{"id":"https://openalex.org/W1997489378","doi":"https://doi.org/10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","title":"Chemotherapy-related hemolytic-uremic syndrome after the treatment of head and neck cancer. A case report","display_name":"Chemotherapy-related hemolytic-uremic syndrome after the treatment of head and neck cancer. A case report","publication_year":1990,"publication_date":"1990-11-01","ids":{"openalex":"https://openalex.org/W1997489378","doi":"https://doi.org/10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","mag":"1997489378","pmid":"https://pubmed.ncbi.nlm.nih.gov/2224786"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","doi":"https://doi.org/10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085028425","display_name":"William John Gradishar","orcid":"https://orcid.org/0000-0002-2772-3140","observed_orcids":["https://orcid.org/0000-0002-2772-3140"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William J. Gradishar","raw_affiliation_strings":["Department of Medicine, University of Chicago, Illinois","Department of Medicine, Section of Hematology/Oncology, Northwestern University, 233 E. Erie, Suite 700, Chicago, IL 60611","Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, Northwestern University, 233 E. Erie, Suite 700, Chicago, IL 60611","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Everett E. Vokes","raw_affiliation_strings":["Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai Ni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Ni","raw_affiliation_strings":["Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109142725","display_name":"William R. Panje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William R. Panje","raw_affiliation_strings":["Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Hematology/Oncology, the Department of Pathology, and the Department of Surgery, Section of Otolaryngology\u2014Head and Neck Surgery, The University of Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085028425"],"corresponding_institution_ids":["https://openalex.org/I111979921","https://openalex.org/I40347166"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.5155,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.62097699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"66","issue":"9","first_page":"1914","last_page":"1918"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemolytic-uremic-syndrome","display_name":"hemolytic uremic syndrome","score":0.9779999852180481},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.8050000071525574},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bleomycin","display_name":"bleomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/autopsy","display_name":"autopsy","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9647456407546997},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.7969659566879272},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7299236059188843},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6216046214103699},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6063398122787476},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.5535265207290649},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.547825276851654},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5007293224334717},{"id":"https://openalex.org/C3019864225","wikidata":"https://www.wikidata.org/wiki/Q5867482","display_name":"Combination chemotherapy","level":3,"score":0.41334834694862366},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.32060524821281433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31075525283813477}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001996","descriptor_name":"Bronchopneumonia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001996","descriptor_name":"Bronchopneumonia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006463","descriptor_name":"Hemolytic-Uremic Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","doi":"https://doi.org/10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-0142(19901101)66:9<1914::aid-cncr2820660910>3.0.co;2-g","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:2224786","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2224786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W36784139","https://openalex.org/W310524666","https://openalex.org/W1871415164","https://openalex.org/W1917101340","https://openalex.org/W1965624945","https://openalex.org/W1991079138","https://openalex.org/W1999210336","https://openalex.org/W2008198181","https://openalex.org/W2012778218","https://openalex.org/W2064832219","https://openalex.org/W2065961310","https://openalex.org/W2076829555","https://openalex.org/W2095433984","https://openalex.org/W2100888057","https://openalex.org/W2256370784","https://openalex.org/W2398993469","https://openalex.org/W4237488345"],"related_works":["https://openalex.org/W2315236928","https://openalex.org/W2045478646","https://openalex.org/W2122507346","https://openalex.org/W1997513066","https://openalex.org/W2398673732","https://openalex.org/W2417795643","https://openalex.org/W2141076873","https://openalex.org/W2169476427","https://openalex.org/W2115620060","https://openalex.org/W1502188499"],"abstract_inverted_index":{"A":[0],"62-year-old":[1],"woman":[2],"who":[3],"was":[4,37],"being":[5],"treated":[6],"for":[7],"squamous":[8],"cell":[9],"carcinoma":[10],"of":[11,25,29,57],"the":[12,22,35,43,53,58,64],"head":[13],"and":[14,32,45],"neck":[15],"developed":[16],"a":[17],"chemotherapy-related":[18],"hemolytic-uremic":[19,59],"syndrome":[20,36,60],"during":[21],"second":[23],"cycle":[24],"neoadjuvant":[26],"chemotherapy":[27],"consisting":[28],"cisplatin,":[30],"bleomycin,":[31],"methotrexate.":[33],"Though":[34],"suspected":[38],"early,":[39],"attempts":[40],"at":[41],"reversing":[42],"hematologic":[44],"renal":[46],"abnormalities":[47],"were":[48,61],"unsuccessful.":[49],"At":[50],"postmortem":[51],"examination,":[52],"characteristic":[54],"microvascular":[55],"lesions":[56],"found":[62],"in":[63],"kidneys.":[65]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
