{"id":"https://openalex.org/W1997598566","doi":"https://doi.org/10.1021/ic034438m","title":"Effect of Equatorial Ligands of Dirhodium(II,II) Complexes on the Efficiency and Mechanism of Transcription Inhibitionin Vitro","display_name":"Effect of Equatorial Ligands of Dirhodium(II,II) Complexes on the Efficiency and Mechanism of Transcription Inhibitionin Vitro","publication_year":2004,"publication_date":"2004-01-10","ids":{"openalex":"https://openalex.org/W1997598566","doi":"https://doi.org/10.1021/ic034438m","mag":"1997598566","pmid":"https://pubmed.ncbi.nlm.nih.gov/14753842"},"language":"en","primary_location":{"id":"doi:10.1021/ic034438m","doi":"https://doi.org/10.1021/ic034438m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic034438m","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005670674","display_name":"Helen T. Chifotides","orcid":"https://orcid.org/0000-0001-8044-4960","observed_orcids":["https://orcid.org/0000-0001-8044-4960"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen T. Chifotides","raw_affiliation_strings":["Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113214650","display_name":"Patty K.\u2010L. Fu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patty K.-L. Fu","raw_affiliation_strings":["Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056201103","display_name":"Kim R. Dunbar","orcid":"https://orcid.org/0000-0001-5728-7805","observed_orcids":["https://orcid.org/0000-0001-5728-7805"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kim R. Dunbar","raw_affiliation_strings":["Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038676358","display_name":"Claudia Turr\u00f3","orcid":"https://orcid.org/0000-0003-3202-5870","observed_orcids":["https://orcid.org/0000-0003-3202-5870"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claudia Turro","raw_affiliation_strings":["Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry, The Ohio State University, Columbus, Ohio 43210, and Texas A&M University, College Station, Texas 77843","institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038676358","https://openalex.org/A5056201103"],"corresponding_institution_ids":["https://openalex.org/I52357470","https://openalex.org/I91045830"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9732,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.84836785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"43","issue":"3","first_page":"1175","last_page":"1183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dirhodium-ii-complexes","display_name":"dirhodium(II) complexes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/transcription-inhibition","display_name":"transcription inhibition","score":0.7860000133514404},{"id":"https://openalex.org/keywords/t7-rna-polymerase","display_name":"T7 RNA polymerase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/equatorial-ligands","display_name":"equatorial ligands","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lewis-acidity","display_name":"Lewis acidity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/ligand-displacement","display_name":"ligand displacement","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9589422941207886},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.6984216570854187},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6586859822273254},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.579432487487793},{"id":"https://openalex.org/C2776449523","wikidata":"https://www.wikidata.org/wiki/Q272631","display_name":"RNA polymerase","level":4,"score":0.5626430511474609},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.503912627696991},{"id":"https://openalex.org/C64350747","wikidata":"https://www.wikidata.org/wiki/Q15334993","display_name":"RNA polymerase II","level":5,"score":0.45973339676856995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24994215369224548},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.22186312079429626},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.2133847177028656},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18691837787628174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10824558138847351},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012238","descriptor_name":"Rhodium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012238","descriptor_name":"Rhodium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012321","descriptor_name":"DNA-Directed RNA Polymerases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012710","descriptor_name":"Serum Albumin, Bovine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017123","descriptor_name":"Bacteriophage T7","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/ic034438m","doi":"https://doi.org/10.1021/ic034438m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic034438m","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:14753842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14753842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W148638240","https://openalex.org/W262406365","https://openalex.org/W612414919","https://openalex.org/W1493170168","https://openalex.org/W1495214474","https://openalex.org/W1499552914","https://openalex.org/W1502334991","https://openalex.org/W1507562524","https://openalex.org/W1520015039","https://openalex.org/W1542268894","https://openalex.org/W1965642201","https://openalex.org/W1968034613","https://openalex.org/W1972115380","https://openalex.org/W1976486382","https://openalex.org/W1980095889","https://openalex.org/W1980242161","https://openalex.org/W1983613391","https://openalex.org/W1983846414","https://openalex.org/W1985403032","https://openalex.org/W1988129027","https://openalex.org/W1989163046","https://openalex.org/W1990059495","https://openalex.org/W1991655119","https://openalex.org/W1995377525","https://openalex.org/W1996888865","https://openalex.org/W1998036609","https://openalex.org/W1998549696","https://openalex.org/W1998551643","https://openalex.org/W2000568632","https://openalex.org/W2012682560","https://openalex.org/W2014591827","https://openalex.org/W2014852723","https://openalex.org/W2020749568","https://openalex.org/W2027032958","https://openalex.org/W2031106427","https://openalex.org/W2032442944","https://openalex.org/W2032737565","https://openalex.org/W2032959348","https://openalex.org/W2034290678","https://openalex.org/W2035473280","https://openalex.org/W2036436175","https://openalex.org/W2039606465","https://openalex.org/W2043610941","https://openalex.org/W2043619369","https://openalex.org/W2043752054","https://openalex.org/W2046729092","https://openalex.org/W2049808944","https://openalex.org/W2052457486","https://openalex.org/W2062546205","https://openalex.org/W2062924200","https://openalex.org/W2065290936","https://openalex.org/W2065433806","https://openalex.org/W2068372433","https://openalex.org/W2068568063","https://openalex.org/W2069967580","https://openalex.org/W2072871721","https://openalex.org/W2073745804","https://openalex.org/W2076020561","https://openalex.org/W2080470063","https://openalex.org/W2081071394","https://openalex.org/W2085737617","https://openalex.org/W2089570339","https://openalex.org/W2089971389","https://openalex.org/W2100962032","https://openalex.org/W2102729115","https://openalex.org/W2104586872","https://openalex.org/W2114167986","https://openalex.org/W2146133266","https://openalex.org/W2162459466","https://openalex.org/W2165214298","https://openalex.org/W2406039446","https://openalex.org/W2460613093","https://openalex.org/W2950991425","https://openalex.org/W2951801838","https://openalex.org/W3138157653","https://openalex.org/W3138348982","https://openalex.org/W4239452431","https://openalex.org/W4289805149"],"related_works":["https://openalex.org/W2149940432","https://openalex.org/W2116427713","https://openalex.org/W2256305538","https://openalex.org/W2082036959","https://openalex.org/W2118345116","https://openalex.org/W2012756940","https://openalex.org/W2009012636","https://openalex.org/W2052173156","https://openalex.org/W2157164007","https://openalex.org/W7146374271"],"abstract_inverted_index":{"The":[0,27,62,108,211],"nature":[1],"of":[2,18,29,42,55,64,72,89,117,135,145,150,154,168,193,197,205,214,225],"the":[3,7,14,43,53,65,73,97,128,136,141,172,194,198,203,215,222,226,229,239],"equatorial":[4,137],"ligands":[5,188,241],"spanning":[6],"dirhodium":[8],"core":[9],"was":[10],"shown":[11],"to":[12,22,37,45,69,78,93,106,127,152,220,235],"affect":[13,221],"ability":[15],"and":[16,34,49,57,124,130,179,209],"mechanism":[17,182],"various":[19],"lantern-type":[20],"complexes":[21,44,67,184,206,227],"inhibit":[23,70],"transcription":[24,30,173,180],"in":[25,60,159,171,177,202],"vitro.":[26],"inhibition":[28,98,181],"by":[31,100,140,191,232],"Rh(2)(mu-O(2)CCF(3))(4),":[32,122,207],"Rh(2)(mu-HNCOCF(3))(4),":[33,123,208],"[Rh(2)(mu-O(2)CCH(3))(2)(CH(3)CN)(6)](2+)":[35,125],"appears":[36],"proceed":[38],"predominantly":[39],"via":[40],"binding":[41,105,126],"T7-RNA":[46],"polymerase":[47],"(T7-RNAP)":[48],"is":[50,91,218],"dependent":[51],"on":[52],"concentration":[54,88],"enzyme":[56,118,129,151,169],"Mg(2+)":[58],"ions":[59],"solution.":[61],"concentrations":[63],"aforementioned":[66],"required":[68,92],"50%":[71],"transcription,":[74],"C(inh)(50),":[75],"are":[76,119,189,242],"similar":[77,95],"that":[79],"measured":[80],"for":[81,112],"activated":[82],"cisplatin,":[83],"whereas":[84],"a":[85,163],"significantly":[86],"higher":[87],"Rh(2)(mu-HNCOCH(3))(4)":[90,101,155],"effect":[94],"inhibition;":[96],"induced":[99],"does":[102,156],"not":[103,157],"involve":[104,132],"T7-RNAP.":[107,146],"spectral":[109,161],"changes":[110],"observed":[111],"each":[113],"complex":[114],"upon":[115],"addition":[116,149],"consistent":[120,165],"with":[121,166,185,228],"may":[131],"partial":[133],"displacement":[134],"(eq)":[138],"groups":[139],"Lewis":[142,195,212],"basic":[143],"sites":[144,201,217],"In":[147],"contrast,":[148],"solutions":[153],"result":[158],"significant":[160],"changes,":[162],"finding":[164],"lack":[167],"dependence":[170],"inhibition.":[174],"These":[175],"differences":[176],"reactivity":[178],"among":[183],"different":[186],"bridging":[187,240],"explained":[190],"variations":[192],"acidity":[196,213],"axial":[199],"(ax)":[200],"series":[204],"Rh(2)(mu-HNCOCH(3))(4).":[210],"ax":[216],"expected":[219],"initial":[223],"interaction":[224],"biomolecules,":[230],"followed":[231],"their":[233],"rearrangement":[234],"eq":[236],"positions":[237],"if":[238],"labile.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}