{"id":"https://openalex.org/W1997495515","doi":"https://doi.org/10.1002/eji.200425081","title":"Small interference RNA modulation of IL\u201010 in human monocyte\u2010derived dendritic cells enhances the Th1 response","display_name":"Small interference RNA modulation of IL\u201010 in human monocyte\u2010derived dendritic cells enhances the Th1 response","publication_year":2004,"publication_date":"2004-05-18","ids":{"openalex":"https://openalex.org/W1997495515","doi":"https://doi.org/10.1002/eji.200425081","mag":"1997495515","pmid":"https://pubmed.ncbi.nlm.nih.gov/15162438"},"language":"en","primary_location":{"id":"doi:10.1002/eji.200425081","doi":"https://doi.org/10.1002/eji.200425081","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200425081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200425081","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200425081","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013615665","display_name":"Gentao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gentao Liu","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, USA","Maxine-Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, USA","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Maxine-Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103575777","display_name":"Hiushan Ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiushan Ng","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103875641","display_name":"Yasuharu Akasaki","orcid":"https://orcid.org/0000-0001-8015-084X","observed_orcids":["https://orcid.org/0000-0001-8015-084X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasuharu Akasaki","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111517803","display_name":"Xiangpeng Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiangpeng Yuan","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020681666","display_name":"Moneeb Ehtesham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moneeb Ehtesham","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037516824","display_name":"Dong Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Yin","raw_affiliation_strings":["Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019253871","display_name":"Keith L. Black","orcid":"https://orcid.org/0000-0002-0546-4934","observed_orcids":["https://orcid.org/0000-0002-0546-4934"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith\u2004L. Black","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064689690","display_name":"John S. Yu","orcid":"https://orcid.org/0000-0003-1230-8494","observed_orcids":["https://orcid.org/0000-0003-1230-8494"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John\u2004S. Yu","raw_affiliation_strings":["Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, USA","institution_ids":["https://openalex.org/I1282927834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5064689690"],"corresponding_institution_ids":["https://openalex.org/I1282927834"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.7625,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.90243902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"34","issue":"6","first_page":"1680","last_page":"1687"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9490000009536743},{"id":"https://openalex.org/keywords/monocyte-derived-dendritic-cells","display_name":"monocyte-derived dendritic cells","score":0.875},{"id":"https://openalex.org/keywords/th1-response","display_name":"Th1 response","score":0.8999999761581421},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.878000020980835},{"id":"https://openalex.org/keywords/cd40","display_name":"CD40","score":0.7829999923706055},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.9959999918937683},{"id":"https://openalex.org/keywords/allogeneic-t-cell-proliferation","display_name":"allogeneic T cell proliferation","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/vaccine-delivery","display_name":"vaccine delivery","score":0.8019999861717224},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8379999995231628},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8659999966621399},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7637288570404053},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.7537984848022461},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7055799961090088},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5932061672210693},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5842025876045227},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.5624790191650391},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5205289125442505},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4768606126308441},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.4598267078399658},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4584678113460541},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.44349074363708496},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38037025928497314},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3205410838127136},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.31118762493133545},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2644205093383789},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.253682017326355},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.18691706657409668},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17197537422180176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019013","descriptor_name":"CD40 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.200425081","doi":"https://doi.org/10.1002/eji.200425081","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200425081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200425081","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15162438","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15162438","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/eji.200425081","doi":"https://doi.org/10.1002/eji.200425081","is_oa":true,"landing_page_url":"https://doi.org/10.1002/eji.200425081","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/eji.200425081","source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997495515.pdf","grobid_xml":"https://content.openalex.org/works/W1997495515.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1497429764","https://openalex.org/W1511803669","https://openalex.org/W1609153296","https://openalex.org/W1611419331","https://openalex.org/W1625863153","https://openalex.org/W1661544713","https://openalex.org/W1958745508","https://openalex.org/W1960538598","https://openalex.org/W1986046751","https://openalex.org/W1998121841","https://openalex.org/W2004135191","https://openalex.org/W2022306557","https://openalex.org/W2047391267","https://openalex.org/W2062813847","https://openalex.org/W2063053561","https://openalex.org/W2064685550","https://openalex.org/W2078176299","https://openalex.org/W2078781814","https://openalex.org/W2098100188","https://openalex.org/W2100699905","https://openalex.org/W2104904748","https://openalex.org/W2107235611","https://openalex.org/W2108473659","https://openalex.org/W2110716288","https://openalex.org/W2116562412","https://openalex.org/W2116716017","https://openalex.org/W2118184788","https://openalex.org/W2120783853","https://openalex.org/W2129932872","https://openalex.org/W2136447541","https://openalex.org/W2138961639","https://openalex.org/W2141895910","https://openalex.org/W2157078151","https://openalex.org/W2157276434","https://openalex.org/W2162415302","https://openalex.org/W2177327503","https://openalex.org/W2191654227","https://openalex.org/W4211039187"],"related_works":["https://openalex.org/W2162415302","https://openalex.org/W7096379961","https://openalex.org/W1576212074","https://openalex.org/W2063865728","https://openalex.org/W3029398890","https://openalex.org/W2157944392","https://openalex.org/W1951081312","https://openalex.org/W2056377806","https://openalex.org/W2394413045","https://openalex.org/W41940266"],"abstract_inverted_index":{"RNA":[0,40],"interference":[1,39],"technology":[2],"has":[3],"been":[4],"used":[5],"to":[6,80,113,168],"modulate":[7],"dendritic":[8],"cell":[9,85,117],"(DC)":[10],"function":[11],"by":[12,61,65,125,141,180],"targeting":[13],"the":[14,78,107,151,170],"expression":[15,49,68,100],"of":[16,31,37,46,59,109,158],"genes":[17],"such":[18],"as":[19,164],"IL-12":[20,70],"and":[21,69,144,175],"NF-kappa":[22],"B.":[23],"In":[24],"this":[25],"paper,":[26],"we":[27],"demonstrate":[28],"that":[29,134,177],"transfection":[30,89],"DC":[32,52,56,76,112,127,137],"with":[33,77,129],"IL-10-specific":[34],"double":[35],"strands":[36],"small":[38],"(siRNA)":[41],"resulted":[42],"in":[43,101],"potent":[44],"suppression":[45],"IL-10":[47,60,87,110,135,160],"gene":[48],"without":[50],"inducing":[51],"apoptosis":[53],"or":[54,98],"blocking":[55],"maturation.":[57],"Inhibition":[58],"siRNA":[62,88],"was":[63],"accompanied":[64],"increased":[66],"CD40":[67],"production":[71],"after":[72],"maturation,":[73],"which":[74],"endowed":[75],"ability":[79,108],"significantly":[81],"enhance":[82],"allogeneic":[83],"T":[84,116,121],"proliferation.":[86],"did":[90],"not":[91],"affect":[92],"MHC":[93],"class":[94],"II,":[95],"CD86,":[96],"CD83,":[97],"CD54":[99],"mature":[102],"DC.":[103],"To":[104],"further":[105],"test":[106],"siRNA-treated":[111],"induce":[114],"a":[115,154],"response,":[118],"naive":[119],"CD4":[120],"cells":[122,163],"were":[123],"stimulated":[124],"autologous":[126],"pulsed":[128],"KLH.":[130],"The":[131],"results":[132],"indicated":[133],"siRNA-transfected":[136,161],"enhanced":[138],"Th1":[139,171,181],"responses":[140],"increasing":[142],"IFN-gamma":[143],"decreasing":[145],"IL-4":[146],"production.":[147],"These":[148],"findings":[149],"suggest":[150],"potential":[152],"for":[153],"novel":[155],"immunotherapeutic":[156],"strategy":[157],"using":[159],"antigen-presenting":[162],"vaccine":[165],"delivery":[166],"agents":[167],"boost":[169],"response":[172],"against":[173],"pathogens":[174],"tumors":[176],"are":[178],"controlled":[179],"immunity.":[182]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}