{"id":"https://openalex.org/W1997795708","doi":"https://doi.org/10.1021/bi00648a007","title":"On the solution conformation of bradykinin and certain fragments","display_name":"On the solution conformation of bradykinin and certain fragments","publication_year":1976,"publication_date":"1976-02-10","ids":{"openalex":"https://openalex.org/W1997795708","doi":"https://doi.org/10.1021/bi00648a007","mag":"1997795708","pmid":"https://pubmed.ncbi.nlm.nih.gov/3198"},"language":"en","primary_location":{"id":"doi:10.1021/bi00648a007","doi":"https://doi.org/10.1021/bi00648a007","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00648a007","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064117583","display_name":"John R. CANN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R. Cann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"John M. Stewart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Stewart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002756514","display_name":"Robert E. London","orcid":"https://orcid.org/0000-0001-9108-8463","observed_orcids":["https://orcid.org/0000-0001-9108-8463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E. London","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111842278","display_name":"Nicholas A. Matwiyoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas Matwiyoff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8677,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.83919205,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"3","first_page":"498","last_page":"504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":1.0},{"id":"https://openalex.org/keywords/peptide-conformation","display_name":"peptide conformation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"circular dichroism","score":0.8989999890327454},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.7960000038146973},{"id":"https://openalex.org/keywords/solute-solvent-interactions","display_name":"solute-solvent interactions","score":0.8769999742507935},{"id":"https://openalex.org/keywords/water-structure","display_name":"water structure","score":0.5659999847412109},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.6899999976158142},{"id":"https://openalex.org/keywords/ph-effect","display_name":"pH effect","score":0.5339999794960022},{"id":"https://openalex.org/keywords/cis-trans-isomerization","display_name":"cis-trans isomerization","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8041439652442932},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.7386105060577393},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.710902988910675},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.6001467108726501},{"id":"https://openalex.org/C192468462","wikidata":"https://www.wikidata.org/wiki/Q533543","display_name":"Chromophore","level":2,"score":0.580207347869873},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5628517270088196},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5075010657310486},{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.45965638756752014},{"id":"https://openalex.org/C189010761","wikidata":"https://www.wikidata.org/wiki/Q7924663","display_name":"Vibrational circular dichroism","level":3,"score":0.4515012800693512},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.44249817728996277},{"id":"https://openalex.org/C126661725","wikidata":"https://www.wikidata.org/wiki/Q903420","display_name":"Isomerization","level":3,"score":0.4405686855316162},{"id":"https://openalex.org/C2780471494","wikidata":"https://www.wikidata.org/wiki/Q146505","display_name":"Solvent","level":2,"score":0.4184321165084839},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.22979485988616943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14455625414848328},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.13985371589660645},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.1254955232143402},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09220856428146362},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001920","descriptor_name":"Bradykinin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00648a007","doi":"https://doi.org/10.1021/bi00648a007","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00648a007","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:3198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.75}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1964371444","https://openalex.org/W1966151964","https://openalex.org/W1977563992","https://openalex.org/W1992525544","https://openalex.org/W2020354534","https://openalex.org/W2022104080","https://openalex.org/W2059014277","https://openalex.org/W2064542810","https://openalex.org/W2074838375","https://openalex.org/W2090604290","https://openalex.org/W2103387360","https://openalex.org/W2136917986","https://openalex.org/W2950331531"],"related_works":["https://openalex.org/W168932348","https://openalex.org/W1584656138","https://openalex.org/W2414349347","https://openalex.org/W2043920377","https://openalex.org/W2069548173","https://openalex.org/W2140754062","https://openalex.org/W2029552077","https://openalex.org/W2005634255","https://openalex.org/W2059176653","https://openalex.org/W1987610549"],"abstract_inverted_index":{"A":[0],"circular":[1],"dichroism":[2],"(CD)":[3],"study":[4],"of":[5,31,36,46,54,67,74,87,115,127,141,153,160,166],"[D-Pro2]-":[6],"and":[7,12,79,117,173],"[D-Pro3]-bradykinin,":[8],"selected":[9],"peptide":[10,143],"fragments,":[11],"the":[13,26,42,47,51,55,64,72,75,85,96,125,139,142,151,155,158,170],"model":[14],"compound.":[15],"N-acetyl-L-phenylalaninamide,":[16],"support":[17],"our":[18],"previous":[19],"conclusion":[20],"(Biochemistry":[21],"12,":[22],"3780,":[23],"1973)":[24],"that":[25,63,124,150],"positive":[27,113],"221-nm":[28],"CD":[29,159],"band":[30,44,53,66],"bradykinin":[32],"is":[33,69,120,162],"a":[34,107,134],"composite":[35],"bands":[37],"due":[38],"to":[39,101,122,183],"two":[40],"chromophores,":[41],"217-nm":[43],"characteristic":[45],"Phe":[48],"residues":[49],"overlying":[50],"223-nm":[52,65],"N-terminal":[56],"sequence,":[57,77],"Arg-Pro-Pro.":[58],"The":[59],"results":[60],"also":[61],"indicate":[62],"Arg-Pro-Pro":[68,88,105,161],"associated":[70],"with":[71,180],"configuration":[73],"Pro-Pro":[76],"Arg-D-Pro-Pro":[78],"Arg-Pro-D-Pro":[80],"virtually":[81],"being":[82],"diastereoisomers.":[83],"Accordingly,":[84],"conformation":[86,140],"was":[89],"probed":[90],"in":[91,137,164],"further":[92],"detail.":[93],"Upon":[94],"increasing":[95],"temperature":[97],"from":[98],"about":[99],"27":[100],"65":[102],"degrees":[103],"C,":[104],"undergoes":[106],"conformational":[108],"transition":[109],"characterized":[110],"by":[111],"large":[112],"values":[114],"deltaHdegrees":[116],"deltaSdegrees,":[118],"which":[119],"interpreted":[121],"mean":[123],"structure":[126],"water":[128],"and,":[129],"thus,":[130],"solute-solvent":[131],"interactions":[132],"play":[133],"dominant":[135],"role":[136],"determining":[138],"13C":[144],"nuclear":[145],"magnetic":[146],"resonance":[147],"spectroscopy":[148],"indicates":[149],"effect":[152],"lowering":[154],"pH":[156,179],"on":[157],"explicable":[163],"terms":[165],"hydrogen-bond":[167],"formation":[168],"between":[169],"carboxyl":[171],"group":[172],"Pro2":[174],"carbonyl":[175],"oxygen":[176],"at":[177],"acid":[178],"concomitant":[181],"cis":[182],"trans":[184],"isomerization.":[185]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
