{"id":"https://openalex.org/W1997451389","doi":"https://doi.org/10.1172/jci114185","title":"Proteolytic inactivation of plasma C1- inhibitor in sepsis.","display_name":"Proteolytic inactivation of plasma C1- inhibitor in sepsis.","publication_year":1989,"publication_date":"1989-08-01","ids":{"openalex":"https://openalex.org/W1997451389","doi":"https://doi.org/10.1172/jci114185","mag":"1997451389","pmid":"https://pubmed.ncbi.nlm.nih.gov/2668333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/548902"},"language":"en","primary_location":{"id":"doi:10.1172/jci114185","doi":"https://doi.org/10.1172/jci114185","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114185","pdf_url":"http://www.jci.org/articles/view/114185/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/114185/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110574052","display_name":"Jan H. Nuijens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Nuijens","raw_affiliation_strings":["Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113768269","display_name":"Anke J. M. Eerenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A J Eerenberg-Belmer","raw_affiliation_strings":["Medical Intensive Care Unit , Free University ofAmsterdam , 1081 A VAmsterdam , The Netherlands","Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Intensive Care Unit , Free University ofAmsterdam , 1081 A VAmsterdam , The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108465771","display_name":"C C M Huijbregts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C C Huijbregts","raw_affiliation_strings":["Medical Intensive Care Unit , Free University ofAmsterdam , 1081 A VAmsterdam , The Netherlands","Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Intensive Care Unit , Free University ofAmsterdam , 1081 A VAmsterdam , The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026013674","display_name":"Willem O. Schreuder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W O Schreuder","raw_affiliation_strings":["Hack Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology , University ofAmsterdam , 1006 AK Amsterdam ; and","Medical Intensive Care Unit, Free University ofAmsterdam, 1081 A VAmsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hack Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology , University ofAmsterdam , 1006 AK Amsterdam ; and","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Medical Intensive Care Unit, Free University ofAmsterdam, 1081 A VAmsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078343938","display_name":"Richelle J. F. Felt-Bersma","orcid":"https://orcid.org/0000-0001-5786-7850","observed_orcids":["https://orcid.org/0000-0001-5786-7850"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R J Felt-Bersma","raw_affiliation_strings":["Hack Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology , University ofAmsterdam , 1006 AK Amsterdam ; and","Medical Intensive Care Unit, Free University ofAmsterdam, 1081 A VAmsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hack Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology , University ofAmsterdam , 1006 AK Amsterdam ; and","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Medical Intensive Care Unit, Free University ofAmsterdam, 1081 A VAmsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012273153","display_name":"Jannie J. Abbink","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J J Abbink","raw_affiliation_strings":["Medical Intensive Care Unit , Free University ofAmsterdam , 1081 A VAmsterdam , The Netherlands","Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Intensive Care Unit , Free University ofAmsterdam , 1081 A VAmsterdam , The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103365058","display_name":"LAMBERTUS G. THIJS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L G Thijs","raw_affiliation_strings":["Hack Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology , University ofAmsterdam , 1006 AK Amsterdam ; and","Medical Intensive Care Unit, Free University ofAmsterdam, 1081 A VAmsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hack Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology , University ofAmsterdam , 1006 AK Amsterdam ; and","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Medical Intensive Care Unit, Free University ofAmsterdam, 1081 A VAmsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080558143","display_name":"C. Erik Hack","orcid":"https://orcid.org/0009-0000-7281-8002","observed_orcids":["https://orcid.org/0009-0000-7281-8002"]},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C E Hack","raw_affiliation_strings":["Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Laboratory ofthe Netherlands Red Cross Blood Transfusion Service and Laboratoryfor Experimental and Clinical Immunology, University ofAmsterdam, 1006 AK Amsterdam;","institution_ids":["https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":5.2954,"has_fulltext":true,"cited_by_count":141,"citation_normalized_percentile":{"value":0.9582875,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"84","issue":"2","first_page":"443","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.890999972820282},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/proteolytic-inactivation","display_name":"proteolytic inactivation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.5929999947547913},{"id":"https://openalex.org/keywords/contact-system","display_name":"contact system","score":0.8650000095367432},{"id":"https://openalex.org/keywords/functional-index","display_name":"functional index","score":0.6809999942779541},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6340000033378601},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7080000042915344},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7571300268173218},{"id":"https://openalex.org/C2779931649","wikidata":"https://www.wikidata.org/wiki/Q416510","display_name":"C1-inhibitor","level":3,"score":0.7146206498146057},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.5661380290985107},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5579097270965576},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5249110460281372},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5098435282707214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.458067923784256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4494110345840454},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41211026906967163},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19612562656402588},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003171","descriptor_name":"Complement Pathway, Classical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci114185","doi":"https://doi.org/10.1172/jci114185","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114185","pdf_url":"http://www.jci.org/articles/view/114185/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:548902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/548902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2668333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2668333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.854.1010","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.854.1010","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dm5migu4zj3pb.cloudfront.net/manuscripts/114000/114185/JCI89114185.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1172/jci114185","doi":"https://doi.org/10.1172/jci114185","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci114185","pdf_url":"http://www.jci.org/articles/view/114185/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997451389.pdf","grobid_xml":"https://content.openalex.org/works/W1997451389.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W75077106","https://openalex.org/W116112267","https://openalex.org/W145388861","https://openalex.org/W156655195","https://openalex.org/W183757317","https://openalex.org/W184708334","https://openalex.org/W276947371","https://openalex.org/W348107195","https://openalex.org/W1274922051","https://openalex.org/W1458582449","https://openalex.org/W1505900720","https://openalex.org/W1541482973","https://openalex.org/W1565281311","https://openalex.org/W1602527749","https://openalex.org/W1818993356","https://openalex.org/W1964923202","https://openalex.org/W1976772170","https://openalex.org/W1980357055","https://openalex.org/W1985484598","https://openalex.org/W1988606065","https://openalex.org/W2003422570","https://openalex.org/W2014720148","https://openalex.org/W2018289835","https://openalex.org/W2022177906","https://openalex.org/W2036688878","https://openalex.org/W2043330027","https://openalex.org/W2048325240","https://openalex.org/W2049332147","https://openalex.org/W2060625943","https://openalex.org/W2061235805","https://openalex.org/W2069700057","https://openalex.org/W2079008038","https://openalex.org/W2085277293","https://openalex.org/W2090763136","https://openalex.org/W2091437216","https://openalex.org/W2091849415","https://openalex.org/W2093869678","https://openalex.org/W2094619261","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2107873069","https://openalex.org/W2117811465","https://openalex.org/W2119874636","https://openalex.org/W2125944425","https://openalex.org/W2151962457","https://openalex.org/W2158396300","https://openalex.org/W2158623312","https://openalex.org/W2188674398","https://openalex.org/W2269828993","https://openalex.org/W2316244541","https://openalex.org/W2320923764","https://openalex.org/W2321234878","https://openalex.org/W2331513080","https://openalex.org/W2333160546","https://openalex.org/W2340244022","https://openalex.org/W2397523915","https://openalex.org/W2397980352","https://openalex.org/W2401352633","https://openalex.org/W2403506032","https://openalex.org/W2404081591","https://openalex.org/W2410956791","https://openalex.org/W2412176855","https://openalex.org/W2425569192","https://openalex.org/W2437480443","https://openalex.org/W2474073582","https://openalex.org/W6712797387"],"related_works":["https://openalex.org/W7097009408","https://openalex.org/W6998435198","https://openalex.org/W197726482","https://openalex.org/W2282416021","https://openalex.org/W2810509284","https://openalex.org/W2232592469","https://openalex.org/W2196930638","https://openalex.org/W2225880445","https://openalex.org/W2048395992","https://openalex.org/W2287297359"],"abstract_inverted_index":{"Activation":[0],"of":[1,10,18,27,35,55,62,86,95,112,149,158,165,228,244],"both":[2,28],"the":[3,7,16,25,33,47,52,60,73,102,110,209,217,226,242],"complement":[4],"system":[5,9],"and":[6,64,92,128],"contact":[8],"intrinsic":[11],"coagulation":[12],"is":[13],"implicated":[14],"in":[15,38,72,147,171,177,187,200,216,230,241],"pathophysiology":[17],"sepsis.":[19,248],"Because":[20],"C1":[21],"inhibitor":[22],"(C1-Inh)":[23],"regulates":[24],"activation":[26],"cascade":[29],"systems,":[30],"we":[31],"studied":[32],"characteristics":[34],"plasma":[36,204],"C1-Inh":[37,66,90,96,98,132,229],"48":[39],"patients":[40,74,173,179,189,202,218,231],"with":[41,75,78,119,190,203,219,232],"severe":[42],"sepsis":[43,76,220,233],"on":[44,160],"admission":[45,161],"to":[46,109,142,154,163,194],"Intensive":[48],"Care":[49],"Unit":[50],"at":[51],"Free":[53],"University":[54],"Amsterdam.":[56],"The":[57,84,185,213],"ratio":[58],"between":[59],"level":[61],"functional":[63,104],"antigenic":[65],"(functional":[67],"index)":[68],"was":[69,106,169,197,211,221],"significantly":[70],"reduced":[71,103],"compared":[77],"healthy":[79],"volunteers":[80],"(P":[81,182],"=":[82,183],"0.004).":[83],"assessment":[85],"modified":[87],"(cleaved),":[88],"inactive":[89],"(iC1-Inh),":[91],"complexed":[93],"forms":[94],"(nonfunctional":[97],"species)":[99],"revealed":[100],"that":[101,225,236],"index":[105],"mainly":[107],"due":[108],"presence":[111],"iC1-Inh.":[113],"On":[114],"SDS-PAGE,":[115],"iC1-Inh":[116,136,159,168,191,205],"species":[117],"migrated":[118],"a":[120,238],"lower":[121],"apparent":[122],"molecular":[123],"weight":[124],"(Mr":[125,133],"98,000,":[126],"91,000,":[127],"86,000)":[129],"than":[130,139,176],"native":[131],"110,000).":[134],"Elevated":[135],"levels":[137,192],"(greater":[138],"or":[140],"equal":[141],"0.13":[143],"microM)":[144],"were":[145],"found":[146],"81%":[148],"all":[150],"patients,":[151],"sometimes":[152],"up":[153,193],"1.6":[155],"microM.":[156],"Levels":[157],"appeared":[162],"be":[164],"prognostic":[166],"value:":[167],"higher":[170],"27":[172],"who":[174,180],"died":[175],"21":[178],"survived":[181],"0.003).":[184],"mortality":[186,210,215],"15":[188],"0.2":[195],"microM":[196],"27%,":[198],"but":[199],"12":[201],"exceeding":[206],"0.44":[207],"microM,":[208],"83%.":[212],"overall":[214],"56%.":[222],"We":[223],"propose":[224],"cleavage":[227],"reflects":[234],"processes":[235],"play":[237],"major":[239],"role":[240],"development":[243],"fatal":[245],"complications":[246],"during":[247]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
