{"id":"https://openalex.org/W1997385350","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.07.005","title":"Glutathione-peroxidase-1 null muscle progenitor cells are globally defective","display_name":"Glutathione-peroxidase-1 null muscle progenitor cells are globally defective","publication_year":2006,"publication_date":"2006-07-13","ids":{"openalex":"https://openalex.org/W1997385350","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.07.005","mag":"1997385350","pmid":"https://pubmed.ncbi.nlm.nih.gov/16962942"},"language":"en","primary_location":{"id":"doi:10.1016/j.freeradbiomed.2006.07.005","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.07.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2006.07.005","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088837918","display_name":"Sukkyoo Lee","orcid":"https://orcid.org/0000-0002-4636-5836","observed_orcids":["https://orcid.org/0000-0002-4636-5836"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sukkyoo Lee","raw_affiliation_strings":["Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30333, USA","Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA","Program in Biochemistry, Cell and Developmental Biology, Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30333, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Program in Biochemistry, Cell and Developmental Biology, Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H. Stella Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Stella Shin","raw_affiliation_strings":["Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058832369","display_name":"Paula Kay Shireman","orcid":"https://orcid.org/0000-0002-9701-5422","observed_orcids":["https://orcid.org/0000-0002-9701-5422"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210144081","display_name":"South Texas Veterans Health Care System","ror":"https://ror.org/03n2ay196","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula K. Shireman","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio, TX, USA","Departments of Surgery and Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA","South Texas Veterans Health Care System (STVHCS), University of Texas Health Sciences Center, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Departments of Surgery and Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"South Texas Veterans Health Care System (STVHCS), University of Texas Health Sciences Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I4210144081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054346772","display_name":"Aphrodite Vasilaki","orcid":"https://orcid.org/0000-0002-5652-0895","observed_orcids":["https://orcid.org/0000-0002-5652-0895"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Aphrodite Vasilaki","raw_affiliation_strings":["Department of Physiology, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000765673","display_name":"Holly Van Remmen","orcid":"https://orcid.org/0000-0003-0883-0642","observed_orcids":["https://orcid.org/0000-0003-0883-0642"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I2802109968","display_name":"Audie L. Murphy Memorial VA Hospital","ror":"https://ror.org/035xhk118","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2802109968","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]},{"id":"https://openalex.org/I4210144081","display_name":"South Texas Veterans Health Care System","ror":"https://ror.org/03n2ay196","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210144023","https://openalex.org/I4210144081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Holly Van Remmen","raw_affiliation_strings":["Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio, TX, USA","Department of Cellular and Structural Biology, University of Texas Health Sciences Center, San Antonio, TX, USA","GRECC (STVHCS), University of Texas Health Sciences Center, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Barshop Institute for Longevity and Aging Studies, University of Texas Health Sciences Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Cellular and Structural Biology, University of Texas Health Sciences Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"GRECC (STVHCS), University of Texas Health Sciences Center, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I2802109968","https://openalex.org/I4210144081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030934220","display_name":"MARIE E. CSETE","orcid":"https://orcid.org/0000-0003-4591-0510","observed_orcids":["https://orcid.org/0000-0003-4591-0510"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marie E. Csete","raw_affiliation_strings":["Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA","Program in Biochemistry, Cell and Developmental Biology, Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Program in Biochemistry, Cell and Developmental Biology, Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5030934220"],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":4240,"currency":"USD","value_usd":4240},"apc_paid":null,"fwci":1.0867,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.72647704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"41","issue":"7","first_page":"1174","last_page":"1184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glutathione-peroxidase-1","display_name":"glutathione peroxidase 1","score":0.9319999814033508},{"id":"https://openalex.org/keywords/muscle-progenitor-cells","display_name":"muscle progenitor cells","score":0.9440000057220459},{"id":"https://openalex.org/keywords/myoblasts","display_name":"myoblasts","score":0.9470000267028809},{"id":"https://openalex.org/keywords/skeletal-muscle-differentiation","display_name":"skeletal muscle differentiation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/myotube-formation","display_name":"myotube formation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6800000071525574},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/muscle-fiber-size","display_name":"muscle fiber size","score":0.531000018119812},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6299999952316284},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.9179903268814087},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.7584503293037415},{"id":"https://openalex.org/C203663253","wikidata":"https://www.wikidata.org/wiki/Q18026456","display_name":"GPX1","level":5,"score":0.6808528900146484},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6729960441589355},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5794275999069214},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5650683641433716},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5643789172172546},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4565351903438568},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.41851866245269775},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.40818116068840027},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.317399799823761},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29374563694000244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10710054636001587},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.06757140159606934},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000094765","descriptor_name":"Glutathione Peroxidase GPX1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032448","descriptor_name":"Myoblasts, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032448","descriptor_name":"Myoblasts, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.freeradbiomed.2006.07.005","doi":"https://doi.org/10.1016/j.freeradbiomed.2006.07.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.freeradbiomed.2006.07.005","pdf_url":null,"source":{"id":"https://openalex.org/S128018148","display_name":"Free Radical Biology and Medicine","issn_l":"0891-5849","issn":["0891-5849","1873-4596"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free Radical Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:16962942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16962942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Free radical biology & medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1244606603","display_name":null,"funder_award_id":"P01 1-386003609-A1","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6212262338","display_name":null,"funder_award_id":"HL074236","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W72927599","https://openalex.org/W1538904872","https://openalex.org/W1601880487","https://openalex.org/W1864601388","https://openalex.org/W1969655939","https://openalex.org/W1980811848","https://openalex.org/W1995723030","https://openalex.org/W1998619406","https://openalex.org/W2002860741","https://openalex.org/W2006313098","https://openalex.org/W2013875783","https://openalex.org/W2016927494","https://openalex.org/W2018917730","https://openalex.org/W2035424880","https://openalex.org/W2052408492","https://openalex.org/W2053796870","https://openalex.org/W2055130924","https://openalex.org/W2062867597","https://openalex.org/W2065212513","https://openalex.org/W2069032421","https://openalex.org/W2104413464","https://openalex.org/W2137726115","https://openalex.org/W2188060873"],"related_works":["https://openalex.org/W2002860741","https://openalex.org/W2123572537","https://openalex.org/W2503508472","https://openalex.org/W2420770616","https://openalex.org/W2017649638","https://openalex.org/W7097221261","https://openalex.org/W2033932776","https://openalex.org/W2026314633","https://openalex.org/W2066940247","https://openalex.org/W2768729274"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
