{"id":"https://openalex.org/W1997666764","doi":"https://doi.org/10.1159/000052942","title":"Is the Zona pellucida Thickness of Metaphase-II Oocytes in an IVF/ICSI Program Influenced by the Patient\u2019s Age?","display_name":"Is the Zona pellucida Thickness of Metaphase-II Oocytes in an IVF/ICSI Program Influenced by the Patient\u2019s Age?","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1997666764","doi":"https://doi.org/10.1159/000052942","mag":"1997666764","pmid":"https://pubmed.ncbi.nlm.nih.gov/11549866"},"language":"en","primary_location":{"id":"doi:10.1159/000052942","doi":"https://doi.org/10.1159/000052942","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000052942","pdf_url":null,"source":{"id":"https://openalex.org/S207793224","display_name":"Gynecologic and Obstetric Investigation","issn_l":"0378-7346","issn":["0378-7346","1423-002X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and Obstetric Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038781886","display_name":"Frank Nawroth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Nawroth","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, University of Cologne, Germany. Frank.Nawroth@medizin.uni-koeln.de","Obstetrics and Gynaecology, University of Cologne"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, University of Cologne, Germany. Frank.Nawroth@medizin.uni-koeln.de","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Obstetrics and Gynaecology, University of Cologne","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036307753","display_name":"P M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pia M\u00fcller","raw_affiliation_strings":["Obstetrics and Gynaecology, Municipal Hospital of Schwedt/O"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology, Municipal Hospital of Schwedt/O","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christian Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Wolf","raw_affiliation_strings":["Obstetrics and Gynaecology, Ernst-Moritz-Arndt-University Greifswald, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Obstetrics and Gynaecology, Ernst-Moritz-Arndt-University Greifswald, and","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081313993","display_name":"Roland Sudik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland Sudik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.10814756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"52","issue":"1","first_page":"55","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zona-pellucida-thickness","display_name":"zona pellucida thickness","score":0.9980000257492065},{"id":"https://openalex.org/keywords/patient-age","display_name":"patient age","score":0.6980000138282776},{"id":"https://openalex.org/keywords/metaphase-ii-oocytes","display_name":"metaphase II oocytes","score":0.9049999713897705},{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.925000011920929},{"id":"https://openalex.org/keywords/intracytoplasmic-sperm-injection","display_name":"intracytoplasmic sperm injection","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ovulation-induction","display_name":"ovulation induction","score":0.9629999995231628},{"id":"https://openalex.org/keywords/fertilization-rate","display_name":"fertilization rate","score":0.9399999976158142},{"id":"https://openalex.org/keywords/oocyte-quality","display_name":"oocyte quality","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2776010925","wikidata":"https://www.wikidata.org/wiki/Q219841","display_name":"Zona pellucida","level":4,"score":0.794945478439331},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.6216611266136169},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5483348369598389},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.46655839681625366},{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.45478925108909607},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.44364020228385925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4148849844932556},{"id":"https://openalex.org/C2776690073","wikidata":"https://www.wikidata.org/wiki/Q3246226","display_name":"Oocyte","level":3,"score":0.3647528290748596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31999796628952026},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.20690670609474182},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15427696704864502},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.10638445615768433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05274587869644165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006062","descriptor_name":"Gonadotropins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008677","descriptor_name":"Metaphase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015044","descriptor_name":"Zona Pellucida","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015044","descriptor_name":"Zona Pellucida","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020554","descriptor_name":"Sperm Injections, Intracytoplasmic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048429","descriptor_name":"Cell Size","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000052942","doi":"https://doi.org/10.1159/000052942","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000052942","pdf_url":null,"source":{"id":"https://openalex.org/S207793224","display_name":"Gynecologic and Obstetric Investigation","issn_l":"0378-7346","issn":["0378-7346","1423-002X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and Obstetric Investigation","raw_type":"journal-article"},{"id":"pmid:11549866","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11549866","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gynecologic and obstetric investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.766700029373169,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W84365585","https://openalex.org/W169339519","https://openalex.org/W226777069","https://openalex.org/W280556660","https://openalex.org/W392978625","https://openalex.org/W1607440817","https://openalex.org/W1840744949","https://openalex.org/W1946032861","https://openalex.org/W1977082455","https://openalex.org/W1986111724","https://openalex.org/W1988515579","https://openalex.org/W1997113689","https://openalex.org/W1998966209","https://openalex.org/W2007746864","https://openalex.org/W2039263318","https://openalex.org/W2042272475","https://openalex.org/W2056866295","https://openalex.org/W2064967258","https://openalex.org/W2068094939","https://openalex.org/W2087831538","https://openalex.org/W2096191707","https://openalex.org/W2098820470","https://openalex.org/W2114344688","https://openalex.org/W2141731481","https://openalex.org/W2182095480","https://openalex.org/W2244166575","https://openalex.org/W2263248065","https://openalex.org/W2334968665","https://openalex.org/W2402466748","https://openalex.org/W2408508354"],"related_works":["https://openalex.org/W7196958318","https://openalex.org/W280556660","https://openalex.org/W2010840258","https://openalex.org/W2059242417","https://openalex.org/W2263248065","https://openalex.org/W2119554593","https://openalex.org/W2380503967","https://openalex.org/W1969906777","https://openalex.org/W1560922660","https://openalex.org/W2009390858"],"abstract_inverted_index":{"Zona":[0],"pellucida":[1],"(Z.p.)":[2],"thickness":[3,23,61,88,115],"is":[4,141],"believed":[5],"to":[6,33,52],"be":[7,151],"considerably":[8],"influenced":[9],"by":[10],"hormonal":[11],"stimulation.":[12],"Assessments":[13],"of":[14,17,41,62,65,89,99,113,159],"the":[15,18,39,42,59,63,90,97,100,109,154],"influence":[16],"patient's":[19],"age":[20,40,98,125],"on":[21],"Z.p.":[22,49,64,91,114,149],"have":[24],"been":[25,74],"at":[26],"variance.":[27],"In":[28],"our":[29],"study":[30],"we":[31,57],"wanted":[32],"investigate,":[34],"among":[35],"several":[36],"other":[37,145],"parameters,":[38],"patient":[43,101],"as":[44],"a":[45,121,147,163],"possible":[46],"factor":[47],"influencing":[48],"thickness.":[50],"Prior":[51],"intracytoplasmatic":[53],"sperm":[54],"injection":[55],"(ICSI)":[56],"determined":[58],"mean":[60,87,111],"843":[66],"metaphase-II":[67],"oocytes":[68],"from":[69],"100":[70],"patients,":[71],"which":[72],"had":[73],"obtained":[75],"after":[76],"ovarian":[77],"stimulation":[78],"in":[79,81,162],"an":[80],"vitro":[82],"fertilization":[83,157],"(IVF)/ICSI":[84],"program.":[85,166],"The":[86],"was":[92,136],"significantly":[93],"positively":[94],"correlated":[95],"with":[96,124],"(p":[102,126],"=":[103,106,117,127,130],"0.000,":[104],"r":[105,129],"0.129).":[107],"When":[108],"intraindividual":[110],"values":[112],"(n":[116],"100)":[118],"were":[119],"used,":[120],"positive":[122],"correlation":[123,135],"0.174,":[128],"0.137)":[131],"remained.":[132],"However,":[133],"this":[134],"no":[137],"longer":[138],"significant.":[139],"It":[140],"concluded":[142],"that,":[143],"beside":[144],"factors,":[146],"thicker":[148],"could":[150],"responsible":[152],"for":[153],"possibly":[155],"lower":[156],"rate":[158],"older":[160],"patients":[161],"conventional":[164],"IVF":[165]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
