{"id":"https://openalex.org/W1997541716","doi":"https://doi.org/10.1016/j.ultrasmedbio.2004.07.006","title":"Effect of shell type on the in vivo backscatter from polymer-encapsulated microbubbles","display_name":"Effect of shell type on the in vivo backscatter from polymer-encapsulated microbubbles","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W1997541716","doi":"https://doi.org/10.1016/j.ultrasmedbio.2004.07.006","mag":"1997541716","pmid":"https://pubmed.ncbi.nlm.nih.gov/15582227"},"language":"en","primary_location":{"id":"doi:10.1016/j.ultrasmedbio.2004.07.006","doi":"https://doi.org/10.1016/j.ultrasmedbio.2004.07.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ultrasmedbio.2004.07.006","pdf_url":null,"source":{"id":"https://openalex.org/S109113098","display_name":"Ultrasound in Medicine & Biology","issn_l":"0301-5629","issn":["0301-5629","1879-291X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in Medicine & Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038862540","display_name":"Flemming Forsberg","orcid":"https://orcid.org/0000-0003-2215-1371","observed_orcids":["https://orcid.org/0000-0003-2215-1371"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Flemming Forsberg","raw_affiliation_strings":["Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA. flemming.forsberg@jefferson.edu","Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA. flemming.forsberg@jefferson.edu","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004589257","display_name":"Justin Durla Lathia","orcid":"https://orcid.org/0000-0003-3168-7290","observed_orcids":["https://orcid.org/0000-0003-3168-7290"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin D. Lathia","raw_affiliation_strings":["School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034236549","display_name":"Daniel A. Merton","orcid":"https://orcid.org/0000-0001-8033-5342","observed_orcids":["https://orcid.org/0000-0001-8033-5342"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Merton","raw_affiliation_strings":["Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072024057","display_name":"Ji\u2010Bin Liu","orcid":"https://orcid.org/0000-0003-2979-9162","observed_orcids":["https://orcid.org/0000-0003-2979-9162"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Bin Liu","raw_affiliation_strings":["Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071791069","display_name":"Ngocyen T. Le","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ngocyen T. Le","raw_affiliation_strings":["School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109564517","display_name":"Barry B. Goldberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry B. Goldberg","raw_affiliation_strings":["Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Thomas Jefferson University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008229350","display_name":"Margaret A. Wheatley","orcid":"https://orcid.org/0000-0001-6917-8972","observed_orcids":["https://orcid.org/0000-0001-6917-8972"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret A. Wheatley","raw_affiliation_strings":["School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Drexel University, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I72816309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038862540"],"corresponding_institution_ids":["https://openalex.org/I149251103"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":2.4461,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.87157076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"30","issue":"10","first_page":"1281","last_page":"1287"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasound-contrast-agents","display_name":"ultrasound contrast agents","score":0.9729999899864197},{"id":"https://openalex.org/keywords/time-intensity-curve","display_name":"time-intensity curve","score":0.6980000138282776},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.49900001287460327},{"id":"https://openalex.org/keywords/renal-imaging","display_name":"kidney imaging","score":0.6620000004768372},{"id":"https://openalex.org/keywords/pulse-inversion-harmonic-imaging","display_name":"pulse inversion harmonic imaging","score":0.6830000281333923},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6625608801841736},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.603865921497345},{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.5682265162467957},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.49686625599861145},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46673333644866943},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.3826110363006592},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33140093088150024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24196484684944153},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.12434956431388855},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.09588193893432617},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.0836186408996582},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077182","descriptor_name":"Polylactic Acid-Polyglycolic Acid Copolymer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001673","descriptor_name":"Biodegradation, Environmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006016","descriptor_name":"Glycolates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011100","descriptor_name":"Polyglycolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ultrasmedbio.2004.07.006","doi":"https://doi.org/10.1016/j.ultrasmedbio.2004.07.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ultrasmedbio.2004.07.006","pdf_url":null,"source":{"id":"https://openalex.org/S109113098","display_name":"Ultrasound in Medicine & Biology","issn_l":"0301-5629","issn":["0301-5629","1879-291X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in Medicine & Biology","raw_type":"journal-article"},{"id":"pmid:15582227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15582227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ultrasound in medicine & biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1501987421","display_name":null,"funder_award_id":"HL-52901","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G625621254","display_name":null,"funder_award_id":"CA 52823","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7633587417","display_name":"Development and Characterization of a Novel Contrast Agent","funder_award_id":"R01HL052901","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8734721189","display_name":"DEVELOPING OF ULTRASONIC TISSUE CHARACTERIZATION METHODS","funder_award_id":"P01CA052823","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1515172420","https://openalex.org/W1534302802","https://openalex.org/W1967720988","https://openalex.org/W1979370702","https://openalex.org/W1986217034","https://openalex.org/W1989309742","https://openalex.org/W1990879541","https://openalex.org/W1995101866","https://openalex.org/W2006162395","https://openalex.org/W2006330627","https://openalex.org/W2008943593","https://openalex.org/W2019242142","https://openalex.org/W2019790121","https://openalex.org/W2020148185","https://openalex.org/W2020326455","https://openalex.org/W2045949549","https://openalex.org/W2058045036","https://openalex.org/W2065741172","https://openalex.org/W2068442870","https://openalex.org/W2073635445","https://openalex.org/W2079886094","https://openalex.org/W2083453052","https://openalex.org/W2099781987","https://openalex.org/W2105029697","https://openalex.org/W2121496050","https://openalex.org/W2134061962","https://openalex.org/W2146555464","https://openalex.org/W2166503538","https://openalex.org/W2245631706","https://openalex.org/W2318502166","https://openalex.org/W2324118158"],"related_works":["https://openalex.org/W2394427568","https://openalex.org/W1983371689","https://openalex.org/W2080883733","https://openalex.org/W2065632269","https://openalex.org/W2152809740","https://openalex.org/W2159775944","https://openalex.org/W2126385628","https://openalex.org/W2472757628","https://openalex.org/W2393693032","https://openalex.org/W1984024205"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}