{"id":"https://openalex.org/W1997756754","doi":"https://doi.org/10.1111/j.1365-2133.1992.tb00003.x","title":"Azoles, a48 llylamines and drug metabolism","display_name":"Azoles, a48 llylamines and drug metabolism","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W1997756754","doi":"https://doi.org/10.1111/j.1365-2133.1992.tb00003.x","mag":"1997756754","pmid":"https://pubmed.ncbi.nlm.nih.gov/1311943"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2133.1992.tb00003.x","doi":"https://doi.org/10.1111/j.1365-2133.1992.tb00003.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1992.tb00003.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111623558","display_name":"David J. Back","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D.J. BACK","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113603410","display_name":"J. Tjia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J.F. TJIA","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":null,"display_name":"S.M. ABEL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.M. ABEL","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111623558"],"corresponding_institution_ids":["https://openalex.org/I146655781"],"apc_list":{"value":3731,"currency":"GBP","value_usd":4920},"apc_paid":null,"fwci":4.7436,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.94683393,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"126","issue":"s39","first_page":"14","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azoles","display_name":"azoles","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ketoconazole","display_name":"ketoconazole","score":0.9120000004768372},{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":1.0},{"id":"https://openalex.org/keywords/fluconazole","display_name":"fluconazole","score":1.0},{"id":"https://openalex.org/keywords/terbinafine","display_name":"terbinafine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cortisol-metabolism","display_name":"cortisol metabolism","score":0.968999981880188},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7350000143051147},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.75},{"id":"https://openalex.org/keywords/antifungal-agents","display_name":"antifungal agents","score":0.6389999985694885},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C2781064554","wikidata":"https://www.wikidata.org/wiki/Q407883","display_name":"Ketoconazole","level":3,"score":0.9717174768447876},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.9535529613494873},{"id":"https://openalex.org/C2778236110","wikidata":"https://www.wikidata.org/wiki/Q415259","display_name":"Terbinafine","level":4,"score":0.857846736907959},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.8533248901367188},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7649298310279846},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.5610882043838501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5386959910392761},{"id":"https://openalex.org/C2778927588","wikidata":"https://www.wikidata.org/wiki/Q417414","display_name":"Allylamine","level":4,"score":0.4229728877544403},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.414715975522995},{"id":"https://openalex.org/C2780315139","wikidata":"https://www.wikidata.org/wiki/Q419639","display_name":"Azole","level":3,"score":0.4130082130432129},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.38126951456069946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27368831634521484},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2156948447227478},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.16240686178207397},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.06873363256454468},{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077291","descriptor_name":"Terbinafine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001393","descriptor_name":"Azoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007654","descriptor_name":"Ketoconazole","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009281","descriptor_name":"Naphthalenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016572","descriptor_name":"Cyclosporine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2133.1992.tb00003.x","doi":"https://doi.org/10.1111/j.1365-2133.1992.tb00003.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2133.1992.tb00003.x","pdf_url":null,"source":{"id":"https://openalex.org/S45720283","display_name":"British Journal of Dermatology","issn_l":"0007-0963","issn":["0007-0963","1365-2133"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Dermatology","raw_type":"journal-article"},{"id":"pmid:1311943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1311943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1951469402","https://openalex.org/W1971920484","https://openalex.org/W1977986691","https://openalex.org/W1987394133","https://openalex.org/W1988858173","https://openalex.org/W1991533040","https://openalex.org/W2001350377","https://openalex.org/W2006096467","https://openalex.org/W2022991426","https://openalex.org/W2031215995","https://openalex.org/W2037930245","https://openalex.org/W2041002279","https://openalex.org/W2056900917","https://openalex.org/W2061782067","https://openalex.org/W2065670181","https://openalex.org/W2067992057","https://openalex.org/W2069956938","https://openalex.org/W2077646228","https://openalex.org/W2086728030","https://openalex.org/W2091509247","https://openalex.org/W2091609012","https://openalex.org/W2118675340","https://openalex.org/W2132378921","https://openalex.org/W2134676888","https://openalex.org/W3189204461"],"related_works":["https://openalex.org/W2127288395","https://openalex.org/W2076565275","https://openalex.org/W1979981878","https://openalex.org/W7146179490","https://openalex.org/W2117005188","https://openalex.org/W2329139209","https://openalex.org/W3126002247","https://openalex.org/W1939608787","https://openalex.org/W2086728030","https://openalex.org/W2005805731"],"abstract_inverted_index":{"Four":[0],"antifungal":[1],"drugs,":[2],"the":[3,10,19,64,67,99,106,156,207],"azoles":[4],"ketoconazole,":[5],"itraconazole":[6,69,165,194],"and":[7,9,25,46,50,57,81,83,133,150,193],"fluconazole,":[8],"allylamine":[11],"terbinafine,":[12],"were":[13,85,93],"studied":[14],"for":[15,95],"their":[16],"effects":[17],"on":[18],"metabolism":[20,112,126],"of":[21,40,53,66,76,98,101,110,124,147,177,184,188],"cyclosporin":[22],"A":[23],"(CyA)":[24],"cortisol":[26,111,125],"by":[27],"human":[28],"liver":[29],"microsomes":[30],"in":[31,198],"vitro":[32],"(n":[33],"=":[34,117,128],"3).":[35],"Ketoconazole":[36,104],"produced":[37,121],"marked":[38,122],"inhibition":[39,123,157],"CyA":[41,189],"hydroxylase":[42],"(to":[43,113],"metabolites":[44],"M17":[45],"M1)":[47],"with":[48,158,164,190],"IC50":[49,116],"Ki":[51],"values":[52],"0.24":[54],"+/-":[55,59,78],"0.01":[56],"0.022":[58],"0.004":[60],"microM,":[61],"respectively.":[62],"On":[63],"basis":[65],"IC50,":[68],"was":[70,105,160],"10":[71],"times":[72],"less":[73,162],"potent":[74,108,145],"(IC50":[75,127],"2.2":[77],"0.2":[79],"microM),":[80,130],"fluconazole":[82,132,159,178,192],"terbinafine":[84,96,134,203],"each":[86],"above":[87],"100":[88],"microM.":[89],"No":[90],"kinetic":[91],"parameters":[92],"calculated":[94],"because":[97],"lack":[100],"inhibitory":[102],"effects.":[103],"most":[107],"inhibitor":[109,146],"6":[114],"beta-hydroxycortisol,":[115],"0.6":[118],"microM).":[119],"Itraconazole":[120],"2.4":[129],"but":[131],"had":[135],"little":[136],"effect.":[137],"These":[138],"data":[139],"confirm":[140],"that":[141,173,183],"ketoconazole":[142],"is":[143],"a":[144],"cytochrome":[148],"P-450-IIIA4,":[149],"this":[151],"has":[152],"clinical":[153],"relevance.":[154],"Although":[155],"much":[161,180],"than":[163,182],"at":[166],"equimolar":[167],"concentrations,":[168],"it":[169],"should":[170],"be":[171],"noted":[172],"in-vivo":[174],"plasma":[175],"concentrations":[176],"are":[179],"greater":[181],"itraconazole.":[185],"Clinical":[186],"interactions":[187],"both":[191],"have":[195,206],"been":[196],"reported;":[197],"contrast":[199],"to":[200],"these":[201],"azoles,":[202],"does":[204],"not":[205],"same":[208],"interaction":[209],"potential.":[210]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}