{"id":"https://openalex.org/W1997502528","doi":"https://doi.org/10.1016/j.amjhyper.2005.06.006","title":"Lactobacillus helveticus Fermented Milk Lowers Blood Pressure in Hypertensive Subjects in 24-h Ambulatory Blood Pressure Measurement","display_name":"Lactobacillus helveticus Fermented Milk Lowers Blood Pressure in Hypertensive Subjects in 24-h Ambulatory Blood Pressure Measurement","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W1997502528","doi":"https://doi.org/10.1016/j.amjhyper.2005.06.006","mag":"1997502528","pmid":"https://pubmed.ncbi.nlm.nih.gov/16364832"},"language":"en","primary_location":{"id":"doi:10.1016/j.amjhyper.2005.06.006","doi":"https://doi.org/10.1016/j.amjhyper.2005.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjhyper.2005.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"T JAUHIAINEN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210098442","display_name":"Valio (Finland)","ror":"https://ror.org/00yb5c421","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210098442"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T JAUHIAINEN","raw_affiliation_strings":["Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","Valio Ltd., Research and Development, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Valio Ltd., Research and Development, Helsinki, Finland","institution_ids":["https://openalex.org/I4210098442"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076752390","display_name":"Heikki Vapaatalo","orcid":"https://orcid.org/0000-0003-4348-8555","observed_orcids":["https://orcid.org/0000-0003-4348-8555"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"H VAPAATALO","raw_affiliation_strings":["Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086805010","display_name":"Tuija Annika Poussa","orcid":"https://orcid.org/0000-0003-1452-0974","observed_orcids":["https://orcid.org/0000-0003-1452-0974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T POUSSA","raw_affiliation_strings":["Stat-Consulting, City of Tampere, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stat-Consulting, City of Tampere, Tampere, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069682113","display_name":"Sinikka Kyr\u00f6npalo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S KYRONPALO","raw_affiliation_strings":["Department of Social Services and Health Care, City of Tampere, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Social Services and Health Care, City of Tampere, Tampere, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M RASMUSSEN","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M RASMUSSEN","raw_affiliation_strings":["Department of Social Services and Health Care, City of Tampere, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Social Services and Health Care, City of Tampere, Tampere, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054047770","display_name":"Riitta Korpela","orcid":"https://orcid.org/0000-0003-0337-9186","observed_orcids":["https://orcid.org/0000-0003-0337-9186"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I4210098442","display_name":"Valio (Finland)","ror":"https://ror.org/00yb5c421","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210098442"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"R KORPELA","raw_affiliation_strings":["Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","Valio Ltd., Research and Development, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]},{"raw_affiliation_string":"Valio Ltd., Research and Development, Helsinki, Finland","institution_ids":["https://openalex.org/I4210098442"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054047770"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I4210098442"],"apc_list":{"value":4814,"currency":"USD","value_usd":4814},"apc_paid":null,"fwci":8.3643,"has_fulltext":false,"cited_by_count":221,"citation_normalized_percentile":{"value":0.97667531,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"18","issue":"12","first_page":"1600","last_page":"1605"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11561","display_name":"Protein Hydrolysis and Bioactive Peptides","score":0.5570999979972839,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.3440000116825104,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.07670000195503235,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactobacillus-helveticus","display_name":"Lactobacillus helveticus","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fermented-milk","display_name":"fermented milk","score":0.9929999709129333},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8809999823570251},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/bioactive-peptides","display_name":"bioactive peptides","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tripeptides","display_name":"tripeptides","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ile-pro-pro","display_name":"Ile-Pro-Pro","score":0.875},{"id":"https://openalex.org/keywords/val-pro-pro","display_name":"Val-Pro-Pro","score":0.9959999918937683},{"id":"https://openalex.org/keywords/24-hour-ambulatory-blood-pressure","display_name":"24-hour ambulatory blood pressure","score":0.8159999847412109},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2776030290","wikidata":"https://www.wikidata.org/wiki/Q142378","display_name":"Lactobacillus helveticus","level":4,"score":0.975178599357605},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8315658569335938},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.743992805480957},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.6022272109985352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5405828356742859},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5309077501296997},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.5145861506462097},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.500643253326416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45374637842178345},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.3887535333633423},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.31019848585128784},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.300570547580719},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.08170723915100098},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008894","descriptor_name":"Milk Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009819","descriptor_name":"Office Visits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018660","descriptor_name":"Blood Pressure Monitoring, Ambulatory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052198","descriptor_name":"Lactobacillus helveticus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.amjhyper.2005.06.006","doi":"https://doi.org/10.1016/j.amjhyper.2005.06.006","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.amjhyper.2005.06.006","pdf_url":null,"source":{"id":"https://openalex.org/S128891601","display_name":"American Journal of Hypertension","issn_l":"0895-7061","issn":["0895-7061","1941-7225"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Hypertension","raw_type":"journal-article"},{"id":"pmid:16364832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16364832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of hypertension","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1417408701","https://openalex.org/W1501811857","https://openalex.org/W1904618591","https://openalex.org/W1984153473","https://openalex.org/W1989761204","https://openalex.org/W2004735541","https://openalex.org/W2004940076","https://openalex.org/W2012762002","https://openalex.org/W2012764005","https://openalex.org/W2015511799","https://openalex.org/W2020620294","https://openalex.org/W2074191403","https://openalex.org/W2116404316","https://openalex.org/W2134511517","https://openalex.org/W2139076190","https://openalex.org/W2149098516"],"related_works":["https://openalex.org/W1417408701","https://openalex.org/W2149098516","https://openalex.org/W1965234985","https://openalex.org/W7100877398","https://openalex.org/W2063148557","https://openalex.org/W2084176383","https://openalex.org/W2088775028","https://openalex.org/W1836577559","https://openalex.org/W2030158716","https://openalex.org/W2055999435"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,109],"present":[2],"study":[3],"was":[4,145,183],"carried":[5],"out":[6],"to":[7],"evaluate":[8],"the":[9,15,99,103,106,126,140,174,179,187,190,222],"blood":[10],"pressure":[11],"(BP)-lowering":[12],"effect":[13,212],"and":[14,77,101,113,130,160,178,216],"safety":[16],"aspects":[17],"of":[18,60,71,105,149,189,225],"Lactobacillus":[19,197],"helveticus":[20,63,128,176,198],"LBK-16H":[21,64,199],"fermented":[22,65,200],"milk":[23,66,201],"with":[24,67],"high":[25,69],"tripeptide":[26],"doses":[27],"on":[28],"hypertensive":[29,47,214],"subjects":[30,215],"using":[31],"24-h":[32],"ambulatory":[33],"measurements":[34],"(ABPM).":[35],"METHODS:":[36],"In":[37],"a":[38,68,83,90,146,161,210,219],"randomized,":[39],"double":[40],"blinded":[41],"placebo-controlled":[42],"parallel":[43],"group":[44,129,177],"study,":[45],"94":[46],"patients":[48],"not":[49],"receiving":[50],"any":[51],"drug":[52],"treatment":[53,224],"were":[54,96,117],"given":[55],"150":[56],"mL":[57],"twice":[58],"daily":[59,206],"either":[61],"L.":[62,127,175],"concentration":[70],"tripeptides":[72],"(Ile-Pro-Pro":[73],"7.5":[74],"mg/100":[75,80],"g":[76],"Val-Pro-Pro":[78],"10":[79,87],"g)":[81],"or":[82],"control":[84,141,180],"product,":[85],"for":[86,221],"weeks":[88],"after":[89],"4-week":[91],"run-in":[92],"period.":[93,108],"Twenty-four-hour":[94],"ABPM":[95],"taken":[97],"at":[98,102],"beginning":[100],"end":[104],"intervention":[107],"average":[110],"baseline":[111],"systolic":[112,156],"diastolic":[114,168],"BP":[115,169],"values":[116],"132.6":[118],"+/-":[119,121,132,135,151,163],"9.9/83.0":[120],"8.0":[122],"mm":[123,137,153,165],"Hg":[124,138,154,166],"in":[125,139,155,167,186,205,213],"130.3":[131],"9.6":[133],"/80.2":[134],"7.0":[136],"group.":[142,181],"RESULTS:":[143],"There":[144,182],"mean":[147],"difference":[148,185],"-4.1":[150],"0.9":[152],"(P":[157,170,193],"=":[158,171,194],".001)":[159],"-1.8":[162],"0.7":[164],".048)":[172],"between":[173],"no":[184],"sum":[188],"adverse":[191],"events":[192],".820).":[195],"CONCLUSIONS:":[196],"containing":[202],"bioactive":[203],"peptides,":[204],"use,":[207],"does":[208],"have":[209],"BP-lowering":[211],"is":[217],"thus":[218],"potential":[220],"dietary":[223],"hypertension.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}