{"id":"https://openalex.org/W1997491649","doi":"https://doi.org/10.1002/jemt.10204","title":"Effect of time of restriction on the decrease in mitochondrial H2O2 production and oxidative DNA damage in the heart of food\u2010restricted rats","display_name":"Effect of time of restriction on the decrease in mitochondrial H2O2 production and oxidative DNA damage in the heart of food\u2010restricted rats","publication_year":2002,"publication_date":"2002-11-06","ids":{"openalex":"https://openalex.org/W1997491649","doi":"https://doi.org/10.1002/jemt.10204","mag":"1997491649","pmid":"https://pubmed.ncbi.nlm.nih.gov/12424788"},"language":"en","primary_location":{"id":"doi:10.1002/jemt.10204","doi":"https://doi.org/10.1002/jemt.10204","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jemt.10204","pdf_url":null,"source":{"id":"https://openalex.org/S6191820","display_name":"Microscopy Research and Technique","issn_l":"1059-910X","issn":["1059-910X","1097-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy Research and Technique","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064017620","display_name":"Ricardo Gredilla","orcid":"https://orcid.org/0000-0003-4501-1355","observed_orcids":["https://orcid.org/0000-0003-4501-1355"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R. Gredilla","raw_affiliation_strings":["Department of Animal Biology-II, Faculty of Biology, Complutense University, Madrid 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Biology-II, Faculty of Biology, Complutense University, Madrid 28040, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046103356","display_name":"M\u00f3nica Lopez\u2010Torres","orcid":"https://orcid.org/0000-0002-7252-3404","observed_orcids":["https://orcid.org/0000-0002-7252-3404"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M. L\u00f3pez\u2010Torres","raw_affiliation_strings":["Department of Animal Biology-II, Faculty of Biology, Complutense University, Madrid 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Biology-II, Faculty of Biology, Complutense University, Madrid 28040, Spain","institution_ids":["https://openalex.org/I121748325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030906936","display_name":"Gustavo Barja","orcid":"https://orcid.org/0000-0001-5736-4735","observed_orcids":["https://orcid.org/0000-0001-5736-4735"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"G. Barja","raw_affiliation_strings":["Department of Animal Biology-II, Faculty of Biology, Complutense University, Madrid 28040, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Biology-II, Faculty of Biology, Complutense University, Madrid 28040, Spain","institution_ids":["https://openalex.org/I121748325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5030906936"],"corresponding_institution_ids":["https://openalex.org/I121748325"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":1.447,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.8187251,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"59","issue":"4","first_page":"273","last_page":"277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.24289999902248383,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caloric-restriction","display_name":"caloric restriction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mitochondrial-dna-damage","display_name":"mitochondrial DNA damage","score":0.8560000061988831},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.8460000157356262},{"id":"https://openalex.org/keywords/free-radical-production","display_name":"free radical generation","score":0.6610000133514404},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.5860000252723694},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.8822180032730103},{"id":"https://openalex.org/C190362976","wikidata":"https://www.wikidata.org/wiki/Q845261","display_name":"Caloric theory","level":2,"score":0.8809096813201904},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.7659939527511597},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.741716206073761},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5548586845397949},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.490882933139801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4897008240222931},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.4816935956478119},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4591919481754303},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3862811028957367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32116177678108215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3055710196495056},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23614171147346497},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11088308691978455}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jemt.10204","doi":"https://doi.org/10.1002/jemt.10204","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jemt.10204","pdf_url":null,"source":{"id":"https://openalex.org/S6191820","display_name":"Microscopy Research and Technique","issn_l":"1059-910X","issn":["1059-910X","1097-0029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy Research and Technique","raw_type":"journal-article"},{"id":"pmid:12424788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12424788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microscopy research and technique","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W835098822","https://openalex.org/W1509408588","https://openalex.org/W1514869730","https://openalex.org/W1565127991","https://openalex.org/W1572696474","https://openalex.org/W1832860099","https://openalex.org/W1925799544","https://openalex.org/W1926649163","https://openalex.org/W1973535295","https://openalex.org/W1982647833","https://openalex.org/W1992933481","https://openalex.org/W2000405107","https://openalex.org/W2016949969","https://openalex.org/W2018185503","https://openalex.org/W2024975059","https://openalex.org/W2026194773","https://openalex.org/W2027395393","https://openalex.org/W2029062218","https://openalex.org/W2032913839","https://openalex.org/W2062088318","https://openalex.org/W2062279766","https://openalex.org/W2074369436","https://openalex.org/W2096816747","https://openalex.org/W2113279188","https://openalex.org/W2138984138","https://openalex.org/W2143996615","https://openalex.org/W2315512556"],"related_works":["https://openalex.org/W2143996615","https://openalex.org/W2089814579","https://openalex.org/W1572696474","https://openalex.org/W1997733893","https://openalex.org/W2004904888","https://openalex.org/W2119227182","https://openalex.org/W2067659770","https://openalex.org/W2016289352","https://openalex.org/W2077496599","https://openalex.org/W2116704528"],"abstract_inverted_index":{"In":[0,124],"the":[1,4,27,45,61,64,68,98,125,167,170,187,195,201],"present":[2,126],"study,":[3],"question":[5],"if":[6],"medium-term":[7,135],"(4":[8,136],"months)":[9,137],"caloric":[10,85,138],"restriction":[11,24,86],"(40%)":[12],"decreases":[13,44],"mitochondrial":[14,46,78,111,128,152,188],"H2O2":[15,129],"production":[16,51,130],"and":[17,55,107,160,175,194],"oxidative":[18,108,155,196],"DNA":[19,112,156],"damage":[20,109,157,197],"was":[21],"investigated.":[22],"Caloric":[23],"(CR)":[25],"is":[26,183],"only":[28],"experimental":[29],"manipulation":[30],"that":[31,42,63,97,177],"increases":[32],"maximum":[33],"life":[34],"span.":[35],"Previous":[36,93],"long-term":[37],"CR":[38,43,102,173],"studies":[39,58,94],"have":[40,95],"showed":[41],"rate":[47,79,189],"of":[48,67,80,122,169,172,190],"free":[49,81,191],"radical":[50,82,105,192],"in":[52,134,142,150,200],"diverse":[53],"tissues":[54],"species.":[56],"Those":[57],"agree":[59],"with":[60,144],"idea":[62],"superior":[65],"longevity":[66],"restricted":[69,139,159],"animals":[70],"can":[71],"be":[72],"partly":[73],"due":[74],"to":[75,110,185,198],"their":[76],"lower":[77],"generation.":[83],"However,":[84],"effects":[87],"strongly":[88],"depend":[89],"on":[90,103],"implementation":[91],"time.":[92],"shown":[96],"decrease":[99,186],"induced":[100],"by":[101],"oxygen":[104],"generation":[106,193],"occurs":[113],"after":[114,119],"1":[115],"year":[116],"but":[117],"not":[118,132],"6":[120],"weeks":[121],"restriction.":[123],"investigation,":[127],"did":[131],"change":[133],"animals,":[140],"and,":[141],"agreement":[143],"that,":[145],"no":[146],"differences":[147],"were":[148],"found":[149],"either":[151],"or":[153],"nuclear":[154],"between":[158],"ad":[161],"libitum-fed":[162],"animals.":[163],"These":[164],"results":[165],"confirm":[166],"importance":[168],"time":[171,178],"implementation,":[174],"show":[176],"longer":[179],"than":[180],"4":[181],"months":[182],"needed":[184],"mtDNA":[199],"rat":[202],"heart.":[203]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}