{"id":"https://openalex.org/W1997458924","doi":"https://doi.org/10.1159/000239146","title":"In vitro Experiments on Catheter-Related Infections Due to Gram-Negative Rods","display_name":"In vitro Experiments on Catheter-Related Infections Due to Gram-Negative Rods","publication_year":2009,"publication_date":"2009-09-11","ids":{"openalex":"https://openalex.org/W1997458924","doi":"https://doi.org/10.1159/000239146","mag":"1997458924","pmid":"https://pubmed.ncbi.nlm.nih.gov/8370325"},"language":"en","primary_location":{"id":"doi:10.1159/000239146","doi":"https://doi.org/10.1159/000239146","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000239146","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J. Penner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"J. Penner","raw_affiliation_strings":["Department of Surgery, University of Innsbruck, Austria","Department of Surgery, Institutes of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]},{"raw_affiliation_string":"Department of Surgery, Institutes of","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080165849","display_name":"Franz J. Allerberger","orcid":"https://orcid.org/0000-0002-0045-8164","observed_orcids":["https://orcid.org/0000-0002-0045-8164"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Allerberger","raw_affiliation_strings":["Department of Immunology and Infectious Diseases, Johns Hopkins University, Baltimore, Md., USA","Hygiene, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Infectious Diseases, Johns Hopkins University, Baltimore, Md., USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Hygiene, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112098000","display_name":"Manfred P. Dierich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.P. Dierich","raw_affiliation_strings":["Hygiene, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hygiene, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044670215","display_name":"Walter Pfaller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"W. Pfaller","raw_affiliation_strings":["Physiology, University of Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology, University of Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111088818","display_name":"J. Hager","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Hager","raw_affiliation_strings":["Department of Surgery, Institutes of"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Institutes of","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7808,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.77163797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"39","issue":"5","first_page":"336","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catheter-related-bacteremia","display_name":"catheter-related bacteremia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/gram-negative-bacilli","display_name":"Gram-negative bacilli","score":0.7390000224113464},{"id":"https://openalex.org/keywords/central-venous-catheters","display_name":"central venous catheters","score":0.9539999961853027},{"id":"https://openalex.org/keywords/silastic-catheter","display_name":"Silastic catheter","score":0.8109999895095825},{"id":"https://openalex.org/keywords/bacterial-adhesion","display_name":"bacterial adhesion","score":0.7829999923706055},{"id":"https://openalex.org/keywords/extracellular-slime","display_name":"extracellular slime","score":0.6650000214576721},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6909999847412109},{"id":"https://openalex.org/keywords/antimicrobial-treatment-failure","display_name":"antimicrobial treatment failure","score":0.4519999921321869},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.7699999809265137},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9179999828338623},{"id":"https://openalex.org/keywords/enterobacter-cloacae","display_name":"Enterobacter cloacae","score":0.9240000247955322},{"id":"https://openalex.org/keywords/serratia-marcescens","display_name":"Serratia marcescens","score":0.9710000157356262},{"id":"https://openalex.org/keywords/catheter-colonization","display_name":"catheter colonization","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7650328874588013},{"id":"https://openalex.org/C2777402170","wikidata":"https://www.wikidata.org/wiki/Q4038096","display_name":"Enterobacter cloacae","level":5,"score":0.5962292551994324},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5905370712280273},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.5260512828826904},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.524703860282898},{"id":"https://openalex.org/C2776309202","wikidata":"https://www.wikidata.org/wiki/Q140004","display_name":"Serratia marcescens","level":4,"score":0.4990220069885254},{"id":"https://openalex.org/C2779631663","wikidata":"https://www.wikidata.org/wiki/Q425152","display_name":"Imipenem","level":4,"score":0.47883203625679016},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.4554765224456787},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.4108848571777344},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3824887275695801},{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.3795086443424225},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37529855966567993},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.22309613227844238},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.19058462977409363},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.17488273978233337},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002404","descriptor_name":"Catheterization","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002404","descriptor_name":"Catheterization","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004755","descriptor_name":"Enterobacteriaceae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004755","descriptor_name":"Enterobacteriaceae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004755","descriptor_name":"Enterobacteriaceae","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004866","descriptor_name":"Equipment Contamination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013212","descriptor_name":"Staphylococcus epidermidis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013212","descriptor_name":"Staphylococcus epidermidis","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015169","descriptor_name":"Colony Count, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000239146","doi":"https://doi.org/10.1159/000239146","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000239146","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},{"id":"pmid:8370325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8370325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2042785780","https://openalex.org/W2014807324","https://openalex.org/W2051163690","https://openalex.org/W2122007991","https://openalex.org/W2087359812","https://openalex.org/W2367674002","https://openalex.org/W2029658925","https://openalex.org/W1158446594","https://openalex.org/W2113702527","https://openalex.org/W1580690954"],"abstract_inverted_index":{"Although":[0],"many":[1,197],"complications":[2],"may":[3],"arise":[4],"with":[5,156,168,250],"the":[6,18,24,35,60,73,86,103,124,162,189,192,201,205,210,216,224,244,255],"use":[7],"of":[8,38,62,75,85,105,112,148,204,209,246],"central":[9,247],"venous":[10,248],"catheters,":[11,114],"catheter-related":[12,41],"bacteremia":[13],"is":[14,31,238],"considered":[15],"to":[16,33,58,71,109,222,241],"be":[17,223],"most":[19,225],"serious":[20],"complication.":[21],"Microflora":[22],"on":[23,93],"patient's":[25],"skin":[26],"(coagulase-negative":[27],"staphylococci,":[28],"Staphylococcus":[29],"aureus)":[30],"thought":[32],"represent":[34],"major":[36],"source":[37],"microorganisms":[39],"causing":[40],"infections.":[42],"Gram-negative":[43],"rods":[44,79,108,252],"are":[45],"increasingly":[46],"observed":[47,154],"as":[48],"causative":[49],"agents.":[50,171],"We":[51],"therefore":[52],"performed":[53],"an":[54,149],"in":[55,180,214,229],"vitro":[56,230],"study":[57,72],"elucidate":[59],"pathogenesis":[61],"polymer-associated":[63],"infections":[64],"caused":[65],"by":[66,97,253],"enterobacteriaceae":[67],"and":[68,70,186],"nonfermenters":[69],"resistance":[74],"polymer":[76],"surface-grown":[77],"gram-negative":[78,107,251],"against":[80],"antibiotics.":[81],"Using":[82],"a":[83,115],"modification":[84],"semiquantitative":[87],"method":[88],"for":[89,118],"culturing":[90],"vascular":[91],"cannulas":[92],"solid":[94],"media":[95],"described":[96],"Maki":[98],"et":[99],"al.,":[100],"we":[101],"studied":[102],"adherence":[104],"various":[106,169,206],"1-cm":[110],"segments":[111,165],"silastic":[113,163],"material":[116],"used":[117,176,195],"Port-A-Cath-systems.":[119],"Organisms":[120],"were":[121,166,175,196],"obtained":[122],"from":[123],"American":[125],"Type":[126],"Culture":[127],"Collection":[128],"(Escherichia":[129],"coli,":[130],"Klebsiella":[131,142],"pneumoniae,":[132],"Serratia":[133],"marcescens,":[134],"Pseudomonas":[135],"aeruginosa,":[136],"Enterobacter":[137],"cloacae).":[138],"All":[139],"organisms":[140],"but":[141],"showed":[143],"extensive":[144],"irreversible":[145],"adherence.":[146],"Production":[147],"extracellular":[150],"slime":[151],"substance":[152],"was":[153,220],"only":[155],"antimicrobially":[157],"treated":[158,167],"Pseudomonas.":[159],"After":[160],"'infection',":[161],"catheter":[164],"antimicrobial":[170,256],"The":[172],"following":[173],"antibiotics":[174,211],"either":[177],"individually":[178],"or":[179],"combination:":[181],"cefotaxime,":[182],"ciprofloxacin,":[183],"imipenem,":[184],"fosfomycin":[185],"gentamicin.":[187],"Despite":[188],"fact":[190],"that":[191,236],"antibiotic":[193],"concentrations":[194],"times":[198],"greater":[199],"than":[200],"respective":[202],"MICs":[203],"antibiotics,":[207],"none":[208],"tested":[212],"succeeded":[213],"eliminating":[215],"organisms.":[217],"E.":[218],"coli":[219],"found":[221],"susceptible":[226],"organism.":[227],"These":[228],"data":[231],"substantiate":[232],"our":[233],"clinical":[234],"impression":[235],"it":[237],"hardly":[239],"possible":[240],"successfully":[242],"eliminate":[243],"colonization":[245],"catheters":[249],"using":[254],"agents":[257],"employed":[258],"here.":[259]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}