{"id":"https://openalex.org/W1997530797","doi":"https://doi.org/10.1073/pnas.0801692105","title":"RNA landscape of evolution for optimal exon and intron discrimination","display_name":"RNA landscape of evolution for optimal exon and intron discrimination","publication_year":2008,"publication_date":"2008-04-07","ids":{"openalex":"https://openalex.org/W1997530797","doi":"https://doi.org/10.1073/pnas.0801692105","mag":"1997530797","pmid":"https://pubmed.ncbi.nlm.nih.gov/18391195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311341"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0801692105","doi":"https://doi.org/10.1073/pnas.0801692105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0801692105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311341","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101692889","display_name":"Chaolin Zhang","orcid":"https://orcid.org/0000-0002-8310-7537","observed_orcids":["https://orcid.org/0000-0002-8310-7537"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaolin Zhang","raw_affiliation_strings":["*Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724;","Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794; and","Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724;","institution_ids":["https://openalex.org/I2750212522"]},{"raw_affiliation_string":"Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794; and","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049358254","display_name":"Wen\u2010Hsiung Li","orcid":"https://orcid.org/0000-0003-2757-5026","observed_orcids":["https://orcid.org/0000-0003-2757-5026","https://orcid.org/0000-0003-1086-1456"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen-Hsiung Li","raw_affiliation_strings":["Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113482239","display_name":"Adrian R. Krainer","orcid":"https://orcid.org/0000-0001-9024-9501","observed_orcids":["https://orcid.org/0000-0001-9024-9501"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian R. Krainer","raw_affiliation_strings":["*Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724;","institution_ids":["https://openalex.org/I2750212522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058814283","display_name":"Michael Q. Zhang","orcid":"https://orcid.org/0000-0002-7022-6115","observed_orcids":["https://orcid.org/0000-0002-7022-6115"]},"institutions":[{"id":"https://openalex.org/I2750212522","display_name":"Cold Spring Harbor Laboratory","ror":"https://ror.org/02qz8b764","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2750212522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Q. Zhang","raw_affiliation_strings":["*Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724;","institution_ids":["https://openalex.org/I2750212522"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.5458,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.93764496,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"105","issue":"15","first_page":"5797","last_page":"5802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pre-mrna-splicing","display_name":"pre-mRNA splicing","score":0.8479999899864197},{"id":"https://openalex.org/keywords/splicing-regulatory-elements","display_name":"splicing regulatory elements","score":0.8450000286102295},{"id":"https://openalex.org/keywords/exonic-splicing-enhancers","display_name":"exonic splicing enhancers","score":0.9819999933242798},{"id":"https://openalex.org/keywords/exonic-splicing-silencer","display_name":"exonic splicing silencer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/intronic-splicing-enhancer","display_name":"intronic splicing enhancer","score":0.9449999928474426},{"id":"https://openalex.org/keywords/strand-asymmetry","display_name":"strand asymmetry","score":0.8479999899864197},{"id":"https://openalex.org/keywords/chargaff-s-second-parity-rule","display_name":"Chargaff's second parity rule","score":0.9070000052452087},{"id":"https://openalex.org/keywords/selective-pressure","display_name":"selection pressure","score":0.328000009059906},{"id":"https://openalex.org/keywords/human-genes","display_name":"human genes","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.8386322259902954},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.8236628770828247},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.737411379814148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6289735436439514},{"id":"https://openalex.org/C42576000","wikidata":"https://www.wikidata.org/wiki/Q5420618","display_name":"Exonic splicing enhancer","level":5,"score":0.6206853985786438},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.603447437286377},{"id":"https://openalex.org/C72994624","wikidata":"https://www.wikidata.org/wiki/Q7226900","display_name":"Polypyrimidine tract","level":5,"score":0.5290471911430359},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.48976826667785645},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.48277536034584045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46403810381889343},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.4545934796333313},{"id":"https://openalex.org/C62257209","wikidata":"https://www.wikidata.org/wiki/Q5487490","display_name":"Splice site mutation","level":5,"score":0.41246822476387024},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.4123995900154114},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4022951126098633},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3917703926563263},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.277463436126709},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10885757207870483}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0801692105","doi":"https://doi.org/10.1073/pnas.0801692105","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0801692105","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2311341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:18391195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18391195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:repository.cshl.edu:27616","doi":null,"is_oa":false,"landing_page_url":"https://repository.cshl.edu/id/eprint/27616/1/Krainer%20and%20Zhang%20PNAS%202008.pdf","pdf_url":"https://repository.cshl.edu/id/eprint/27616/1/Krainer%20and%20Zhang%20PNAS%202008.pdf","source":{"id":"https://openalex.org/S4306402288","display_name":"Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Paper"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2311341","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2311341","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2854603552","display_name":null,"funder_award_id":"GM74688","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4885390686","display_name":"Computational and experimental modeling of RNA Splicing","funder_award_id":"R01GM074688","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W214734757","https://openalex.org/W1836860525","https://openalex.org/W1973646952","https://openalex.org/W1983227372","https://openalex.org/W1994643925","https://openalex.org/W2012032914","https://openalex.org/W2013235753","https://openalex.org/W2020164044","https://openalex.org/W2023648355","https://openalex.org/W2024034350","https://openalex.org/W2029760674","https://openalex.org/W2030955818","https://openalex.org/W2033144162","https://openalex.org/W2038921819","https://openalex.org/W2041998806","https://openalex.org/W2063318299","https://openalex.org/W2076793571","https://openalex.org/W2087627409","https://openalex.org/W2102304447","https://openalex.org/W2106075602","https://openalex.org/W2106767328","https://openalex.org/W2109936378","https://openalex.org/W2114858580","https://openalex.org/W2132117253","https://openalex.org/W2141419420","https://openalex.org/W2147781659","https://openalex.org/W2149063231","https://openalex.org/W2150083385","https://openalex.org/W2157613837","https://openalex.org/W2168909179","https://openalex.org/W2792152836","https://openalex.org/W7095221652"],"related_works":["https://openalex.org/W3034103023","https://openalex.org/W2185476414","https://openalex.org/W1985300809","https://openalex.org/W2031141147","https://openalex.org/W2524523168","https://openalex.org/W2066628520","https://openalex.org/W2273325256","https://openalex.org/W1994643925","https://openalex.org/W2152051682","https://openalex.org/W2109362348"],"abstract_inverted_index":{"Accurate":[0],"pre-mRNA":[1,113],"splicing":[2,5,26,30,34,39],"requires":[3],"primary":[4],"signals,":[6],"including":[7],"the":[8,47,69,75,135,173,180,185,212],"splice":[9,48,70],"sites,":[10],"a":[11,15,89,99,112,127,201],"polypyrimidine":[12],"tract,":[13],"and":[14,37,62,139,151,155,191,197,228],"branch":[16],"site,":[17],"other":[18],"splicing-regulatory":[19],"elements":[20],"(SREs).":[21],"The":[22],"SREs":[23,78,125,206],"include":[24],"exonic":[25,29,61],"enhancers":[27,35],"(ESEs),":[28],"silencers":[31,40],"(ESSs),":[32],"intronic":[33,38,63,166],"(ISEs),":[36],"(ISSs),":[41],"which":[42],"are":[43,147,193],"typically":[44],"located":[45],"near":[46],"sites.":[49,71],"However,":[50,115],"it":[51],"is":[52,132,176],"unclear":[53],"to":[54],"what":[55],"extent":[56],"splicing-driven":[57],"selective":[58],"pressure":[59],"constrains":[60],"sequences,":[64,167],"especially":[65],"those":[66],"distant":[67],"from":[68],"Here,":[72],"we":[73,116],"studied":[74],"distribution":[76,110],"of":[77,84,121,172,189,195,215],"in":[79,82,144,149,153],"human":[80,221],"genes":[81,222],"terms":[83],"DNA":[85],"strand-asymmetry":[86,129],"patterns.":[87],"Under":[88],"neutral":[90,136],"evolution":[91,137],"model,":[92,138],"each":[93],"mononucleotide":[94,181],"or":[95,105],"oligonucleotide":[96],"should":[97],"have":[98,223],"symmetric":[100],"(Chargaff's":[101],"second":[102],"parity":[103],"rule),":[104],"weakly":[106],"asymmetric":[107,186],"yet":[108],"uniform,":[109],"throughout":[111],"transcript.":[114],"found":[117],"that":[118,131,184,203,220],"large":[119],"sets":[120],"unbiased,":[122],"experimentally":[123],"determined":[124],"show":[126],"distinct":[128],"pattern":[130],"inconsistent":[133],"with":[134],"reflects":[140],"their":[141],"functional":[142],"roles":[143],"splicing.":[145],"ESEs":[146,196],"selected":[148],"exons":[150,190],"depleted":[152],"introns":[154,192],"vice":[156],"versa":[157],"for":[158,169,226],"ESSs.":[159,198],"Surprisingly,":[160],"this":[161],"trend":[162],"extends":[163],"into":[164],"deep":[165],"accounting":[168],"one":[170],"third":[171],"genome.":[174],"Selection":[175],"detectable":[177],"even":[178],"at":[179],"level,":[182],"so":[183],"base":[187],"compositions":[188],"predictive":[194],"We":[199],"developed":[200],"method":[202],"effectively":[204],"predicts":[205],"based":[207],"on":[208],"strand":[209],"asymmetry,":[210],"expanding":[211],"current":[213],"catalog":[214],"SREs.":[216],"Our":[217],"results":[218],"suggest":[219],"been":[224],"optimized":[225],"exon":[227],"intron":[229],"discrimination":[230],"through":[231],"an":[232],"RNA":[233],"landscape":[234],"shaped":[235],"during":[236],"evolution.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}