{"id":"https://openalex.org/W1997662291","doi":"https://doi.org/10.1074/jbc.m109.020495","title":"Negative Regulation of Stat3 by Activating PTPN11 Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia","display_name":"Negative Regulation of Stat3 by Activating PTPN11 Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia","publication_year":2009,"publication_date":"2009-06-11","ids":{"openalex":"https://openalex.org/W1997662291","doi":"https://doi.org/10.1074/jbc.m109.020495","mag":"1997662291","pmid":"https://pubmed.ncbi.nlm.nih.gov/19509418","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2755958"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.020495","doi":"https://doi.org/10.1074/jbc.m109.020495","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.020495","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m109.020495","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100447810","display_name":"Wenjun Zhang","orcid":"https://orcid.org/0000-0001-9801-0634","observed_orcids":["https://orcid.org/0000-0001-9801-0634"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenjun Zhang","raw_affiliation_strings":["Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Riley Heart Research Center, Indianapolis, Indiana 46202; the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202","Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","Riley Heart Research Center, Indianapolis, Indiana 46202","the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Riley Heart Research Center, Indianapolis, Indiana 46202; the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"Riley Heart Research Center, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101867505","display_name":"Rebecca J. Chan","orcid":"https://orcid.org/0000-0003-4044-3431","observed_orcids":["https://orcid.org/0000-0003-4044-3431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca J. Chan","raw_affiliation_strings":["Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202","Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114514362","display_name":"Hanying Chen","orcid":"https://orcid.org/0000-0001-9358-9210","observed_orcids":["https://orcid.org/0000-0001-9358-9210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanying Chen","raw_affiliation_strings":["Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100511948","display_name":"Zhenyun Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhenyun Yang","raw_affiliation_strings":["Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101497092","display_name":"Yantao He","orcid":"https://orcid.org/0000-0002-2692-0345","observed_orcids":["https://orcid.org/0000-0002-2692-0345"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yantao He","raw_affiliation_strings":["Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438832","display_name":"Xian Zhang","orcid":"https://orcid.org/0000-0001-9674-7886","observed_orcids":["https://orcid.org/0000-0001-9674-7886"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xian Zhang","raw_affiliation_strings":["Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong Luo","raw_affiliation_strings":["Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015713478","display_name":"Fuqing Yin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuqing Yin","raw_affiliation_strings":["Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041501498","display_name":"Akira Moh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira Moh","raw_affiliation_strings":["the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027056401","display_name":"Lucy Miller","orcid":"https://orcid.org/0009-0002-7668-0586","observed_orcids":["https://orcid.org/0009-0002-7668-0586"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucy C. Miller","raw_affiliation_strings":["Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neonatology, Department of Pediatrics, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059699120","display_name":"Ronald Mark Payne","orcid":"https://orcid.org/0000-0002-6232-3628","observed_orcids":["https://orcid.org/0000-0002-6232-3628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Mark Payne","raw_affiliation_strings":["Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Riley Heart Research Center, Indianapolis, Indiana 46202","Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","Riley Heart Research Center, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Riley Heart Research Center, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"Riley Heart Research Center, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101802542","display_name":"Zhong\u2010Yin Zhang","orcid":"https://orcid.org/0000-0001-5527-7910","observed_orcids":["https://orcid.org/0000-0001-5527-7910"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhong-Yin Zhang","raw_affiliation_strings":["Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113609909","display_name":"Xin-Yuan Fu","orcid":"https://orcid.org/0000-0002-3466-5313","observed_orcids":["https://orcid.org/0000-0002-3466-5313","https://orcid.org/0000-0002-3199-4269"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xin-Yuan Fu","raw_affiliation_strings":["the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Microbiology and Immunology, Indianapolis, Indiana 46202","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010229862","display_name":"Weinian Shou","orcid":"https://orcid.org/0000-0001-5538-9605","observed_orcids":["https://orcid.org/0000-0001-5538-9605"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weinian Shou","raw_affiliation_strings":["Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Riley Heart Research Center, Indianapolis, Indiana 46202; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","Riley Heart Research Center, Indianapolis, Indiana 46202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202; Riley Heart Research Center, Indianapolis, Indiana 46202; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]},{"raw_affiliation_string":"Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202","institution_ids":["https://openalex.org/I4394709130"]},{"raw_affiliation_string":"Herman B. Wells Center for Pediatric Research, Indianapolis, Indiana 46202","institution_ids":[]},{"raw_affiliation_string":"Riley Heart Research Center, Indianapolis, Indiana 46202","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010229862","https://openalex.org/A5113609909"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4284,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.79142563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"284","issue":"33","first_page":"22353","last_page":"22363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noonan-syndrome","display_name":"Noonan syndrome","score":0.9409999847412109},{"id":"https://openalex.org/keywords/juvenile-myelomonocytic-leukemia","display_name":"juvenile myelomonocytic leukemia","score":0.9399999976158142},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7960000038146973},{"id":"https://openalex.org/keywords/ptpn11","display_name":"PTPN11","score":0.9150000214576721},{"id":"https://openalex.org/keywords/shp2","display_name":"SHP2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/protein-tyrosine-phosphatase","display_name":"protein tyrosine phosphatase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.8939999938011169},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.824999988079071},{"id":"https://openalex.org/keywords/pulmonary-stenosis","display_name":"pulmonary stenosis","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hematopoietic-cells","display_name":"hematopoietic cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C31734879","wikidata":"https://www.wikidata.org/wiki/Q14905494","display_name":"PTPN11","level":5,"score":0.9433718323707581},{"id":"https://openalex.org/C2779157977","wikidata":"https://www.wikidata.org/wiki/Q2578247","display_name":"Juvenile myelomonocytic leukemia","level":4,"score":0.8611141443252563},{"id":"https://openalex.org/C2776149932","wikidata":"https://www.wikidata.org/wiki/Q1543446","display_name":"Noonan syndrome","level":2,"score":0.6486358642578125},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5964744687080383},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5576815605163574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5544631481170654},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4928012192249298},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.46390292048454285},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4490051865577698},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43002861738204956},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.41509127616882324},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4130606949329376},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.30895960330963135},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2765573263168335},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25258636474609375},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14905592799186707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10017290711402893},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.08983588218688965},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009634","descriptor_name":"Noonan Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054429","descriptor_name":"Leukemia, Myelomonocytic, Juvenile","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054429","descriptor_name":"Leukemia, Myelomonocytic, Juvenile","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D054592","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 11","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054592","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 11","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054592","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 11","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m109.020495","doi":"https://doi.org/10.1074/jbc.m109.020495","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.020495","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:19509418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19509418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2755958","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2755958/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.020495","doi":"https://doi.org/10.1074/jbc.m109.020495","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.020495","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1197853785","display_name":"Activating PTPN11 and c-kit Mutations in Myeloproliferative Disorder","funder_award_id":"R01HL082981","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2055753464","display_name":"The Role of BMP-10 in Cardiac Development","funder_award_id":"R01HL070259","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2407751470","display_name":"Molecular Pathway in Myocardium Development","funder_award_id":"R01HL081092","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5113930931","display_name":"Genetics and Treatment of Heart Failure in the Young","funder_award_id":"P01HL085098","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000892625","display_name":"Structure/Function of Protein Tyrosine Phosphatases","funder_award_id":"R01CA069202","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W220016304","https://openalex.org/W1488372279","https://openalex.org/W1964480633","https://openalex.org/W1972449266","https://openalex.org/W1977681992","https://openalex.org/W1980704335","https://openalex.org/W1981799488","https://openalex.org/W1983166456","https://openalex.org/W1983831457","https://openalex.org/W1987403356","https://openalex.org/W1988127794","https://openalex.org/W1995612782","https://openalex.org/W2000813775","https://openalex.org/W2011653532","https://openalex.org/W2019392609","https://openalex.org/W2022248034","https://openalex.org/W2023350410","https://openalex.org/W2024802365","https://openalex.org/W2029581491","https://openalex.org/W2034421608","https://openalex.org/W2034706365","https://openalex.org/W2038106655","https://openalex.org/W2041725750","https://openalex.org/W2043160859","https://openalex.org/W2049847654","https://openalex.org/W2056835764","https://openalex.org/W2057044649","https://openalex.org/W2059338259","https://openalex.org/W2065086280","https://openalex.org/W2068804834","https://openalex.org/W2070085859","https://openalex.org/W2072138658","https://openalex.org/W2074356752","https://openalex.org/W2080549930","https://openalex.org/W2082448876","https://openalex.org/W2087032518","https://openalex.org/W2088478532","https://openalex.org/W2091898207","https://openalex.org/W2098174002","https://openalex.org/W2099203843","https://openalex.org/W2103422355","https://openalex.org/W2128211642","https://openalex.org/W2129901774","https://openalex.org/W2132298090","https://openalex.org/W2148996267","https://openalex.org/W2159532830","https://openalex.org/W2162099878","https://openalex.org/W2166692731","https://openalex.org/W2171897899","https://openalex.org/W3135637599","https://openalex.org/W3143653395","https://openalex.org/W4249713142"],"related_works":["https://openalex.org/W2584798333","https://openalex.org/W2132298090","https://openalex.org/W2303077328","https://openalex.org/W2023350410","https://openalex.org/W2051832425","https://openalex.org/W2563129601","https://openalex.org/W2340020351","https://openalex.org/W2053899257","https://openalex.org/W2011653532","https://openalex.org/W2000813775"],"abstract_inverted_index":{"Noonan":[0],"syndrome":[1],"(NS)":[2],"is":[3,70,91,119],"an":[4,120],"autosomal":[5],"dominant":[6],"congenital":[7],"disorder":[8],"characterized":[9],"by":[10,136],"multiple":[11],"birth":[12],"defects":[13,16],"including":[14],"heart":[15],"and":[17,49,58,84,96,131],"myeloproliferative":[18],"disease":[19],"(MPD).":[20],"Approximately":[21],"50%":[22],"of":[23,44,129],"NS":[24,78,130],"patients":[25,79],"have":[26],"germline":[27],"gain-of-function":[28,138],"mutations":[29],"in":[30,46,73,109],"PTPN11,":[31],"which":[32],"encodes":[33],"the":[34,63,127],"protein-tyrosine":[35],"phosphatase,":[36],"Shp2.":[37],"We":[38],"provide":[39],"evidence":[40],"that":[41,88,97,117],"conditional":[42],"ablation":[43],"Stat3":[45,100,118],"hematopoietic":[47],"cells":[48,76],"cardiac":[50],"valvular":[51],"tissues":[52],"leads":[53],"to":[54,62,93,126],"myeloid":[55],"progenitor":[56],"hyperplasia":[57],"pulmonary":[59],"stenosis":[60],"due":[61],"leaflet":[64],"thickening,":[65],"respectively.":[66],"Consistently,":[67],"STAT3":[68],"activation":[69],"significantly":[71],"compromised":[72],"peripheral":[74],"blood":[75],"from":[77],"bearing":[80],"Shp2-activating":[81],"mutations.":[82,139],"Biochemical":[83],"functional":[85],"analyses":[86],"demonstrate":[87],"activated":[89],"Shp2":[90],"able":[92],"down-regulate":[94],"Tyr(P)-Stat3":[95],"constitutively":[98],"active":[99],"rescues":[101],"activating":[102],"mutant":[103],"Shp2-induced":[104],"granulocyte-macrophage":[105],"colony-stimulating":[106],"factor":[107],"hypersensitivity":[108],"bone":[110],"marrow":[111],"cells.":[112],"Collectively,":[113],"our":[114],"work":[115],"demonstrates":[116],"essential":[121],"signaling":[122],"component":[123],"potentially":[124],"contributing":[125],"pathogenesis":[128],"juvenile":[132],"myelomonocytic":[133],"leukemia":[134],"caused":[135],"PTPN11":[137]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
