{"id":"https://openalex.org/W1997443498","doi":"https://doi.org/10.1152/ajpendo.00494.2014","title":"Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis","display_name":"Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis","publication_year":2015,"publication_date":"2015-03-04","ids":{"openalex":"https://openalex.org/W1997443498","doi":"https://doi.org/10.1152/ajpendo.00494.2014","mag":"1997443498","pmid":"https://pubmed.ncbi.nlm.nih.gov/25738783"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00494.2014","doi":"https://doi.org/10.1152/ajpendo.00494.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00494.2014","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002917296","display_name":"Gustavo Abreu-Vieira","orcid":"https://orcid.org/0000-0003-2861-4023","observed_orcids":["https://orcid.org/0000-0003-2861-4023"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gustavo Abreu-Vieira","raw_affiliation_strings":["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006562733","display_name":"Carolina E. Hagberg","orcid":"https://orcid.org/0000-0002-5497-2855","observed_orcids":["https://orcid.org/0000-0002-5497-2855"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Carolina E. Hagberg","raw_affiliation_strings":["Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029161591","display_name":"Kirsty L. Spalding","orcid":"https://orcid.org/0000-0002-5189-7028","observed_orcids":["https://orcid.org/0000-0002-5189-7028"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kirsty L. Spalding","raw_affiliation_strings":["Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089321330","display_name":"Barbara Cannon","orcid":"https://orcid.org/0000-0001-6594-2363","observed_orcids":["https://orcid.org/0000-0001-6594-2363"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Barbara Cannon","raw_affiliation_strings":["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019374149","display_name":"Jan Nedergaard","orcid":"https://orcid.org/0000-0003-2070-1587","observed_orcids":["https://orcid.org/0000-0003-2070-1587"]},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jan Nedergaard","raw_affiliation_strings":["Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; and","institution_ids":["https://openalex.org/I161593684"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5019374149"],"corresponding_institution_ids":["https://openalex.org/I161593684"],"apc_list":null,"apc_paid":null,"fwci":3.9428,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.93388777,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"308","issue":"9","first_page":"E822","last_page":"E829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11109","display_name":"Thermoregulation and physiological responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thermogenesis","display_name":"thermogenesis","score":0.6919999718666077},{"id":"https://openalex.org/keywords/tissue-blood-flow","display_name":"tissue blood flow","score":0.8669999837875366},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9390000104904175},{"id":"https://openalex.org/keywords/adrenergic-stimulation","display_name":"adrenergic stimulation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ucp1","display_name":"UCP1","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cold-acclimation","display_name":"cold acclimation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/inguinal-white-adipose-tissue","display_name":"inguinal adipose tissue","score":0.8209999799728394},{"id":"https://openalex.org/keywords/laser-doppler-imaging","display_name":"laser Doppler imaging","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tissue-perfusion","display_name":"tissue perfusion","score":0.843999981880188},{"id":"https://openalex.org/keywords/glucose-injection","display_name":"glucose injection","score":0.6489999890327454},{"id":"https://openalex.org/keywords/heat-generation","display_name":"heat generation","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C151279926","wikidata":"https://www.wikidata.org/wiki/Q965695","display_name":"Thermogenesis","level":3,"score":0.9310410618782043},{"id":"https://openalex.org/C2780642333","wikidata":"https://www.wikidata.org/wiki/Q901269","display_name":"Brown adipose tissue","level":3,"score":0.8929504156112671},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.7630355358123779},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7066158652305603},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6983230113983154},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6829785704612732},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.6326720714569092},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.6164321899414062},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5788462162017822},{"id":"https://openalex.org/C81979416","wikidata":"https://www.wikidata.org/wiki/Q419493","display_name":"Thermogenin","level":4,"score":0.5697588920593262},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5002291202545166},{"id":"https://openalex.org/C100564792","wikidata":"https://www.wikidata.org/wiki/Q190259","display_name":"Thermoregulation","level":2,"score":0.4635777771472931},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.45324602723121643},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.4302242696285248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3725087642669678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14577427506446838},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.05311360955238342}],"mesh":[{"descriptor_ui":"D000064","descriptor_name":"Acclimatization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002001","descriptor_name":"Adipose Tissue, Brown","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017078","descriptor_name":"Laser-Doppler Flowmetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018663","descriptor_name":"Adrenergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D022722","descriptor_name":"Thermogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.00494.2014","doi":"https://doi.org/10.1152/ajpendo.00494.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00494.2014","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:25738783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25738783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3515156265","display_name":null,"funder_award_id":"NNF12OC1016064","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320311794","display_name":"Wilhelm och Else Stockmanns Stiftelse","ror":"https://ror.org/02e6tmy71"},{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1519878440","https://openalex.org/W1705611056","https://openalex.org/W1965747223","https://openalex.org/W1966851117","https://openalex.org/W1968469802","https://openalex.org/W1971352655","https://openalex.org/W1979026577","https://openalex.org/W1987735654","https://openalex.org/W1990056505","https://openalex.org/W1995041388","https://openalex.org/W2006222285","https://openalex.org/W2019432521","https://openalex.org/W2020696631","https://openalex.org/W2028836294","https://openalex.org/W2047596481","https://openalex.org/W2049507372","https://openalex.org/W2061777482","https://openalex.org/W2062073832","https://openalex.org/W2066357535","https://openalex.org/W2068127708","https://openalex.org/W2070657629","https://openalex.org/W2077324701","https://openalex.org/W2098457930","https://openalex.org/W2111189180","https://openalex.org/W2112236821","https://openalex.org/W2113489963","https://openalex.org/W2131464004","https://openalex.org/W2132358997","https://openalex.org/W2132719901","https://openalex.org/W2139237034","https://openalex.org/W2149975392","https://openalex.org/W2151470490","https://openalex.org/W2154358935","https://openalex.org/W2240484171"],"related_works":["https://openalex.org/W2068133150","https://openalex.org/W2043510270","https://openalex.org/W2132719901","https://openalex.org/W2303763506","https://openalex.org/W4400023319","https://openalex.org/W2063871415","https://openalex.org/W2125804052","https://openalex.org/W2152303460","https://openalex.org/W2093271206","https://openalex.org/W2023537541"],"abstract_inverted_index":{"Brown":[0],"adipose":[1,141,148],"tissue":[2,137],"(BAT)":[3],"thermogenesis":[4],"relies":[5],"on":[6],"blood":[7,40,67,80,111,122,159,182],"flow":[8,41,68,81,112,123,160,183],"to":[9,24,34,47,114,118,128,153,163,172],"be":[10],"supplied":[11],"with":[12],"nutrients":[13],"and":[14,16,44,86,156,186,192,206],"oxygen":[15],"for":[17,60,200],"the":[18,21,25,28,36,201],"distribution":[19],"of":[20,27,65,190,203],"generated":[22],"heat":[23,207],"rest":[26],"body.":[29],"Therefore,":[30],"it":[31,194],"is":[32,42,90,184,195],"fundamental":[33],"understand":[35],"mechanisms":[37],"by":[38,93],"which":[39],"regulated":[43],"its":[45],"relation":[46],"thermogenesis.":[48,120],"Here,":[49],"we":[50,73,98,176],"present":[51],"high-resolution":[52],"laser-Doppler":[53],"imaging":[54],"(HR-LDR)":[55],"as":[56,145],"a":[57,83,146,168,197],"novel":[58,169],"method":[59,171],"noninvasive":[61,170],"in":[62,69,82,161],"vivo":[63],"measurement":[64],"BAT":[66,79,110,121,174,181,204],"mice.":[70],"Using":[71],"HR-LDR,":[72],"found":[74,99],"that":[75,87,100,178],"norepinephrine":[76,115],"stimulation":[77],"increases":[78],"dose-dependent":[84],"manner":[85],"this":[88],"response":[89,113,162],"profoundly":[91],"modulated":[92],"environmental":[94],"temperature":[95],"acclimation.":[96],"Surprisingly,":[97],"mice":[101],"lacking":[102],"uncoupling":[103],"protein":[104],"1":[105],"(UCP1)":[106],"have":[107],"fully":[108,188],"preserved":[109],"despite":[116],"failing":[117],"perform":[119],"was":[124,150],"not":[125,196],"directly":[126],"correlated":[127],"systemic":[129],"glycemia,":[130],"but":[131],"glucose":[132],"injections":[133],"could":[134],"transiently":[135],"increase":[136],"perfusion.":[138],"Inguinal":[139],"white":[140],"tissue,":[142,149],"also":[143,151],"known":[144],"brite/beige":[147],"sensitive":[152],"cold":[154],"acclimation":[155],"similarly":[157],"increased":[158],"norepinephrine.":[164],"In":[165],"conclusion,":[166],"using":[167],"detect":[173],"perfusion,":[175],"demonstrate":[177],"adrenergically":[179],"stimulated":[180],"qualitatively":[185],"quantitatively":[187],"independent":[189],"thermogenesis,":[191],"therefore,":[193],"reliable":[198],"parameter":[199],"estimation":[202],"activation":[205],"generation.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
