{"id":"https://openalex.org/W1997491195","doi":"https://doi.org/10.1016/s0169-409x(02)00112-6","title":"Skin constructs for replacement of skin tissues for in vitro testing","display_name":"Skin constructs for replacement of skin tissues for in vitro testing","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W1997491195","doi":"https://doi.org/10.1016/s0169-409x(02)00112-6","mag":"1997491195","pmid":"https://pubmed.ncbi.nlm.nih.gov/12460713"},"language":"en","primary_location":{"id":"doi:10.1016/s0169-409x(02)00112-6","doi":"https://doi.org/10.1016/s0169-409x(02)00112-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-409x(02)00112-6","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108125821","display_name":"Maria Ponec","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Maria Ponec","raw_affiliation_strings":["Department of Dermatology, Leiden University Medical Centre, Sylvius Laboratory, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands. m.h.ponec-waelsch@lumc.nl","Department of Dermatology, Leiden University Medical Centre, Sylvius Laboratory, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Leiden University Medical Centre, Sylvius Laboratory, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands. m.h.ponec-waelsch@lumc.nl","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Dermatology, Leiden University Medical Centre, Sylvius Laboratory, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108125821"],"corresponding_institution_ids":["https://openalex.org/I2800006345"],"apc_list":{"value":5550,"currency":"USD","value_usd":5550},"apc_paid":null,"fwci":0.2143,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.16572505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"54","issue":null,"first_page":"S19","last_page":"S30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.2671000063419342,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.15780000388622284,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.10279999673366547,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-substitutes","display_name":"skin substitutes","score":0.5669999718666077},{"id":"https://openalex.org/keywords/alternatives-to-animal-testing","display_name":"alternatives to animal testing","score":0.8109999895095825},{"id":"https://openalex.org/keywords/skin-toxicity-testing","display_name":"skin toxicity testing","score":0.8840000033378601},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.7450000047683716},{"id":"https://openalex.org/keywords/dermis","display_name":"dermis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9810000061988831},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9210000038146973},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/skin-diseases","display_name":"skin diseases","score":0.7739999890327454},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.732248067855835},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.6921890377998352},{"id":"https://openalex.org/C2776391296","wikidata":"https://www.wikidata.org/wiki/Q7535389","display_name":"Skin equivalent","level":4,"score":0.5873070955276489},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5180559158325195},{"id":"https://openalex.org/C2777789703","wikidata":"https://www.wikidata.org/wiki/Q192102","display_name":"Skin cancer","level":3,"score":0.4383632242679596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4371755123138428},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3206004500389099},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.3172991871833801},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16704398393630981},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10854896903038025},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001704","descriptor_name":"Biopolymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017768","descriptor_name":"Skin, Artificial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035843","descriptor_name":"Biomedical Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0169-409x(02)00112-6","doi":"https://doi.org/10.1016/s0169-409x(02)00112-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0169-409x(02)00112-6","pdf_url":null,"source":{"id":"https://openalex.org/S114437232","display_name":"Advanced Drug Delivery Reviews","issn_l":"0169-409X","issn":["0169-409X","1872-8294"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Drug Delivery Reviews","raw_type":"journal-article"},{"id":"pmid:12460713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12460713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced drug delivery reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W180788089","https://openalex.org/W211861978","https://openalex.org/W339637454","https://openalex.org/W581657805","https://openalex.org/W1894252271","https://openalex.org/W1945471866","https://openalex.org/W1968183627","https://openalex.org/W1968432125","https://openalex.org/W1978263016","https://openalex.org/W1982030251","https://openalex.org/W1986851297","https://openalex.org/W1987052865","https://openalex.org/W1990428293","https://openalex.org/W1990896467","https://openalex.org/W1992104579","https://openalex.org/W1993044058","https://openalex.org/W2012317026","https://openalex.org/W2024409040","https://openalex.org/W2025086681","https://openalex.org/W2025135094","https://openalex.org/W2030068752","https://openalex.org/W2039672934","https://openalex.org/W2041345554","https://openalex.org/W2046341979","https://openalex.org/W2049921327","https://openalex.org/W2051355492","https://openalex.org/W2052429067","https://openalex.org/W2063816876","https://openalex.org/W2071809465","https://openalex.org/W2076896780","https://openalex.org/W2079214615","https://openalex.org/W2081426168","https://openalex.org/W2110265874","https://openalex.org/W2124050936","https://openalex.org/W2129959377","https://openalex.org/W2168851344","https://openalex.org/W2279881803","https://openalex.org/W2341889758","https://openalex.org/W2346607550","https://openalex.org/W2413692212","https://openalex.org/W2737447326","https://openalex.org/W4298205649"],"related_works":["https://openalex.org/W1976324099","https://openalex.org/W3121071086","https://openalex.org/W1925741418","https://openalex.org/W7097015349","https://openalex.org/W2044839735","https://openalex.org/W1921284129","https://openalex.org/W1769666049","https://openalex.org/W1810210824","https://openalex.org/W7207140474","https://openalex.org/W1894252271"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
