{"id":"https://openalex.org/W1997914899","doi":"https://doi.org/10.1046/j.1468-2982.1992.1205308.x","title":"Treatment of Migraine Attacks with Subcutaneous Sumatriptan: First Placebo-Controlled Study","display_name":"Treatment of Migraine Attacks with Subcutaneous Sumatriptan: First Placebo-Controlled Study","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W1997914899","doi":"https://doi.org/10.1046/j.1468-2982.1992.1205308.x","mag":"1997914899","pmid":"https://pubmed.ncbi.nlm.nih.gov/1330318"},"language":"en","primary_location":{"id":"doi:10.1046/j.1468-2982.1992.1205308.x","doi":"https://doi.org/10.1046/j.1468-2982.1992.1205308.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1468-2982.1992.1205308.x","pdf_url":null,"source":{"id":"https://openalex.org/S141866484","display_name":"Cephalalgia","issn_l":"0333-1024","issn":["0333-1024","1468-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033768921","display_name":"W. Hester Visser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W Hester Visser","raw_affiliation_strings":["Department of Neurology1, University Hospital Leiden, The Netherlands","Department of Neurology, University Hospital Leiden, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology1, University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurology, University Hospital Leiden, The Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel D Ferrari","raw_affiliation_strings":["Department of Neurology1, University Hospital Leiden, The Netherlands","Department of Neurology, University Hospital Leiden, The Netherlands;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology1, University Hospital Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurology, University Hospital Leiden, The Netherlands;","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025054862","display_name":"Evelyn M Bayliss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evelyn M Bayliss","raw_affiliation_strings":["Glaxo Group Research Ltd2, Greenford, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Group Research Ltd2, Greenford, Middlesex, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027235675","display_name":"Susan Ludlow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Ludlow","raw_affiliation_strings":["Glaxo Group Research Ltd2, Greenford, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Group Research Ltd2, Greenford, Middlesex, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017428431","display_name":"Alison Pilgrim","orcid":"https://orcid.org/0000-0001-8192-566X","observed_orcids":["https://orcid.org/0000-0001-8192-566X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alison J Pilgrim","raw_affiliation_strings":["Glaxo Group Research Ltd2, Greenford, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaxo Group Research Ltd2, Greenford, Middlesex, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":2.5119,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.8843094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"5","first_page":"308","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sumatriptan","display_name":"sumatriptan","score":0.9340000152587891},{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.7860000133514404},{"id":"https://openalex.org/keywords/subcutaneous-administration","display_name":"subcutaneous administration","score":0.9559999704360962},{"id":"https://openalex.org/keywords/5-ht1-receptor-agonists","display_name":"5-HT1 receptor agonists","score":0.8550000190734863},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.8159999847412109},{"id":"https://openalex.org/keywords/headache-intensity","display_name":"headache severity","score":0.8140000104904175},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.6769999861717224},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2778871607","wikidata":"https://www.wikidata.org/wiki/Q416978","display_name":"Sumatriptan","level":4,"score":0.9554617404937744},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8848041296005249},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.8164587020874023},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6788856387138367},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5240179300308228},{"id":"https://openalex.org/C2911171718","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine Disorders","level":3,"score":0.412002831697464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22270920872688293},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.13766688108444214},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.08120563626289368},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017366","descriptor_name":"Serotonin Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018170","descriptor_name":"Sumatriptan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1468-2982.1992.1205308.x","doi":"https://doi.org/10.1046/j.1468-2982.1992.1205308.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1468-2982.1992.1205308.x","pdf_url":null,"source":{"id":"https://openalex.org/S141866484","display_name":"Cephalalgia","issn_l":"0333-1024","issn":["0333-1024","1468-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia","raw_type":"journal-article"},{"id":"pmid:1330318","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1330318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia : an international journal of headache","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1439104425","https://openalex.org/W1504964973","https://openalex.org/W1556294939","https://openalex.org/W1559051873","https://openalex.org/W1585029032","https://openalex.org/W1890116900","https://openalex.org/W1968081766","https://openalex.org/W1971575080","https://openalex.org/W2007830665","https://openalex.org/W2024285166","https://openalex.org/W2045530969","https://openalex.org/W2055064537","https://openalex.org/W2055895292","https://openalex.org/W2059402725","https://openalex.org/W2059473001","https://openalex.org/W2066109424","https://openalex.org/W2070339814","https://openalex.org/W2091580738","https://openalex.org/W2099275034","https://openalex.org/W2323888388","https://openalex.org/W2388992503","https://openalex.org/W2734650613","https://openalex.org/W2735945141","https://openalex.org/W3036818463","https://openalex.org/W4251406403","https://openalex.org/W4322701861"],"related_works":["https://openalex.org/W1978365721","https://openalex.org/W4322701861","https://openalex.org/W1982089628","https://openalex.org/W2007830665","https://openalex.org/W1985762969","https://openalex.org/W1986907391","https://openalex.org/W2106016859","https://openalex.org/W1489220976","https://openalex.org/W2018834848","https://openalex.org/W2527558851"],"abstract_inverted_index":{"The":[0],"results":[1],"of":[2,27,30,38,67,84,92],"the":[3,11,23,182],"very":[4],"first":[5],"large-scale":[6],"placebo-controlled":[7],"dose-response":[8],"trial":[9],"with":[10,95,103,112],"novel":[12],"selective":[13],"5-hydroxytryptamine1-like":[14],"(5HT1-like)":[15],"receptor":[16],"agonist":[17],"sumatriptan":[18,39,106,133,141,158,169,186,197,206],"are":[19],"presented.":[20],"We":[21,202],"studied":[22],"efficacy":[24,75],"and":[25,35,53,58,87,107,134,192,200,218],"tolerability":[26],"subcutaneous":[28,168,205],"injections":[29],"1":[31,96,124],"mg,":[32],"2":[33,104,131],"mg":[34,37,97,105,114,125,132,140,166,217],"3":[36,113,139,165,214,216],"in":[40,44,79,88,210],"alleviating":[41],"migraine":[42,150,222],"attacks":[43],"a":[45],"double-blind,":[46],"placebo-controlled,":[47],"parallel-group,":[48],"multicentre":[49],"clinical":[50],"trial.":[51],"Six-hundred":[52],"ninety":[54],"patients":[55,86,93],"were":[56,119,152,198],"randomized":[57],"685":[59],"received":[60],"study":[61],"medication.":[62],"At":[63],"30":[64],"min,":[65],"reduction":[66],"headache":[68],"severity":[69],"to":[70,172,185,189,213],"mild":[71],"or":[72,174],"none":[73],"(primary":[74],"endpoint)":[76],"was":[77,170],"achieved":[78],"22%":[80,127],"(95%":[81],"CI:":[82],"15-28%)":[83],"placebo-treated":[85],"39%":[89],"(CI:":[90,100,109,121,128,136],"31-46%)":[91],"treated":[94,102,111,156],"sumatriptan,":[98,126],"44%":[99],"36-51%)":[101],"55%":[108],"48-63%)":[110],"sumatriptan.":[115],"Differences":[116],"from":[117],"placebo":[118],"17%":[120],"8-27%)":[122],"for":[123,130,138,145],"13-32%)":[129],"34%":[135],"24-44%)":[137],"(p":[142],"<":[143],"0.001":[144],"all":[146],"three":[147],"comparisons).":[148],"Other":[149],"symptoms":[151],"also":[153],"more":[154],"effectively":[155],"by":[157,160],"than":[159],"placebo.":[161],"Subsequently,":[162],"an":[163],"open-label":[164],"dose":[167,181],"given":[171],"partial":[173],"non-responders.":[175],"Thirty":[176],"minutes":[177],"after":[178,196],"this":[179],"open":[180],"response":[183],"rate":[184],"had":[187],"improved":[188],"between":[190],"70":[191],"80%.":[193],"Adverse":[194],"events":[195],"minor":[199],"short-lived.":[201],"conclude":[203],"that":[204],"is":[207],"well":[208],"tolerated":[209],"doses":[211],"up":[212],"+":[215],"may":[219],"rapidly":[220],"abort":[221],"attacks.":[223]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
