{"id":"https://openalex.org/W1997500340","doi":"https://doi.org/10.1186/1471-2334-14-s4-o4","title":"The challenges of managing antiretroviral treatment in children perinatally infected with HIV in Romania","display_name":"The challenges of managing antiretroviral treatment in children perinatally infected with HIV in Romania","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W1997500340","doi":"https://doi.org/10.1186/1471-2334-14-s4-o4","mag":"1997500340"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2334-14-s4-o4","doi":"https://doi.org/10.1186/1471-2334-14-s4-o4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-14-s4-o4","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2334-14-S4-O4.pdf","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/1471-2334-14-S4-O4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040311522","display_name":"Alina Cibea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alina Cibea","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035793454","display_name":"Mariana M\u0103rd\u0103rescu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariana M\u0103rd\u0103rescu","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108262913","display_name":"Cristina Petre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Petre","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079794740","display_name":"Ruxandra Neagu\u2010Dr\u00e3ghicenoiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruxandra Neagu-Dr\u0103ghicenoiu","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086920123","display_name":"Rodica Ungurianu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodica Ungurianu","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104080555","display_name":"Sorin Petrea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sorin Petrea","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109160110","display_name":"Ana Maria Tudor","orcid":"https://orcid.org/0000-0002-6514-0122","observed_orcids":["https://orcid.org/0000-0002-6514-0122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Maria Tudor","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039405955","display_name":"Delia Adelina Vlad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delia Vlad","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012898733","display_name":"Carina Matei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carina Matei","raw_affiliation_strings":["National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Infectious Diseases \u201cProf. Dr. Matei Bal\u015f\u201d, Bucharest, Romania","institution_ids":[]},{"raw_affiliation_string":"National Institute of Infectious Diseases Prof. Dr. Matei Bals, Bucharest, Romania","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040311522"],"corresponding_institution_ids":[],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1071227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"S4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perinatal-hiv-infection","display_name":"perinatal HIV infection","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pediatric-hiv","display_name":"pediatric HIV","score":0.859000027179718},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/treatment-failure","display_name":"treatment failure","score":0.8109999895095825},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7179999947547913},{"id":"https://openalex.org/keywords/vertical-transmission","display_name":"vertical transmission","score":0.5220000147819519},{"id":"https://openalex.org/keywords/viral-suppression","display_name":"viral suppression","score":0.7379999756813049},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.6949999928474426},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.5059999823570251},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.905463457107544},{"id":"https://openalex.org/C190612196","wikidata":"https://www.wikidata.org/wiki/Q180502","display_name":"Parasitology","level":2,"score":0.8241198062896729},{"id":"https://openalex.org/C3019165603","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral treatment","level":5,"score":0.7848913669586182},{"id":"https://openalex.org/C185032368","wikidata":"https://www.wikidata.org/wiki/Q1365243","display_name":"Tropical medicine","level":2,"score":0.7383874654769897},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6713535785675049},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6438746452331543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5226259827613831},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44891342520713806},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.40935108065605164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3332092761993408},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2689172625541687},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13074764609336853}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1471-2334-14-s4-o4","doi":"https://doi.org/10.1186/1471-2334-14-s4-o4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-14-s4-o4","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2334-14-S4-O4.pdf","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3044950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4072325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4072325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4072325","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infect Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1471-2334-14-s4-o4","doi":"https://doi.org/10.1186/1471-2334-14-s4-o4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2334-14-s4-o4","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2334-14-S4-O4.pdf","source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997500340.pdf","grobid_xml":"https://content.openalex.org/works/W1997500340.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987137301","https://openalex.org/W2344385793","https://openalex.org/W2908274759","https://openalex.org/W1991668498","https://openalex.org/W2012968373","https://openalex.org/W2089934265","https://openalex.org/W2402462373","https://openalex.org/W2099045580","https://openalex.org/W7140830226","https://openalex.org/W2811123709"],"abstract_inverted_index":{"In":[0,244],"the":[1,5,18,28,37,40,52,60,79,106,149,185,204,248],"past":[2],"few":[3],"years,":[4,126],"rate":[6,172],"of":[7,17,21,42,54,81,109,141,148,151,173,175,178,181,203,242,246,277,296,314],"HIV":[8,56,90,121,136,157,176,209,304],"perinatally":[9,88,156,167],"exposed":[10,168],"children":[11,58,123,153,159,271,284,300],"has":[12],"increased":[13],"as":[14],"a":[15,95,171,222],"consequence":[16],"expanding":[19],"number":[20],"infected":[22,49,57,122,158,193],"women.":[23],"These":[24],"women":[25],"belong,":[26],"on":[27,36],"one":[29,256],"hand,":[30],"to":[31,39,66,77,184,280,290,292,309],"Romania\u2019s":[32],"1990s":[33],"cohort,":[34],"and":[35,76,144,189,219,253,318],"other":[38],"group":[41],"new":[43],"sexually":[44,196],"or":[45,197,264],"intravenously":[46],"(i.v.)":[47],"drug":[48,200,316],"women.\r\n\r\nTo":[50],"report":[51],"characteristics":[53],"vertically":[55,302],"in":[59,64,70,84,94,105,127,130,162,299],"last":[61],"six":[62,240],"years":[63],"Romania,":[65],"investigate":[67],"temporal":[68],"trends":[69],"their":[71],"evolution":[72,150],"with":[73,87,154,170,194,208,255,301],"antiretroviral":[74,293,297],"treatment":[75,82,298],"characterize":[78],"causes":[80],"failure":[83],"these":[85,152],"children.\r\n\r\nChildren":[86],"acquired":[89,303],"infection":[91,177,210,305],"were":[92,160,191,206],"followed":[93],"retrospective":[96],"case":[97],"series.":[98],"The":[99],"cohort":[100,188],"included":[101],"43":[102],"children,":[103,169],"evaluated":[104,161],"National":[107],"Institute":[108],"Infectious":[110],"Diseases":[111],"\u201cProf.":[112],"Dr.":[113],"Matei":[114],"Bals\u201d,":[115],"born":[116],"between":[117],"2008-2013,":[118],"from":[119,165],"86":[120],"under":[124],"6":[125],"active":[128],"records":[129],"Romania.":[131],"We":[132],"assessed":[133],"maternal":[134],"characteristics,":[135],"vertical":[137],"transmission":[138,174],"prophylaxis,":[139],"timing":[140],"diagnosis,":[142],"immunological":[143],"virologic":[145,249],"status,":[146],"features":[147],"ART.\r\n\r\n43":[155],"our":[163],"clinic":[164],"396":[166],"10.8%.":[179],"16%":[180],"mothers":[182],"belonged":[183],"Romanian":[186],"\u201990s":[187],"84%":[190],"recently":[192],"HIV,":[195],"through":[198],"i.v.":[199],"use.":[201],"41%":[202],"subjects":[205],"diagnosed":[207],"at":[211],"birth.":[212],"Their":[213],"median":[214,225],"entry":[215,226],"CD4%":[216],"was":[217,229,251],"23%":[218],"49%":[220],"had":[221,235,273],"CD4":[223],">25%;":[224],"viral":[227,237,278],"load":[228,238,279],"7":[230],"log.":[231],"16":[232],"patients":[233],"(37%)":[234],"undetectable":[236,281],"after":[239],"months":[241],"treatment.":[243],"87.5%":[245],"them,":[247],"suppression":[250,276],"achieved":[252,275],"maintained":[254],"single":[257],"regimen":[258],"(2":[259],"NRTIs":[260,266],"+":[261,267],"1":[262,268],"NNRTI":[263],"2":[265],"PI/r).":[269],"15":[270],"(35%)":[272],"never":[274],"levels.":[282],"19":[283],"(44%)":[285],"faced":[286],"special":[287],"issues":[288],"related":[289],"adherence":[291],"treatment.\r\n\r\nThe":[294],"management":[295],"is":[306],"challenging,":[307],"due":[308],"limited":[310],"therapeutic":[311],"options,":[312],"lack":[313],"adherence,":[315],"interactions":[317],"adverse":[319],"events.":[320]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
