{"id":"https://openalex.org/W1997656535","doi":"https://doi.org/10.1002/ptr.1264","title":"Inhibitory effect of magnolol on tumour metastasis in mice","display_name":"Inhibitory effect of magnolol on tumour metastasis in mice","publication_year":2003,"publication_date":"2003-09-01","ids":{"openalex":"https://openalex.org/W1997656535","doi":"https://doi.org/10.1002/ptr.1264","mag":"1997656535","pmid":"https://pubmed.ncbi.nlm.nih.gov/13680828"},"language":"en","primary_location":{"id":"doi:10.1002/ptr.1264","doi":"https://doi.org/10.1002/ptr.1264","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1264","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110515847","display_name":"Koji Ikeda","orcid":"https://orcid.org/0000-0002-2632-2580","observed_orcids":["https://orcid.org/0000-0002-2632-2580"]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Ikeda","raw_affiliation_strings":["Department of Hygienics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, Japan 502-8585"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, Japan 502-8585","institution_ids":["https://openalex.org/I173865709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112330458","display_name":"Yoshimichi Sakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshimichi Sakai","raw_affiliation_strings":["Gifu Prefectural Institute of Forest Science, Mino, Gifu, Japan 501-3714"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifu Prefectural Institute of Forest Science, Mino, Gifu, Japan 501-3714","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037934016","display_name":"Hisamitsu Nagase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173865709","display_name":"Gifu Pharmaceutical University","ror":"https://ror.org/0372t5741","country_code":"JP","type":"education","lineage":["https://openalex.org/I173865709"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hisamitsu Nagase","raw_affiliation_strings":["Department of Hygienics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, Japan 502-8585"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygienics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, Japan 502-8585","institution_ids":["https://openalex.org/I173865709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037934016"],"corresponding_institution_ids":["https://openalex.org/I173865709"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.8048,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.83034836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"17","issue":"8","first_page":"933","last_page":"937"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13677","display_name":"Magnolia and Illicium research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnolol","display_name":"magnolol","score":1.0},{"id":"https://openalex.org/keywords/magnolia-obovata","display_name":"Magnolia obovata","score":0.9269999861717224},{"id":"https://openalex.org/keywords/antimetastatic-effect","display_name":"antimetastatic effect","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumour-metastasis","display_name":"tumour metastasis","score":0.984000027179718},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8349999785423279},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/splenic-metastasis","display_name":"splenic metastasis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/b16-bl6-melanoma","display_name":"B16-BL6 melanoma","score":0.9649999737739563},{"id":"https://openalex.org/keywords/reconstituted-basement-membrane","display_name":"reconstituted basement membrane","score":0.7789999842643738},{"id":"https://openalex.org/keywords/matrigel","display_name":"Matrigel","score":0.7609999775886536},{"id":"https://openalex.org/keywords/natural-phenolic-compounds","display_name":"natural phenolic compounds","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2781009524","wikidata":"https://www.wikidata.org/wiki/Q6732002","display_name":"Magnolol","level":2,"score":0.9609384536743164},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.8106645345687866},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7367384433746338},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.6017469167709351},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5265614986419678},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5192525386810303},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4779938757419586},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4558509588241577},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.441975474357605},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42855334281921387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32730162143707275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2826213836669922},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23992210626602173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22379523515701294},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.1274850070476532},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008517","descriptor_name":"Phytotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008546","descriptor_name":"Melanoma, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013160","descriptor_name":"Splenic Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D013160","descriptor_name":"Splenic Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D031566","descriptor_name":"Magnolia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ptr.1264","doi":"https://doi.org/10.1002/ptr.1264","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ptr.1264","pdf_url":null,"source":{"id":"https://openalex.org/S206789554","display_name":"Phytotherapy Research","issn_l":"0951-418X","issn":["0951-418X","1099-1573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy Research","raw_type":"journal-article"},{"id":"pmid:13680828","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13680828","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phytotherapy research : PTR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W37222717","https://openalex.org/W201036967","https://openalex.org/W1513691409","https://openalex.org/W1514421181","https://openalex.org/W1515744449","https://openalex.org/W1607369242","https://openalex.org/W1826834816","https://openalex.org/W1968017285","https://openalex.org/W1987719934","https://openalex.org/W2004715647","https://openalex.org/W2005151288","https://openalex.org/W2030611702","https://openalex.org/W2056597496","https://openalex.org/W2057675024","https://openalex.org/W2071179688","https://openalex.org/W2092660931","https://openalex.org/W2113554746","https://openalex.org/W2116838015","https://openalex.org/W2121584804","https://openalex.org/W2163614155"],"related_works":["https://openalex.org/W2030611702","https://openalex.org/W2065448275","https://openalex.org/W2052421628","https://openalex.org/W4297988289","https://openalex.org/W2027374248","https://openalex.org/W7144829435","https://openalex.org/W2355320810","https://openalex.org/W2389015323","https://openalex.org/W2118087421","https://openalex.org/W7113060742"],"abstract_inverted_index":{"It":[0],"has":[1],"previously":[2],"been":[3],"reported":[4],"that":[5,155,162],"magnolol,":[6],"a":[7,166],"phenolic":[8],"compound":[9,168],"isolated":[10],"from":[11,149],"Magnolia":[12],"obovata,":[13],"inhibited":[14,132],"tumour":[15,34,118,126,187],"cell":[16,134,145,188],"invasion":[17,135],"in":[18,36,151],"vitro.":[19],"The":[20,49,172],"purpose":[21],"of":[22,31,52,81,86,110,113,136,175],"this":[23],"study":[24],"was":[25],"to":[26,45,179,182,185],"investigate":[27],"the":[28,47,99,137,150],"antimetastatic":[29,50,159,173],"effect":[30],"magnolol":[32,53,87,114,130,156,176],"on":[33],"metastasis":[35,42,62,73,93,102,123],"vivo":[37,152],"with":[38],"experimental":[39,58,69],"and":[40,44,60,70,91,116,124,161],"spontaneous":[41,71,100],"models":[43],"clarify":[46],"mechanism.":[48],"effects":[51],"were":[54],"evaluated":[55],"by":[56],"an":[57,68],"liver":[59,90],"spleen":[61,92],"model":[63,74,103],"using":[64,75,104],"L5178Y-ML25":[65],"lymphoma,":[66],"or":[67,83,94],"lung":[72,95,101,122],"B16-BL6":[76,105,133],"melanoma.":[77],"Intraperitoneal":[78],"(i.p.)":[79],"administration":[80],"2":[82],"10":[84,111],"mg/kg":[85,112],"significantly":[88,120,131],"suppressed":[89,121],"metastasis.":[96],"As":[97],"for":[98,169],"melanoma,":[106],"multiple":[107],"i.p.":[108],"administrations":[109],"after":[115],"before":[117],"inoculation":[119],"primary":[125],"growth.":[127,146],"In":[128],"addition,":[129],"reconstituted":[138],"basement":[139],"membrane":[140],"(Matrigel,":[141],"MG)":[142],"without":[143],"affecting":[144],"These":[147],"data":[148],"experiments":[153],"suggest":[154],"possesses":[157],"strong":[158],"ability":[160,184],"it":[163],"may":[164],"be":[165,180],"lead":[167],"drug":[170],"development.":[171],"action":[174],"is":[177],"considered":[178],"due":[181],"its":[183],"inhibit":[186],"invasion.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}