{"id":"https://openalex.org/W1997658323","doi":"https://doi.org/10.1097/00000539-200006000-00038","title":"A Simple Method for Detecting Plasma Propofol","display_name":"A Simple Method for Detecting Plasma Propofol","publication_year":2000,"publication_date":"2000-06-01","ids":{"openalex":"https://openalex.org/W1997658323","doi":"https://doi.org/10.1097/00000539-200006000-00038","mag":"1997658323","pmid":"https://pubmed.ncbi.nlm.nih.gov/10825340"},"language":"en","primary_location":{"id":"doi:10.1097/00000539-200006000-00038","doi":"https://doi.org/10.1097/00000539-200006000-00038","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-200006000-00038","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Akihiko Fujita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]},{"id":"https://openalex.org/I78274823","display_name":"Dokkyo Medical University","ror":"https://ror.org/05k27ay38","country_code":"JP","type":"education","lineage":["https://openalex.org/I78274823"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akihiko Fujita","raw_affiliation_strings":["Second Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi, Japan","Second Department of Anesthesiology and \u2020Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan","reprint requests to Akihiko Fujita, MD, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi, Japan","institution_ids":["https://openalex.org/I109009565"]},{"raw_affiliation_string":"Second Department of Anesthesiology and \u2020Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan","institution_ids":["https://openalex.org/I109009565"]},{"raw_affiliation_string":"reprint requests to Akihiko Fujita, MD, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan","institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110400311","display_name":"Jun Higuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Jun Higuchi","raw_affiliation_strings":["Second Department of Anesthesiology and \u2020Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Anesthesiology and \u2020Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan","institution_ids":["https://openalex.org/I109009565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103397433","display_name":"Toshiaki Nagai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiaki Nagai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103496048","display_name":"Shogo Tokudome","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shogo Tokudome","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041271767","display_name":"Hideaki Sakio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I109009565","display_name":"Dokkyo University","ror":"https://ror.org/01vj3cz23","country_code":"JP","type":"education","lineage":["https://openalex.org/I109009565"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideaki Sakio","raw_affiliation_strings":["Second Department of Anesthesiology and \u2020Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of Anesthesiology and \u2020Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan","institution_ids":["https://openalex.org/I109009565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041271767","https://openalex.org/A5110400311"],"corresponding_institution_ids":["https://openalex.org/I109009565","https://openalex.org/I78274823"],"apc_list":null,"apc_paid":null,"fwci":0.4328,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.608618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"90","issue":"6","first_page":"1452","last_page":"1454"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.5259000062942505,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.2833999991416931,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propofol","display_name":"propofol","score":0.972000002861023},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7649999856948853},{"id":"https://openalex.org/keywords/headspace-gas-chromatography","display_name":"headspace gas chromatography","score":0.7480000257492065},{"id":"https://openalex.org/keywords/solid-phase-microextraction","display_name":"solid-phase microextraction","score":1.0},{"id":"https://openalex.org/keywords/anesthesia-monitoring","display_name":"anesthesia monitoring","score":0.6520000100135803},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8488538861274719},{"id":"https://openalex.org/C2776277131","wikidata":"https://www.wikidata.org/wiki/Q422740","display_name":"Propofol","level":2,"score":0.7748250365257263},{"id":"https://openalex.org/C82706917","wikidata":"https://www.wikidata.org/wiki/Q10251","display_name":"Plasma","level":2,"score":0.6145699620246887},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.60532546043396},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5740442872047424},{"id":"https://openalex.org/C2778533135","wikidata":"https://www.wikidata.org/wiki/Q903970","display_name":"Solid-phase microextraction","level":4,"score":0.5688733458518982},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.47753798961639404},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.438441663980484},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.4383397400379181},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.374663770198822},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24440088868141174},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.12492653727531433},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.06434646248817444},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.06332972645759583},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0513346791267395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002849","descriptor_name":"Chromatography, Gas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015742","descriptor_name":"Propofol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018686","descriptor_name":"Anesthetics, Intravenous","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000539-200006000-00038","doi":"https://doi.org/10.1097/00000539-200006000-00038","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-200006000-00038","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:10825340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10825340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1971966881","https://openalex.org/W1988168304","https://openalex.org/W2029525304","https://openalex.org/W2088473033","https://openalex.org/W2103959513","https://openalex.org/W2146375752","https://openalex.org/W2576720067"],"related_works":["https://openalex.org/W2515992019","https://openalex.org/W1988168304","https://openalex.org/W3193773173","https://openalex.org/W2025601922","https://openalex.org/W1997008357","https://openalex.org/W2001352031","https://openalex.org/W7014756226","https://openalex.org/W1986976317","https://openalex.org/W2171169592","https://openalex.org/W3093569910"],"abstract_inverted_index":{"IMPLICATIONS:":[0],"We":[1],"measured":[2],"plasma":[3],"propofol":[4],"levels":[5],"by":[6],"head":[7],"space-gas":[8],"chromatography":[9],"analysis":[10],"using":[11],"solid-phase":[12],"microextraction.":[13],"This":[14],"method":[15],"saves":[16],"time,":[17],"and":[18],"does":[19],"not":[20],"require":[21],"elimination":[22],"of":[23],"interfering":[24],"substances":[25],"in":[26],"the":[27],"plasma.":[28],"The":[29,36],"coefficient":[30],"variation":[31],"was":[32,39],"+/-5%":[33],"to":[34],"+/-30%.":[35],"detection":[37],"limit":[38],"10":[40],"ng/mL.":[41]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}