{"id":"https://openalex.org/W1997555153","doi":"https://doi.org/10.1016/j.advenzreg.2010.09.008","title":"Diphosphoinositol polyphosphates: What are the mechanisms?","display_name":"Diphosphoinositol polyphosphates: What are the mechanisms?","publication_year":2010,"publication_date":"2010-10-29","ids":{"openalex":"https://openalex.org/W1997555153","doi":"https://doi.org/10.1016/j.advenzreg.2010.09.008","mag":"1997555153","pmid":"https://pubmed.ncbi.nlm.nih.gov/21035493","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3507380"},"language":"en","primary_location":{"id":"doi:10.1016/j.advenzreg.2010.09.008","doi":"https://doi.org/10.1016/j.advenzreg.2010.09.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.advenzreg.2010.09.008","pdf_url":null,"source":{"id":"https://openalex.org/S4210167908","display_name":"Advances in Enzyme Regulation","issn_l":"0065-2571","issn":["0065-2571","1873-2437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Enzyme Regulation","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3507380","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013107971","display_name":"Stephen B. Shears","orcid":"https://orcid.org/0000-0001-7309-8916","observed_orcids":["https://orcid.org/0000-0001-7309-8916"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen B. Shears","raw_affiliation_strings":["Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. Shears@niehs.nih.gov","Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. Shears@niehs.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]},{"raw_affiliation_string":"Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077548230","display_name":"Nikhil Gokhale","orcid":"https://orcid.org/0009-0008-3772-0040","observed_orcids":["https://orcid.org/0009-0008-3772-0040"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil A. Gokhale","raw_affiliation_strings":["Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045321370","display_name":"Huanchen Wang","orcid":"https://orcid.org/0000-0003-2701-7155","observed_orcids":["https://orcid.org/0000-0003-2701-7155"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huanchen Wang","raw_affiliation_strings":["Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057807073","display_name":"Angelika Zaremba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210095140","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelika Zaremba","raw_affiliation_strings":["Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013107971"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210095140"],"apc_list":null,"apc_paid":null,"fwci":0.2795,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.21501421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"51","issue":"1","first_page":"13","last_page":"25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.14579999446868896,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.7160000205039978},{"id":"https://openalex.org/keywords/signaling-mechanisms","display_name":"signaling mechanisms","score":0.6740000247955322},{"id":"https://openalex.org/keywords/phosphoinositide-metabolism","display_name":"phosphoinositide metabolism","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.8427293300628662},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.614745020866394},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5758072137832642},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.5753517746925354},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.5101747512817383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4291123151779175},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4289205074310303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3720824420452118},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.28979313373565674},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.281341016292572}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.advenzreg.2010.09.008","doi":"https://doi.org/10.1016/j.advenzreg.2010.09.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.advenzreg.2010.09.008","pdf_url":null,"source":{"id":"https://openalex.org/S4210167908","display_name":"Advances in Enzyme Regulation","issn_l":"0065-2571","issn":["0065-2571","1873-2437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Enzyme Regulation","raw_type":"journal-article"},{"id":"pmid:21035493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21035493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in enzyme regulation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3507380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3507380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Enzyme Regul","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3507380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3507380","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Enzyme Regul","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2817643744","display_name":"Inositol Signalling","funder_award_id":"ZIAES080046","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W59201476","https://openalex.org/W1485488844","https://openalex.org/W1507232548","https://openalex.org/W1665506700","https://openalex.org/W1782999734","https://openalex.org/W1789455264","https://openalex.org/W1819159746","https://openalex.org/W1888156959","https://openalex.org/W1964006621","https://openalex.org/W1964365069","https://openalex.org/W1966683993","https://openalex.org/W1966812211","https://openalex.org/W1970513264","https://openalex.org/W1971359603","https://openalex.org/W1972897065","https://openalex.org/W1975881825","https://openalex.org/W1976064745","https://openalex.org/W1976398980","https://openalex.org/W1981273047","https://openalex.org/W1982832802","https://openalex.org/W1988158937","https://openalex.org/W1990668649","https://openalex.org/W1992637717","https://openalex.org/W1993256647","https://openalex.org/W2003853159","https://openalex.org/W2005222967","https://openalex.org/W2008245136","https://openalex.org/W2009503877","https://openalex.org/W2011073796","https://openalex.org/W2016906437","https://openalex.org/W2021635852","https://openalex.org/W2021710604","https://openalex.org/W2021933017","https://openalex.org/W2022494306","https://openalex.org/W2022517367","https://openalex.org/W2022665276","https://openalex.org/W2023065755","https://openalex.org/W2024298422","https://openalex.org/W2024708954","https://openalex.org/W2030039682","https://openalex.org/W2031755602","https://openalex.org/W2032671506","https://openalex.org/W2034502645","https://openalex.org/W2042127371","https://openalex.org/W2043427242","https://openalex.org/W2044593393","https://openalex.org/W2046122733","https://openalex.org/W2048806742","https://openalex.org/W2053499358","https://openalex.org/W2054154217","https://openalex.org/W2054418156","https://openalex.org/W2057046131","https://openalex.org/W2059763365","https://openalex.org/W2063693187","https://openalex.org/W2064600278","https://openalex.org/W2066075443","https://openalex.org/W2067082658","https://openalex.org/W2068361003","https://openalex.org/W2071555141","https://openalex.org/W2073057480","https://openalex.org/W2080052604","https://openalex.org/W2080209900","https://openalex.org/W2086986542","https://openalex.org/W2087107956","https://openalex.org/W2087867196","https://openalex.org/W2090000122","https://openalex.org/W2094696609","https://openalex.org/W2094942425","https://openalex.org/W2098940989","https://openalex.org/W2101168569","https://openalex.org/W2102247469","https://openalex.org/W2102872728","https://openalex.org/W2104192993","https://openalex.org/W2126076915","https://openalex.org/W2126788666","https://openalex.org/W2127764420","https://openalex.org/W2129713711","https://openalex.org/W2132595013","https://openalex.org/W2135424721","https://openalex.org/W2137417976","https://openalex.org/W2144157059","https://openalex.org/W2146718650","https://openalex.org/W2149281930","https://openalex.org/W2149781029","https://openalex.org/W2150225976","https://openalex.org/W2157252649","https://openalex.org/W2157498064","https://openalex.org/W2163093841","https://openalex.org/W2164300744","https://openalex.org/W2164577098","https://openalex.org/W2168615296","https://openalex.org/W4243068419"],"related_works":["https://openalex.org/W125983278","https://openalex.org/W2035138755","https://openalex.org/W2149781029","https://openalex.org/W2104550693","https://openalex.org/W2085060555","https://openalex.org/W4236560032","https://openalex.org/W2009103987","https://openalex.org/W1992739092","https://openalex.org/W2116078288","https://openalex.org/W2557173468"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
