{"id":"https://openalex.org/W1997744972","doi":"https://doi.org/10.1016/j.jaut.2011.05.001","title":"Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: Studies using HLA transgenic mice","display_name":"Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: Studies using HLA transgenic mice","publication_year":2011,"publication_date":"2011-06-22","ids":{"openalex":"https://openalex.org/W1997744972","doi":"https://doi.org/10.1016/j.jaut.2011.05.001","mag":"1997744972","pmid":"https://pubmed.ncbi.nlm.nih.gov/21632210","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173604"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaut.2011.05.001","doi":"https://doi.org/10.1016/j.jaut.2011.05.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaut.2011.05.001","pdf_url":null,"source":{"id":"https://openalex.org/S187826688","display_name":"Journal of Autoimmunity","issn_l":"0896-8411","issn":["0896-8411","1095-9157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autoimmunity","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173604","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111730342","display_name":"David H. Luckey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Luckey","raw_affiliation_strings":["Immunology Department, Mayo Clinic, 200 Ist ST SW, Rochester, MN 55905, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Department, Mayo Clinic, 200 Ist ST SW, Rochester, MN 55905, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022564183","display_name":"Dikshya Bastakoty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dikshya Bastakoty","raw_affiliation_strings":["Immunology Department, Mayo Clinic, 200 Ist ST SW, Rochester, MN 55905, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Department, Mayo Clinic, 200 Ist ST SW, Rochester, MN 55905, United States","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005548506","display_name":"Ashutosh Kumar Mangalam","orcid":"https://orcid.org/0000-0002-9926-2531","observed_orcids":["https://orcid.org/0000-0002-9926-2531"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashutosh K. Mangalam","raw_affiliation_strings":["Immunology Department, Mayo Clinic, 200 Ist ST SW, Rochester, MN 55905, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Department, Mayo Clinic, 200 Ist ST SW, Rochester, MN 55905, United States","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005548506"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5420,"currency":"USD","value_usd":5420},"apc_paid":null,"fwci":4.8722,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.95075547,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"37","issue":"2","first_page":"122","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hla-class-ii","display_name":"HLA class II","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hla-dr3","display_name":"HLA-DR3","score":0.9549999833106995},{"id":"https://openalex.org/keywords/hla-dq6","display_name":"HLA-DQ6","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hla-dq8","display_name":"HLA-DQ8","score":1.0},{"id":"https://openalex.org/keywords/hla-transgenic-mice","display_name":"HLA transgenic mice","score":0.9269999861717224},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.5400000214576721},{"id":"https://openalex.org/keywords/disease-resistance","display_name":"disease resistance","score":0.9229999780654907},{"id":"https://openalex.org/keywords/epistasis","display_name":"epistasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.9919999837875366},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8220000267028809},{"id":"https://openalex.org/keywords/il-17","display_name":"IL-17","score":0.9610000252723694},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.578000009059906},{"id":"https://openalex.org/keywords/autoimmune-disease-genetics","display_name":"autoimmune disease genetics","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6099850535392761},{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.5918771028518677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5902294516563416},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5748823881149292},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5517305731773376},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5160486102104187},{"id":"https://openalex.org/C2779910283","wikidata":"https://www.wikidata.org/wiki/Q5630144","display_name":"HLA-DQ","level":5,"score":0.5091728568077087},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4992702007293701},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4286724328994751},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.4265742301940918},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.4124809503555298},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38048917055130005},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.25754308700561523},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2559318542480469},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25332075357437134},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2083958089351654}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005802","descriptor_name":"Genes, MHC Class II","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006680","descriptor_name":"HLA Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018991","descriptor_name":"Myelin Proteolipid Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059647","descriptor_name":"Gene-Environment Interaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.jaut.2011.05.001","doi":"https://doi.org/10.1016/j.jaut.2011.05.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jaut.2011.05.001","pdf_url":null,"source":{"id":"https://openalex.org/S187826688","display_name":"Journal of Autoimmunity","issn_l":"0896-8411","issn":["0896-8411","1095-9157"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autoimmunity","raw_type":"journal-article"},{"id":"pmid:21632210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21632210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of autoimmunity","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2434379","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173604","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3173604","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173604","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Autoimmun","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2434379","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3173604","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4529276145","display_name":null,"funder_award_id":"NS52173","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6584409915","display_name":"Role of HLA Class II Genes in Demyelination","funder_award_id":"R01NS052173","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1499797787","https://openalex.org/W1523316823","https://openalex.org/W1543555882","https://openalex.org/W1563564485","https://openalex.org/W1656161741","https://openalex.org/W1959664751","https://openalex.org/W1964111698","https://openalex.org/W1964368494","https://openalex.org/W1971405237","https://openalex.org/W1972772893","https://openalex.org/W1977658278","https://openalex.org/W1983983303","https://openalex.org/W1986545980","https://openalex.org/W1986600083","https://openalex.org/W1987961062","https://openalex.org/W1988266758","https://openalex.org/W1989848313","https://openalex.org/W1992731679","https://openalex.org/W1993276441","https://openalex.org/W1993399246","https://openalex.org/W1994469616","https://openalex.org/W1997738088","https://openalex.org/W1999081805","https://openalex.org/W2008269948","https://openalex.org/W2013942488","https://openalex.org/W2023183597","https://openalex.org/W2024490058","https://openalex.org/W2033196846","https://openalex.org/W2036686265","https://openalex.org/W2036981744","https://openalex.org/W2038079382","https://openalex.org/W2043938939","https://openalex.org/W2048327985","https://openalex.org/W2051917792","https://openalex.org/W2053141800","https://openalex.org/W2054025178","https://openalex.org/W2054254705","https://openalex.org/W2063798082","https://openalex.org/W2067673683","https://openalex.org/W2075242957","https://openalex.org/W2077915791","https://openalex.org/W2083272188","https://openalex.org/W2083903006","https://openalex.org/W2087398290","https://openalex.org/W2087963310","https://openalex.org/W2088437362","https://openalex.org/W2090074842","https://openalex.org/W2097276049","https://openalex.org/W2098496021","https://openalex.org/W2098814367","https://openalex.org/W2100395699","https://openalex.org/W2103780230","https://openalex.org/W2104212738","https://openalex.org/W2110093006","https://openalex.org/W2111536363","https://openalex.org/W2116104996","https://openalex.org/W2117789067","https://openalex.org/W2118000101","https://openalex.org/W2119308919","https://openalex.org/W2122985749","https://openalex.org/W2123918701","https://openalex.org/W2128103207","https://openalex.org/W2134156548","https://openalex.org/W2145741730","https://openalex.org/W2161881476","https://openalex.org/W2161929126","https://openalex.org/W2162655879","https://openalex.org/W2169117079","https://openalex.org/W2169908075","https://openalex.org/W2171571685","https://openalex.org/W2171925564","https://openalex.org/W2173694857","https://openalex.org/W2312996869","https://openalex.org/W6633609642"],"related_works":["https://openalex.org/W1656161741","https://openalex.org/W1543555882","https://openalex.org/W4313408001","https://openalex.org/W2077915791","https://openalex.org/W4313305882","https://openalex.org/W14232561","https://openalex.org/W3192179077","https://openalex.org/W1560339503","https://openalex.org/W1992731679","https://openalex.org/W2104144522"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}