{"id":"https://openalex.org/W1997600339","doi":"https://doi.org/10.3109/10428199309047863","title":"CML: Mechanisms of Disease Initiation and Progression","display_name":"CML: Mechanisms of Disease Initiation and Progression","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W1997600339","doi":"https://doi.org/10.3109/10428199309047863","mag":"1997600339","pmid":"https://pubmed.ncbi.nlm.nih.gov/8251916"},"language":"en","primary_location":{"id":"doi:10.3109/10428199309047863","doi":"https://doi.org/10.3109/10428199309047863","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10428199309047863","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia & Lymphoma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039028985","display_name":"Meir Wetzler","orcid":"https://orcid.org/0000-0003-1397-5942","observed_orcids":["https://orcid.org/0000-0003-1397-5942"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meir Wetzler","raw_affiliation_strings":["Department of Clinical Investigation, University of Texas, M.D. Anderson Cancer Center, Houston 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, University of Texas, M.D. Anderson Cancer Center, Houston 77030","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011529063","display_name":"Moshe Talpaz","orcid":"https://orcid.org/0000-0003-3361-3981","observed_orcids":["https://orcid.org/0000-0003-3361-3981"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moshe Talpaz","raw_affiliation_strings":["Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084290698","display_name":"Zeev E. Estrov","orcid":"https://orcid.org/0000-0002-1623-3613","observed_orcids":["https://orcid.org/0000-0002-1623-3613"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeev Estrov","raw_affiliation_strings":["Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Investigation, University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.678,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.67190339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"sup1","first_page":"47","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7699999809265137},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.7480000257492065},{"id":"https://openalex.org/keywords/philadelphia-chromosome-translocation","display_name":"Philadelphia chromosome translocation","score":0.800000011920929},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.7599999904632568},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.9789999723434448},{"id":"https://openalex.org/keywords/h-ras","display_name":"H-Ras","score":0.8080000281333923},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinoblastoma-gene","display_name":"retinoblastoma gene","score":0.9449999928474426},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9449999928474426},{"id":"https://openalex.org/keywords/p190-bcr-abl","display_name":"p190 BCR-ABL","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/blast-crisis","display_name":"blast crisis","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6197580695152283},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.6106602549552917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6000784635543823},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.5189732909202576},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.4959624707698822},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.49563491344451904},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4630131423473358},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.4568215012550354},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.45127102732658386},{"id":"https://openalex.org/C2778904597","wikidata":"https://www.wikidata.org/wiki/Q1129111","display_name":"Philadelphia chromosome","level":4,"score":0.44283345341682434},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43122604489326477},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40515613555908203},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30548787117004395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28015899658203125},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1265575885772705},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.11974868178367615},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0700497031211853}],"mesh":[{"descriptor_ui":"D001752","descriptor_name":"Blast Crisis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001752","descriptor_name":"Blast Crisis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015465","descriptor_name":"Leukemia, Myeloid, Accelerated Phase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015465","descriptor_name":"Leukemia, Myeloid, Accelerated Phase","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015973","descriptor_name":"Gene Expression Regulation, Leukemic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016313","descriptor_name":"Genes, abl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/10428199309047863","doi":"https://doi.org/10.3109/10428199309047863","is_oa":false,"landing_page_url":"https://doi.org/10.3109/10428199309047863","pdf_url":null,"source":{"id":"https://openalex.org/S27064115","display_name":"Leukemia & lymphoma/Leukemia and lymphoma","issn_l":"1026-8022","issn":["1026-8022","1029-2403","1042-8194"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia & Lymphoma","raw_type":"journal-article"},{"id":"pmid:8251916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8251916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia & lymphoma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W129878118","https://openalex.org/W186063976","https://openalex.org/W207528665","https://openalex.org/W236534077","https://openalex.org/W1543644132","https://openalex.org/W1754111038","https://openalex.org/W1772305653","https://openalex.org/W1975812434","https://openalex.org/W1981428235","https://openalex.org/W1998191493","https://openalex.org/W1998919839","https://openalex.org/W1998979789","https://openalex.org/W2006518962","https://openalex.org/W2041440798","https://openalex.org/W2076372887","https://openalex.org/W2085307511","https://openalex.org/W2089697181","https://openalex.org/W2095787255","https://openalex.org/W2112732129","https://openalex.org/W2171593969","https://openalex.org/W2244637994","https://openalex.org/W2339475636","https://openalex.org/W2342898717","https://openalex.org/W2404349331","https://openalex.org/W2410606477","https://openalex.org/W2416469616","https://openalex.org/W2418118875","https://openalex.org/W2418638740","https://openalex.org/W2425555163"],"related_works":["https://openalex.org/W2142962837","https://openalex.org/W4239426042","https://openalex.org/W2051593267","https://openalex.org/W2502061088","https://openalex.org/W7217625764","https://openalex.org/W1563120671","https://openalex.org/W2039787813","https://openalex.org/W2507946790","https://openalex.org/W2104294853","https://openalex.org/W2163794002"],"abstract_inverted_index":{"Chronic":[0],"myelogenous":[1],"leukemia":[2],"(CML)":[3],"is":[4,44,72],"a":[5,20,78],"hematological":[6],"stem":[7],"cell":[8],"disorder":[9],"characterized":[10],"by":[11,24],"excessive":[12,156],"proliferation":[13],"of":[14,42,64,84,141,146,172,192],"the":[15,25,28,32,45,55,82,87,93,96,100,112,144,168,173],"myeloid":[16],"lineage.":[17],"It":[18],"has":[19,67],"progressive":[21],"course":[22],"typified":[23],"transition":[26,94],"from":[27,95],"chronic":[29,97],"phase":[30,34],"to":[31,37,81,99,121,185],"accelerated":[33],"and":[35,50,70,134,188],"on":[36],"blast":[38,197],"crisis.":[39],"The":[40,61],"hallmark":[41],"CML":[43],"translocation":[46],"between":[47],"chromosomes":[48],"9":[49],"22":[51],"that":[52,74,180,189],"results":[53],"in":[54,77,130,161,167,196],"chimeric":[56],"BCR-ABL":[57],"gene":[58],"encoding":[59],"p210BCR-ABL.":[60],"oncogenic":[62],"potential":[63],"this":[65],"protein":[66],"been":[68],"validated,":[69],"it":[71,75],"believed":[73],"contributes":[76],"critical":[79],"way":[80],"initiation":[83],"CML.":[85,118,147],"However,":[86],"secondary":[88],"genetic":[89,123,193],"forces":[90],"responsible":[91],"for":[92,108,155],"state":[98],"fully":[101],"blastic":[102],"stage":[103],"are":[104],"not":[105],"clear.":[106],"Evidence":[107],"chromosomal":[109],"instability":[110],"includes":[111],"clonal":[113],"evolution":[114],"which":[115],"characterizes":[116],"advanced":[117,170],"In":[119,148],"regard":[120],"specific":[122],"aberrations,":[124],"sporadic":[125],"reports":[126],"have":[127,151],"shown":[128],"alterations":[129,194],"H-RAS,":[131],"c-MYC,":[132],"retinoblastoma,":[133],"P53":[135],"genes,":[136],"as":[137,139],"well":[138],"production":[140],"p190BCR-ABL":[142],"during":[143],"progression":[145],"addition,":[149],"we":[150],"recently":[152],"found":[153],"evidence":[154],"interleukin-1":[157],"beta":[158],"production,":[159],"acting":[160],"an":[162],"autocrine":[163],"and/or":[164],"paracrine":[165],"manner,":[166],"more":[169],"stages":[171],"disease.":[174],"Taken":[175],"together,":[176],"current":[177],"data":[178],"suggest":[179],"multiple":[181],"molecular":[182],"pathways":[183],"lead":[184],"disease":[186],"progression,":[187],"distinct":[190],"subsets":[191],"exist":[195],"crisis":[198],"patients.":[199]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}