{"id":"https://openalex.org/W1997883792","doi":"https://doi.org/10.1016/j.juro.2012.11.012","title":"B7-H1 as a Biomarker for Therapy Failure in Patients with Favorable Histology Wilms Tumor","display_name":"B7-H1 as a Biomarker for Therapy Failure in Patients with Favorable Histology Wilms Tumor","publication_year":2012,"publication_date":"2012-11-12","ids":{"openalex":"https://openalex.org/W1997883792","doi":"https://doi.org/10.1016/j.juro.2012.11.012","mag":"1997883792","pmid":"https://pubmed.ncbi.nlm.nih.gov/23154206"},"language":"en","primary_location":{"id":"doi:10.1016/j.juro.2012.11.012","doi":"https://doi.org/10.1016/j.juro.2012.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2012.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087419823","display_name":"Jonathan C. Routh","orcid":"https://orcid.org/0000-0002-7731-963X","observed_orcids":["https://orcid.org/0000-0002-7731-963X"]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Routh","raw_affiliation_strings":["Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087530499","display_name":"Paul Edward Grundy","orcid":"https://orcid.org/0000-0003-2645-8266","observed_orcids":["https://orcid.org/0000-0003-2645-8266"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paul E. Grundy","raw_affiliation_strings":["Department of Pediatrics and Oncology, University of Alberta, Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Oncology, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028949419","display_name":"James Robert Anderson","orcid":"https://orcid.org/0000-0002-3107-0672","observed_orcids":["https://orcid.org/0000-0002-3107-0672"]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. Anderson","raw_affiliation_strings":["College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082496651","display_name":"Alan B. Retik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan B. Retik","raw_affiliation_strings":["Department of Urology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028191819","display_name":"Kyle C. Kurek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle C. Kurek","raw_affiliation_strings":["Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.6422,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.64656796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"189","issue":"4","first_page":"1487","last_page":"1492"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms tumor","score":0.8529999852180481},{"id":"https://openalex.org/keywords/favorable-histology","display_name":"favorable histology","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.628000020980835},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.6800000071525574},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9850000143051147},{"id":"https://openalex.org/keywords/blastema","display_name":"blastema","score":0.7839999794960022},{"id":"https://openalex.org/keywords/pediatric-renal-tumors","display_name":"pediatric renal tumors","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8519492149353027},{"id":"https://openalex.org/C2775999222","wikidata":"https://www.wikidata.org/wiki/Q756289","display_name":"Wilms' tumor","level":2,"score":0.8250494003295898},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.5183473825454712},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.477325975894928},{"id":"https://openalex.org/C2993838110","wikidata":"https://www.wikidata.org/wiki/Q494230","display_name":"Medical school","level":2,"score":0.4110743999481201},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39264291524887085},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34307581186294556},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009396","descriptor_name":"Wilms Tumor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D060890","descriptor_name":"B7-H1 Antigen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.juro.2012.11.012","doi":"https://doi.org/10.1016/j.juro.2012.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.juro.2012.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Urology","raw_type":"journal-article"},{"id":"pmid:23154206","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23154206","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1556730386","https://openalex.org/W1568317937","https://openalex.org/W1870078228","https://openalex.org/W1883916287","https://openalex.org/W1913539970","https://openalex.org/W1972806916","https://openalex.org/W1981153972","https://openalex.org/W1985577912","https://openalex.org/W1998466036","https://openalex.org/W2016983859","https://openalex.org/W2022188846","https://openalex.org/W2036549340","https://openalex.org/W2045087550","https://openalex.org/W2049403590","https://openalex.org/W2073034411","https://openalex.org/W2105469253","https://openalex.org/W2117694169","https://openalex.org/W2121988130","https://openalex.org/W2129647998","https://openalex.org/W2137737429","https://openalex.org/W2138635670","https://openalex.org/W2149748445","https://openalex.org/W2157030129","https://openalex.org/W2157357637","https://openalex.org/W2163804741","https://openalex.org/W2171862017","https://openalex.org/W2186878636","https://openalex.org/W4205811845","https://openalex.org/W4230861071"],"related_works":["https://openalex.org/W1998466036","https://openalex.org/W2794851582","https://openalex.org/W2794874316","https://openalex.org/W2080685973","https://openalex.org/W2018597144","https://openalex.org/W6958363066","https://openalex.org/W2919983481","https://openalex.org/W2134656015","https://openalex.org/W2904298646","https://openalex.org/W7203871642"],"abstract_inverted_index":{"PURPOSE:":[0],"A":[1],"minority":[2],"of":[3,23,44,63,166,213,230,232],"children":[4,76,107],"with":[5,115,124,147,164,173,191,226],"Wilms":[6,35,52,69,89,222],"tumor":[7,10,30,90,99,214,223],"will":[8],"experience":[9],"recurrence.":[11],"In":[12],"a":[13,47,59],"previous":[14],"pilot":[15],"study":[16,62],"we":[17],"found":[18],"an":[19,24,227],"association":[20,208],"between":[21],"expression":[22,161,218],"immune":[25],"costimulatory":[26],"molecule,":[27],"B7-H1,":[28],"and":[29,80,93,101,121,154],"recurrence":[31],"in":[32,49,151,157],"favorable":[33,50,87,220],"histology":[34,51,88,221],"tumor.":[36,53],"We":[37,57,72,112],"sought":[38],"to":[39,106,210],"verify":[40],"the":[41,66,102,137],"prognostic":[42],"value":[43],"B7-H1":[45,133,145,160,179,197,217],"as":[46],"biomarker":[48],"MATERIALS":[54],"AND":[55],"METHODS:":[56],"performed":[58],"nested":[60],"case-control":[61],"tumors":[64,174,192],"from":[65],"Fifth":[67],"National":[68],"Tumor":[70,128],"Study.":[71],"randomly":[73],"selected":[74],"44":[75],"unsuccessfully":[77],"treated":[78,85,123],"(cases)":[79],"49":[81],"who":[82,108],"were":[83,95,130,182,200],"successfully":[84],"for":[86,132,186,204],"(controls).":[91],"Cases":[92],"controls":[94],"matched":[96],"based":[97],"on":[98],"stage,":[100],"analysis":[103],"was":[104,162],"restricted":[105],"underwent":[109],"initial":[110,167,233],"resection.":[111],"excluded":[113],"patients":[114],"stage":[116],"IV":[117],"or":[118,126],"V":[119],"disease":[120],"those":[122,190],"chemotherapy":[125],"radiation.":[127],"specimens":[129],"stained":[131],"expression.":[134],"RESULTS:":[135],"Of":[136],"93":[138],"total":[139],"samples":[140],"analyzed":[141],"60":[142],"(65%)":[143],"demonstrated":[144],"staining,":[146],"staining":[148],"diffusely":[149],"present":[150],"13":[152],"(22%)":[153],"blastema":[155],"predominant":[156],"34":[158],"(57%).":[159],"associated":[163,225],"failure":[165,231],"therapy":[168],"(p":[169],"=":[170],"0.006).":[171],"Patients":[172],"showing":[175],"less":[176],"than":[177,195],"20%":[178],"positive":[180,198],"cells":[181,199],"at":[183,201],"lower":[184],"risk":[185,203,229],"treatment":[187,205],"failure,":[188],"while":[189],"exhibiting":[193],"greater":[194,202],"60%":[196],"failure.":[206],"This":[207],"appeared":[209],"be":[211],"independent":[212],"stage.":[215],"CONCLUSIONS:":[216],"by":[219],"is":[224],"increased":[228],"therapy.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}