{"id":"https://openalex.org/W1997833744","doi":"https://doi.org/10.1002/biot.200800213","title":"Efficacy of recombinant anthrax vaccine against Bacillus anthracis aerosol spore challenge: Preclinical evaluation in rabbits and Rhesus monkeys","display_name":"Efficacy of recombinant anthrax vaccine against Bacillus anthracis aerosol spore challenge: Preclinical evaluation in rabbits and Rhesus monkeys","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W1997833744","doi":"https://doi.org/10.1002/biot.200800213","mag":"1997833744","pmid":"https://pubmed.ncbi.nlm.nih.gov/19296443"},"language":"en","primary_location":{"id":"doi:10.1002/biot.200800213","doi":"https://doi.org/10.1002/biot.200800213","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.200800213","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066843652","display_name":"Anil Kumar Chawla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107947710","display_name":"Panacea Biotec (India)","ror":"https://ror.org/01ew11x49","country_code":"IN","type":"company","lineage":["https://openalex.org/I107947710"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anil Chawla","raw_affiliation_strings":["Panacea Biotec Ltd., New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Panacea Biotec Ltd., New Delhi, India","institution_ids":["https://openalex.org/I107947710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006542760","display_name":"Shuchi Midha","orcid":"https://orcid.org/0000-0002-1768-2736","observed_orcids":["https://orcid.org/0000-0002-1768-2736"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shuchi Midha","raw_affiliation_strings":["School of Biotechnology, Jawaharlal Nehru University, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Jawaharlal Nehru University, New Delhi, India","institution_ids":["https://openalex.org/I152429107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015254541","display_name":"Rakesh Bhatnagar","orcid":"https://orcid.org/0000-0001-7184-6378","observed_orcids":["https://orcid.org/0000-0001-7184-6378"]},"institutions":[{"id":"https://openalex.org/I152429107","display_name":"Jawaharlal Nehru University","ror":"https://ror.org/0567v8t28","country_code":"IN","type":"education","lineage":["https://openalex.org/I152429107"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rakesh Bhatnagar","raw_affiliation_strings":["School of Biotechnology, Jawaharlal Nehru University, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biotechnology, Jawaharlal Nehru University, New Delhi, India","institution_ids":["https://openalex.org/I152429107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.6703,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.65946562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"4","issue":"3","first_page":"391","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11515","display_name":"Bacillus and Francisella bacterial research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthrax-vaccine","display_name":"anthrax vaccine","score":0.828000009059906},{"id":"https://openalex.org/keywords/bacillus-anthracis","display_name":"Bacillus anthracis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/protective-efficacy","display_name":"protective efficacy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/toxin-neutralizing-antibodies","display_name":"toxin-neutralizing antibodies","score":0.8320000171661377},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5149999856948853},{"id":"https://openalex.org/keywords/secondary-immune-response","display_name":"secondary immune response","score":0.7379999756813049},{"id":"https://openalex.org/keywords/revaccination","display_name":"revaccination","score":0.9300000071525574},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.7730000019073486},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.6000000238418579},{"id":"https://openalex.org/keywords/lagomorphs","display_name":"lagomorphs","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2780239966","wikidata":"https://www.wikidata.org/wiki/Q614156","display_name":"Bacillus anthracis","level":3,"score":0.872563362121582},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8568828701972961},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.6893607378005981},{"id":"https://openalex.org/C2777289321","wikidata":"https://www.wikidata.org/wiki/Q4007170","display_name":"Anthrax vaccines","level":5,"score":0.6796661615371704},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5728987455368042},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5535896420478821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4880329668521881},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.4833199977874756},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.4635109007358551},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.4633996784687042},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4295833706855774},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42677366733551025},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42482230067253113},{"id":"https://openalex.org/C41810244","wikidata":"https://www.wikidata.org/wiki/Q1935986","display_name":"Anthrax toxin","level":5,"score":0.4217204451560974},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4118482768535614},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.37552598118782043},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.21993917226791382},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10652264952659607},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.08028551936149597},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000336","descriptor_name":"Aerosols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000881","descriptor_name":"Anthrax","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013171","descriptor_name":"Spores, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014614","descriptor_name":"Vaccines, Synthetic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D022122","descriptor_name":"Anthrax Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D022122","descriptor_name":"Anthrax Vaccines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/biot.200800213","doi":"https://doi.org/10.1002/biot.200800213","is_oa":false,"landing_page_url":"https://doi.org/10.1002/biot.200800213","pdf_url":null,"source":{"id":"https://openalex.org/S31411064","display_name":"Biotechnology Journal","issn_l":"1860-6768","issn":["1860-6768","1860-7314"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:19296443","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19296443","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W128966539","https://openalex.org/W1528997679","https://openalex.org/W1548119357","https://openalex.org/W1595576640","https://openalex.org/W1988827698","https://openalex.org/W1990457946","https://openalex.org/W1999871797","https://openalex.org/W2009180810","https://openalex.org/W2030093389","https://openalex.org/W2060463358","https://openalex.org/W2061952369","https://openalex.org/W2076371060","https://openalex.org/W2083603978","https://openalex.org/W2099691221","https://openalex.org/W2103828083","https://openalex.org/W2111635135","https://openalex.org/W2122451783","https://openalex.org/W2135069977","https://openalex.org/W2144645983","https://openalex.org/W2149033760","https://openalex.org/W2149712848","https://openalex.org/W2156440716","https://openalex.org/W2166295037","https://openalex.org/W2189100742","https://openalex.org/W3217730596","https://openalex.org/W4231530219","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2149712848","https://openalex.org/W2060463358","https://openalex.org/W2088014563","https://openalex.org/W2122451783","https://openalex.org/W2138955136","https://openalex.org/W2156740701","https://openalex.org/W2061952369","https://openalex.org/W1996413486","https://openalex.org/W4210516669","https://openalex.org/W2133957205"],"abstract_inverted_index":{"This":[0],"report":[1],"describes":[2],"the":[3,45,58,64,77,84,104,113,123,135,143,159,167],"immunogenicity":[4],"and":[5,20,50,69,91],"protective":[6,12],"efficacy":[7],"of":[8,47,60,67,80,118,142,185,188,191],"Escherichia":[9],"coli-expressed":[10],"recombinant":[11],"antigen":[13],"(rPA)":[14],"in":[15,39,97,107,112,126,132],"New":[16],"Zealand":[17],"White":[18],"rabbits":[19,127],"Rhesus":[21],"Macaques":[22],"against":[23,181],"an":[24],"aerosol":[25],"challenge":[26,180],"with":[27,83],"Bacillus":[28,192],"anthracis":[29],"spores":[30,190],"(IVRI":[31],"strain,":[32],"tox+cap+).":[33],"A":[34],"dose-ranging":[35],"study":[36],"was":[37,54,73,138,164],"performed":[38],"which":[40],"it":[41],"became":[42],"evident":[43],"that":[44,131,170],"level":[46],"anti-PA":[48],"IgG":[49],"toxin-neutralizing":[51],"antibody":[52],"titer":[53,148],"directly":[55],"proportional":[56],"to":[57,109,158],"dose":[59,87,137,184],"rPA":[61],"administered.":[62,139],"However,":[63,140],"onset":[65],"time":[66],"primary":[68],"secondary":[70,93,124],"immune":[71,114],"response":[72,125],"not":[74],"dependent":[75],"on":[76],"dosage.":[78],"Revaccination":[79],"primed":[81],"animals":[82],"same":[85],"threshold":[86],"yielded":[88],"a":[89,119,179,182],"robust":[90],"rapid":[92],"response.":[94],"Quantitative":[95],"differences":[96,111],"peak":[98],"titers":[99,152],"were":[100],"obtained":[101],"for":[102,153,166],"both":[103],"animal":[105],"models,":[106],"addition":[108],"qualitative":[110],"kinetics.":[115],"In":[116],"spite":[117],"weak":[120],"priming":[121],"response,":[122],"peaked":[128],"earlier":[129],"than":[130],"macaques":[133],"once":[134],"booster":[136],"evaluation":[141],"post-challenge":[144],"quantitative":[145],"anti-rPA":[146],"ELISA":[147],"measurements":[149],"indicated":[150],"higher":[151],"non-human":[154],"primates":[155],"as":[156],"compared":[157],"lagomorphs.":[160],"Importantly,":[161],"100%":[162],"protection":[163],"seen":[165],"dosage":[168],"groups":[169],"received":[171],">":[172],"or":[173],"=":[174],"25":[175],"microg":[176],"rPA,":[177],"following":[178],"target":[183],"1000":[186],"LD(50)":[187],"aerosolized":[189],"anthracis.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
