{"id":"https://openalex.org/W1997874446","doi":"https://doi.org/10.1016/j.jinorgbio.2009.11.006","title":"How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?","display_name":"How does a valine residue that modulates heme-NO binding kinetics in inducible NO synthase regulate enzyme catalysis?","publication_year":2009,"publication_date":"2009-11-19","ids":{"openalex":"https://openalex.org/W1997874446","doi":"https://doi.org/10.1016/j.jinorgbio.2009.11.006","mag":"1997874446","pmid":"https://pubmed.ncbi.nlm.nih.gov/20006999"},"language":"en","primary_location":{"id":"doi:10.1016/j.jinorgbio.2009.11.006","doi":"https://doi.org/10.1016/j.jinorgbio.2009.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jinorgbio.2009.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S155362585","display_name":"Journal of Inorganic Biochemistry","issn_l":"0162-0134","issn":["0162-0134","1873-3344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inorganic Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100404761","display_name":"Zhiqiang Wang","orcid":"https://orcid.org/0000-0003-3637-8286","observed_orcids":["https://orcid.org/0000-0003-3637-8286"]},"institutions":[{"id":"https://openalex.org/I149910238","display_name":"Kent State University","ror":"https://ror.org/049pfb863","country_code":"US","type":"education","lineage":["https://openalex.org/I149910238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhi-Qiang Wang","raw_affiliation_strings":["Department of Chemistry, Kent State University Tuscarawas, New Philadelphia, OH 44663, United States. zwang3@kent.edu","Department of Chemistry, Kent State University Tuscarawas, New Philadelphia, OH 44663, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Kent State University Tuscarawas, New Philadelphia, OH 44663, United States. zwang3@kent.edu","institution_ids":["https://openalex.org/I149910238"]},{"raw_affiliation_string":"Department of Chemistry, Kent State University Tuscarawas, New Philadelphia, OH 44663, United States","institution_ids":["https://openalex.org/I149910238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025964769","display_name":"Chin\u2010Chuan Wei","orcid":"https://orcid.org/0000-0001-6453-9409","observed_orcids":["https://orcid.org/0000-0001-6453-9409"]},"institutions":[{"id":"https://openalex.org/I87547150","display_name":"Southern Illinois University Edwardsville","ror":"https://ror.org/04cqs5j56","country_code":"US","type":"education","lineage":["https://openalex.org/I2801502357","https://openalex.org/I87547150"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin-Chuan Wei","raw_affiliation_strings":["Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL 62026, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL 62026, United States","institution_ids":["https://openalex.org/I87547150"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067430639","display_name":"Dennis J. Stuehr","orcid":"https://orcid.org/0000-0002-0960-6848","observed_orcids":["https://orcid.org/0000-0002-0960-6848"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dennis J. Stuehr","raw_affiliation_strings":["Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067430639","https://openalex.org/A5100404761"],"corresponding_institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I149910238","https://openalex.org/I4405287411"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":1.2822,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.80614331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"104","issue":"3","first_page":"349","last_page":"356"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.4058000147342682,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.05770000070333481,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.984000027179718},{"id":"https://openalex.org/keywords/nitric-oxide-release","display_name":"nitric oxide release","score":0.48100000619888306},{"id":"https://openalex.org/keywords/nadph-consumption","display_name":"NADPH consumption","score":0.7400000095367432},{"id":"https://openalex.org/keywords/nitrate-formation","display_name":"nitrate formation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"enzyme catalysis","score":0.5139999985694885},{"id":"https://openalex.org/keywords/kinetic-modeling","display_name":"kinetic modeling","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9667266607284546},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.7157822847366333},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.6811609268188477},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6469460725784302},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.6329987049102783},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.6020828485488892},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5499743819236755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.502587080001831},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.47701549530029297},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.4416499733924866},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.1489085555076599},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.11950823664665222},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006418","descriptor_name":"Heme","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009566","descriptor_name":"Nitrates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009573","descriptor_name":"Nitrites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jinorgbio.2009.11.006","doi":"https://doi.org/10.1016/j.jinorgbio.2009.11.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jinorgbio.2009.11.006","pdf_url":null,"source":{"id":"https://openalex.org/S155362585","display_name":"Journal of Inorganic Biochemistry","issn_l":"0162-0134","issn":["0162-0134","1873-3344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Inorganic Biochemistry","raw_type":"journal-article"},{"id":"pmid:20006999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20006999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of inorganic biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1265858740","display_name":null,"funder_award_id":"HL076491","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1934500543","display_name":null,"funder_award_id":"CA-53914","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5516667309","display_name":"Oxidation in Inflammation and Cardiovascular Disease","funder_award_id":"P01HL076491","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5949373188","display_name":null,"funder_award_id":"GM51491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7542777358","display_name":"Control Mechanisms of the Nitric Oxide Synthases","funder_award_id":"R01GM051491","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1481149004","https://openalex.org/W1487443561","https://openalex.org/W1966617758","https://openalex.org/W1967966166","https://openalex.org/W1968973334","https://openalex.org/W1969185821","https://openalex.org/W1971902632","https://openalex.org/W1979424014","https://openalex.org/W1980437634","https://openalex.org/W1986398709","https://openalex.org/W1992392409","https://openalex.org/W1998464495","https://openalex.org/W2000481471","https://openalex.org/W2005280380","https://openalex.org/W2005819238","https://openalex.org/W2012670303","https://openalex.org/W2015242997","https://openalex.org/W2019648546","https://openalex.org/W2025195907","https://openalex.org/W2026623916","https://openalex.org/W2027459039","https://openalex.org/W2045639174","https://openalex.org/W2045814548","https://openalex.org/W2052010010","https://openalex.org/W2052232788","https://openalex.org/W2056420994","https://openalex.org/W2060034829","https://openalex.org/W2063791381","https://openalex.org/W2070314700","https://openalex.org/W2076291690","https://openalex.org/W2077437981","https://openalex.org/W2088330312","https://openalex.org/W2111308105","https://openalex.org/W2114000416","https://openalex.org/W2115153703","https://openalex.org/W2121358285","https://openalex.org/W2137361619","https://openalex.org/W2145892327","https://openalex.org/W2160969115","https://openalex.org/W2166125504","https://openalex.org/W2804007336"],"related_works":["https://openalex.org/W1968973334","https://openalex.org/W2137361619","https://openalex.org/W2573063416","https://openalex.org/W1986398709","https://openalex.org/W63675330","https://openalex.org/W2076291690","https://openalex.org/W2056420994","https://openalex.org/W2927112364","https://openalex.org/W2000481471","https://openalex.org/W2020667687"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}