{"id":"https://openalex.org/W1997808348","doi":"https://doi.org/10.1016/s0005-7894(89)80068-1","title":"Neurobiological aspects of PTSD: Review of clinical and preclinical studies","display_name":"Neurobiological aspects of PTSD: Review of clinical and preclinical studies","publication_year":1989,"publication_date":"1989-01-01","ids":{"openalex":"https://openalex.org/W1997808348","doi":"https://doi.org/10.1016/s0005-7894(89)80068-1","mag":"1997808348"},"language":"en","primary_location":{"id":"doi:10.1016/s0005-7894(89)80068-1","doi":"https://doi.org/10.1016/s0005-7894(89)80068-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0005-7894(89)80068-1","pdf_url":null,"source":{"id":"https://openalex.org/S56240272","display_name":"Behavior Therapy","issn_l":"0005-7894","issn":["0005-7894","1878-1888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavior Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0005-7894(89)80068-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071039477","display_name":"John Harrison Krystal","orcid":"https://orcid.org/0000-0001-6952-1726","observed_orcids":["https://orcid.org/0000-0001-6952-1726"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John H. Krystal","raw_affiliation_strings":["Yale University School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071214414","display_name":"Thomas R. Kosten","orcid":"https://orcid.org/0000-0003-1505-555X","observed_orcids":["https://orcid.org/0000-0003-1505-555X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Kosten","raw_affiliation_strings":["Yale University School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009280110","display_name":"Steven Mark Southwick","orcid":"https://orcid.org/0000-0001-6382-4590","observed_orcids":["https://orcid.org/0000-0001-6382-4590"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Southwick","raw_affiliation_strings":["Yale University School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111688232","display_name":"John W Mason","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John W. Mason","raw_affiliation_strings":["Yale University School of Medicine, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale University School of Medicine, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101852828","display_name":"Bruce D. Perry","orcid":"https://orcid.org/0000-0002-5224-1020","observed_orcids":["https://orcid.org/0000-0002-5224-1020"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce D. Perry","raw_affiliation_strings":["University of Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019326658","display_name":"Earl L. Giller","orcid":"https://orcid.org/0000-0003-1273-3650","observed_orcids":["https://orcid.org/0000-0003-1273-3650"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Earl L. Giller","raw_affiliation_strings":["University of Connecticut Health Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut Health Center, USA","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071039477"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":{"value":3600,"currency":"USD","value_usd":3600},"fwci":11.0214,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.98674399,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"2","first_page":"177","last_page":"198"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10242","display_name":"Posttraumatic Stress Disorder Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/posttraumatic-stress-disorder","display_name":"post-traumatic stress disorder","score":1.0},{"id":"https://openalex.org/keywords/neurobiology-of-ptsd","display_name":"neurobiology of PTSD","score":0.8100000023841858},{"id":"https://openalex.org/keywords/noradrenergic-system","display_name":"noradrenergic system","score":0.8730000257492065},{"id":"https://openalex.org/keywords/central-noradrenergic-system","display_name":"central noradrenergic system","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.8100000023841858},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.7667263150215149},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5620391964912415},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.45356297492980957},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.4306425452232361},{"id":"https://openalex.org/C2778159538","wikidata":"https://www.wikidata.org/wiki/Q16920843","display_name":"Traumatic stress","level":2,"score":0.41950929164886475},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.39631569385528564},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3226003646850586}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0005-7894(89)80068-1","doi":"https://doi.org/10.1016/s0005-7894(89)80068-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0005-7894(89)80068-1","pdf_url":null,"source":{"id":"https://openalex.org/S56240272","display_name":"Behavior Therapy","issn_l":"0005-7894","issn":["0005-7894","1878-1888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavior Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0005-7894(89)80068-1","doi":"https://doi.org/10.1016/s0005-7894(89)80068-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0005-7894(89)80068-1","pdf_url":null,"source":{"id":"https://openalex.org/S56240272","display_name":"Behavior Therapy","issn_l":"0005-7894","issn":["0005-7894","1878-1888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavior Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":129,"referenced_works":["https://openalex.org/W64840021","https://openalex.org/W84757814","https://openalex.org/W144537577","https://openalex.org/W169719707","https://openalex.org/W216195138","https://openalex.org/W305771979","https://openalex.org/W395325289","https://openalex.org/W1485941496","https://openalex.org/W1495361958","https://openalex.org/W1496228533","https://openalex.org/W1533541462","https://openalex.org/W1536005845","https://openalex.org/W1608244379","https://openalex.org/W1632330746","https://openalex.org/W1794165588","https://openalex.org/W1941492178","https://openalex.org/W1963657327","https://openalex.org/W1965174921","https://openalex.org/W1965486589","https://openalex.org/W1967411514","https://openalex.org/W1970873815","https://openalex.org/W1975899950","https://openalex.org/W1977777390","https://openalex.org/W1986182757","https://openalex.org/W1990763137","https://openalex.org/W1992075553","https://openalex.org/W1993695183","https://openalex.org/W1997076092","https://openalex.org/W1997619239","https://openalex.org/W1998463401","https://openalex.org/W2005499716","https://openalex.org/W2008392891","https://openalex.org/W2009107728","https://openalex.org/W2009637266","https://openalex.org/W2010831794","https://openalex.org/W2011124290","https://openalex.org/W2012190885","https://openalex.org/W2012660314","https://openalex.org/W2015393465","https://openalex.org/W2015915038","https://openalex.org/W2016014417","https://openalex.org/W2018305202","https://openalex.org/W2019052063","https://openalex.org/W2019246999","https://openalex.org/W2020351798","https://openalex.org/W2022360250","https://openalex.org/W2023396068","https://openalex.org/W2023627293","https://openalex.org/W2023920288","https://openalex.org/W2024465718","https://openalex.org/W2025074303","https://openalex.org/W2025620801","https://openalex.org/W2038458953","https://openalex.org/W2039022088","https://openalex.org/W2039787804","https://openalex.org/W2040149431","https://openalex.org/W2043851316","https://openalex.org/W2045518055","https://openalex.org/W2048526432","https://openalex.org/W2050611097","https://openalex.org/W2053936534","https://openalex.org/W2058912717","https://openalex.org/W2059061558","https://openalex.org/W2061444572","https://openalex.org/W2067210690","https://openalex.org/W2067854158","https://openalex.org/W2069618749","https://openalex.org/W2069937065","https://openalex.org/W2070294070","https://openalex.org/W2074309550","https://openalex.org/W2076550025","https://openalex.org/W2077624336","https://openalex.org/W2078629064","https://openalex.org/W2079613053","https://openalex.org/W2080951134","https://openalex.org/W2081565428","https://openalex.org/W2083040408","https://openalex.org/W2084234201","https://openalex.org/W2084407974","https://openalex.org/W2086052014","https://openalex.org/W2087519774","https://openalex.org/W2088739421","https://openalex.org/W2090216900","https://openalex.org/W2090770416","https://openalex.org/W2091845852","https://openalex.org/W2092524391","https://openalex.org/W2093659331","https://openalex.org/W2094700723","https://openalex.org/W2095159956","https://openalex.org/W2098896251","https://openalex.org/W2099676946","https://openalex.org/W2106528529","https://openalex.org/W2113962949","https://openalex.org/W2117124138","https://openalex.org/W2126659959","https://openalex.org/W2133466515","https://openalex.org/W2133753087","https://openalex.org/W2142520629","https://openalex.org/W2147942172","https://openalex.org/W2148824045","https://openalex.org/W2155062443","https://openalex.org/W2163586068","https://openalex.org/W2163665549","https://openalex.org/W2271338879","https://openalex.org/W2275523919","https://openalex.org/W2279003107","https://openalex.org/W2284117571","https://openalex.org/W2284807647","https://openalex.org/W2311458018","https://openalex.org/W2315640557","https://openalex.org/W2317595466","https://openalex.org/W2322395010","https://openalex.org/W2324000709","https://openalex.org/W2336762688","https://openalex.org/W2397295349","https://openalex.org/W2408639507","https://openalex.org/W2409174854","https://openalex.org/W2412767205","https://openalex.org/W2413756602","https://openalex.org/W2415792362","https://openalex.org/W2418364368","https://openalex.org/W2432696810","https://openalex.org/W2469628954","https://openalex.org/W2502062134","https://openalex.org/W2581969695","https://openalex.org/W2801694951","https://openalex.org/W2971932065","https://openalex.org/W3025807491","https://openalex.org/W6694704313"],"related_works":["https://openalex.org/W7220641537","https://openalex.org/W2085725087","https://openalex.org/W2076507685","https://openalex.org/W1973801497","https://openalex.org/W2382079394","https://openalex.org/W1976482293","https://openalex.org/W2079922358","https://openalex.org/W1762395023","https://openalex.org/W2550807593","https://openalex.org/W7223208900"],"abstract_inverted_index":{"Although":[0],"physiologic":[1],"studies":[2,33],"of":[3,46],"post-traumatic":[4],"stress":[5],"disorder":[6],"(PTSD)":[7],"date":[8],"to":[9,35],"World":[10],"War":[11],"I,":[12],"clinical":[13,30],"neuroscience":[14],"has":[15],"only":[16],"recently":[17],"explored":[18],"biological":[19,36],"mechanisms":[20],"involved":[21],"in":[22,50],"this":[23],"disorder.":[24],"This":[25],"review":[26],"will":[27],"selectively":[28],"consider":[29],"and":[31,38],"preclinical":[32],"pertaining":[34],"theories":[37],"pharmacological":[39],"treatments":[40],"for":[41],"PTSD,":[42],"highlighting":[43],"the":[44],"role":[45],"central":[47],"noradrenergic":[48],"systems":[49],"its":[51],"pathophysiology.":[52]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}