{"id":"https://openalex.org/W1997476481","doi":"https://doi.org/10.1021/bi992645l","title":"Crystal Structure at 2.4 \u00c5 Resolution of Borrelia burgdorferi Inosine 5\u2018-Monophosphate Dehydrogenase: Evidence of a Substrate-Induced Hinged-Lid Motion by Loop 6,","display_name":"Crystal Structure at 2.4 \u00c5 Resolution of Borrelia burgdorferi Inosine 5\u2018-Monophosphate Dehydrogenase: Evidence of a Substrate-Induced Hinged-Lid Motion by Loop 6,","publication_year":2000,"publication_date":"2000-03-23","ids":{"openalex":"https://openalex.org/W1997476481","doi":"https://doi.org/10.1021/bi992645l","mag":"1997476481","pmid":"https://pubmed.ncbi.nlm.nih.gov/10758003"},"language":"en","primary_location":{"id":"doi:10.1021/bi992645l","doi":"https://doi.org/10.1021/bi992645l","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi992645l","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004460843","display_name":"Fiona M. McMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona M. McMillan","raw_affiliation_strings":["The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454","The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454, USA","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059710006","display_name":"Marguerite Cahoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marguerite Cahoon","raw_affiliation_strings":["The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028683198","display_name":"Andr\u00e9 White","orcid":"https://orcid.org/0000-0002-4393-1062","observed_orcids":["https://orcid.org/0000-0002-4393-1062"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 White","raw_affiliation_strings":["The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083404534","display_name":"Lizbeth Hedstrom","orcid":"https://orcid.org/0000-0001-8432-3322","observed_orcids":["https://orcid.org/0000-0001-8432-3322"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lizbeth Hedstrom","raw_affiliation_strings":["The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007934367","display_name":"Gregory A. Petsko","orcid":"https://orcid.org/0000-0003-3668-3694","observed_orcids":["https://orcid.org/0000-0003-3668-3694"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory A. Petsko","raw_affiliation_strings":["The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014900252","display_name":"Dagmar Ringe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dagmar Ringe","raw_affiliation_strings":["The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rosenstiel Basic Medical Sciences Research Center and Department of Biochemistry, Brandeis University, Waltham, Massachussetts 02454","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014900252"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.722,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.66973413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"39","issue":"15","first_page":"4533","last_page":"4542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inosine-5-monophosphate-dehydrogenase","display_name":"inosine 5'-monophosphate dehydrogenase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":0.996999979019165},{"id":"https://openalex.org/keywords/conformational-change","display_name":"conformational change","score":0.8270000219345093},{"id":"https://openalex.org/keywords/purine-biosynthesis","display_name":"purine biosynthesis","score":0.6890000104904175},{"id":"https://openalex.org/keywords/sulfate-binding","display_name":"sulfate binding","score":0.4569999873638153},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.375},{"id":"https://openalex.org/keywords/enzyme-active-site","display_name":"enzyme active site","score":0.3230000138282776}],"concepts":[{"id":"https://openalex.org/C38596361","wikidata":"https://www.wikidata.org/wiki/Q6036610","display_name":"IMP dehydrogenase","level":4,"score":0.6955969929695129},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.6069160103797913},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5667319297790527},{"id":"https://openalex.org/C2777610669","wikidata":"https://www.wikidata.org/wiki/Q422564","display_name":"Inosine","level":3,"score":0.5177282691001892},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48318830132484436},{"id":"https://openalex.org/C2909748322","wikidata":"https://www.wikidata.org/wiki/Q255933","display_name":"Inosine monophosphate","level":4,"score":0.46541500091552734},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.4235379099845886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40397071838378906},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.3957889974117279},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2922316789627075},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C2778033501","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolic acid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007168","descriptor_name":"IMP Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007168","descriptor_name":"IMP Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007291","descriptor_name":"Inosine Monophosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012265","descriptor_name":"Ribonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015748","descriptor_name":"Borrelia burgdorferi Group","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018583","descriptor_name":"Pliability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019820","descriptor_name":"Xanthine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi992645l","doi":"https://doi.org/10.1021/bi992645l","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi992645l","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:10758003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10758003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2699771633","display_name":null,"funder_award_id":"GM-32415","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2852935024","display_name":"IMP Dehydrogenase","funder_award_id":"R01GM054403","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4570313523","display_name":null,"funder_award_id":"GM54403","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1489790705","https://openalex.org/W1519817796","https://openalex.org/W1578213890","https://openalex.org/W1756233575","https://openalex.org/W1916722273","https://openalex.org/W2016273346","https://openalex.org/W2028231353","https://openalex.org/W2031338911","https://openalex.org/W2052666471","https://openalex.org/W2080476827","https://openalex.org/W2080864148","https://openalex.org/W2091969321","https://openalex.org/W2127702556"],"related_works":["https://openalex.org/W2165319386","https://openalex.org/W2498963051","https://openalex.org/W2108044948","https://openalex.org/W2160566653","https://openalex.org/W7098794043","https://openalex.org/W2050007774","https://openalex.org/W4300990726","https://openalex.org/W1991178000","https://openalex.org/W4408521310","https://openalex.org/W2090993509"],"abstract_inverted_index":{"The":[0,169],"conversion":[1],"of":[2,34,42,51,76,104,109,141,162,165,171,183,205,209,233],"inosine":[3],"5'-monophosphate":[4,8],"(IMP)":[5],"to":[6,36,48,180,188,246,252],"xanthosine":[7],"(XMP)":[9],"is":[10,27,59,100,127,146],"the":[11,28,32,39,73,81,94,101,107,114,121,131,206,210,215],"committed":[12],"and":[13,67,176,203,220,237,248,251],"rate-limiting":[14],"reaction":[15],"in":[16,55,93,106,130,156,214],"de":[17],"novo":[18],"guanine":[19],"nucleotide":[20],"biosynthesis.":[21],"Inosine":[22],"5'-":[23],"monophosphate":[24],"dehydrogenase":[25],"(IMPDH)":[26],"enzyme":[29],"that":[30,84,136,226,239],"catalyzes":[31],"oxidation":[33],"IMP":[35,95],"XMP":[37],"with":[38,88],"concomitant":[40],"reduction":[41],"nicotinamide":[43],"adenine":[44],"dinucleotide":[45],"(from":[46],"NAD(+)":[47],"NADH).":[49],"Because":[50],"its":[52,154],"critical":[53],"role":[54],"purine":[56],"biosynthesis,":[57],"IMPDH":[58,77,105,179,219,224,240],"a":[60,89,137,166,181,193,230],"drug":[61],"design":[62],"target":[63],"for":[64],"anticancer,":[65],"antiinfective,":[66],"immunosuppressive":[68],"chemotherapy.":[69],"We":[70,134],"have":[71],"determined":[72],"crystal":[74],"structure":[75,103],"from":[78,153],"Borrelia":[79],"burgdorferi,":[80],"bacterial":[82],"spirochete":[83],"causes":[85],"Lyme":[86],"disease,":[87],"sulfate":[90],"ion":[91],"bound":[92],"phosphate":[96],"binding":[97],"site.":[98],"This":[99],"first":[102],"absence":[108],"substrate":[110,159,250],"or":[111,158],"cofactor":[112],"where":[113],"active-site":[115],"loop":[116,142,173,191,211,227,244],"(loop":[117],"6),":[118],"which":[119],"contains":[120],"essential":[122,255],"catalytic":[123,256],"residue":[124,139],"Cys":[125],"229,":[126],"clearly":[128],"defined":[129],"electron":[132],"density.":[133],"report":[135],"seven":[138],"region":[140,213],"6,":[143],"including":[144],"Cys229,":[145],"tilted":[147],"more":[148],"than":[149],"6":[150,212,228,245],"A":[151],"away":[152],"position":[155],"substrate-":[157],"analogue-bound":[160],"structures":[161],"IMPDH,":[163],"suggestive":[164],"conformational":[167],"change.":[168],"location":[170],"this":[172,190],"between":[174],"beta6":[175],"alpha6":[177],"links":[178],"family":[182],"beta/alpha":[184],"barrel":[185],"enzymes":[186],"known":[187],"utilize":[189],"as":[192],"functional":[194],"lid":[195],"during":[196],"catalysis.":[197],"Least-squares":[198],"minimization,":[199],"root-mean-square":[200],"deviation":[201],"analysis,":[202],"inspection":[204],"molecular":[207],"surface":[208],"substrate-free":[216],"B.":[217],"burgdorferi":[218],"XMP-bound":[221],"Chinese":[222],"hamster":[223],"show":[225],"follows":[229],"similar":[231],"pattern":[232],"hinged":[234],"rigid-body":[235],"motion":[236],"indicates":[238],"may":[241],"be":[242],"using":[243],"bind":[247],"sequester":[249],"recruit":[253],"an":[254],"residue.":[257]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}