{"id":"https://openalex.org/W1997440481","doi":"https://doi.org/10.1152/ajpendo.00655.2006","title":"Basal and insulin-regulated free fatty acid and glucose metabolism in humans","display_name":"Basal and insulin-regulated free fatty acid and glucose metabolism in humans","publication_year":2007,"publication_date":"2007-02-14","ids":{"openalex":"https://openalex.org/W1997440481","doi":"https://doi.org/10.1152/ajpendo.00655.2006","mag":"1997440481","pmid":"https://pubmed.ncbi.nlm.nih.gov/17299081"},"language":"en","primary_location":{"id":"doi:10.1152/ajpendo.00655.2006","doi":"https://doi.org/10.1152/ajpendo.00655.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00655.2006","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076566992","display_name":"Samyah Shadid","orcid":"https://orcid.org/0000-0002-6601-0944","observed_orcids":["https://orcid.org/0000-0002-6601-0944"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samyah Shadid","raw_affiliation_strings":["Endocrine Research Unit, 5-194 Joseph, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrine Research Unit, 5-194 Joseph, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028679785","display_name":"Jill A. Kanaley","orcid":"https://orcid.org/0000-0002-6558-4401","observed_orcids":["https://orcid.org/0000-0002-6558-4401"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jill A. Kanaley","raw_affiliation_strings":["","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039072842","display_name":"Michael T. Sheehan","orcid":"https://orcid.org/0000-0001-8512-7980","observed_orcids":["https://orcid.org/0000-0001-8512-7980"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael T. Sheehan","raw_affiliation_strings":["","Mayo Clinic Rochester-MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Mayo Clinic Rochester-MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002850016","display_name":"Michael D. Jensen","orcid":"https://orcid.org/0000-0001-5589-8389","observed_orcids":["https://orcid.org/0000-0001-5589-8389"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael D. Jensen","raw_affiliation_strings":["","Endocrinology, Diabetes, Metabolism, and Nutrition"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Endocrinology, Diabetes, Metabolism, and Nutrition","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2747,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.87146715,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"292","issue":"6","first_page":"E1770","last_page":"E1774"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.8925999999046326,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-fatty-acid-metabolism","display_name":"free fatty acid metabolism","score":0.9340000152587891},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9860000014305115},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.4860000014305115},{"id":"https://openalex.org/keywords/resting-energy-expenditure","display_name":"resting energy expenditure","score":0.7860000133514404},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.6959999799728394},{"id":"https://openalex.org/keywords/fat-free-mass","display_name":"fat-free mass","score":0.9700000286102295},{"id":"https://openalex.org/keywords/body-fat-percentage","display_name":"body fat percentage","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hyperinsulinemic-euglycemic-clamp","display_name":"hyperinsulinemic-euglycemic clamp","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glucose-disposal","display_name":"glucose disposal","score":0.8040000200271606},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.699999988079071},{"id":"https://openalex.org/keywords/physical-fitness","display_name":"physical fitness","score":0.8090000152587891}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8776420950889587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8551950454711914},{"id":"https://openalex.org/C2780988686","wikidata":"https://www.wikidata.org/wiki/Q14375936","display_name":"Hyperinsulinemia","level":4,"score":0.8540186882019043},{"id":"https://openalex.org/C140985366","wikidata":"https://www.wikidata.org/wiki/Q898489","display_name":"Lipolysis","level":3,"score":0.8086252212524414},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.6956254243850708},{"id":"https://openalex.org/C82736064","wikidata":"https://www.wikidata.org/wiki/Q623293","display_name":"Basal metabolic rate","level":2,"score":0.6680688858032227},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5523918867111206},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.4981820583343506},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.4485793709754944},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44587093591690063},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.44355830550193787},{"id":"https://openalex.org/C2778808658","wikidata":"https://www.wikidata.org/wiki/Q2975183","display_name":"Glucose clamp technique","level":5,"score":0.42706534266471863},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4156959354877472},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.387840211391449},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.3441237211227417},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.2686361074447632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1738627552986145}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006946","descriptor_name":"Hyperinsulinism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008066","descriptor_name":"Lipolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012146","descriptor_name":"Rest","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015309","descriptor_name":"Glucose Clamp Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpendo.00655.2006","doi":"https://doi.org/10.1152/ajpendo.00655.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpendo.00655.2006","pdf_url":null,"source":{"id":"https://openalex.org/S196637695","display_name":"American Journal of Physiology-Endocrinology and Metabolism","issn_l":"0193-1849","issn":["0193-1849","1522-1555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Endocrinology and Metabolism","raw_type":"journal-article"},{"id":"pmid:17299081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17299081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1140699873","display_name":null,"funder_award_id":"DK 40484","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1778465572","display_name":"Minnesota Obesity Center","funder_award_id":"P30DK050456","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5918705860","display_name":"General Clinical Research Center","funder_award_id":"M01RR000585","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306143","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1494649290","https://openalex.org/W1700458277","https://openalex.org/W1787494974","https://openalex.org/W1978270587","https://openalex.org/W1981456793","https://openalex.org/W1988287975","https://openalex.org/W2014324412","https://openalex.org/W2046591933","https://openalex.org/W2058262736","https://openalex.org/W2079309060","https://openalex.org/W2094116954","https://openalex.org/W2112834655","https://openalex.org/W2117753563","https://openalex.org/W2123105661","https://openalex.org/W2130200187","https://openalex.org/W2136906985","https://openalex.org/W2157836159","https://openalex.org/W2162185202","https://openalex.org/W2162546421","https://openalex.org/W2275629185","https://openalex.org/W2327187346"],"related_works":["https://openalex.org/W1497142418","https://openalex.org/W2378113572","https://openalex.org/W1982483611","https://openalex.org/W2020807319","https://openalex.org/W2187334442","https://openalex.org/W1974371613","https://openalex.org/W2072282314","https://openalex.org/W2111521799","https://openalex.org/W2088824767","https://openalex.org/W1981989730"],"abstract_inverted_index":{"These":[0],"studies":[1],"were":[2],"done":[3],"to":[4,42,153,193,210],"examine":[5],"the":[6,92,203,215],"effects":[7,216],"of":[8,95,217],"body":[9,102,135,168,197],"composition,":[10],"resting":[11],"energy":[12],"expenditure":[13],"(REE),":[14],"sex,":[15],"and":[16,20,23,35,55,81,106,170,196],"fitness":[17],"on":[18,219],"basal":[19,62,85,96,110,187],"insulin-regulated":[21],"FFA":[22,56,86,155,171,207],"glucose":[24,97,111,188],"metabolism.":[25],"We":[26,184],"performed":[27],"137":[28],"experiments":[29],"in":[30,99,206],"101":[31],"nondiabetic,":[32],"premenopausal":[33],"women":[34],"men,":[36],"ranging":[37],"from":[38],"low":[39],"normal":[40],"weight":[41],"class":[43],"III":[44],"obese":[45],"(BMI":[46],"18.0-40.5":[47],"kg/m2).":[48],"Glucose":[49,157],"flux":[50,112],"was":[51,91,104,149,161],"measured":[52],"using":[53],"[6-(2)H2]glucose":[54],"kinetics":[57],"with":[58,76,109,125,164,182],"[9,10-(3)H]oleate":[59],"under":[60],"either":[61],"(74":[63],"experiments)":[64],"or":[65],"euglycemic":[66],"hyperinsulinemic":[67],"(1.0":[68],"mU.kg":[69],"FFM(-1).min(-1))":[70],"clamp":[71],"conditions":[72],"(63":[73],"experiments).":[74],"Consistent":[75],"our":[77],"previous":[78],"findings,":[79],"REE":[80,126],"sex":[82,148,204],"independently":[83,105,162,191],"predicted":[84],"flux,":[87],"whereas":[88,147],"fat-free":[89],"mass":[90],"best":[93],"predictor":[94],"flux;":[98],"addition,":[100,200],"percent":[101,134,167],"fat":[103,136],"positively":[107],"associated":[108,124,163],"(total":[113,139,173],"r2":[114,141,174],"=":[115,128,142,175],"0.52,":[116],"P":[117,130,144,177],"<":[118,131,145,178],"0.0001).":[119],"Insulin-suppressed":[120],"lipolysis":[121],"remained":[122],"significantly":[123,151],"(r":[127],"0.25,":[129],"0.05),":[132],"but":[133,180,212],"also":[137],"contributed":[138],"adjusted":[140],"0.36,":[143],"0.0001),":[146],"not":[150,181],"related":[152,192],"insulin-suppressed":[154],"flux.":[156],"disposal":[158],"during":[159],"hyperinsulinemia":[160,201],"peak":[165],"VO2,":[166],"fat,":[169],"concentrations":[172],"0.63,":[176],"0.0001)":[179],"sex.":[183],"conclude":[185],"that":[186],"production":[189],"is":[190],"both":[194],"FFM":[195],"fatness.":[198],"In":[199],"obscures":[202],"differences":[205],"release":[208],"relative":[209],"REE,":[211],"brings":[213],"out":[214],"fatness":[218],"lipolysis.":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
