{"id":"https://openalex.org/W1997816482","doi":"https://doi.org/10.1371/journal.pone.0021193","title":"Rescue of Photoreceptor Degeneration by Curcumin in Transgenic Rats with P23H Rhodopsin Mutation","display_name":"Rescue of Photoreceptor Degeneration by Curcumin in Transgenic Rats with P23H Rhodopsin Mutation","publication_year":2011,"publication_date":"2011-06-29","ids":{"openalex":"https://openalex.org/W1997816482","doi":"https://doi.org/10.1371/journal.pone.0021193","mag":"1997816482","pmid":"https://pubmed.ncbi.nlm.nih.gov/21738619","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126808"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0021193","doi":"https://doi.org/10.1371/journal.pone.0021193","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021193","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021193&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021193&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083751316","display_name":"Vidyullatha Vasireddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidyullatha Vasireddy","raw_affiliation_strings":["Jacobs Retina Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012716024","display_name":"Venkata Ramana Murthy Chavali","orcid":"https://orcid.org/0000-0003-3439-3490","observed_orcids":["https://orcid.org/0000-0003-3439-3490"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkata R. M. Chavali","raw_affiliation_strings":["Jacobs Retina Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090624364","display_name":"Victory T. Joseph","orcid":"https://orcid.org/0000-0002-7816-9047","observed_orcids":["https://orcid.org/0000-0002-7816-9047"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victory T. Joseph","raw_affiliation_strings":["Department of Pathology, University of California, San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109012178","display_name":"Rajendra S. Kadam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajendra Kadam","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091772109","display_name":"Jonathan H. Lin","orcid":"https://orcid.org/0000-0002-7438-6941","observed_orcids":["https://orcid.org/0000-0002-7438-6941"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan H. Lin","raw_affiliation_strings":["Department of Pathology, University of California, San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110206874","display_name":"Jeffrey Adam Jamison","orcid":"https://orcid.org/0009-0000-3472-3467","observed_orcids":["https://orcid.org/0009-0000-3472-3467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey A. Jamison","raw_affiliation_strings":["Opthy-DS Inc., Mattawan, Michigan, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Opthy-DS Inc., Mattawan, Michigan, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059534716","display_name":"Uday B. Kompella","orcid":"https://orcid.org/0000-0003-4341-9656","observed_orcids":["https://orcid.org/0000-0003-4341-9656"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uday B. Kompella","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021310920","display_name":"G. Bhanuprakash Reddy","orcid":"https://orcid.org/0000-0003-4787-3944","observed_orcids":["https://orcid.org/0000-0003-4787-3944"]},"institutions":[{"id":"https://openalex.org/I53421241","display_name":"National Institute of Nutrition","ror":"https://ror.org/04970qw83","country_code":"IN","type":"facility","lineage":["https://openalex.org/I37048141","https://openalex.org/I53421241"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Geereddy Bhanuprakash Reddy","raw_affiliation_strings":["National Institute of Nutrition, Hyderabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Nutrition, Hyderabad, India","institution_ids":["https://openalex.org/I53421241"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081971877","display_name":"Radha Ayyagari","orcid":"https://orcid.org/0000-0002-6804-7740","observed_orcids":["https://orcid.org/0000-0002-6804-7740"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Radha Ayyagari","raw_affiliation_strings":["Jacobs Retina Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jacobs Retina Center, Department of Ophthalmology, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081971877"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.9835,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.919407,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"6","issue":"6","first_page":"e21193","last_page":"e21193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinitis-pigmentosa","display_name":"retinitis pigmentosa","score":0.8740000128746033},{"id":"https://openalex.org/keywords/photoreceptor-degeneration","display_name":"photoreceptor degeneration","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/aggregate-dissociation","display_name":"aggregate dissociation","score":0.6869999766349792},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9900000095367432},{"id":"https://openalex.org/keywords/transgenic-rats","display_name":"transgenic rats","score":0.6740000247955322},{"id":"https://openalex.org/keywords/retinal-degeneration-treatment","display_name":"retinal degeneration treatment","score":0.5809999704360962},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C202033177","wikidata":"https://www.wikidata.org/wiki/Q423107","display_name":"Rhodopsin","level":3,"score":0.9207562804222107},{"id":"https://openalex.org/C2781114197","wikidata":"https://www.wikidata.org/wiki/Q847057","display_name":"Retinitis pigmentosa","level":3,"score":0.8036062717437744},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.7570816278457642},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7303370237350464},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.6939181089401245},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6187219023704529},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.524635374546051},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.518017590045929},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5165097117424011},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45304372906684875},{"id":"https://openalex.org/C136238340","wikidata":"https://www.wikidata.org/wiki/Q7251455","display_name":"Protein aggregation","level":2,"score":0.44845977425575256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3278977870941162},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.306765079498291},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2717415690422058},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2222919464111328}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012243","descriptor_name":"Rhodopsin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055647","descriptor_name":"Rats, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0021193","doi":"https://doi.org/10.1371/journal.pone.0021193","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021193","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021193&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3126808","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3126808","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21738619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21738619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.799.4131","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.799.4131","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/dc/f2/pone.0021193.PMC3126808.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:4ba6948e92fe41898a70b7bee8cb27b5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4ba6948e92fe41898a70b7bee8cb27b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 6, p e21193 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0021193","doi":"https://doi.org/10.1371/journal.pone.0021193","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0021193","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0021193&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1027077320","display_name":null,"funder_award_id":"EY018313","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2645995138","display_name":"Influence of eye pigmentation and diabetes on retinal drug delivery","funder_award_id":"R01EY017533","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2856488450","display_name":null,"funder_award_id":"EY020361","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G2920650513","display_name":null,"funder_award_id":"EY 13198","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G5618846443","display_name":"Endoplasmic  Reticulum Stress in Retinal Degeneration","funder_award_id":"K08EY018313","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6638705685","display_name":"Endoplasmic Reticulum Stress in Retinal Degeneration","funder_award_id":"R01EY020846","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G6778246021","display_name":null,"funder_award_id":"EY017533","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8138460794","display_name":"Molecular Mechanisms Underlying Macular Degenerations","funder_award_id":"R01EY013198","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8372365635","display_name":"Development of Small Heat Shock Proteins as Therapeutic Agents in the Eye","funder_award_id":"RC1EY020361","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997816482.pdf","grobid_xml":"https://content.openalex.org/works/W1997816482.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W74993898","https://openalex.org/W110244466","https://openalex.org/W205550050","https://openalex.org/W296450459","https://openalex.org/W1488354648","https://openalex.org/W1522870006","https://openalex.org/W1560301419","https://openalex.org/W1914622032","https://openalex.org/W1923091024","https://openalex.org/W1935939906","https://openalex.org/W1964598017","https://openalex.org/W1964955754","https://openalex.org/W1970286448","https://openalex.org/W1972179974","https://openalex.org/W1974723031","https://openalex.org/W1975398550","https://openalex.org/W1975981582","https://openalex.org/W1983354967","https://openalex.org/W1986168235","https://openalex.org/W1992285241","https://openalex.org/W1993085222","https://openalex.org/W1994019984","https://openalex.org/W1996064503","https://openalex.org/W1996245481","https://openalex.org/W1997149430","https://openalex.org/W2002886165","https://openalex.org/W2003181300","https://openalex.org/W2009633186","https://openalex.org/W2013945303","https://openalex.org/W2017252693","https://openalex.org/W2018935876","https://openalex.org/W2025368485","https://openalex.org/W2039442647","https://openalex.org/W2043158483","https://openalex.org/W2044129677","https://openalex.org/W2044826456","https://openalex.org/W2045806227","https://openalex.org/W2046034472","https://openalex.org/W2047660508","https://openalex.org/W2052717453","https://openalex.org/W2053071424","https://openalex.org/W2056468898","https://openalex.org/W2058095641","https://openalex.org/W2064319275","https://openalex.org/W2065483848","https://openalex.org/W2067574216","https://openalex.org/W2068534497","https://openalex.org/W2072232906","https://openalex.org/W2077000316","https://openalex.org/W2077508733","https://openalex.org/W2079847552","https://openalex.org/W2092917096","https://openalex.org/W2099944142","https://openalex.org/W2104862661","https://openalex.org/W2111320164","https://openalex.org/W2112622836","https://openalex.org/W2122833167","https://openalex.org/W2124162221","https://openalex.org/W2129537255","https://openalex.org/W2131260081","https://openalex.org/W2131357228","https://openalex.org/W2132488072","https://openalex.org/W2136310012","https://openalex.org/W2137101268","https://openalex.org/W2139298839","https://openalex.org/W2141354154","https://openalex.org/W2149788223","https://openalex.org/W2150202137","https://openalex.org/W2159466552","https://openalex.org/W2159879659","https://openalex.org/W2313300734","https://openalex.org/W2318841795","https://openalex.org/W2414341229"],"related_works":["https://openalex.org/W3035215263","https://openalex.org/W2567891411","https://openalex.org/W4221008891","https://openalex.org/W2133655934","https://openalex.org/W2107701611","https://openalex.org/W1994776779","https://openalex.org/W2137101268","https://openalex.org/W3205369287","https://openalex.org/W4213345256","https://openalex.org/W2039442647"],"abstract_inverted_index":{"The":[0],"P23H":[1,146],"mutation":[2,148],"in":[3,47,79,123,140],"the":[4,145],"rhodopsin":[5,8,75,147],"gene":[6,105],"causes":[7],"misfolding,":[9],"altered":[10],"trafficking":[11,157],"and":[12,21,85,107,121,149],"formation":[13],"of":[14,40,45,57,70,81,95,109,116],"insoluble":[15],"aggregates":[16,42,84],"leading":[17],"to":[18,32,97,144],"photoreceptor":[19],"degeneration":[20],"autosomal":[22],"dominant":[23],"retinitis":[24],"pigmentosa":[25],"(RP).":[26],"There":[27],"are":[28],"no":[29],"effective":[30],"therapies":[31],"treat":[33],"this":[34,64],"condition.":[35],"Compounds":[36],"that":[37,68,93,114,131],"enhance":[38],"dissociation":[39,80],"protein":[41,83,156],"may":[43,133],"be":[44],"value":[46],"developing":[48],"new":[49],"treatments":[50],"for":[51],"such":[52],"diseases.":[53],"Anti-protein":[54],"aggregating":[55],"activity":[56],"curcumin":[58,77,96,117,132],"has":[59],"been":[60],"reported":[61],"earlier.":[62],"In":[63],"study":[65],"we":[66,91],"present":[67],"treatment":[69],"COS-7":[71],"cells":[72],"expressing":[73],"mutant":[74,82],"with":[76],"results":[78],"decreases":[86],"endoplasmic":[87],"reticulum":[88],"stress.":[89],"Furthermore":[90],"demonstrate":[92],"administration":[94],"P23H-rhodopsin":[98,124],"transgenic":[99,125],"rats":[100],"improves":[101,118],"retinal":[102,119],"morphology,":[103],"physiology,":[104],"expression":[106],"localization":[108],"rhodopsin.":[110],"Our":[111],"findings":[112],"indicate":[113],"supplementation":[115],"structure":[120],"function":[122],"rats.":[126],"This":[127],"data":[128],"also":[129],"suggest":[130],"serve":[134],"as":[135],"a":[136],"potential":[137],"therapeutic":[138],"agent":[139],"treating":[141],"RP":[142],"due":[143],"perhaps":[150],"other":[151],"degenerative":[152],"diseases":[153],"caused":[154],"by":[155],"defects.":[158]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
