{"id":"https://openalex.org/W1997656455","doi":"https://doi.org/10.1111/j.1525-1594.1988.tb02748.x","title":"In Vitro Development of Automatic Control for the Actively Filled Electrohydraulic Heart","display_name":"In Vitro Development of Automatic Control for the Actively Filled Electrohydraulic Heart","publication_year":1988,"publication_date":"1988-04-01","ids":{"openalex":"https://openalex.org/W1997656455","doi":"https://doi.org/10.1111/j.1525-1594.1988.tb02748.x","mag":"1997656455","pmid":"https://pubmed.ncbi.nlm.nih.gov/3291829"},"language":"en","primary_location":{"id":"doi:10.1111/j.1525-1594.1988.tb02748.x","doi":"https://doi.org/10.1111/j.1525-1594.1988.tb02748.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-1594.1988.tb02748.x","pdf_url":null,"source":{"id":"https://openalex.org/S40391745","display_name":"Artificial Organs","issn_l":"0160-564X","issn":["0160-564X","1525-1594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Organs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021943529","display_name":"Anthony P. Lioi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony P. Lioi","raw_affiliation_strings":["Institute for Biomedical Engineering, University of Utah, Salt Lake City","Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, University of Utah, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]},{"raw_affiliation_string":"Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060194499","display_name":"Jeffrey L. Orth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L. Orth","raw_affiliation_strings":["Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070063615","display_name":"K.R. Crump","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin R. Crump","raw_affiliation_strings":["Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105799964","display_name":"Glenn Diffee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn Diffee","raw_affiliation_strings":["Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058951875","display_name":"PAMELA A. DEW","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela A. Dew","raw_affiliation_strings":["Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087564474","display_name":"Steve D. Nielsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve D. Nielsen","raw_affiliation_strings":["Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110390641","display_name":"Don B. Olsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don B. Olsen","raw_affiliation_strings":["Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Biomedical Engineering, Artificial Heart Research Laboratory, University of Utah, Salt Lake City, Utah, U.S.A","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021943529"],"corresponding_institution_ids":["https://openalex.org/I223532165"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":5.2977,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.95711974,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"2","first_page":"152","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/total-artificial-heart","display_name":"total artificial heart","score":0.9800000190734863},{"id":"https://openalex.org/keywords/automatic-control","display_name":"automatic control","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mean-aortic-pressure","display_name":"mean aortic pressure","score":0.9070000052452087},{"id":"https://openalex.org/keywords/afterload","display_name":"afterload","score":0.7049999833106995},{"id":"https://openalex.org/keywords/microprocessor-control","display_name":"microprocessor control","score":0.5370000004768372},{"id":"https://openalex.org/keywords/motor-speed-control","display_name":"motor speed control","score":0.7129999995231628},{"id":"https://openalex.org/keywords/atrial-pressure","display_name":"atrial pressure","score":0.6809999942779541},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6888282895088196},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.4589364230632782},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4270557761192322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33502572774887085},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.30023401975631714},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.25924941897392273},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11509808897972107},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07884445786476135}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001981","descriptor_name":"Bronchial Arteries","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006354","descriptor_name":"Heart, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1525-1594.1988.tb02748.x","doi":"https://doi.org/10.1111/j.1525-1594.1988.tb02748.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1525-1594.1988.tb02748.x","pdf_url":null,"source":{"id":"https://openalex.org/S40391745","display_name":"Artificial Organs","issn_l":"0160-564X","issn":["0160-564X","1525-1594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Organs","raw_type":"journal-article"},{"id":"pmid:3291829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3291829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial organs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7034359511","display_name":null,"funder_award_id":"5-RO1-HL-24338-04","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W593338668","https://openalex.org/W606085991","https://openalex.org/W858691112","https://openalex.org/W1572968121","https://openalex.org/W1989315642","https://openalex.org/W2064842955","https://openalex.org/W2292822133","https://openalex.org/W2380129598","https://openalex.org/W2395498514","https://openalex.org/W2395767174","https://openalex.org/W2400394243","https://openalex.org/W2405701472","https://openalex.org/W2406620877","https://openalex.org/W2407927304","https://openalex.org/W2411463154","https://openalex.org/W2414412920","https://openalex.org/W2420620877"],"related_works":["https://openalex.org/W857070035","https://openalex.org/W2029566345","https://openalex.org/W2395498514","https://openalex.org/W2248783244","https://openalex.org/W2164431147","https://openalex.org/W57230488","https://openalex.org/W2474342918","https://openalex.org/W2001681136","https://openalex.org/W2182521405","https://openalex.org/W2016003405"],"abstract_inverted_index":{"The":[0],"in":[1,79,95,105,120],"vitro":[2],"development":[3],"of":[4,7,22,48,75,138],"automatic":[5],"control":[6,47,74],"the":[8,20,189],"actively":[9],"filled,":[10],"alternately":[11,171],"pumped,":[12],"volumetrically":[13],"coupled,":[14],"electrohydraulic":[15,173],"total":[16],"artificial":[17],"heart":[18,174],"was":[19,59,122,126,152,175],"goal":[21],"this":[23],"investigation.":[24],"Control":[25],"features":[26],"under":[27],"study":[28],"were":[29,198],"(a)":[30],"cardiac":[31],"output":[32],"(CO)":[33],"response":[34,191],"to":[35,40,56,83,99,113,130,158,178,181],"preload;":[36],"(b)":[37],"CO":[38,96,121,143,190],"relationship":[39],"mean":[41,106,161],"aortic":[42],"pressure":[43,67,109,164],"(AoP);":[44],"and":[45,72,144],"(c)":[46],"balanced":[49,195],"ventricular":[50,196],"outputs.":[51],"A":[52],"modified":[53],"pulmonic":[54],"valve":[55],"increase":[57],"backflow":[58],"used":[60],"as":[61,124],"a":[62,80,93,103,135],"balancing":[63],"mechanism.":[64],"Hydraulic":[65],"fluid":[66],"transducers":[68],"monitored":[69],"diastolic":[70],"pressures,":[71],"microprocessor":[73],"motor":[76],"speed":[77],"maintained":[78,153],"mild":[81],"suction":[82],"yield":[84],"filling":[85],"rate":[86],"dependent":[87],"on":[88,142,149],"atrial":[89,108,163],"pressure.":[90],"Results":[91],"indicated":[92],"rise":[94],"from":[97,111,128],"5":[98],"9":[100],"L/min,":[101],"with":[102,134,160],"change":[104],"right":[107],"(RAP)":[110],"0":[112],"7":[114],"mm":[115,132,147,168],"Hg.":[116,169],"No":[117],"significant":[118],"difference":[119],"found":[123],"AoP":[125],"varied":[127],"80":[129],"120":[131],"Hg":[133,148],"maximum":[136],"variation":[137],"+/-":[139,145],"0.5":[140],"L/min":[141],"1":[146],"RAP.":[150],"Balance":[151],"for":[154],"bronchial":[155],"flows":[156],"up":[157],"50%":[159],"left":[162],"never":[165],"exceeding":[166],"15":[167],"An":[170],"pumped":[172],"automatically":[176],"controlled":[177],"respond":[179],"sensitively":[180],"preload":[182],"changes.":[183],"Afterload":[184],"changes":[185],"did":[186],"not":[187],"alter":[188],"curve.":[192],"Automatically":[193],"controlled,":[194],"outputs":[197],"maintained.":[199]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}