{"id":"https://openalex.org/W1997406677","doi":"https://doi.org/10.1111/j.1464-410x.2006.06069.x","title":"Diagnostic utility of a p63/\u03b1\u2010methyl coenzyme A racemase (p504s) cocktail in ambiguous lesions of the prostate upon needle biopsy","display_name":"Diagnostic utility of a p63/\u03b1\u2010methyl coenzyme A racemase (p504s) cocktail in ambiguous lesions of the prostate upon needle biopsy","publication_year":2006,"publication_date":"2006-04-06","ids":{"openalex":"https://openalex.org/W1997406677","doi":"https://doi.org/10.1111/j.1464-410x.2006.06069.x","mag":"1997406677","pmid":"https://pubmed.ncbi.nlm.nih.gov/16643500"},"language":"en","primary_location":{"id":"doi:10.1111/j.1464-410x.2006.06069.x","doi":"https://doi.org/10.1111/j.1464-410x.2006.06069.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2006.06069.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083305562","display_name":"Vincent Molini\u00e9","orcid":"https://orcid.org/0000-0003-1465-6580","observed_orcids":["https://orcid.org/0000-0003-1465-6580"]},"institutions":[{"id":"https://openalex.org/I4210135272","display_name":"H\u00f4pital Paris Saint-Joseph","ror":"https://ror.org/046bx1082","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135272","https://openalex.org/I4405287512"]},{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"VINCENT MOLINI\u00c9","raw_affiliation_strings":["Department of Pathology, H\u00f4pital Saint-Joseph, Paris, France. vmolinie@hopital-saint-joseph.org","Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, H\u00f4pital Saint-Joseph, Paris, France. vmolinie@hopital-saint-joseph.org","institution_ids":["https://openalex.org/I4210135272"]},{"raw_affiliation_string":"Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110085798","display_name":"Jean-Marie Herv\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135272","display_name":"H\u00f4pital Paris Saint-Joseph","ror":"https://ror.org/046bx1082","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135272","https://openalex.org/I4405287512"]},{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"JEAN MARIE HERV\u00c9","raw_affiliation_strings":["Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]},{"raw_affiliation_string":"Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111608845","display_name":"Pierre Marie Lugagne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135272","display_name":"H\u00f4pital Paris Saint-Joseph","ror":"https://ror.org/046bx1082","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135272","https://openalex.org/I4405287512"]},{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"PIERRE MARIE LUGAGNE","raw_affiliation_strings":["Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]},{"raw_affiliation_string":"Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025728291","display_name":"Thierry Lebr\u00e9t","orcid":"https://orcid.org/0000-0002-8664-3861","observed_orcids":["https://orcid.org/0000-0002-8664-3861"]},"institutions":[{"id":"https://openalex.org/I4210135272","display_name":"H\u00f4pital Paris Saint-Joseph","ror":"https://ror.org/046bx1082","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135272","https://openalex.org/I4405287512"]},{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"THIERRY LEBRET","raw_affiliation_strings":["Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]},{"raw_affiliation_string":"Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086511542","display_name":"Henry Botto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135272","display_name":"H\u00f4pital Paris Saint-Joseph","ror":"https://ror.org/046bx1082","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210135272","https://openalex.org/I4405287512"]},{"id":"https://openalex.org/I4210156825","display_name":"H\u00f4pital Foch","ror":"https://ror.org/058td2q88","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210156825"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"HENRY BOTTO","raw_affiliation_strings":["Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ho\u0302pital Saint-Joseph, Paris, and Department of Urology, Ho\u0302pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]},{"raw_affiliation_string":"Department of Pathology, H\u00f4pital Saint\u2010Joseph, Paris, and Department of Urology, H\u00f4pital Foch, Suresnes, France","institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083305562"],"corresponding_institution_ids":["https://openalex.org/I4210135272","https://openalex.org/I4210156825"],"apc_list":{"value":4770,"currency":"USD","value_usd":4770},"apc_paid":null,"fwci":3.3905,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.9115487,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"97","issue":"5","first_page":"1109","last_page":"1115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12866","display_name":"Urologic and reproductive health conditions","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer-diagnosis","display_name":"prostate cancer diagnosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/p63","display_name":"p63","score":0.8730000257492065},{"id":"https://openalex.org/keywords/alpha-methylacyl-coa-racemase","display_name":"AMACR","score":0.8600000143051147},{"id":"https://openalex.org/keywords/needle-biopsy","display_name":"needle biopsy","score":0.7289999723434448},{"id":"https://openalex.org/keywords/prostatic-intraepithelial-neoplasia","display_name":"prostatic intraepithelial neoplasia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/atypical-small-acinar-proliferation","display_name":"atypical small acinar proliferation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/atypical-adenomatous-hyperplasia","display_name":"atypical adenomatous hyperplasia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/basal-cell-markers","display_name":"basal cell markers","score":0.7419999837875366},{"id":"https://openalex.org/keywords/false-negative-results","display_name":"false-negative results","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7739828824996948},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7733043432235718},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7714544534683228},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6884602308273315},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.6218410134315491},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5681057572364807},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.5525675415992737},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.459994912147522},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.44096195697784424},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.32341623306274414},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19694548845291138}],"mesh":[{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011467","descriptor_name":"Prostate","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019998","descriptor_name":"Racemases and Epimerases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1464-410x.2006.06069.x","doi":"https://doi.org/10.1111/j.1464-410x.2006.06069.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2006.06069.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},{"id":"pmid:16643500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16643500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU international","raw_type":"Evaluation Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W63047210","https://openalex.org/W1584759442","https://openalex.org/W1930548389","https://openalex.org/W1966056172","https://openalex.org/W1968149100","https://openalex.org/W1991192859","https://openalex.org/W1992062087","https://openalex.org/W1999678872","https://openalex.org/W2009359714","https://openalex.org/W2022133687","https://openalex.org/W2022904488","https://openalex.org/W2034415197","https://openalex.org/W2035936829","https://openalex.org/W2037527594","https://openalex.org/W2044803749","https://openalex.org/W2053535373","https://openalex.org/W2055774906","https://openalex.org/W2056523741","https://openalex.org/W2060768796","https://openalex.org/W2063023403","https://openalex.org/W2066357085","https://openalex.org/W2066867399","https://openalex.org/W2067746951","https://openalex.org/W2074571842","https://openalex.org/W2080851462","https://openalex.org/W2082887107","https://openalex.org/W2083664020","https://openalex.org/W2084656721","https://openalex.org/W2086284944","https://openalex.org/W2090526822","https://openalex.org/W2095128237","https://openalex.org/W2095335519","https://openalex.org/W2095421687","https://openalex.org/W2096623626","https://openalex.org/W2118756632","https://openalex.org/W2127625592","https://openalex.org/W2133763650","https://openalex.org/W2154264549","https://openalex.org/W2416281108","https://openalex.org/W2416978655","https://openalex.org/W2417341902","https://openalex.org/W2424766243","https://openalex.org/W2462563568","https://openalex.org/W2792373231"],"related_works":["https://openalex.org/W2025855191","https://openalex.org/W2072177768","https://openalex.org/W2151365159","https://openalex.org/W2087493048","https://openalex.org/W2353439626","https://openalex.org/W2389848369","https://openalex.org/W1981014170","https://openalex.org/W1968149100","https://openalex.org/W1803194864","https://openalex.org/W4239067074"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,73,148,155],"potential":[4],"utility":[5],"of":[6,19,32,60,72,93,111,150],"a":[7,30,35,117,126],"new":[8],"combined":[9],"immunostaining":[10,144],"technique":[11],"for":[12,120,157],"diagnosing":[13],"prostate":[14,46,52,85,121],"cancer":[15,47,53,122],"from":[16],"histological":[17],"analysis":[18],"needle":[20,65],"biopsy":[21],"specimens.":[22],"MATERIALS":[23],"AND":[24],"METHODS:":[25],"Tissue":[26],"was":[27],"immunostained":[28],"with":[29],"combination":[31],"antibodies":[33],"against":[34],"basal":[36],"cell":[37],"marker":[38,119,128],"(p63),":[39],"and":[40,57,106,123,134,136,154],"an":[41],"enzyme":[42],"commonly":[43],"overexpressed":[44],"in":[45,64],"(p504s),":[48],"on":[49],"63":[50],"small":[51,89],"foci":[54],"(<1":[55],"mm)":[56],"109":[58],"cases":[59],"ambiguous":[61,74,152],"lesions":[62,75,153],"observed":[63],"biopsies.":[66,159],"RESULTS:":[67],"After":[68],"p63/p504s":[69],"immunostaining,":[70],"93%":[71],"(102/109)":[76],"were":[77],"classified.":[78],"The":[79],"final":[80],"diagnoses":[81],"retained":[82],"were:":[83],"92":[84],"cancers,":[86],"seven":[87],"atypical":[88,103],"acinar":[90],"proliferations":[91],"suspected":[92],"being":[94],"malignant":[95],"but":[96],"undiagnosed,":[97],"21":[98],"prostatic":[99],"intraepithelial":[100],"neoplasia,":[101],"five":[102],"adenomatous":[104],"hyperplasia,":[105],"36":[107],"atrophic":[108],"benign":[109],"mimickers":[110],"cancer.":[112],"CONCLUSIONS:":[113],"Combining":[114],"p504s":[115],"as":[116,125],"positive":[118],"p63":[124],"negative":[127],"might":[129],"improve":[130],"diagnostic":[131],"performance,":[132],"sensitivity":[133],"specificity,":[135],"lead":[137],"to":[138],"fewer":[139],"false-negative":[140],"results.":[141],"This":[142],"simple":[143],"procedure":[145],"should":[146],"reduce":[147],"percentage":[149],"residual":[151],"need":[156],"additional":[158]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}