{"id":"https://openalex.org/W1997623360","doi":"https://doi.org/10.1093/nar/gkf673","title":"Identification of cellular mRNA targets for RNA-binding protein Sam68","display_name":"Identification of cellular mRNA targets for RNA-binding protein Sam68","publication_year":2002,"publication_date":"2002-12-15","ids":{"openalex":"https://openalex.org/W1997623360","doi":"https://doi.org/10.1093/nar/gkf673","mag":"1997623360","pmid":"https://pubmed.ncbi.nlm.nih.gov/12490714","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/140046"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkf673","doi":"https://doi.org/10.1093/nar/gkf673","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/gkf673","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC140046","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021776714","display_name":"Michiyasu Itoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"M. Itoh","raw_affiliation_strings":["Department of Microbiology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021776714"],"corresponding_institution_ids":["https://openalex.org/I126884977"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":1.2429,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.76131318,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"30","issue":"24","first_page":"5452","last_page":"5464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sam68","display_name":"Sam68","score":1.0},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mrna-targets","display_name":"mRNA targets","score":0.718999981880188},{"id":"https://openalex.org/keywords/hnrnpa2b1","display_name":"HNRNPA2B1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/beta-actin","display_name":"beta-actin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/poly-u-binding","display_name":"poly(U) binding","score":0.8140000104904175},{"id":"https://openalex.org/keywords/rna-binding-domain","display_name":"RNA-binding domain","score":0.847000002861023},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/rna-secondary-structure","display_name":"RNA secondary structure","score":0.5389999747276306},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.6880000233650208},{"id":"https://openalex.org/keywords/differential-display","display_name":"differential display","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9176422357559204},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.6480170488357544},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.5925959348678589},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5785151720046997},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5153998136520386},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5020806789398193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4189436733722687},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38345077633857727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3767852485179901},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21515759825706482},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020413","descriptor_name":"3' Untranslated Regions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034441","descriptor_name":"Heterogeneous-Nuclear Ribonucleoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/nar/gkf673","doi":"https://doi.org/10.1093/nar/gkf673","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nar/gkf673","pdf_url":null,"source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:157182","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC140046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:140046","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/140046","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:12490714","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12490714","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.537.8226","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.537.8226","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://nar.oxfordjournals.org/content/30/24/5452.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:157182","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC140046","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W139215279","https://openalex.org/W1494559921","https://openalex.org/W1519185585","https://openalex.org/W1534572953","https://openalex.org/W1536283209","https://openalex.org/W1546173464","https://openalex.org/W1546652468","https://openalex.org/W1810235651","https://openalex.org/W1934896939","https://openalex.org/W1964859372","https://openalex.org/W1970588342","https://openalex.org/W1976500290","https://openalex.org/W1982799289","https://openalex.org/W1983394338","https://openalex.org/W1995976925","https://openalex.org/W2006755812","https://openalex.org/W2014856018","https://openalex.org/W2016388851","https://openalex.org/W2019903076","https://openalex.org/W2024195275","https://openalex.org/W2025893957","https://openalex.org/W2026506733","https://openalex.org/W2027590165","https://openalex.org/W2036894544","https://openalex.org/W2037959640","https://openalex.org/W2044028282","https://openalex.org/W2044468018","https://openalex.org/W2055723458","https://openalex.org/W2067020273","https://openalex.org/W2078300727","https://openalex.org/W2079321730","https://openalex.org/W2092185729","https://openalex.org/W2099817755","https://openalex.org/W2101679570","https://openalex.org/W2105420135","https://openalex.org/W2109074647","https://openalex.org/W2110061443","https://openalex.org/W2110112927","https://openalex.org/W2117011078","https://openalex.org/W2126690485","https://openalex.org/W2127802201","https://openalex.org/W2133613945","https://openalex.org/W2137251783","https://openalex.org/W2140073418","https://openalex.org/W2153599010","https://openalex.org/W2168788116","https://openalex.org/W2316819217","https://openalex.org/W2395008887"],"related_works":["https://openalex.org/W7098145747","https://openalex.org/W1981607999","https://openalex.org/W3201917680","https://openalex.org/W2006755812","https://openalex.org/W2067867820","https://openalex.org/W2037959640","https://openalex.org/W2034394097","https://openalex.org/W2048709308","https://openalex.org/W1975452779","https://openalex.org/W1994659814"],"abstract_inverted_index":{"Sam68":[0,32,77,93,126,142,180],"(Src-associated":[1],"in":[2,17,41,47,90,94,114,119,127,168,189],"mitosis,":[3],"68":[4],"kDa),":[5],"a":[6,15,21,79,169],"nuclear":[7],"RNA-binding":[8,96],"protein,":[9],"has":[10],"been":[11],"postulated":[12],"to":[13,35,37,92,111,193],"play":[14],"role":[16],"cell-growth":[18],"control":[19],"as":[20,116,118],"modulator":[22],"of":[23,28,73,125,132,136],"signal":[24],"transduction":[25],"and":[26,44,61,107,156,161,186],"activation":[27],"RNA":[29],"metabolism.":[30],"Although":[31],"was":[33],"demonstrated":[34],"bind":[36,89,112],"the":[38,49,58,101,122,128,137,183],"UAAA":[39,151,184],"sequences":[40,165,188],"synthetic":[42],"oligoribonucleotides":[43],"poly(U)":[45,187],"homopolymers":[46],"vitro,":[48,120],"legitimate":[50],"cellular":[51,194],"mRNA":[52,86,102,155],"target":[53,195],"remained":[54],"unclear.":[55],"By":[56],"using":[57],"differential":[59],"display":[60],"cDNA-representational":[62],"difference":[63],"analysis":[64],"techniques,":[65],"followed":[66],"by":[67,174],"reverse":[68],"transcription":[69],"polymerase":[70],"chain":[71],"reaction":[72],"RNAs":[74],"co-immunoprecipitated":[75],"with":[76,144],"from":[78],"HeLa":[80],"cell":[81],"lysate,":[82],"we":[83],"identified":[84],"10":[85],"species":[87,103],"that":[88,141,162,179],"vivo":[91,115,190],"an":[95],"domain-dependent":[97],"manner.":[98],"Among":[99],"them,":[100],"for":[104,152,158,172,191],"hnRNP":[105,153],"A2/B1":[106,154],"beta-actin":[108,159],"were":[109],"found":[110],"prominently":[113],"well":[117],"suggesting":[121],"possible":[123],"involvement":[124],"post-":[129],"transcriptional":[130],"regulation":[131],"these":[133,145],"genes.":[134],"Mapping":[135],"Sam68-binding":[138],"sequence":[139],"revealed":[140],"associates":[143],"mRNAs":[146],"through":[147],"different":[148],"nucleotide":[149],"motifs,":[150],"UUUUUU":[157],"mRNA,":[160],"both":[163,182],"binding":[164,192],"must":[166],"reside":[167],"loop":[170],"structure":[171],"recognition":[173],"Sam68.":[175],"The":[176],"results":[177],"indicated":[178],"recognizes":[181],"motif":[185],"mRNAs.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
