{"id":"https://openalex.org/W1997874823","doi":"https://doi.org/10.1073/pnas.102154799","title":"Genome-wide screening for trait conferring genes using DNA microarrays","display_name":"Genome-wide screening for trait conferring genes using DNA microarrays","publication_year":2002,"publication_date":"2002-05-07","ids":{"openalex":"https://openalex.org/W1997874823","doi":"https://doi.org/10.1073/pnas.102154799","mag":"1997874823","pmid":"https://pubmed.ncbi.nlm.nih.gov/11997466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/124523"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.102154799","doi":"https://doi.org/10.1073/pnas.102154799","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.102154799","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/124523","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060354556","display_name":"Ryan T. Gill","orcid":"https://orcid.org/0000-0003-2062-303X","observed_orcids":["https://orcid.org/0000-0003-2062-303X","https://orcid.org/0000-0003-1858-1731","https://orcid.org/0000-0002-4545-233X"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. T. Gill","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I188538660","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062569760","display_name":"Sheryl Wildt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Wildt","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I188538660","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009166110","display_name":"Yea-Tyng Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. T. Yang","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I188538660","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075439582","display_name":"Sara Ziesman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Ziesman","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I188538660","https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I107672454","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22","country_code":"US","type":"education","lineage":["https://openalex.org/I107672454"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139; Dartmouth College Thayer School of Engineering, 8000 Cummings Hall, Hanover, NH 03755; GlycoFi, Inc., 34 South Main Street, Hanover, NH 03755; and Department of Chemical Engineering, UCB424/ECCH111, University of Colorado, Boulder, CO 80309","institution_ids":["https://openalex.org/I107672454","https://openalex.org/I188538660","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4243,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.92761194,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"99","issue":"10","first_page":"7033","last_page":"7038"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.8374000191688538,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.10239999741315842,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-genomics","display_name":"functional genomics","score":0.7649999856948853},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.621999979019165},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8320000171661377},{"id":"https://openalex.org/keywords/plasmid-library","display_name":"plasmid library","score":0.6330000162124634},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.49300000071525574},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.46299999952316284},{"id":"https://openalex.org/keywords/industrial-fermentation","display_name":"industrial fermentation","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8371769189834595},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.807539701461792},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7374213933944702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.609591543674469},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.543170690536499},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5076795816421509},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4664570391178131},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.42335397005081177},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.41917678713798523},{"id":"https://openalex.org/C13575015","wikidata":"https://www.wikidata.org/wiki/Q1562492","display_name":"Genomic library","level":4,"score":0.41460856795310974},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.33392032980918884},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29242146015167236},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.102154799","doi":"https://doi.org/10.1073/pnas.102154799","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.102154799","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:124523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/124523","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:11997466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11997466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:works.bepress.com:thomas_yang-1139","doi":null,"is_oa":false,"landing_page_url":"https://works.bepress.com/thomas_yang/72","pdf_url":null,"source":{"id":"https://openalex.org/S4377196356","display_name":"Scholarly Commons (Embry\u2013Riddle Aeronautical University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84475105","host_organization_name":"Embry\u2013Riddle Aeronautical University","host_organization_lineage":["https://openalex.org/I84475105"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thomas Yang","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:124523","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/124523","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.40450000762939453,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5329720183","display_name":"LINKING GENOMICS TO FUNCTION VIA METABOLIC PHENOTYPING","funder_award_id":"R01DK058533","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1501009591","https://openalex.org/W1512810258","https://openalex.org/W1551627361","https://openalex.org/W1955800727","https://openalex.org/W1970156673","https://openalex.org/W1983849784","https://openalex.org/W1985064413","https://openalex.org/W2073036100","https://openalex.org/W2088445807","https://openalex.org/W2091120384","https://openalex.org/W2105291362","https://openalex.org/W2109465768","https://openalex.org/W2140948740","https://openalex.org/W2144634347","https://openalex.org/W2165011536","https://openalex.org/W2165054897","https://openalex.org/W2313890802","https://openalex.org/W2314225431"],"related_works":["https://openalex.org/W2122784014","https://openalex.org/W1551627361","https://openalex.org/W7098214919","https://openalex.org/W2121593790","https://openalex.org/W2090745153","https://openalex.org/W2122639310","https://openalex.org/W2165701675","https://openalex.org/W2012032664","https://openalex.org/W2082527969","https://openalex.org/W2051199480"],"abstract_inverted_index":{"We":[0,111],"report":[1],"a":[2,19,49,60,63,121,131],"DNA":[3,80,157,166],"microarray-based":[4],"method":[5,56,114,216],"for":[6,128],"genome-wide":[7],"monitoring":[8],"of":[9,36,58,93,137,175,178,188,198,214,222],"competitively":[10],"grown":[11,171],"transformants":[12,71,129],"to":[13,82,227,233],"identify":[14,86],"genes":[15,29,45,99,208,223,230,243,255],"whose":[16],"overexpression":[17],"confers":[18],"specific":[20,50],"cellular":[21,38],"phenotype.":[22],"Whereas":[23],"transcriptional":[24],"profiling":[25],"identifies":[26],"differentially":[27],"expressed":[28],"that":[30,46],"are":[31],"correlated":[32],"with":[33,62,120,201],"particular":[34],"aspects":[35],"the":[37,67,73,87,113,135,138,173,195,211],"phenotype,":[39],"this":[40,215],"functional":[41],"genomics":[42],"approach":[43],"determines":[44],"result":[47],"in":[48,70,108,134,172,225,240,247],"physiology.":[51],"This":[52],"parallel":[53],"gene-trait":[54],"mapping":[55],"consists":[57],"transforming":[59,116],"strain":[61],"genomic":[64,122],"library,":[65],"enriching":[66],"cell":[68,248,252],"population":[69],"containing":[72,159],"trait":[74],"conferring":[75,100,143],"gene(s),":[76],"and":[77,85,126,186,191,261],"finally":[78],"using":[79],"microarrays":[81,158],"simultaneously":[83],"isolate":[84],"enriched":[88,202],"gene":[89,163],"inserts.":[90],"Various":[91],"methods":[92],"enrichment":[94],"can":[95],"be":[96],"used;":[97],"here,":[98],"low-level":[101],"antibiotic":[102,218],"resistance":[103,197,207,219,226,232],"were":[104,152,181],"identified":[105,153,209],"by":[106,115,154,184,193,210],"growth":[107,132,246,257],"selective":[109],"media.":[110],"demonstrated":[112],"Escherichia":[117],"coli":[118,124,162],"cells":[119,170,199],"E.":[123,161],"library":[125,204],"selecting":[127],"exhibiting":[130],"advantage":[133],"presence":[136,174],"anti-microbial":[139],"agent":[140],"Pine-Sol.":[141,179],"Genes":[142],"Pine-Sol":[144,196],"tolerance":[145],"(19":[146],"genes)":[147,151],"or":[148,205,250],"sensitivity":[149],"(27":[150],"hybridizing,":[155],"on":[156,258],"1,160":[160],"probes,":[164],"extra-chromosomal":[165],"isolated":[167],"from":[168],"transformed":[169,200],"various":[176],"levels":[177],"Results":[180],"further":[182],"validated":[183],"plating":[185],"sequencing":[187],"individual":[189,206],"colonies,":[190],"also":[192],"assessing":[194],"plasmid":[203],"microarrays.":[212],"Applications":[213],"beyond":[217],"include":[220],"identification":[221],"resulting":[224],"chemotherapeutic":[228],"agents,":[229],"yielding":[231],"toxic":[234],"products":[235],"(recombinant":[236],"proteins,":[237],"chemical":[238],"feedstocks)":[239],"industrial":[241],"fermentations,":[242,254],"providing":[244],"enhanced":[245],"culture":[249],"high":[251],"density":[253],"facilitating":[256],"unconventional":[259],"substrates,":[260],"others.":[262]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
