{"id":"https://openalex.org/W1997505180","doi":"https://doi.org/10.1210/en.2014-1109","title":"Chondrocytes Play a Major Role in the Stimulation of Bone Growth by Thyroid Hormone","display_name":"Chondrocytes Play a Major Role in the Stimulation of Bone Growth by Thyroid Hormone","publication_year":2014,"publication_date":"2014-06-10","ids":{"openalex":"https://openalex.org/W1997505180","doi":"https://doi.org/10.1210/en.2014-1109","mag":"1997505180","pmid":"https://pubmed.ncbi.nlm.nih.gov/24914940"},"language":"en","primary_location":{"id":"doi:10.1210/en.2014-1109","doi":"https://doi.org/10.1210/en.2014-1109","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2014-1109","pdf_url":"https://academic.oup.com/endo/article-pdf/155/8/3123/10828787/endo3123.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/endo/article-pdf/155/8/3123/10828787/endo3123.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044655806","display_name":"Cl\u00e9mence Desjardin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129272","display_name":"G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative","ror":"https://ror.org/03rkgeb39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210129272"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cl\u00e9mence Desjardin","raw_affiliation_strings":["Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210129272","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076716945","display_name":"Cyril Charles","orcid":"https://orcid.org/0000-0002-6930-039X","observed_orcids":["https://orcid.org/0000-0002-6930-039X"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210125167","display_name":"Institut de G\u00e9nomique Fonctionnelle de Lyon","ror":"https://ror.org/038fcbc74","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210088668","https://openalex.org/I4210125167"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyril Charles","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS) UMR 5242 (C.C.), ENS Lyon, Institut de G\u00e9nomique Fonctionnelle, Universit\u00e9 de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS) UMR 5242 (C.C.), ENS Lyon, Institut de G\u00e9nomique Fonctionnelle, Universit\u00e9 de Lyon, Lyon, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210125167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029418581","display_name":"Catherine Benoist-Lasselin","orcid":"https://orcid.org/0000-0003-1779-0312","observed_orcids":["https://orcid.org/0000-0003-1779-0312"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Benoist-Lasselin","raw_affiliation_strings":["Institut Imagine (C.B.-L., L.L.-G.) Institut National de la Sant\u00e9 et de la Recherche Medicale, U1163, Universit\u00e9 Paris Descartes, 75015 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Imagine (C.B.-L., L.L.-G.) Institut National de la Sant\u00e9 et de la Recherche Medicale, U1163, Universit\u00e9 Paris Descartes, 75015 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210165077","https://openalex.org/I4387156284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074751975","display_name":"Julie Rivi\u00e8re","orcid":"https://orcid.org/0000-0002-5857-6665","observed_orcids":["https://orcid.org/0000-0002-5857-6665"]},"institutions":[{"id":"https://openalex.org/I4210129272","display_name":"G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative","ror":"https://ror.org/03rkgeb39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210129272"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Riviere","raw_affiliation_strings":["Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210129272","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014222534","display_name":"Ma\u00eflys Gilles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129272","display_name":"G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative","ror":"https://ror.org/03rkgeb39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210129272"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mailys Gilles","raw_affiliation_strings":["Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210129272","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053513463","display_name":"Olivier Chassande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I4387152649","display_name":"Laboratory for the Bioengineering of Tissues","ror":"https://ror.org/012zmcc30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4387152649"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Chassande","raw_affiliation_strings":["University of Bordeaux (O.C.), U1026, Bioing\u00e9nierie Tissulaire, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bordeaux (O.C.), U1026, Bioing\u00e9nierie Tissulaire, Bordeaux, France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4387152649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017009554","display_name":"Caroline Morgenthaler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129272","display_name":"G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative","ror":"https://ror.org/03rkgeb39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210129272"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Caroline Morgenthaler","raw_affiliation_strings":["Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210129272","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016868874","display_name":"D\u00e9nis Lalo\u00eb","orcid":"https://orcid.org/0000-0001-8359-0760","observed_orcids":["https://orcid.org/0000-0001-8359-0760"]},"institutions":[{"id":"https://openalex.org/I4210129272","display_name":"G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative","ror":"https://ror.org/03rkgeb39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210129272"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Lalo\u00e9","raw_affiliation_strings":["Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210129272","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056643974","display_name":"J\u00e9r\u00f4me Lecardonnel","orcid":"https://orcid.org/0009-0007-0971-6557","observed_orcids":["https://orcid.org/0009-0007-0971-6557"]},"institutions":[{"id":"https://openalex.org/I4210129272","display_name":"G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative","ror":"https://ror.org/03rkgeb39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210129272"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"J\u00e9r\u00f4me Lecardonnel","raw_affiliation_strings":["Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210129272","https://openalex.org/I4387154544"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055826574","display_name":"Fr\u00e9d\u00e9ric Flamant","orcid":"https://orcid.org/0000-0002-3360-2345","observed_orcids":["https://orcid.org/0000-0002-3360-2345"]},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210125167","display_name":"Institut de G\u00e9nomique Fonctionnelle de Lyon","ror":"https://ror.org/038fcbc74","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I203339264","https://openalex.org/I4210088668","https://openalex.org/I4210125167"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fr\u00e9d\u00e9ric Flamant","raw_affiliation_strings":["Institut de G\u00e9nomique Fonctionnelle de Lyon (F.F.), Universit\u00e9 de Lyon, CNRS, INRA, \u00c9cole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de G\u00e9nomique Fonctionnelle de Lyon (F.F.), Universit\u00e9 de Lyon, CNRS, INRA, \u00c9cole Normale Sup\u00e9rieure de Lyon, 69364 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210125167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012453905","display_name":"Laurence Legeai\u2010Mallet","orcid":"https://orcid.org/0000-0003-4989-5856","observed_orcids":["https://orcid.org/0000-0003-4989-5856"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210165077","display_name":"Institut des Maladies G\u00e9n\u00e9tiques Imagine","ror":"https://ror.org/05rq3rb55","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210100892","https://openalex.org/I4210165077"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Legeai-Mallet","raw_affiliation_strings":["Institut Imagine (C.B.-L., L.L.-G.) Institut National de la Sant\u00e9 et de la Recherche Medicale, U1163, Universit\u00e9 Paris Descartes, 75015 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Imagine (C.B.-L., L.L.-G.) Institut National de la Sant\u00e9 et de la Recherche Medicale, U1163, Universit\u00e9 Paris Descartes, 75015 Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210165077","https://openalex.org/I4387156284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034076193","display_name":"Laurent Schibler","orcid":"https://orcid.org/0000-0003-3137-0859","observed_orcids":["https://orcid.org/0000-0003-3137-0859"]},"institutions":[{"id":"https://openalex.org/I4210129272","display_name":"G\u00e9n\u00e9tique Animale et Biologie Int\u00e9grative","ror":"https://ror.org/03rkgeb39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210129272"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Schibler","raw_affiliation_strings":["Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Recherche Agronomique (INRA) (C.D., J.R., M.G., C.M., D.L., J.L., L.S.), UMR1313, Biologie Int\u00e9grative et G\u00e9n\u00e9tique Animale, Jouy-en-Josas, France","institution_ids":["https://openalex.org/I4210129272","https://openalex.org/I4387154544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5055826574"],"corresponding_institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I4210125167"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.9237,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.93823836,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"155","issue":"8","first_page":"3123","last_page":"3135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.23360000550746918,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.14820000529289246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9309999942779541},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-alpha-1","display_name":"thyroid hormone receptor alpha 1","score":0.7570000290870667},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor-beta-1","display_name":"thyroid hormone receptor beta 1","score":0.7379999756813049},{"id":"https://openalex.org/keywords/dominant-negative-receptor","display_name":"dominant negative receptor","score":0.5979999899864197},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cartilage-maturation","display_name":"cartilage maturation","score":0.859000027179718},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.7129999995231628},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.8629999756813049},{"id":"https://openalex.org/keywords/skull-deformation","display_name":"skull deformation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.45899999141693115},{"id":"https://openalex.org/keywords/signaling-crosstalk","display_name":"signaling crosstalk","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.8115628957748413},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7526228427886963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7268096208572388},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6165724396705627},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.5674680471420288},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.529748797416687},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5042029619216919},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.4534563720226288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45083558559417725},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4496229588985443},{"id":"https://openalex.org/C2778842504","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Ossification","level":2,"score":0.4367179870605469},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.43636634945869446},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.42796581983566284},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4236324429512024},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4034667909145355},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.173182874917984},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.15903407335281372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13450047373771667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07401183247566223}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020239","descriptor_name":"Receptor Cross-Talk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037021","descriptor_name":"Thyroid Hormone Receptors alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.2014-1109","doi":"https://doi.org/10.1210/en.2014-1109","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2014-1109","pdf_url":"https://academic.oup.com/endo/article-pdf/155/8/3123/10828787/endo3123.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:24914940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24914940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-01193997v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-01193997","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrinology, 2014, 155 (8), pp.3123-3135. ⟨10.1210/en.2014-1109⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1210/en.2014-1109","doi":"https://doi.org/10.1210/en.2014-1109","is_oa":true,"landing_page_url":"https://doi.org/10.1210/en.2014-1109","pdf_url":"https://academic.oup.com/endo/article-pdf/155/8/3123/10828787/endo3123.pdf","source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320323910","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997505180.pdf","grobid_xml":"https://content.openalex.org/works/W1997505180.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W105894409","https://openalex.org/W134033052","https://openalex.org/W1490193151","https://openalex.org/W1555132893","https://openalex.org/W1964583412","https://openalex.org/W1970341919","https://openalex.org/W1976348381","https://openalex.org/W1978781687","https://openalex.org/W1980108247","https://openalex.org/W1980577578","https://openalex.org/W1986428182","https://openalex.org/W1990329100","https://openalex.org/W1990780034","https://openalex.org/W1993317384","https://openalex.org/W1998141080","https://openalex.org/W2001151867","https://openalex.org/W2004926708","https://openalex.org/W2005378018","https://openalex.org/W2009199530","https://openalex.org/W2011929115","https://openalex.org/W2012505775","https://openalex.org/W2013616695","https://openalex.org/W2014459865","https://openalex.org/W2018029991","https://openalex.org/W2021507484","https://openalex.org/W2023061695","https://openalex.org/W2025515198","https://openalex.org/W2027585225","https://openalex.org/W2028427583","https://openalex.org/W2031397263","https://openalex.org/W2036468940","https://openalex.org/W2036698185","https://openalex.org/W2042922152","https://openalex.org/W2056496886","https://openalex.org/W2059310956","https://openalex.org/W2060512014","https://openalex.org/W2068978817","https://openalex.org/W2069058870","https://openalex.org/W2070969828","https://openalex.org/W2072820535","https://openalex.org/W2073002574","https://openalex.org/W2075471983","https://openalex.org/W2086831062","https://openalex.org/W2087378917","https://openalex.org/W2091518548","https://openalex.org/W2095535117","https://openalex.org/W2096459042","https://openalex.org/W2098416198","https://openalex.org/W2102876765","https://openalex.org/W2105368463","https://openalex.org/W2107695708","https://openalex.org/W2108897036","https://openalex.org/W2110450018","https://openalex.org/W2113871823","https://openalex.org/W2123563900","https://openalex.org/W2128528209","https://openalex.org/W2130333682","https://openalex.org/W2132779244","https://openalex.org/W2140034839","https://openalex.org/W2142415307","https://openalex.org/W2142568074","https://openalex.org/W2145133713","https://openalex.org/W2149885497","https://openalex.org/W2150980895","https://openalex.org/W2153204201","https://openalex.org/W2156620354","https://openalex.org/W2158852889","https://openalex.org/W2160697532","https://openalex.org/W2165230232","https://openalex.org/W2281775143","https://openalex.org/W2413659977","https://openalex.org/W2578332904","https://openalex.org/W4285719527","https://openalex.org/W6605421397","https://openalex.org/W6641285228","https://openalex.org/W6716054392","https://openalex.org/W7073644036"],"related_works":["https://openalex.org/W2156620354","https://openalex.org/W2001151867","https://openalex.org/W2005378018","https://openalex.org/W7213288418","https://openalex.org/W2076665011","https://openalex.org/W2752002079","https://openalex.org/W2009861114","https://openalex.org/W2047036559","https://openalex.org/W2060512014","https://openalex.org/W2009199530"],"abstract_inverted_index":{"Thyroid":[0],"hormone":[1],"(T3)":[2],"is":[3,89],"required":[4],"for":[5,101,106],"postnatal":[6,63],"skeletal":[7,164],"growth.":[8,165],"It":[9],"exerts":[10],"its":[11],"effect":[12],"by":[13,141],"binding":[14],"to":[15,43,50,69,91,158],"nuclear":[16],"receptors,":[17],"TRs":[18],"including":[19],"TR\u03b11":[20],"and":[21,35,60,108,163],"TR\u03b21,":[22],"which":[23,40],"are":[24,41],"present":[25],"in":[26,58,76,87,96,111,115,123,137,143],"most":[27],"cell":[28,31],"types.":[29],"These":[30,145],"types":[32],"include":[33],"chondrocytes":[34,59,88,112,160],"osteoblasts,":[36],"the":[37,52,93,119],"interactions":[38],"of":[39,55,135],"known":[42],"regulate":[44],"endochondral":[45],"bone":[46],"formation.":[47],"In":[48,118],"order":[49],"analyze":[51],"respective":[53],"functions":[54],"T3":[56,85,149],"stimulation":[57],"osteoblasts":[61,125],"during":[62],"growth,":[64],"we":[65],"use":[66],"Cre/loxP":[67],"recombination":[68],"express":[70],"a":[71,77,133],"dominant-negative":[72],"TR\u03b11(L400R)":[73,110,121,142],"mutant":[74],"receptor":[75],"cell-specific":[78],"manner.":[79],"Phenotype":[80],"analysis":[81,131],"revealed":[82],"that":[83,148],"inhibiting":[84],"response":[86],"sufficient":[90],"reproduce":[92],"defects":[94],"observed":[95],"hypothyroid":[97],"mice,":[98],"not":[99],"only":[100],"cartilage":[102],"maturation,":[103],"but":[104],"also":[105,113],"ossification":[107],"mineralization.":[109],"results":[114],"skull":[116],"deformation.":[117],"meantime,":[120],"expression":[122,139],"mature":[124],"has":[126],"no":[127],"visible":[128],"effect.":[129],"Transcriptome":[130],"identifies":[132],"number":[134],"changes":[136,146],"gene":[138],"induced":[140],"cartilage.":[144],"suggest":[147],"normally":[150],"cross":[151],"talks":[152],"with":[153],"several":[154],"other":[155],"signaling":[156],"pathways":[157],"promote":[159],"proliferation,":[161],"differentiation,":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}