[238],"deriving":[242],"disproportionately":[244],"larger":[245],"benefit":[246],"from":[247],"CRT-D.":[248]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
