{"id":"https://openalex.org/W1997883398","doi":"https://doi.org/10.1021/jp307526f","title":"Unusual Optical Resolution of All Four Tryptophan Residues in MPT63 Protein by Phosphorescence Spectroscopy: Assignment and Significance","display_name":"Unusual Optical Resolution of All Four Tryptophan Residues in MPT63 Protein by Phosphorescence Spectroscopy: Assignment and Significance","publication_year":2012,"publication_date":"2012-09-21","ids":{"openalex":"https://openalex.org/W1997883398","doi":"https://doi.org/10.1021/jp307526f","mag":"1997883398","pmid":"https://pubmed.ncbi.nlm.nih.gov/22998652"},"language":"en","primary_location":{"id":"doi:10.1021/jp307526f","doi":"https://doi.org/10.1021/jp307526f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp307526f","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101029906","display_name":"Ranendu Ghosh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ranendu Ghosh","raw_affiliation_strings":["Structural Biology & Bio-Informatics Division, Indian Institute of Chemical Biology, Kolkata-700 032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology & Bio-Informatics Division, Indian Institute of Chemical Biology, Kolkata-700 032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113595408","display_name":"Manini Mukherjee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Manini Mukherjee","raw_affiliation_strings":["Department of Chemistry, Presidency University, Kolkata 700 073, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Presidency University, Kolkata 700 073, India","institution_ids":["https://openalex.org/I157674215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052537544","display_name":"Krishnananda Chattopadhyay","orcid":"https://orcid.org/0000-0002-1449-8909","observed_orcids":["https://orcid.org/0000-0002-1449-8909"]},"institutions":[{"id":"https://openalex.org/I160344538","display_name":"Indian Institute of Chemical Biology","ror":"https://ror.org/01kh0x418","country_code":"IN","type":"facility","lineage":["https://openalex.org/I160344538","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Krishnananda Chattopadhyay","raw_affiliation_strings":["Structural Biology & Bio-Informatics Division, Indian Institute of Chemical Biology, Kolkata-700 032, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Structural Biology & Bio-Informatics Division, Indian Institute of Chemical Biology, Kolkata-700 032, India","institution_ids":["https://openalex.org/I160344538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070568880","display_name":"Sanjib Ghosh","orcid":"https://orcid.org/0000-0002-5014-9466","observed_orcids":["https://orcid.org/0000-0002-5014-9466"]},"institutions":[{"id":"https://openalex.org/I157674215","display_name":"Presidency University","ror":"https://ror.org/04xgbph11","country_code":"IN","type":"education","lineage":["https://openalex.org/I157674215"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sanjib Ghosh","raw_affiliation_strings":["Department of Chemistry, Presidency University, Kolkata 700 073, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Presidency University, Kolkata 700 073, India","institution_ids":["https://openalex.org/I157674215"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052537544","https://openalex.org/A5070568880"],"corresponding_institution_ids":["https://openalex.org/I157674215","https://openalex.org/I160344538"],"apc_list":null,"apc_paid":null,"fwci":0.7168,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.6337087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"116","issue":"41","first_page":"12489","last_page":"12500"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.39089998602867126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.3571999967098236,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11129","display_name":"Photochemistry and Electron Transfer Studies","score":0.12770000100135803,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tryptophan-microenvironment","display_name":"tryptophan microenvironment","score":0.7310000061988831},{"id":"https://openalex.org/keywords/protein-folding","display_name":"protein folding","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C181817918","wikidata":"https://www.wikidata.org/wiki/Q192275","display_name":"Phosphorescence","level":3,"score":0.9269869327545166},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.7681760787963867},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.6596124172210693},{"id":"https://openalex.org/C138268822","wikidata":"https://www.wikidata.org/wiki/Q1051925","display_name":"Resolution (logic)","level":2,"score":0.5951690673828125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5501221418380737},{"id":"https://openalex.org/C3019883945","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Low resolution","level":3,"score":0.41898614168167114},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.369515061378479},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.3408270478248596},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1667231023311615},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.1574108600616455},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13195598125457764},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1109241247177124},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.10619708895683289},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.09662100672721863},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0858512818813324},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008163","descriptor_name":"Luminescent Measurements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D055620","descriptor_name":"Optical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jp307526f","doi":"https://doi.org/10.1021/jp307526f","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp307526f","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:22998652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22998652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W335769971","https://openalex.org/W1964603841","https://openalex.org/W1964873238","https://openalex.org/W1964933270","https://openalex.org/W1967275727","https://openalex.org/W1973945311","https://openalex.org/W1976700149","https://openalex.org/W1979029534","https://openalex.org/W1980930434","https://openalex.org/W1982157929","https://openalex.org/W1982329510","https://openalex.org/W1987203170","https://openalex.org/W1990321877","https://openalex.org/W1991863242","https://openalex.org/W1993089067","https://openalex.org/W1994514758","https://openalex.org/W1999696779","https://openalex.org/W2007943170","https://openalex.org/W2019801529","https://openalex.org/W2021033525","https://openalex.org/W2025685750","https://openalex.org/W2025904219","https://openalex.org/W2027259280","https://openalex.org/W2028551158","https://openalex.org/W2037657477","https://openalex.org/W2038875173","https://openalex.org/W2038948119","https://openalex.org/W2048995169","https://openalex.org/W2050185410","https://openalex.org/W2053867269","https://openalex.org/W2059158694","https://openalex.org/W2061507271","https://openalex.org/W2069344962","https://openalex.org/W2070334781","https://openalex.org/W2072408484","https://openalex.org/W2075941885","https://openalex.org/W2076962448","https://openalex.org/W2078040293","https://openalex.org/W2079248219","https://openalex.org/W2081237255","https://openalex.org/W2091784315","https://openalex.org/W2092278798","https://openalex.org/W2094517427","https://openalex.org/W2095507447","https://openalex.org/W2109454628","https://openalex.org/W2120675400","https://openalex.org/W2129995310","https://openalex.org/W2136919736","https://openalex.org/W2137902859","https://openalex.org/W2164450010","https://openalex.org/W2167373328","https://openalex.org/W3134519519"],"related_works":["https://openalex.org/W7128401660","https://openalex.org/W2038948119","https://openalex.org/W2046747392","https://openalex.org/W2019801529","https://openalex.org/W2092278798","https://openalex.org/W2069344962","https://openalex.org/W2025685750","https://openalex.org/W2051899270","https://openalex.org/W1987203170","https://openalex.org/W2080030506"],"abstract_inverted_index":{"MPT63,":[0],"a":[1,14,58],"secreted":[2],"protein":[3,55],"of":[4,37,63,78,89,94,134,196,202,214,232,242],"unknown":[5],"function":[6],"that":[7,201,211],"is":[8,107,127,147,167,226],"specific":[9],"to":[10,68,149,200],"Mycobacterium":[11],"tuberculosis":[12],"and":[13,29,61,92,100,165,184,193,222,250],"potential":[15],"drug":[16],"target,":[17],"contains":[18],"four":[19,39,69],"Tryptophan":[20],"(Trp/W)":[21],"residues":[22,41,65,175,236],"located":[23],"at":[24,51,140],"positions":[25],"26,":[26],"48,":[27],"82,":[28],"129":[30],"in":[31,73,96,159,163,228,246,251],"the":[32,38,74,97,101,128,151,160,185,190,197,203,212,215,234,240,247,252],"amino":[33],"acid":[34],"sequence.":[35],"All":[36],"Trp":[40,64,80,90,95,105,145,174,235,244],"have":[42],"been":[43],"optically":[44],"resolved":[45],"by":[46,109,169,177],"simple":[47],"inexpensive":[48],"phosphorescence":[49,75,208],"spectroscopy":[50],"77":[52],"K.":[53],"The":[54,136],"architecture":[56],"provides":[57],"delicate":[59],"micro-environment":[60],"location":[62],"giving":[66],"rise":[67],"different":[70,216],"(0,0)":[71,137,154,217],"bands":[72,218],"spectra.":[76,179],"Calculation":[77],"intra":[79],"energy":[81,133,206],"transfer":[82],"(ET)":[83],"efficiency,":[84],"accessible":[85],"surface":[86],"area":[87],"(ASA)":[88],"residues,":[91],"environment":[93],"wild-type":[98],"(WT)":[99],"mutant":[102,198],"W26F":[103,166],"[where,":[104],"26":[106,146],"replaced":[108],"phenyl":[110],"alanine":[111],"(Phe/F)]":[112],"reveal:":[113],"E(T1)":[114,117,120,123,126],"(W82)":[115],">":[116,119,122],"(W48)":[118],"(W129)":[121],"(W26),":[124],"where":[125],"lowest":[129],"(\u03c0-\u03c0*)":[130],"triplet":[131],"state":[132],"Trp.":[135],"band":[138,155],"observed":[139],"421.6":[141],"nm":[142],"assigned":[143],"for":[144],"found":[148],"be":[150,220],"longest":[152],"wavelength":[153],"so":[156],"far":[157],"reported":[158],"literature.":[161],"Fluorescence":[162],"WT":[164],"dominated":[168],"buried":[170],"or":[171],"partially":[172],"exposed":[173],"indicated":[176],"time-resolved":[178,186],"Circular":[180],"Dichroism":[181],"(CD)":[182],"studies":[183],"anisotropy":[187],"measurement":[188],"confirm":[189],"unaltered":[191],"secondary":[192],"tertiary":[194],"structure":[195],"compared":[199],"WT.":[204],"Excitation":[205],"dependent":[207],"spectra":[209],"suggest":[210],"intensity":[213],"could":[219],"tuned":[221],"Tyrosine":[223],"(Tyr/Y)":[224],"residue":[225,245],"silent":[227],"emission.":[229],"Optical":[230],"resolution":[231],"all":[233],"will":[237],"help":[238],"understand":[239],"role":[241],"each":[243],"folding/unfolding":[248],"mechanism":[249],"interaction":[253],"with":[254],"other":[255],"systems.":[256]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
