{"id":"https://openalex.org/W1997883336","doi":"https://doi.org/10.1006/nbdi.2001.0406","title":"Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease","display_name":"Creatine Increases Survival and Delays Motor Symptoms in a Transgenic Animal Model of Huntington's Disease","publication_year":2001,"publication_date":"2001-06-01","ids":{"openalex":"https://openalex.org/W1997883336","doi":"https://doi.org/10.1006/nbdi.2001.0406","mag":"1997883336","pmid":"https://pubmed.ncbi.nlm.nih.gov/11447996"},"language":"en","primary_location":{"id":"doi:10.1006/nbdi.2001.0406","doi":"https://doi.org/10.1006/nbdi.2001.0406","is_oa":false,"landing_page_url":"https://doi.org/10.1006/nbdi.2001.0406","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/c7919301b51e4f6c8b3393673832e9df","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020215901","display_name":"Ole A. Andreassen","orcid":"https://orcid.org/0000-0002-4461-3568","observed_orcids":["https://orcid.org/0000-0002-4461-3568"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ole A. Andreassen","raw_affiliation_strings":["Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusets, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusets, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004541689","display_name":"Alpaslan Dedeoglu","orcid":"https://orcid.org/0000-0003-1156-0874","observed_orcids":["https://orcid.org/0000-0003-1156-0874"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alpaslan Dedeoglu","raw_affiliation_strings":["Neurochemistry Laboratory, Neurology Service, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochemistry Laboratory, Neurology Service, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026075478","display_name":"Robert J. Ferrante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I2800300635","display_name":"Edith Nourse Rogers Memorial Veterans Hospital","ror":"https://ror.org/015nymp25","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2800300635","https://openalex.org/I4210095851"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Ferrante","raw_affiliation_strings":["Department of Neurology, Pathology, and Psychiatry, Boston University School of Medicine, Boston, Massachusetts","Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford, Massachusetts","Boston University","VA Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Pathology, and Psychiatry, Boston University School of Medicine, Boston, Massachusetts","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Geriatric Research Education and Clinical Center, Bedford VA Medical Center, Bedford, Massachusetts","institution_ids":["https://openalex.org/I2800300635"]},{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"VA Medical Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109986965","display_name":"Bruce G. Jenkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce G. Jenkins","raw_affiliation_strings":["Neurology Service, MGH-NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, MGH-NMR Center, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087987819","display_name":"Kimberly L. Ferrante","orcid":"https://orcid.org/0000-0002-6069-9226","observed_orcids":["https://orcid.org/0000-0002-6069-9226"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly L. Ferrante","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","Neurochemistry Laboratory, Neurology Service, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Harvard University","New York Presbyterian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Neurochemistry Laboratory, Neurology Service, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"New York Presbyterian Hospital","institution_ids":["https://openalex.org/I1340179700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013110210","display_name":"Melissa K. Thomas","orcid":"https://orcid.org/0000-0001-9848-2834","observed_orcids":["https://orcid.org/0000-0001-9848-2834"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa Thomas","raw_affiliation_strings":["Neurology Service, Department of Radiology, Molecular Endocrinology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Service, Department of Radiology, Molecular Endocrinology Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113624012","display_name":"Avi L. Friedlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avi Friedlich","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","New York Presbyterian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295"]},{"raw_affiliation_string":"New York Presbyterian Hospital","institution_ids":["https://openalex.org/I1340179700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022054634","display_name":"Susan E. Browne","orcid":"https://orcid.org/0000-0003-1785-1429","observed_orcids":["https://orcid.org/0000-0003-1785-1429"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan E. Browne","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","New York Presbyterian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295"]},{"raw_affiliation_string":"New York Presbyterian Hospital","institution_ids":["https://openalex.org/I1340179700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027263074","display_name":"Gabriele Schilling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriele Schilling","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University, Baltimore, Maryland","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038629622","display_name":"David Borchelt","orcid":"https://orcid.org/0000-0002-0813-6979","observed_orcids":["https://orcid.org/0000-0002-0813-6979"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Borchelt","raw_affiliation_strings":["Department of Pathology, Johns Hopkins University, Baltimore, Maryland","Johns Hopkins University ("],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Johns Hopkins University (","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032351341","display_name":"Steven M. Hersch","orcid":"https://orcid.org/0000-0001-5948-6672","observed_orcids":["https://orcid.org/0000-0001-5948-6672"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven M. Hersch","raw_affiliation_strings":["Department of Neurology, Emory University, Atlanta, Georgia","Emory University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Emory University, Atlanta, Georgia","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Emory University","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072055814","display_name":"Christopher A. Ross","orcid":"https://orcid.org/0000-0003-1882-5847","observed_orcids":["https://orcid.org/0000-0003-1882-5847"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A. Ross","raw_affiliation_strings":["Departments of Psychiatry and Neuroscience, Johns Hopkins University, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry and Neuroscience, Johns Hopkins University, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110231276","display_name":"M. Flint Beal","orcid":"https://orcid.org/0009-0003-9295-2884","observed_orcids":["https://orcid.org/0009-0003-9295-2884"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.Flint Beal","raw_affiliation_strings":["Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","Neurochemistry Laboratory, Neurology Service, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","Harvard University","New York Presbyterian Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Neurochemistry Laboratory, Neurology Service, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"New York Presbyterian Hospital","institution_ids":["https://openalex.org/I1340179700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":7.9736,"has_fulltext":false,"cited_by_count":292,"citation_normalized_percentile":{"value":0.985829,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"8","issue":"3","first_page":"479","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/creatine-supplementation","display_name":"creatine supplementation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.7590000033378601},{"id":"https://openalex.org/keywords/polyglutamine-expansion","display_name":"polyglutamine expansion","score":0.7269999980926514},{"id":"https://openalex.org/keywords/n-terminal-huntingtin-fragments","display_name":"N-terminal huntingtin fragments","score":0.7089999914169312},{"id":"https://openalex.org/keywords/motor-symptoms","display_name":"motor symptoms","score":0.621999979019165},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.9570000171661377},{"id":"https://openalex.org/keywords/brain-atrophy","display_name":"brain atrophy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/intranuclear-inclusions","display_name":"intranuclear inclusions","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mitochondrial-permeability-transition","display_name":"mitochondrial permeability transition","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.9471726417541504},{"id":"https://openalex.org/C2778626300","wikidata":"https://www.wikidata.org/wiki/Q1984607","display_name":"Phosphocreatine","level":3,"score":0.8416566848754883},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.8237873315811157},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.780908465385437},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6637392044067383},{"id":"https://openalex.org/C2910011555","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin Protein","level":5,"score":0.653715193271637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6221511363983154},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.597922682762146},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5821644067764282},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5216900706291199},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.4550233781337738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4256075620651245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3375657796859741},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26268261671066284},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2317308485507965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20761829614639282},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.18803825974464417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10669475793838501}],"mesh":[{"descriptor_ui":"D000071058","descriptor_name":"Huntingtin Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006816","descriptor_name":"Huntington Disease","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1006/nbdi.2001.0406","doi":"https://doi.org/10.1006/nbdi.2001.0406","is_oa":false,"landing_page_url":"https://doi.org/10.1006/nbdi.2001.0406","pdf_url":null,"source":{"id":"https://openalex.org/S35878148","display_name":"Neurobiology of Disease","issn_l":"0969-9961","issn":["0969-9961","1095-953X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of Disease","raw_type":"journal-article"},{"id":"pmid:11447996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11447996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurobiology of disease","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c7919301b51e4f6c8b3393673832e9df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c7919301b51e4f6c8b3393673832e9df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 8, Iss 3, Pp 479-491 (2001)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:c7919301b51e4f6c8b3393673832e9df","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c7919301b51e4f6c8b3393673832e9df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neurobiology of Disease, Vol 8, Iss 3, Pp 479-491 (2001)","raw_type":"article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1064289161","display_name":null,"funder_award_id":"AG 12992","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1856555311","display_name":null,"funder_award_id":"AT00613","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G1964600565","display_name":null,"funder_award_id":"AG 13846","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2087613279","display_name":null,"funder_award_id":"NS37102","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2137558941","display_name":null,"funder_award_id":"NS16375","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2466425206","display_name":null,"funder_award_id":"NS 35255","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G34571175","display_name":"OXIDATIVE INJURY IN PARKINSONS DISEASE","funder_award_id":"5r29ns037102-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3645877733","display_name":null,"funder_award_id":"NS 38144","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5354394171","display_name":null,"funder_award_id":"NS38180","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5521144907","display_name":"HUNTINGTON PROTEIN AND THE HUNTINGTON'S DISEASE MUTATION","funder_award_id":"R01NS035255","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6290449138","display_name":"Transgenic Models of Huntington's Disease","funder_award_id":"R01NS038144","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7618461031","display_name":"Boston University Alzheimer's Disease Center","funder_award_id":"P30AG013846","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8121766383","display_name":"OXIDATIVE AND EXCITATORY TOXICITY IN NEURODEGENERATION","funder_award_id":"P01AG012992","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1485896673","https://openalex.org/W1489780864","https://openalex.org/W1491889797","https://openalex.org/W1493206792","https://openalex.org/W1522048223","https://openalex.org/W1531415074","https://openalex.org/W1565043637","https://openalex.org/W1565788467","https://openalex.org/W1568727003","https://openalex.org/W1575063854","https://openalex.org/W1577751242","https://openalex.org/W1750171938","https://openalex.org/W1849159432","https://openalex.org/W1962249623","https://openalex.org/W1965271056","https://openalex.org/W1971233715","https://openalex.org/W1972991508","https://openalex.org/W1973055895","https://openalex.org/W1976314401","https://openalex.org/W1976683766","https://openalex.org/W1978190113","https://openalex.org/W1978608872","https://openalex.org/W1985474993","https://openalex.org/W1990623139","https://openalex.org/W1994285647","https://openalex.org/W1996934176","https://openalex.org/W2009789089","https://openalex.org/W2025014286","https://openalex.org/W2026295108","https://openalex.org/W2039376206","https://openalex.org/W2044244805","https://openalex.org/W2051385624","https://openalex.org/W2053836019","https://openalex.org/W2059193992","https://openalex.org/W2062682951","https://openalex.org/W2072396956","https://openalex.org/W2076307303","https://openalex.org/W2090262904","https://openalex.org/W2098203591","https://openalex.org/W2100531197","https://openalex.org/W2102430316","https://openalex.org/W2111856493","https://openalex.org/W2121642311","https://openalex.org/W2125591463","https://openalex.org/W2130826999","https://openalex.org/W2139826556","https://openalex.org/W2143116460","https://openalex.org/W2150489515","https://openalex.org/W2153353641","https://openalex.org/W2166930817","https://openalex.org/W2769888961","https://openalex.org/W2777548161","https://openalex.org/W3141598437","https://openalex.org/W4296930909"],"related_works":["https://openalex.org/W1750171938","https://openalex.org/W1797863618","https://openalex.org/W2009066210","https://openalex.org/W2010411261","https://openalex.org/W2061184262","https://openalex.org/W3195564845","https://openalex.org/W2169307072","https://openalex.org/W2181013731","https://openalex.org/W1966311382","https://openalex.org/W2147480509"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
