{"id":"https://openalex.org/W1997462779","doi":"https://doi.org/10.3109/1040841x.2011.559944","title":"IMP-type metallo-\u03b2-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons","display_name":"IMP-type metallo-\u03b2-lactamases in Gram-negative bacilli: distribution, phylogeny, and association with integrons","publication_year":2011,"publication_date":"2011-03-29","ids":{"openalex":"https://openalex.org/W1997462779","doi":"https://doi.org/10.3109/1040841x.2011.559944","mag":"1997462779","pmid":"https://pubmed.ncbi.nlm.nih.gov/21707466"},"language":"en","primary_location":{"id":"doi:10.3109/1040841x.2011.559944","doi":"https://doi.org/10.3109/1040841x.2011.559944","is_oa":false,"landing_page_url":"https://doi.org/10.3109/1040841x.2011.559944","pdf_url":null,"source":{"id":"https://openalex.org/S6081579","display_name":"Critical Reviews in Microbiology","issn_l":"1040-841X","issn":["1040-841X","1549-7828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100694249","display_name":"Weihua Zhao","orcid":"https://orcid.org/0000-0002-5672-7132","observed_orcids":["https://orcid.org/0000-0002-5672-7132"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Wei-Hua Zhao","raw_affiliation_strings":["Department of Microbiology and Immunology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan. whzhao@med.showa-u.ac.jp","Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan. whzhao@med.showa-u.ac.jp","institution_ids":["https://openalex.org/I119182057"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo Japan","institution_ids":["https://openalex.org/I119182057"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102807718","display_name":"Zhiqing Hu","orcid":"https://orcid.org/0000-0002-3334-2002","observed_orcids":["https://orcid.org/0000-0002-3334-2002"]},"institutions":[{"id":"https://openalex.org/I119182057","display_name":"SHOWA Medical University","ror":"https://ror.org/04mzk4q39","country_code":"JP","type":"education","lineage":["https://openalex.org/I119182057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zhi-Qing Hu","raw_affiliation_strings":["Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I119182057"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100694249"],"corresponding_institution_ids":["https://openalex.org/I119182057"],"apc_list":null,"apc_paid":null,"fwci":0.4171,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.32374101,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"37","issue":"3","first_page":"214","last_page":"226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gram-negative-bacilli","display_name":"Gram-negative bacilli","score":0.949999988079071},{"id":"https://openalex.org/keywords/class-1-integron","display_name":"class 1 integron","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gene-cassettes","display_name":"gene cassettes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/horizontal-gene-transfer","display_name":"horizontal gene transfer","score":0.8270000219345093},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7929999828338623},{"id":"https://openalex.org/keywords/blaoxa","display_name":"blaOXA","score":0.9729999899864197},{"id":"https://openalex.org/keywords/transposable-elements","display_name":"transposable elements","score":0.6850000023841858},{"id":"https://openalex.org/keywords/plasmids","display_name":"plasmids","score":0.9279999732971191},{"id":"https://openalex.org/keywords/phylogeny","display_name":"phylogeny","score":0.7720000147819519},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8505367040634155},{"id":"https://openalex.org/C92938381","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Horizontal gene transfer","level":4,"score":0.7692310810089111},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7201265096664429},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.6816959381103516},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.67192542552948},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6666457653045654},{"id":"https://openalex.org/C2776870249","wikidata":"https://www.wikidata.org/wiki/Q149128","display_name":"Bacilli","level":3,"score":0.6465264558792114},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.46965494751930237},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.45881491899490356},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.39124104380607605},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3578392267227173},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.24111434817314148},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.1820278763771057}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022761","descriptor_name":"Gene Transfer, Horizontal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032023","descriptor_name":"Integrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/1040841x.2011.559944","doi":"https://doi.org/10.3109/1040841x.2011.559944","is_oa":false,"landing_page_url":"https://doi.org/10.3109/1040841x.2011.559944","pdf_url":null,"source":{"id":"https://openalex.org/S6081579","display_name":"Critical Reviews in Microbiology","issn_l":"1040-841X","issn":["1040-841X","1549-7828"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Microbiology","raw_type":"journal-article"},{"id":"pmid:21707466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21707466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W202679724","https://openalex.org/W1902535075","https://openalex.org/W1965723097","https://openalex.org/W1966976567","https://openalex.org/W1970539992","https://openalex.org/W1976001424","https://openalex.org/W1979120097","https://openalex.org/W1980604425","https://openalex.org/W1984479212","https://openalex.org/W1987932415","https://openalex.org/W1990504694","https://openalex.org/W1990532919","https://openalex.org/W1997873483","https://openalex.org/W2004689193","https://openalex.org/W2007638964","https://openalex.org/W2009690857","https://openalex.org/W2011210667","https://openalex.org/W2014241893","https://openalex.org/W2019971395","https://openalex.org/W2024989380","https://openalex.org/W2030735422","https://openalex.org/W2035312424","https://openalex.org/W2040131913","https://openalex.org/W2047415025","https://openalex.org/W2047606370","https://openalex.org/W2049478621","https://openalex.org/W2050497945","https://openalex.org/W2052710525","https://openalex.org/W2053817052","https://openalex.org/W2056357195","https://openalex.org/W2056360421","https://openalex.org/W2058729834","https://openalex.org/W2059540297","https://openalex.org/W2061397442","https://openalex.org/W2067647269","https://openalex.org/W2067981587","https://openalex.org/W2070082468","https://openalex.org/W2076994582","https://openalex.org/W2081988169","https://openalex.org/W2083626085","https://openalex.org/W2083629457","https://openalex.org/W2086269511","https://openalex.org/W2097378554","https://openalex.org/W2098688781","https://openalex.org/W2099004335","https://openalex.org/W2099897863","https://openalex.org/W2104186571","https://openalex.org/W2105018756","https://openalex.org/W2107234657","https://openalex.org/W2108395383","https://openalex.org/W2113763076","https://openalex.org/W2116849741","https://openalex.org/W2117536857","https://openalex.org/W2118193766","https://openalex.org/W2119223614","https://openalex.org/W2121661901","https://openalex.org/W2122344670","https://openalex.org/W2122768722","https://openalex.org/W2123807406","https://openalex.org/W2129913898","https://openalex.org/W2131573558","https://openalex.org/W2133676327","https://openalex.org/W2135275247","https://openalex.org/W2136653513","https://openalex.org/W2136690324","https://openalex.org/W2137457147","https://openalex.org/W2137899692","https://openalex.org/W2140563889","https://openalex.org/W2142855469","https://openalex.org/W2143277136","https://openalex.org/W2143874510","https://openalex.org/W2145288338","https://openalex.org/W2145463306","https://openalex.org/W2145660300","https://openalex.org/W2146502343","https://openalex.org/W2148298053","https://openalex.org/W2151985744","https://openalex.org/W2152413896","https://openalex.org/W2153116802","https://openalex.org/W2158119633","https://openalex.org/W2158895633","https://openalex.org/W2159579053","https://openalex.org/W2159875661","https://openalex.org/W2160181674","https://openalex.org/W2161804223","https://openalex.org/W2162825747","https://openalex.org/W2165213620","https://openalex.org/W2167453934","https://openalex.org/W2170033805","https://openalex.org/W2171000901","https://openalex.org/W2171500736","https://openalex.org/W2172070265","https://openalex.org/W2208772631","https://openalex.org/W2222312033","https://openalex.org/W2290501259","https://openalex.org/W4237575000"],"related_works":["https://openalex.org/W2130164345","https://openalex.org/W4405661802","https://openalex.org/W7096270108","https://openalex.org/W2099004335","https://openalex.org/W4412612145","https://openalex.org/W2148298053","https://openalex.org/W2124320246","https://openalex.org/W2180752492","https://openalex.org/W2024989380","https://openalex.org/W2162151303"],"abstract_inverted_index":{"Twenty-nine":[0],"IMP-type":[1],"\u03b2-lactamases":[2],"(IMPs)":[3],"have":[4],"been":[5],"identified":[6],"in":[7,36,62,95],"at":[8],"least":[9],"26":[10],"species":[11],"of":[12,23,71,82,97],"clinically":[13],"important":[14],"Gram-negative":[15],"bacilli":[16],"from":[17],"more":[18],"than":[19],"24":[20],"countries/regions.":[21],"Most":[22],"bla(IMP)":[24,47,73,90],"genes":[25,48,91],"are":[26,33,76,92],"harbored":[27],"by":[28],"class":[29,84],"1":[30,85],"integrons":[31],"that":[32,88],"usually":[34,49],"embedded":[35],"transposons":[37],"and/or":[38],"plasmids,":[39],"footnoting":[40],"their":[41],"horizontal":[42],"transfer":[43],"and":[44,59],"worldwide":[45],"distribution.":[46],"co-exist":[50],"with":[51],"other":[52,67],"resistance":[53],"genes,":[54],"such":[55],"as":[56],"aacA,":[57],"catB,":[58],"bla(OXA),":[60],"resulting":[61],"multi-drug":[63],"resistance.":[64],"Compared":[65],"to":[66,79],"gene":[68,74],"cassettes,":[69],"76.3%":[70],"the":[72,83,89],"cassettes":[75],"located":[77],"adjacent":[78],"Pc":[80],"promoter":[81],"integrons,":[86],"indicating":[87],"readily":[93],"expressed":[94],"most":[96],"bacterial":[98],"hosts.":[99]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}