{"id":"https://openalex.org/W1997733749","doi":"https://doi.org/10.2165/00063030-200013050-00007","title":"Are There Differences in Methotrexate Kinetics Between Responding and Nonresponding Patients with Rheumatoid Arthritis?","display_name":"Are There Differences in Methotrexate Kinetics Between Responding and Nonresponding Patients with Rheumatoid Arthritis?","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W1997733749","doi":"https://doi.org/10.2165/00063030-200013050-00007","mag":"1997733749","pmid":"https://pubmed.ncbi.nlm.nih.gov/18034543"},"language":"en","primary_location":{"id":"doi:10.2165/00063030-200013050-00007","doi":"https://doi.org/10.2165/00063030-200013050-00007","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00063030-200013050-00007","pdf_url":null,"source":{"id":"https://openalex.org/S143194599","display_name":"BioDrugs","issn_l":"1172-7039","issn":["1172-7039","1173-8804","1179-190X","2195-8351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioDrugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112094532","display_name":"Dom\u00eanico Capone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Domenico Capone","raw_affiliation_strings":["Department of Neurosciences, Section of Pharmacology, School of Medicine, Federico II University, Naples, Italy. domenicocapone@hotmail.com","Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, Federico II University, Naples, Italy. domenicocapone@hotmail.com","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103333642","display_name":"Angelo Span\u00f2","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Spano","raw_affiliation_strings":["Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101451574","display_name":"Antonio Gentile","orcid":"https://orcid.org/0000-0001-6861-4234","observed_orcids":["https://orcid.org/0000-0001-6861-4234"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Gentile","raw_affiliation_strings":["Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Via S. Pansini, 5-80131, Naples, Italy","Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Via S. Pansini, 5-80131, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030415829","display_name":"Giuseppe Ferrara","orcid":"https://orcid.org/0000-0002-0774-8279","observed_orcids":["https://orcid.org/0000-0002-0774-8279","https://orcid.org/0009-0000-5666-7355"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Ferrara","raw_affiliation_strings":["Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050284054","display_name":"Elena Itto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elena Itto","raw_affiliation_strings":["Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079709551","display_name":"Giuseppe Palmiero","orcid":"https://orcid.org/0000-0002-5102-7460","observed_orcids":["https://orcid.org/0000-0002-5102-7460"]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppe Palmiero","raw_affiliation_strings":["Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Via S. Pansini, 5-80131, Naples, Italy","Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Via S. Pansini, 5-80131, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vincenzo Basile","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Basile","raw_affiliation_strings":["Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Via S. Pansini, 5-80131, Naples, Italy","Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Via S. Pansini, 5-80131, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]},{"raw_affiliation_string":"Department of Neurosciences, Section of Pharmacology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111627155","display_name":"Pasquale Oriente","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasquale Oriente","raw_affiliation_strings":["Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Rheumatology, School of Medicine, \u2018Federico II\u2019 University, Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112094532"],"corresponding_institution_ids":["https://openalex.org/I71267560"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.2188,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.53982995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"5","first_page":"373","last_page":"379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7950000166893005},{"id":"https://openalex.org/keywords/intramuscular-methotrexate","display_name":"intramuscular methotrexate","score":0.8019999861717224},{"id":"https://openalex.org/keywords/low-dose-methotrexate","display_name":"low-dose methotrexate","score":0.871999979019165},{"id":"https://openalex.org/keywords/time-to-maximum-concentration","display_name":"time to peak concentration","score":0.6880000233650208},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.6019999980926514},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.8919209241867065},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8435392379760742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.601883590221405},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5625675320625305},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4719392657279968},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4323105216026306},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4250366985797882},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30475935339927673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29997339844703674},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2165/00063030-200013050-00007","doi":"https://doi.org/10.2165/00063030-200013050-00007","is_oa":false,"landing_page_url":"https://doi.org/10.2165/00063030-200013050-00007","pdf_url":null,"source":{"id":"https://openalex.org/S143194599","display_name":"BioDrugs","issn_l":"1172-7039","issn":["1172-7039","1173-8804","1179-190X","2195-8351"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioDrugs","raw_type":"journal-article"},{"id":"pmid:18034543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18034543","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W6014000","https://openalex.org/W46893447","https://openalex.org/W103028884","https://openalex.org/W152090583","https://openalex.org/W161304231","https://openalex.org/W180088576","https://openalex.org/W189292382","https://openalex.org/W1974528604","https://openalex.org/W1983953162","https://openalex.org/W1986827858","https://openalex.org/W1995000196","https://openalex.org/W2001477230","https://openalex.org/W2033423092","https://openalex.org/W2041260334","https://openalex.org/W2047690012","https://openalex.org/W2054888624","https://openalex.org/W2065419533","https://openalex.org/W2076669590","https://openalex.org/W2084062481","https://openalex.org/W2104482697","https://openalex.org/W2106809401","https://openalex.org/W2116208134","https://openalex.org/W2131658103","https://openalex.org/W2152348310","https://openalex.org/W2159106700","https://openalex.org/W2160877509","https://openalex.org/W2312546750","https://openalex.org/W2320562573","https://openalex.org/W2331320446","https://openalex.org/W2395588997","https://openalex.org/W2402319180","https://openalex.org/W2419103830","https://openalex.org/W2421517926","https://openalex.org/W2438136946","https://openalex.org/W2462121844","https://openalex.org/W2798688526"],"related_works":["https://openalex.org/W2395588997","https://openalex.org/W2151059087","https://openalex.org/W152090583","https://openalex.org/W2074614918","https://openalex.org/W2414561905","https://openalex.org/W4292707850","https://openalex.org/W2402319180","https://openalex.org/W1984327413","https://openalex.org/W1985753770","https://openalex.org/W7027713593"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}