{"id":"https://openalex.org/W1997828131","doi":"https://doi.org/10.1038/nrc1190","title":"Tobacco carcinogens, their biomarkers and tobacco-induced cancer","display_name":"Tobacco carcinogens, their biomarkers and tobacco-induced cancer","publication_year":2003,"publication_date":"2003-11-24","ids":{"openalex":"https://openalex.org/W1997828131","doi":"https://doi.org/10.1038/nrc1190","mag":"1997828131","pmid":"https://pubmed.ncbi.nlm.nih.gov/14570033"},"language":"en","primary_location":{"id":"doi:10.1038/nrc1190","doi":"https://doi.org/10.1038/nrc1190","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc1190","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen S. Hecht","raw_affiliation_strings":["University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA. hecht002@umn.edu","University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA. hecht002@umn.edu","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033402104"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"],"apc_list":null,"apc_paid":null,"fwci":1.9832,"has_fulltext":false,"cited_by_count":1552,"citation_normalized_percentile":{"value":0.90196078,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"3","issue":"10","first_page":"733","last_page":"744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tobacco-carcinogens","display_name":"tobacco carcinogens","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.5619999766349792},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.4690000116825104},{"id":"https://openalex.org/keywords/tobacco-dependence","display_name":"tobacco dependence","score":0.46299999952316284},{"id":"https://openalex.org/keywords/cancer-mechanisms","display_name":"cancer mechanisms","score":0.4790000021457672},{"id":"https://openalex.org/keywords/cancer-mortality","display_name":"cancer mortality","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.8242007493972778},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.799332857131958},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5916783213615417},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.537841796875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5150165557861328},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.4227501451969147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19303447008132935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.091244637966156},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.08148649334907532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07224112749099731}],"mesh":[{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrc1190","doi":"https://doi.org/10.1038/nrc1190","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc1190","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},{"id":"pmid:14570033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14570033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":139,"referenced_works":["https://openalex.org/W32456633","https://openalex.org/W57421333","https://openalex.org/W160168834","https://openalex.org/W164675594","https://openalex.org/W625259072","https://openalex.org/W1042522063","https://openalex.org/W1271072108","https://openalex.org/W1436329033","https://openalex.org/W1526215225","https://openalex.org/W1552528612","https://openalex.org/W1591607269","https://openalex.org/W1603203793","https://openalex.org/W1623520338","https://openalex.org/W1686101687","https://openalex.org/W1753299421","https://openalex.org/W1831956105","https://openalex.org/W1833006660","https://openalex.org/W1839220209","https://openalex.org/W1845273124","https://openalex.org/W1898796903","https://openalex.org/W1908561757","https://openalex.org/W1927465893","https://openalex.org/W1937410408","https://openalex.org/W1959216631","https://openalex.org/W1959953651","https://openalex.org/W1963682115","https://openalex.org/W1963799462","https://openalex.org/W1966368391","https://openalex.org/W1968058930","https://openalex.org/W1973223683","https://openalex.org/W1973556836","https://openalex.org/W1974639168","https://openalex.org/W1975066159","https://openalex.org/W1976056213","https://openalex.org/W1980950142","https://openalex.org/W1981969682","https://openalex.org/W1983090896","https://openalex.org/W1988151751","https://openalex.org/W1992744358","https://openalex.org/W1993423395","https://openalex.org/W1995599815","https://openalex.org/W1997414386","https://openalex.org/W1998880088","https://openalex.org/W1999052515","https://openalex.org/W1999163677","https://openalex.org/W2000051517","https://openalex.org/W2001284911","https://openalex.org/W2007158219","https://openalex.org/W2008778396","https://openalex.org/W2009379675","https://openalex.org/W2009976761","https://openalex.org/W2013597197","https://openalex.org/W2014162693","https://openalex.org/W2014375283","https://openalex.org/W2016455125","https://openalex.org/W2026195203","https://openalex.org/W2028524763","https://openalex.org/W2029484352","https://openalex.org/W2035490871","https://openalex.org/W2040581776","https://openalex.org/W2047015636","https://openalex.org/W2054793011","https://openalex.org/W2054815209","https://openalex.org/W2054909375","https://openalex.org/W2057851080","https://openalex.org/W2058105231","https://openalex.org/W2058284416","https://openalex.org/W2061240002","https://openalex.org/W2061805255","https://openalex.org/W2065634382","https://openalex.org/W2065785187","https://openalex.org/W2068287372","https://openalex.org/W2070611230","https://openalex.org/W2072879324","https://openalex.org/W2076244798","https://openalex.org/W2078466401","https://openalex.org/W2078936452","https://openalex.org/W2084308031","https://openalex.org/W2086498123","https://openalex.org/W2087190470","https://openalex.org/W2088340814","https://openalex.org/W2091661023","https://openalex.org/W2093694529","https://openalex.org/W2095619460","https://openalex.org/W2101324933","https://openalex.org/W2102019569","https://openalex.org/W2102516237","https://openalex.org/W2106195907","https://openalex.org/W2107840333","https://openalex.org/W2109896839","https://openalex.org/W2116515415","https://openalex.org/W2120782836","https://openalex.org/W2122179629","https://openalex.org/W2122499737","https://openalex.org/W2127419402","https://openalex.org/W2130251223","https://openalex.org/W2132373914","https://openalex.org/W2134389473","https://openalex.org/W2135114425","https://openalex.org/W2138076916","https://openalex.org/W2139996385","https://openalex.org/W2140023920","https://openalex.org/W2140729816","https://openalex.org/W2142127718","https://openalex.org/W2143749938","https://openalex.org/W2154784355","https://openalex.org/W2157252210","https://openalex.org/W2158935969","https://openalex.org/W2160139329","https://openalex.org/W2163262670","https://openalex.org/W2164105087","https://openalex.org/W2165328568","https://openalex.org/W2166075028","https://openalex.org/W2166592024","https://openalex.org/W2166625995","https://openalex.org/W2168277240","https://openalex.org/W2168378066","https://openalex.org/W2171924267","https://openalex.org/W2171952036","https://openalex.org/W2182050182","https://openalex.org/W2184491143","https://openalex.org/W2185744628","https://openalex.org/W2189617136","https://openalex.org/W2197835777","https://openalex.org/W2310489318","https://openalex.org/W2318178900","https://openalex.org/W2322496622","https://openalex.org/W2325233893","https://openalex.org/W2413327694","https://openalex.org/W2436681267","https://openalex.org/W2487561638","https://openalex.org/W2507945794","https://openalex.org/W2508807672","https://openalex.org/W2609825121","https://openalex.org/W3022554220","https://openalex.org/W4235739337","https://openalex.org/W4252780045","https://openalex.org/W4300111660","https://openalex.org/W7165159512"],"related_works":["https://openalex.org/W2022981145","https://openalex.org/W2332404483","https://openalex.org/W2115270048","https://openalex.org/W2033670595","https://openalex.org/W1970486150","https://openalex.org/W2047516780","https://openalex.org/W1996479013","https://openalex.org/W1991718233","https://openalex.org/W2074112763","https://openalex.org/W2028690197"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":42},{"year":2025,"cited_by_count":62},{"year":2024,"cited_by_count":67},{"year":2023,"cited_by_count":75},{"year":2022,"cited_by_count":73},{"year":2021,"cited_by_count":111},{"year":2020,"cited_by_count":66},{"year":2019,"cited_by_count":72},{"year":2018,"cited_by_count":71},{"year":2017,"cited_by_count":66},{"year":2016,"cited_by_count":66},{"year":2015,"cited_by_count":67},{"year":2014,"cited_by_count":82},{"year":2013,"cited_by_count":80},{"year":2012,"cited_by_count":79}],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2025-10-10T00:00:00"}