{"id":"https://openalex.org/W1997423398","doi":"https://doi.org/10.1073/pnas.1110156109","title":"Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages","display_name":"Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages","publication_year":2012,"publication_date":"2012-03-26","ids":{"openalex":"https://openalex.org/W1997423398","doi":"https://doi.org/10.1073/pnas.1110156109","mag":"1997423398","pmid":"https://pubmed.ncbi.nlm.nih.gov/22451944","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3341041"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1110156109","doi":"https://doi.org/10.1073/pnas.1110156109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1110156109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3341041/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029662334","display_name":"Kate Schroder","orcid":"https://orcid.org/0000-0001-9261-3805","observed_orcids":["https://orcid.org/0000-0001-9261-3805"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kate Schroder","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057306266","display_name":"Katharine M. Irvine","orcid":"https://orcid.org/0000-0002-6716-1605","observed_orcids":["https://orcid.org/0000-0002-6716-1605"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katharine M. Irvine","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008886339","display_name":"Martin S. Taylor","orcid":"https://orcid.org/0000-0001-7656-330X","observed_orcids":["https://orcid.org/0000-0001-7656-330X"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin S. Taylor","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, United Kingdom;","Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, United Kingdom;","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom;","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I4387154614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045080298","display_name":"Nilesh J. Bokil","orcid":"https://orcid.org/0000-0003-3202-9249","observed_orcids":["https://orcid.org/0000-0003-3202-9249"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nilesh J. Bokil","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091163780","display_name":"Kim\u2010Anh L\u00ea Cao","orcid":"https://orcid.org/0000-0003-3923-1116","observed_orcids":["https://orcid.org/0000-0003-3923-1116"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kim-Anh Le Cao","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061971721","display_name":"Kelly\u2010Anne Masterman","orcid":"https://orcid.org/0000-0002-7137-9404","observed_orcids":["https://orcid.org/0000-0002-7137-9404"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kelly-Anne Masterman","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061906689","display_name":"Larisa I. Labzin","orcid":"https://orcid.org/0000-0001-9098-4493","observed_orcids":["https://orcid.org/0000-0001-9098-4493"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Larisa I. Labzin","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034298865","display_name":"Colin A M Semple","orcid":"https://orcid.org/0000-0003-1765-4118","observed_orcids":["https://orcid.org/0000-0003-1765-4118"]},"institutions":[{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I4387154614","display_name":"MRC Human Genetics Unit","ror":"https://ror.org/011jsc803","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4387154614","https://openalex.org/I90344618","https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin A. Semple","raw_affiliation_strings":["Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom;","institution_ids":["https://openalex.org/I2800150677","https://openalex.org/I4387154614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008638526","display_name":"Ronan Kap\u00e9tanovic","orcid":"https://orcid.org/0000-0002-2908-1014","observed_orcids":["https://orcid.org/0000-0002-2908-1014"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ronan Kapetanovic","raw_affiliation_strings":["Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023039855","display_name":"Lynsey Fairbairn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lynsey Fairbairn","raw_affiliation_strings":["Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058400078","display_name":"Altuna Akalin","orcid":"https://orcid.org/0000-0002-0468-0117","observed_orcids":["https://orcid.org/0000-0002-0468-0117"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Altuna Akalin","raw_affiliation_strings":["Department of Physiology and Biophysics and the Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, NY 10065;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics and the Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, NY 10065;","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040882194","display_name":"Geoffrey J. Faulkner","orcid":"https://orcid.org/0000-0001-5769-4494","observed_orcids":["https://orcid.org/0000-0001-5769-4494"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geoffrey J. Faulkner","raw_affiliation_strings":["Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030523023","display_name":"John Kenneth Baillie","orcid":"https://orcid.org/0000-0001-5258-793X","observed_orcids":["https://orcid.org/0000-0001-5258-793X"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Kenneth Baillie","raw_affiliation_strings":["Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074206951","display_name":"Milena Gongora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Milena Gongora","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082300031","display_name":"Carsten O. Daub","orcid":"https://orcid.org/0000-0002-3295-8729","observed_orcids":["https://orcid.org/0000-0002-3295-8729"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Carsten O. Daub","raw_affiliation_strings":["RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;","institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051284054","display_name":"Hideya Kawaji","orcid":"https://orcid.org/0000-0002-0575-0308","observed_orcids":["https://orcid.org/0000-0002-0575-0308"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideya Kawaji","raw_affiliation_strings":["RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;","institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057375178","display_name":"Geoffrey John McLachlan","orcid":"https://orcid.org/0000-0002-5921-3145","observed_orcids":["https://orcid.org/0000-0002-5921-3145"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Geoffrey J. McLachlan","raw_affiliation_strings":["Department of Mathematics, University of Queensland, Brisbane 4072, Australia; and","Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Queensland, Brisbane 4072, Australia; and","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020967139","display_name":"Nick Goldman","orcid":"https://orcid.org/0000-0001-8486-2211","observed_orcids":["https://orcid.org/0000-0001-8486-2211"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Goldman","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, United Kingdom;","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040120471","display_name":"Sean Michael Grimmond","orcid":"https://orcid.org/0000-0002-8102-7998","observed_orcids":["https://orcid.org/0000-0002-8102-7998"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sean M. Grimmond","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072131150","display_name":"Piero Carninci","orcid":"https://orcid.org/0000-0001-7202-7243","observed_orcids":["https://orcid.org/0000-0001-7202-7243"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Piero Carninci","raw_affiliation_strings":["RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;","institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018063097","display_name":"Harukazu Suzuki","orcid":"https://orcid.org/0000-0002-8087-0836","observed_orcids":["https://orcid.org/0000-0002-8087-0836"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harukazu Suzuki","raw_affiliation_strings":["RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;","institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032097008","display_name":"Yoshihide Hayashizaki","orcid":"https://orcid.org/0000-0002-0561-2802","observed_orcids":["https://orcid.org/0000-0002-0561-2802"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210150921","display_name":"RIKEN Center for Integrative Medical Sciences","ror":"https://ror.org/04mb6s476","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihide Hayashizaki","raw_affiliation_strings":["RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Omics Science Center, RIKEN Yokohama Institute, Kanagawa 230-0045, Japan;","institution_ids":["https://openalex.org/I4210110652","https://openalex.org/I4210150921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052661284","display_name":"Boris Lenhard","orcid":"https://orcid.org/0000-0002-1114-1509","observed_orcids":["https://orcid.org/0000-0002-1114-1509"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Boris Lenhard","raw_affiliation_strings":["Medical Research Council Clinical Sciences Centre, Institute of Clinical Sciences, Imperial College London, London W12 0NN, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Clinical Sciences Centre, Institute of Clinical Sciences, Imperial College London, London W12 0NN, United Kingdom","institution_ids":["https://openalex.org/I47508984","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121544496","display_name":"David Arthur Hume","orcid":"https://orcid.org/0000-0002-2615-1478","observed_orcids":["https://orcid.org/0000-0002-2615-1478"]},"institutions":[{"id":"https://openalex.org/I133960621","display_name":"Roslin Institute","ror":"https://ror.org/01920rj20","country_code":"GB","type":"facility","lineage":["https://openalex.org/I133960621","https://openalex.org/I2799693246","https://openalex.org/I4210087105","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David A. Hume","raw_affiliation_strings":["Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom;","institution_ids":["https://openalex.org/I133960621","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026924357","display_name":"Matthew J. Sweet","orcid":"https://orcid.org/0000-0002-0406-8139","observed_orcids":["https://orcid.org/0000-0002-0406-8139"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]},{"id":"https://openalex.org/I4405277047","display_name":"Institute for Molecular Bioscience","ror":"https://ror.org/018kjjj71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Matthew J. Sweet","raw_affiliation_strings":["Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia;","institution_ids":["https://openalex.org/I165143802","https://openalex.org/I4405277047"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":14,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.8752,"has_fulltext":false,"cited_by_count":319,"citation_normalized_percentile":{"value":0.98880454,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"109","issue":"16","first_page":"E944","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9150000214576721},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9399999976158142},{"id":"https://openalex.org/keywords/human-mouse-comparison","display_name":"human-mouse comparison","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tlr6","display_name":"TLR6","score":0.9139999747276306},{"id":"https://openalex.org/keywords/promoter-conservation","display_name":"promoter conservation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/cpg-islands","display_name":"CpG islands","score":0.703000009059906},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.9390000104904175},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.777999997138977},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8405300378799438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.662299633026123},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.585029125213623},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5115910172462463},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5070953369140625},{"id":"https://openalex.org/C103077935","wikidata":"https://www.wikidata.org/wiki/Q5508811","display_name":"Functional divergence","level":5,"score":0.4861316382884979},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.47914618253707886},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4602692425251007},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.45541051030158997},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4190075099468231},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38461053371429443},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3697892427444458},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.24603959918022156}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054382","descriptor_name":"Chemokine CXCL13","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054418","descriptor_name":"Chemokine CCL20","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.1110156109","doi":"https://doi.org/10.1073/pnas.1110156109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1110156109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:22451944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22451944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3341041","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3341041/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04387254v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.inrae.fr/hal-04387254","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (16), &#x27E8;10.1073/pnas.1110156109&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:edoc.mdc-berlin.de:14464","doi":null,"is_oa":false,"landing_page_url":"https://edoc.mdc-berlin.de/14464/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:opus.lib.uts.edu.au:10453/115115","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10453/115115","pdf_url":null,"source":{"id":"https://openalex.org/S4306401357","display_name":"UTS ePRESS (University of Technology Sydney)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114017466","host_organization_name":"University of Technology Sydney","host_organization_lineage":["https://openalex.org/I114017466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3341041","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3341041/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1219388671","display_name":"Novel strategies to control virus infection and disease","funder_award_id":"BBS/E/D/20241866","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2100175564","display_name":"Identifying mechanisms regulating central nervous system homeostasis","funder_award_id":"BBS/E/D/20251969","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2665813248","display_name":"Mechanistic understanding of virus pathogenesis and resistance","funder_award_id":"BBS/E/D/20241864","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4337423275","display_name":"Host genetic resistance to viruses","funder_award_id":"BBS/E/D/20241863","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G7506046965","display_name":"A complete transcriptional map of the human body: systems biology in toto","funder_award_id":"BB/I024801/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G8475430463","display_name":null,"funder_award_id":"BB/I024801/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1574350448","https://openalex.org/W1649565066","https://openalex.org/W1967635792","https://openalex.org/W1973831834","https://openalex.org/W1976445111","https://openalex.org/W1995234326","https://openalex.org/W1995744610","https://openalex.org/W2006828798","https://openalex.org/W2007222211","https://openalex.org/W2008403719","https://openalex.org/W2012033797","https://openalex.org/W2017077979","https://openalex.org/W2023922058","https://openalex.org/W2027455260","https://openalex.org/W2027846315","https://openalex.org/W2033343333","https://openalex.org/W2033819389","https://openalex.org/W2033831809","https://openalex.org/W2040232066","https://openalex.org/W2060256600","https://openalex.org/W2062700377","https://openalex.org/W2069298307","https://openalex.org/W2072569268","https://openalex.org/W2074692187","https://openalex.org/W2081719540","https://openalex.org/W2090803844","https://openalex.org/W2095005830","https://openalex.org/W2095178364","https://openalex.org/W2099468911","https://openalex.org/W2109963121","https://openalex.org/W2111267560","https://openalex.org/W2112084358","https://openalex.org/W2114216755","https://openalex.org/W2114703458","https://openalex.org/W2117023724","https://openalex.org/W2118852675","https://openalex.org/W2121391159","https://openalex.org/W2122935607","https://openalex.org/W2124580054","https://openalex.org/W2124644693","https://openalex.org/W2125912444","https://openalex.org/W2128969076","https://openalex.org/W2130353827","https://openalex.org/W2134497859","https://openalex.org/W2141137217","https://openalex.org/W2143492752","https://openalex.org/W2144796452","https://openalex.org/W2145221987","https://openalex.org/W2145343991","https://openalex.org/W2146195472","https://openalex.org/W2151464048","https://openalex.org/W2154770881","https://openalex.org/W2170033314","https://openalex.org/W2171556560"],"related_works":["https://openalex.org/W1984093225","https://openalex.org/W143481878","https://openalex.org/W3044089756","https://openalex.org/W1522842079","https://openalex.org/W2278214458","https://openalex.org/W16944264","https://openalex.org/W152489955","https://openalex.org/W1967467892","https://openalex.org/W2089926265","https://openalex.org/W1996790111"],"abstract_inverted_index":{"Evolutionary":[0],"change":[1],"in":[2,27,65,92,152,158],"gene":[3,68,140,175],"expression":[4,69],"is":[5],"generally":[6],"considered":[7],"to":[8,37,130,217],"be":[9],"a":[10,47,170],"major":[11],"driver":[12],"of":[13,31,57,75,87,138,174],"phenotypic":[14],"differences":[15,26],"between":[16,70],"species.":[17],"We":[18,82],"investigated":[19],"innate":[20],"immune":[21],"diversification":[22],"by":[23,144,203],"analyzing":[24],"interspecies":[25,196],"the":[28,38,200,214],"transcriptional":[29],"responses":[30,151],"primary":[32,93],"human":[33,156],"and":[34,72,114,177],"mouse":[35,153],"macrophages":[36],"Toll-like":[39],"receptor":[40],"(TLR)-4":[41],"agonist":[42],"lipopolysaccharide":[43],"(LPS).":[44],"By":[45],"using":[46],"custom":[48],"platform":[49],"permitting":[50],"cross-species":[51],"interrogation":[52],"coupled":[53],"with":[54,160,169,194],"deep":[55],"sequencing":[56],"mRNA":[58],"5'":[59],"ends,":[60],"we":[61],"identified":[62,78],"extensive":[63],"divergence":[64,190],"LPS-regulated":[66],"orthologous":[67],"humans":[71],"mice":[73],"(24%":[74],"orthologues":[76,98],"were":[77,99,132,142,167],"as":[79,107,118],"\"divergently":[80],"regulated\").":[81],"further":[83],"demonstrate":[84],"concordant":[85],"regulation":[86,141,211],"human-specific":[88],"LPS":[89,146],"target":[90],"genes":[91,102,166,201],"pig":[94],"macrophages.":[95],"Divergently":[96,164],"regulated":[97,165],"enriched":[100],"for":[101],"encoding":[103],"cellular":[104],"\"inputs\"":[105],"such":[106,117],"cell":[108],"surface":[109],"receptors":[110],"(e.g.,":[111,121],"TLR6,":[112],"IL-7R\u03b1)":[113],"functional":[115],"\"outputs\"":[116],"inflammatory":[119],"cytokines/chemokines":[120],"CCL20,":[122],"CXCL13).":[123],"Conversely,":[124],"intracellular":[125],"signaling":[126],"components":[127],"linking":[128],"inputs":[129],"outputs":[131],"typically":[133],"concordantly":[134],"regulated.":[135],"Functional":[136],"consequences":[137],"divergent":[139],"confirmed":[143],"showing":[145],"pretreatment":[147],"boosts":[148],"subsequent":[149],"TLR6":[150,162],"but":[154],"not":[155],"macrophages,":[157],"keeping":[159],"mouse-specific":[161],"induction.":[163],"associated":[168,193],"large":[171],"dynamic":[172,210],"range":[173],"expression,":[176],"specific":[178],"promoter":[179,197],"architectural":[180],"features":[181],"(TATA":[182],"box":[183],"enrichment,":[184],"CpG":[185],"island":[186],"depletion).":[187],"Surprisingly,":[188],"regulatory":[189],"was":[191],"also":[192,213],"enhanced":[195],"conservation.":[198],"Thus,":[199],"controlled":[202],"complex,":[204],"highly":[205],"conserved":[206],"promoters":[207],"that":[208],"facilitate":[209],"are":[212],"most":[215],"susceptible":[216],"evolutionary":[218],"change.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
