{"id":"https://openalex.org/W1997653290","doi":"https://doi.org/10.1074/jbc.272.36.22385","title":"The Tat Protein of HIV-1 Induces Tumor Necrosis Factor-\u03b1 Production","display_name":"The Tat Protein of HIV-1 Induces Tumor Necrosis Factor-\u03b1 Production","publication_year":1997,"publication_date":"1997-09-01","ids":{"openalex":"https://openalex.org/W1997653290","doi":"https://doi.org/10.1074/jbc.272.36.22385","mag":"1997653290","pmid":"https://pubmed.ncbi.nlm.nih.gov/9278385"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.272.36.22385","doi":"https://doi.org/10.1074/jbc.272.36.22385","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.36.22385","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.272.36.22385","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103139713","display_name":"Peiqin Chen","orcid":"https://orcid.org/0009-0003-4013-8194","observed_orcids":["https://orcid.org/0009-0003-4013-8194"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peiqin Chen","raw_affiliation_strings":["Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025091161","display_name":"Michael B. Mayne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael Mayne","raw_affiliation_strings":["Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038583170","display_name":"Christopher Power","orcid":"https://orcid.org/0000-0002-5131-9711","observed_orcids":["https://orcid.org/0000-0002-5131-9711"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher Power","raw_affiliation_strings":["Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000097172","display_name":"Avindra Nath","orcid":"https://orcid.org/0000-0003-0927-5855","observed_orcids":["https://orcid.org/0000-0003-0927-5855"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Avindra Nath","raw_affiliation_strings":["Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Section of Neurology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3","institution_ids":["https://openalex.org/I46247651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000097172"],"corresponding_institution_ids":["https://openalex.org/I46247651"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.7364,"has_fulltext":false,"cited_by_count":219,"citation_normalized_percentile":{"value":0.94524336,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"272","issue":"36","first_page":"22385","last_page":"22388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-tat","display_name":"HIV-1 Tat protein","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/hiv-associated-dementia","display_name":"HIV-associated dementia","score":0.796999990940094},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.878000020980835},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9860000014305115},{"id":"https://openalex.org/keywords/glial-activation","display_name":"glial activation","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6684931516647339},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.5693158507347107},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5629587173461914},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45106345415115356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3874739408493042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35063308477401733},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3205825686454773},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3049383759498596}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015696","descriptor_name":"Gene Products, tat","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015696","descriptor_name":"Gene Products, tat","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054322","descriptor_name":"tat Gene Products, Human Immunodeficiency Virus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.272.36.22385","doi":"https://doi.org/10.1074/jbc.272.36.22385","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.36.22385","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9278385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9278385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.272.36.22385","doi":"https://doi.org/10.1074/jbc.272.36.22385","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.272.36.22385","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W120911793","https://openalex.org/W281134522","https://openalex.org/W1524845305","https://openalex.org/W1543084458","https://openalex.org/W1547412330","https://openalex.org/W1595980407","https://openalex.org/W1602964111","https://openalex.org/W1605376961","https://openalex.org/W1753366134","https://openalex.org/W1790169325","https://openalex.org/W1870780415","https://openalex.org/W1900380445","https://openalex.org/W1961629671","https://openalex.org/W1975803523","https://openalex.org/W1976213001","https://openalex.org/W1992277399","https://openalex.org/W2001751662","https://openalex.org/W2005807968","https://openalex.org/W2007463249","https://openalex.org/W2007500354","https://openalex.org/W2009156709","https://openalex.org/W2024285818","https://openalex.org/W2030244466","https://openalex.org/W2040528920","https://openalex.org/W2043736935","https://openalex.org/W2047062904","https://openalex.org/W2049659704","https://openalex.org/W2061434349","https://openalex.org/W2064824796","https://openalex.org/W2065426442","https://openalex.org/W2077012020","https://openalex.org/W2089421056","https://openalex.org/W2097972613","https://openalex.org/W2099644089","https://openalex.org/W2099982795","https://openalex.org/W2108499384","https://openalex.org/W2120658132","https://openalex.org/W2147638621","https://openalex.org/W2150627157","https://openalex.org/W2152115109","https://openalex.org/W2186668620","https://openalex.org/W2321808822","https://openalex.org/W2431486073","https://openalex.org/W2472030091","https://openalex.org/W4230229878"],"related_works":["https://openalex.org/W1964982578","https://openalex.org/W2010358244","https://openalex.org/W2160939409","https://openalex.org/W1984731944","https://openalex.org/W7066331653","https://openalex.org/W1981068673","https://openalex.org/W1990291362","https://openalex.org/W2413928963","https://openalex.org/W2010160468","https://openalex.org/W2792976230"],"abstract_inverted_index":{"Human":[0],"immunodeficiency":[1],"virus":[2],"(HIV)":[3],"infection":[4],"may":[5,59,126],"cause":[6],"a":[7],"dementing":[8],"illness.":[9],"HIV-mediated":[10],"dementia":[11],"is":[12,53],"clinically":[13],"and":[14,23,69,86,133,137],"pathologically":[15],"correlated":[16],"with":[17],"the":[18,46,61],"infiltration":[19],"of":[20,26,32,38,41,63,117],"activated":[21],"macrophages":[22,75],"elevated":[24],"levels":[25],"tumor":[27],"necrosis":[28],"factor":[29],"(TNF)-alpha,":[30],"both":[31],"which":[33,52],"occur":[34],"in":[35,74,78],"an":[36,128],"environment":[37],"small":[39],"numbers":[40],"infected":[42,57],"cells.":[43,80],"We":[44],"examined":[45],"possibility":[47],"that":[48,124],"HIV":[49,132,143],"protein":[50,70,92,96,118],"Tat,":[51],"released":[54],"extracellularly":[55],"from":[56],"cells,":[58],"induce":[60],"production":[62,71],"TNF-alpha.":[64],"Tat":[65,113,125],"induced":[66],"TNF-alpha":[67,82,103],"mRNA":[68],"dose-dependently,":[72],"primarily":[73],"but":[76],"also":[77,106],"astrocytic":[79],"The":[81],"induction":[83],"was":[84,105],"NF-kappaB-dependent":[85],"could":[87],"be":[88],"eliminated":[89],"by":[90],"inhibiting":[91],"kinase":[93,98,119],"A":[94],"or":[95],"tyrosine":[97],"activity.":[99],"In":[100],"addition,":[101],"Tat-induced":[102],"release":[104],"linked":[107],"to":[108],"phospholipase":[109],"C":[110],"activation.":[111],"However,":[112],"effects":[114],"were":[115],"independent":[116],"C.":[120],"These":[121],"observations":[122],"suggest":[123,138],"provide":[127],"important":[129],"link":[130],"between":[131],"macrophage/glial":[134],"cell":[135],"activation":[136],"new":[139],"therapeutic":[140],"approaches":[141],"for":[142],"dementia.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
