{"id":"https://openalex.org/W1997453128","doi":"https://doi.org/10.1006/cbir.1996.0044","title":"SLOW INDUCTION OF GELATINASE B mRNA BY ACIDIC CULTURE CONDITIONS IN MOUSE METASTATIC MELANOMA CELLS","display_name":"SLOW INDUCTION OF GELATINASE B mRNA BY ACIDIC CULTURE CONDITIONS IN MOUSE METASTATIC MELANOMA CELLS","publication_year":1996,"publication_date":"1996-05-01","ids":{"openalex":"https://openalex.org/W1997453128","doi":"https://doi.org/10.1006/cbir.1996.0044","mag":"1997453128","pmid":"https://pubmed.ncbi.nlm.nih.gov/8688855"},"language":"en","primary_location":{"id":"doi:10.1006/cbir.1996.0044","doi":"https://doi.org/10.1006/cbir.1996.0044","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cbir.1996.0044","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078475231","display_name":"Yukio Kato","orcid":"https://orcid.org/0000-0003-0192-9324","observed_orcids":["https://orcid.org/0000-0003-0192-9324"]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"YASUMASA KATO","raw_affiliation_strings":["Department of Oral Biochemistry, Kanagawa Dental College, Yokosuka, Japan","Department of Oral Biochemistry, Kanagawa Dental college, 82, Inaoka-cho, Yokosuka 238, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biochemistry, Kanagawa Dental College, Yokosuka, Japan","institution_ids":["https://openalex.org/I47951555"]},{"raw_affiliation_string":"Department of Oral Biochemistry, Kanagawa Dental college, 82, Inaoka-cho, Yokosuka 238, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031087403","display_name":"Satoru Ozono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47951555","display_name":"Kanagawa Dental University","ror":"https://ror.org/0514c4d93","country_code":"JP","type":"education","lineage":["https://openalex.org/I47951555"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SATORU OZONO","raw_affiliation_strings":["Department of Oral Pathology, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, 238, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Pathology, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, 238, Japan","institution_ids":["https://openalex.org/I47951555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159926","display_name":"Taro Shuin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TARO SHUIN","raw_affiliation_strings":["Department of Urology, Yokohama City University School of Medicine, 3\u20139 Fukuura, Kanazawa-ku, Yokohama, 236, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Yokohama City University School of Medicine, 3\u20139 Fukuura, Kanazawa-ku, Yokohama, 236, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009882274","display_name":"Kaoru Miyazaki","orcid":"https://orcid.org/0000-0002-2831-2183","observed_orcids":["https://orcid.org/0000-0002-2831-2183"]},"institutions":[{"id":"https://openalex.org/I1283532511","display_name":"Kihara Institute for Biological Research","ror":"https://ror.org/007hwje16","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1283532511"]},{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAORU MIYAZAKI","raw_affiliation_strings":["Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, 641-12 Maioka, Yokohama, 244, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cell Biology, Kihara Institute for Biological Research, Yokohama City University, 641-12 Maioka, Yokohama, 244, Japan","institution_ids":["https://openalex.org/I1283532511","https://openalex.org/I89630735"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078475231"],"corresponding_institution_ids":["https://openalex.org/I47951555"],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.4821,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.60084346,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":"5","first_page":"375","last_page":"377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9750000238418579},{"id":"https://openalex.org/keywords/low-ph","display_name":"low pH","score":0.6859999895095825},{"id":"https://openalex.org/keywords/gene-induction","display_name":"gene induction","score":0.6710000038146973},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"metastatic melanoma","score":0.9309999942779541},{"id":"https://openalex.org/keywords/b16f10-melanoma-cells","display_name":"B16F10 melanoma cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gelatin-zymography","display_name":"gelatin zymography","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C2776232661","wikidata":"https://www.wikidata.org/wiki/Q5530373","display_name":"Gelatinase","level":3,"score":0.8923160433769226},{"id":"https://openalex.org/C2776223131","wikidata":"https://www.wikidata.org/wiki/Q13033733","display_name":"Gelatinase A","level":3,"score":0.8120356798171997},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6727855205535889},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6155576109886169},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5915223360061646},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.5822864770889282},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.5211465358734131},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4820488393306732},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.45660972595214844},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45552927255630493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4269178807735443},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4235043525695801},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42125511169433594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3831849992275238},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37665897607803345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32079076766967773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2508685290813446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05912142992019653}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007773","descriptor_name":"Lactates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019344","descriptor_name":"Lactic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/cbir.1996.0044","doi":"https://doi.org/10.1006/cbir.1996.0044","is_oa":false,"landing_page_url":"https://doi.org/10.1006/cbir.1996.0044","pdf_url":null,"source":{"id":"https://openalex.org/S7325069","display_name":"Cell Biology International","issn_l":"1065-6995","issn":["1065-6995","1095-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology International","raw_type":"journal-article"},{"id":"pmid:8688855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8688855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1511488764","https://openalex.org/W1967251768","https://openalex.org/W1989391836","https://openalex.org/W1998811052","https://openalex.org/W1999639081","https://openalex.org/W2042509472","https://openalex.org/W2042763933","https://openalex.org/W2077680450","https://openalex.org/W2161027243"],"related_works":["https://openalex.org/W1511488764","https://openalex.org/W2158132102","https://openalex.org/W2117883091","https://openalex.org/W7096941760","https://openalex.org/W261462733","https://openalex.org/W2148051205","https://openalex.org/W2380481833","https://openalex.org/W7014919616","https://openalex.org/W2067952373","https://openalex.org/W1545130123"],"abstract_inverted_index":{"Gelatinase":[0],"B":[1,38,58,81,108],"has":[2],"been":[3],"thought":[4],"to":[5,73,89],"be":[6],"a":[7,94,116],"key":[8],"enzyme":[9],"for":[10],"degradation":[11],"of":[12,27,36,106,118],"extracellular":[13],"matrix":[14],"in":[15,40],"tumour":[16],"invasion":[17],"and":[18,69,91],"metastasis.":[19],"In":[20],"this":[21],"study,":[22],"we":[23,54],"examined":[24],"the":[25,34,62,104,119],"effect":[26],"acidic":[28,63,111],"culture":[29,64,112],"medium":[30,65,113],"(pH":[31],"5.9)":[32],"on":[33],"expression":[35],"gelatinase":[37,57,80,107],"mRNA":[39],"mouse":[41],"metastatic":[42],"melanoma":[43],"cell":[44],"line":[45],"(B16-F10).":[46],"Using":[47],"reverse":[48],"transcription-polymerase":[49],"chain":[50],"reaction":[51],"(RT-PCR)":[52],"analysis,":[53,79],"found":[55],"that":[56,103],"was":[59,82],"induced":[60],"by":[61,110],"at":[66,85,96],"24":[67,86],"h,":[68,87],"then":[70,92],"gradually":[71],"diminished":[72],"72":[74],"h.":[75,99],"By":[76],"gelatin":[77],"zymographic":[78],"first":[83],"detected":[84],"continued":[88],"increase":[90],"reached":[93],"plateau":[95],"around":[97],"48":[98],"These":[100],"results":[101],"suggest":[102],"induction":[105],"secretion":[109],"occurs":[114],"as":[115],"result":[117],"gene":[120],"expression.":[121]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
