{"id":"https://openalex.org/W1997673869","doi":"https://doi.org/10.1002/jcp.20692","title":"Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53\u2010dependent mechanism and inhibition of prostate cancer cell growth","display_name":"Prostate derived factor in human prostate cancer cells: Gene induction by vitamin D via a p53\u2010dependent mechanism and inhibition of prostate cancer cell growth","publication_year":2006,"publication_date":"2006-06-01","ids":{"openalex":"https://openalex.org/W1997673869","doi":"https://doi.org/10.1002/jcp.20692","mag":"1997673869","pmid":"https://pubmed.ncbi.nlm.nih.gov/16741990"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.20692","doi":"https://doi.org/10.1002/jcp.20692","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.20692","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102728824","display_name":"James R. Lambert","orcid":"https://orcid.org/0000-0002-4317-0523","observed_orcids":["https://orcid.org/0000-0002-4317-0523"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James R. Lambert","raw_affiliation_strings":["Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA. jim.lambert@uchsc.edu","Department of Pathology, University of Colorado Health Sciences Center; Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA. jim.lambert@uchsc.edu","institution_ids":["https://openalex.org/I4210087413"]},{"raw_affiliation_string":"Department of Pathology, University of Colorado Health Sciences Center; Aurora, Colorado","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Julie A. Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie A. Kelly","raw_affiliation_strings":["Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011767634","display_name":"Minsub Shim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minsub Shim","raw_affiliation_strings":["Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111627735","display_name":"William E. Huffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Huffer","raw_affiliation_strings":["Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024951508","display_name":"Steven K. Nordeen","orcid":"https://orcid.org/0000-0001-8803-8617","observed_orcids":["https://orcid.org/0000-0001-8803-8617"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven K. Nordeen","raw_affiliation_strings":["Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009464125","display_name":"Seung Joon Baek","orcid":"https://orcid.org/0000-0001-7866-7778","observed_orcids":["https://orcid.org/0000-0001-7866-7778"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seung Joon Baek","raw_affiliation_strings":["Department of Pathobiology, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064125146","display_name":"Thomas E. Eling","orcid":"https://orcid.org/0009-0006-5980-1189","observed_orcids":["https://orcid.org/0009-0006-5980-1189"]},"institutions":[{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Eling","raw_affiliation_strings":["Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina","institution_ids":["https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072384926","display_name":"Marshall Scott Lucia","orcid":"https://orcid.org/0000-0003-4974-7378","observed_orcids":["https://orcid.org/0000-0003-4974-7378"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Scott Lucia","raw_affiliation_strings":["Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102728824"],"corresponding_institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I51713134"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":5.6147,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95754451,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"208","issue":"3","first_page":"566","last_page":"574"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.7865999937057495,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.18539999425411224,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7139999866485596},{"id":"https://openalex.org/keywords/1-25-dihydroxyvitamin-d3","display_name":"1,25-dihydroxyvitamin D3","score":0.953000009059906},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tgf-beta-superfamily","display_name":"TGF-beta superfamily","score":0.8420000076293945},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5690000057220459},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7070000171661377},{"id":"https://openalex.org/keywords/lncap-cells","display_name":"LNCaP cells","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.7269999980926514},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.7749999761581421},{"id":"https://openalex.org/keywords/soft-agar-cloning","display_name":"soft agar cloning","score":0.5540000200271606},{"id":"https://openalex.org/keywords/dominant-negative-p53","display_name":"dominant-negative p53","score":0.8330000042915344}],"concepts":[{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.9037091135978699},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.8183748722076416},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.696342408657074},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6362756490707397},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5786499977111816},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.49311563372612},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45257091522216797},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.42912399768829346},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.41277679800987244},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3798246681690216},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3468063473701477},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.32555532455444336},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2969231903553009},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25548678636550903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09088858962059021}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002117","descriptor_name":"Calcitriol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011923","descriptor_name":"Rats, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055436","descriptor_name":"Growth Differentiation Factor 15","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.20692","doi":"https://doi.org/10.1002/jcp.20692","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.20692","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:16741990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16741990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W63149615","https://openalex.org/W1482212046","https://openalex.org/W1487662609","https://openalex.org/W1598913124","https://openalex.org/W1977138354","https://openalex.org/W1984041392","https://openalex.org/W1989468717","https://openalex.org/W1996432413","https://openalex.org/W2004891808","https://openalex.org/W2005673476","https://openalex.org/W2005808983","https://openalex.org/W2010467812","https://openalex.org/W2023097049","https://openalex.org/W2030908134","https://openalex.org/W2031300004","https://openalex.org/W2041149796","https://openalex.org/W2051891844","https://openalex.org/W2053042661","https://openalex.org/W2053516868","https://openalex.org/W2065858724","https://openalex.org/W2072264680","https://openalex.org/W2074092638","https://openalex.org/W2074735516","https://openalex.org/W2084657101","https://openalex.org/W2086623605","https://openalex.org/W2090909765","https://openalex.org/W2098716725","https://openalex.org/W2099958646","https://openalex.org/W2108324242","https://openalex.org/W2109560931","https://openalex.org/W2111038476","https://openalex.org/W2112185910","https://openalex.org/W2120225922","https://openalex.org/W2126294962","https://openalex.org/W2126527070","https://openalex.org/W2134400516","https://openalex.org/W2138563742","https://openalex.org/W2147490704","https://openalex.org/W2157330336","https://openalex.org/W2158690110","https://openalex.org/W2185056510","https://openalex.org/W2226282764","https://openalex.org/W2301143748","https://openalex.org/W2338655541","https://openalex.org/W2405633970","https://openalex.org/W4238013230","https://openalex.org/W4388205687"],"related_works":["https://openalex.org/W1998843836","https://openalex.org/W1986527803","https://openalex.org/W2048123305","https://openalex.org/W1972422162","https://openalex.org/W4237622006","https://openalex.org/W2057773030","https://openalex.org/W1915790967","https://openalex.org/W2164970912","https://openalex.org/W2132600165","https://openalex.org/W3022216491"],"abstract_inverted_index":{"The":[0],"secosteroid":[1],"hormone":[2],"1alpha,":[3],"25-dihydroxyvitamin":[4],"D3":[5],"(1,25D)":[6],"has":[7,98],"been":[8,32,99],"shown":[9],"to":[10,197],"regulate":[11],"the":[12,23,41,52,59,76,94,147,155,193,242],"growth":[13],"and":[14,74,97,111,120,131,181,218,233],"differentiation":[15],"of":[16,44,66,93,104,128,146,157,171,183,195,244],"human":[17,68],"prostate":[18,79],"cancer":[19],"(PCa)":[20],"cells,":[21,190],"although":[22],"precise":[24],"molecular":[25],"mechanisms":[26],"mediating":[27],"these":[28],"effects":[29,43],"have":[30],"not":[31],"defined.":[33],"Previous":[34],"studies":[35,116],"in":[36,101,133,159,187,207,211,246],"our":[37],"laboratory":[38],"demonstrated":[39],"that":[40,125,154,192,225],"antiproliferative":[42,110],"1,25D":[45,72,118,237,245],"on":[46,138,166,230],"PCa":[47,69,134,161,174,189,231],"cells":[48,70,135,175,209,232],"are":[49],"mediated":[50],"through":[51],"nuclear":[53],"vitamin":[54],"D":[55],"receptor":[56],"(VDR).":[57],"In":[58],"present":[60],"study,":[61],"we":[62,152],"performed":[63],"gene":[64],"profiling":[65],"LNCaP":[67,188],"following":[71],"treatment":[73],"identified":[75],"antitumorigenic":[77,228],"gene,":[78],"derived":[80],"factor":[81],"(PDF),":[82],"as":[83],"being":[84],"highly":[85],"induced":[86],"by":[87,236],"1,25D.":[88],"PDF":[89,129,141,158,199,205,226],"is":[90,136,142,164],"a":[91,102,121,143,177],"member":[92],"TGF-beta":[95],"superfamily":[96],"implicated":[100],"variety":[103],"functions":[105],"directly":[106],"related":[107],"totumorigenicity":[108],"including":[109],"pro-apoptotic":[112],"effects.":[113],"Gene":[114],"expression":[115,156,179,182,206],"using":[117],"analogs":[119],"VDR":[122,139,196],"antagonist":[123],"demonstrate":[124,224],"1,25D-mediated":[126],"induction":[127],"message":[130],"protein":[132],"dependent":[137,165],"action.":[140],"transcriptional":[144],"target":[145],"tumor":[148,220],"suppressor,":[149],"p53.":[150,168,202],"Here":[151],"show":[153,191],"nine":[160],"cell":[162,213],"lines":[163],"functional":[167,201],"Additionally,":[169],"transfection":[170],"p53-null":[172],"ALVA-31":[173],"with":[176],"p53":[178,186],"plasmid,":[180],"dominant":[184],"negative":[185],"ability":[194],"induce":[198],"requires":[200],"Importantly,":[203],"forced":[204],"PC-3":[208],"results":[210],"decreased":[212],"proliferation,":[214],"soft":[215],"agar":[216],"cloning,":[217],"xenograft":[219],"size.":[221],"These":[222],"data":[223],"exerts":[227],"properties":[229],"its":[234],"regulation":[235],"may":[238],"provide":[239],"insights":[240],"into":[241],"action":[243],"PCa.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
