{"id":"https://openalex.org/W1997548360","doi":"https://doi.org/10.1016/j.cca.2008.09.024","title":"Combination of alpha-1-acid glycoprotein and alpha-fetoprotein as an improved diagnostic tool for hepatocellular carcinoma","display_name":"Combination of alpha-1-acid glycoprotein and alpha-fetoprotein as an improved diagnostic tool for hepatocellular carcinoma","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W1997548360","doi":"https://doi.org/10.1016/j.cca.2008.09.024","mag":"1997548360","pmid":"https://pubmed.ncbi.nlm.nih.gov/18926809"},"language":"en","primary_location":{"id":"doi:10.1016/j.cca.2008.09.024","doi":"https://doi.org/10.1016/j.cca.2008.09.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cca.2008.09.024","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075848788","display_name":"Indra Bachtiar","orcid":"https://orcid.org/0000-0002-4212-9959","observed_orcids":["https://orcid.org/0000-0002-4212-9959"]},"institutions":[{"id":"https://openalex.org/I4405265902","display_name":"Mochtar Riady Institute for Nanotechnology","ror":"https://ror.org/00t1q3132","country_code":"ID","type":"facility","lineage":["https://openalex.org/I102669525","https://openalex.org/I4405265902"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Indra Bachtiar","raw_affiliation_strings":["Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia","institution_ids":["https://openalex.org/I4405265902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073974442","display_name":"Julian Mulya Santoso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265902","display_name":"Mochtar Riady Institute for Nanotechnology","ror":"https://ror.org/00t1q3132","country_code":"ID","type":"facility","lineage":["https://openalex.org/I102669525","https://openalex.org/I4405265902"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Julian Mulya Santoso","raw_affiliation_strings":["Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia","institution_ids":["https://openalex.org/I4405265902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034536798","display_name":"Benny Atmanegara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265902","display_name":"Mochtar Riady Institute for Nanotechnology","ror":"https://ror.org/00t1q3132","country_code":"ID","type":"facility","lineage":["https://openalex.org/I102669525","https://openalex.org/I4405265902"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Benny Atmanegara","raw_affiliation_strings":["Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia","institution_ids":["https://openalex.org/I4405265902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046433298","display_name":"Rino Alvani Gani","orcid":"https://orcid.org/0000-0003-4009-7938","observed_orcids":["https://orcid.org/0000-0003-4009-7938"]},"institutions":[{"id":"https://openalex.org/I4210155152","display_name":"Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo","ror":"https://ror.org/05am7x020","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210155152"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Rino Alvani Gani","raw_affiliation_strings":["Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210155152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084266287","display_name":"Irsan Hasan","orcid":"https://orcid.org/0000-0001-6702-2659","observed_orcids":["https://orcid.org/0000-0001-6702-2659"]},"institutions":[{"id":"https://openalex.org/I4210155152","display_name":"Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo","ror":"https://ror.org/05am7x020","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210155152"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Irsan Hasan","raw_affiliation_strings":["Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210155152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007162667","display_name":"Laurentius Adrianto Lesmana","orcid":"https://orcid.org/0000-0001-7072-7051","observed_orcids":["https://orcid.org/0000-0001-7072-7051"]},"institutions":[{"id":"https://openalex.org/I4210155152","display_name":"Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo","ror":"https://ror.org/05am7x020","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210155152"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Laurentius Adrianto Lesmana","raw_affiliation_strings":["Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210155152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109111992","display_name":"Ali Sulaiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210155152","display_name":"Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo","ror":"https://ror.org/05am7x020","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210155152"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ali Sulaiman","raw_affiliation_strings":["Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210155152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110305797","display_name":"Jianren Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianren Gu","raw_affiliation_strings":["Shanghai Cancer Institute, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Cancer Institute, Shanghai, China","institution_ids":["https://openalex.org/I4210110011"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085478687","display_name":"Susan S. W. Tai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265902","display_name":"Mochtar Riady Institute for Nanotechnology","ror":"https://ror.org/00t1q3132","country_code":"ID","type":"facility","lineage":["https://openalex.org/I102669525","https://openalex.org/I4405265902"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Susan Tai","raw_affiliation_strings":["Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mochtar Riady Institute for Nanotechnology, Lippo Karawaci, Banten, Indonesia","institution_ids":["https://openalex.org/I4405265902"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075848788"],"corresponding_institution_ids":["https://openalex.org/I4405265902"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":3.0407,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.90777969,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"399","issue":"1-2","first_page":"97","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/alpha-1-acid-glycoprotein","display_name":"alpha-1-acid glycoprotein","score":1.0},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":1.0},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.902999997138977},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6240000128746033},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.8519999980926514},{"id":"https://openalex.org/keywords/combined-biomarker-detection","display_name":"combined biomarker detection","score":0.5569999814033508},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.901672899723053},{"id":"https://openalex.org/C2780624289","wikidata":"https://www.wikidata.org/wiki/Q306076","display_name":"Alpha-fetoprotein","level":3,"score":0.8358927369117737},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6926031708717346},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6923643350601196},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6430191397666931},{"id":"https://openalex.org/C30787643","wikidata":"https://www.wikidata.org/wiki/Q24779782","display_name":"Orosomucoid","level":3,"score":0.5946135520935059},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5356554388999939},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5229523777961731},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.521356463432312},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5130671262741089},{"id":"https://openalex.org/C2779102576","wikidata":"https://www.wikidata.org/wiki/Q5113984","display_name":"Chronic liver disease","level":3,"score":0.46487003564834595},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4282623529434204},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.26052653789520264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15873616933822632},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.10672345757484436},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08898156881332397},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000509","descriptor_name":"alpha-Fetoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009961","descriptor_name":"Orosomucoid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cca.2008.09.024","doi":"https://doi.org/10.1016/j.cca.2008.09.024","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cca.2008.09.024","pdf_url":null,"source":{"id":"https://openalex.org/S207549998","display_name":"Clinica Chimica Acta","issn_l":"0009-8981","issn":["0009-8981","1873-3492"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica Chimica Acta","raw_type":"journal-article"},{"id":"pmid:18926809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18926809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinica chimica acta; international journal of clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1859096580","https://openalex.org/W1977706128","https://openalex.org/W1978294500","https://openalex.org/W1987525830","https://openalex.org/W1994073443","https://openalex.org/W2003254336","https://openalex.org/W2013256718","https://openalex.org/W2019987582","https://openalex.org/W2030726979","https://openalex.org/W2033980298","https://openalex.org/W2034244313","https://openalex.org/W2038457699","https://openalex.org/W2040141270","https://openalex.org/W2050280734","https://openalex.org/W2069517597","https://openalex.org/W2076609047","https://openalex.org/W2088685439","https://openalex.org/W2112703544","https://openalex.org/W2126871433","https://openalex.org/W2155626305","https://openalex.org/W4211107801","https://openalex.org/W4366740104"],"related_works":["https://openalex.org/W3203083223","https://openalex.org/W2462690840","https://openalex.org/W2827065634","https://openalex.org/W2016140791","https://openalex.org/W1855735923","https://openalex.org/W3011646690","https://openalex.org/W2371774273","https://openalex.org/W2032355210","https://openalex.org/W2747519011","https://openalex.org/W2000881039"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}