{"id":"https://openalex.org/W1997495457","doi":"https://doi.org/10.1177/153331750101600407","title":"Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease","display_name":"Interaction between apolipoprotein-E and angiotensin-converting enzyme genotype in Alzheimer's disease","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W1997495457","doi":"https://doi.org/10.1177/153331750101600407","mag":"1997495457","pmid":"https://pubmed.ncbi.nlm.nih.gov/11501342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10833823"},"language":"en","primary_location":{"id":"doi:10.1177/153331750101600407","doi":"https://doi.org/10.1177/153331750101600407","is_oa":false,"landing_page_url":"https://doi.org/10.1177/153331750101600407","pdf_url":null,"source":{"id":"https://openalex.org/S1037846118","display_name":"American Journal of Alzheimer s Disease & Other Dementias\u00ae","issn_l":"0888-4897","issn":["0888-4897","0895-5336","1082-5207","1533-3175","1938-2731","2162-9978","2162-9986"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Alzheimer's Disease & Other Dementias\u00ae","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10833823/pdf/10.1177_153331750101600407.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085424411","display_name":"Turgay \u0130\u015fbir","orcid":"https://orcid.org/0000-0002-7350-6032","observed_orcids":["https://orcid.org/0000-0002-7350-6032","https://orcid.org/0000-0001-7949-2674"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Turgay Isbir","raw_affiliation_strings":["University of Istanbul, Institute for Experimental Medical Research Department of Molecular Medicine, Istanbul, Turkey","Department Head of Molecular Medicine, University of Istanbul, Institute for Experimental Medical Research Department of Molecular Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Istanbul, Institute for Experimental Medical Research Department of Molecular Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]},{"raw_affiliation_string":"Department Head of Molecular Medicine, University of Istanbul, Institute for Experimental Medical Research Department of Molecular Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110694000","display_name":"Bedia A\u011fa\u00e7han","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bedia Aga\u00e7han","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058006139","display_name":"H\u00fclya Y\u0131lmaz","orcid":"https://orcid.org/0000-0002-8837-6664","observed_orcids":["https://orcid.org/0000-0002-8837-6664"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H\u00fclya Yilmaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618976","display_name":"Makbule Ayd\u0131n","orcid":"https://orcid.org/0000-0002-4541-793X","observed_orcids":["https://orcid.org/0000-0002-4541-793X"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Makbule Aydin","raw_affiliation_strings":["Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Medical Research, Department of Molecular Medicine, University of Istanbul, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042414004","display_name":"\u0130hsan Kara","orcid":"https://orcid.org/0000-0002-6741-2929","observed_orcids":["https://orcid.org/0000-0002-6741-2929","https://orcid.org/0000-0001-6701-5870"]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ihsan Kara","raw_affiliation_strings":["Institute of Experimental Medical Research, Department of Neurological Science, University of Istanbul, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Medical Research, Department of Neurological Science, University of Istanbul, Istanbul, Turkey","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019949568","display_name":"Deniz Eker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deniz Eker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089584516","display_name":"Engin Eker","orcid":"https://orcid.org/0000-0001-9316-7026","observed_orcids":["https://orcid.org/0000-0001-9316-7026"]},"institutions":[{"id":"https://openalex.org/I4210112471","display_name":"Istanbul University-Cerrahpa\u015fa","ror":"https://ror.org/01dzn5f42","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210112471"]},{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Engin Eker","raw_affiliation_strings":["Department of Neurogeriatrics, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurogeriatrics, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey","institution_ids":["https://openalex.org/I4210112471","https://openalex.org/I67581229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.5275,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.53421093,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"4","first_page":"205","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9750000238418579},{"id":"https://openalex.org/keywords/angiotensin-converting-enzyme","display_name":"angiotensin-converting enzyme","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ace-insertion-deletion-polymorphism","display_name":"ACE I/D polymorphism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7379999756813049},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7879999876022339},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.7329999804496765},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"allele frequency","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.8152162432670593},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7571084499359131},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.7492244839668274},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.6953063011169434},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.6075833439826965},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5818273425102234},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.5349489450454712},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.5346808433532715},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4906822443008423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45058247447013855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4363044500350952},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.4274541437625885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4256765842437744},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38965198397636414},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3703334927558899},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28254249691963196},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.21880760788917542},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007703","descriptor_name":"Peptidyl-Dipeptidase A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/153331750101600407","doi":"https://doi.org/10.1177/153331750101600407","is_oa":false,"landing_page_url":"https://doi.org/10.1177/153331750101600407","pdf_url":null,"source":{"id":"https://openalex.org/S1037846118","display_name":"American Journal of Alzheimer s Disease & Other Dementias\u00ae","issn_l":"0888-4897","issn":["0888-4897","0895-5336","1082-5207","1533-3175","1938-2731","2162-9978","2162-9986"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Alzheimer's Disease & Other Dementias\u00ae","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10833823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10833823","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10833823/pdf/10.1177_153331750101600407.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Alzheimers Dis Other Demen","raw_type":"Text"},{"id":"pmid:11501342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11501342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of Alzheimer's disease and other dementias","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10833823","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10833823","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10833823/pdf/10.1177_153331750101600407.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Alzheimers Dis Other Demen","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997495457.pdf","grobid_xml":"https://content.openalex.org/works/W1997495457.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1582334575","https://openalex.org/W1770880387","https://openalex.org/W1982120496","https://openalex.org/W1992351338","https://openalex.org/W1997830586","https://openalex.org/W1999631936","https://openalex.org/W2004940289","https://openalex.org/W2006436888","https://openalex.org/W2013709047","https://openalex.org/W2021181758","https://openalex.org/W2024841768","https://openalex.org/W2031528749","https://openalex.org/W2035236207","https://openalex.org/W2036362108","https://openalex.org/W2039210191","https://openalex.org/W2043600435","https://openalex.org/W2054875225","https://openalex.org/W2066644955","https://openalex.org/W2069096459","https://openalex.org/W2069761589","https://openalex.org/W2069863984","https://openalex.org/W2091939326","https://openalex.org/W2093736722","https://openalex.org/W2117543363","https://openalex.org/W2118094114","https://openalex.org/W2118267556","https://openalex.org/W2147413218","https://openalex.org/W2150541142","https://openalex.org/W2150669018","https://openalex.org/W2156220037","https://openalex.org/W2411976265","https://openalex.org/W4233622592","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7008062349","https://openalex.org/W2355380693","https://openalex.org/W2364352745","https://openalex.org/W2080123209","https://openalex.org/W2361662076","https://openalex.org/W1731392670","https://openalex.org/W1976220692","https://openalex.org/W1976824780","https://openalex.org/W2171812064","https://openalex.org/W2007467018"],"abstract_inverted_index":{"Both":[0],"apolipoprotein-E":[1],"(apo-E)":[2],"epsilon":[3,28,142,144,147,166,168,171,188],"4":[4,29,148,172,189],"allele":[5,30,116,135,160,190],"and":[6,41,63,79,93,104,112,120,128,146,154,170,178,186],"angiotensin-converting":[7],"enzyme":[8],"(ACE)":[9],"deletion":[10],"(D)":[11],"polymorphism":[12,62,91],"have":[13],"been":[14,33],"associated":[15],"with":[16,37,82,199],"a":[17],"high":[18],"risk":[19],"for":[20,141,165],"coronary":[21],"heart":[22],"disease.":[23],"Increased":[24],"frequency":[25],"of":[26,39,49,68,76,109,162],"the":[27,55,59,74,77,102,138,204],"has":[31],"also":[32],"reported":[34],"in":[35,137,197,203],"patients":[36,119,198],"late-onset":[38],"familial":[40],"sporadic":[42],"Alzheimer's":[43,200],"disease":[44,201],"(AD).":[45],"The":[46,65,107,158],"primary":[47],"aim":[48,67],"this":[50,69],"study":[51,70],"is":[52,71],"to":[53,72,100,193],"examine":[54],"possible":[56],"relationship":[57],"between":[58],"ACE":[60,78,105,110,113,184],"gene":[61],"AD.":[64,83],"second":[66],"explore":[73],"relation":[75],"apo-E":[80,103,159],"genotypes":[81],"Polymerase":[84],"chain":[85],"reaction":[86],"(PCR),":[87],"restriction":[88],"fragment":[89],"length":[90],"(RFLP),":[92],"agarose":[94],"gel":[95],"electrophoresis":[96],"techniques":[97],"were":[98,122,173,191],"used":[99],"determine":[101],"genotypes.":[106],"frequencies":[108,136,161],"D":[111,185],"insertion":[114],"(I)":[115],"among":[117],"AD":[118,139],"controls":[121],"55.7":[123],"percent":[124,127],"versus":[125,130],"44.2":[126],"51.7":[129],"48.2":[131],"percent,":[132,151,153,156,175,177,180],"respectively.":[133,157,181],"Apo-E":[134],"group":[140],"2,":[143,167],"3":[145,169],"were,":[149],"1.7":[150,155,179],"96.5":[152],"healthy":[163],"groups":[164],"1":[174],"56":[176],"In":[182],"conclusion":[183],"apo":[187],"found":[192],"be":[194],"more":[195],"frequent":[196],"than":[202],"control":[205],"group.":[206]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}