{"id":"https://openalex.org/W1997374513","doi":"https://doi.org/10.1002/dvg.1020140307","title":"Differential induction of regulatory genes during mesoderm formation in Xenopus laevis embryos","display_name":"Differential induction of regulatory genes during mesoderm formation in Xenopus laevis embryos","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W1997374513","doi":"https://doi.org/10.1002/dvg.1020140307","mag":"1997374513","pmid":"https://pubmed.ncbi.nlm.nih.gov/8395366"},"language":"en","primary_location":{"id":"doi:10.1002/dvg.1020140307","doi":"https://doi.org/10.1002/dvg.1020140307","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvg.1020140307","pdf_url":null,"source":{"id":"https://openalex.org/S138282212","display_name":"Developmental Genetics","issn_l":"0192-253X","issn":["0192-253X","1520-6408"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054978399","display_name":"Takafumi Tadano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takafumi Tadano","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20814","Laboratory of Molecular, Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20814","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular, Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000652565","display_name":"Hiroki Otani","orcid":"https://orcid.org/0000-0002-0331-3008","observed_orcids":["https://orcid.org/0000-0002-0331-3008"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroki Otani","raw_affiliation_strings":["Laboratory of Molecular, Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular, Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007105432","display_name":"Masanori Taira","orcid":"https://orcid.org/0000-0003-0981-4927","observed_orcids":["https://orcid.org/0000-0003-0981-4927"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masanori Taira","raw_affiliation_strings":["Laboratory of Molecular, Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular, Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064390918","display_name":"Igor B. Dawid","orcid":"https://orcid.org/0000-0003-0579-5693","observed_orcids":["https://orcid.org/0000-0003-0579-5693"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Igor B. Dawid","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland","Laboratory of Molecular Genetics, National Inst. of Child Health and Human Development, NIH, Bethesda, MD 20814"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Inst. of Child Health and Human Development, NIH, Bethesda, MD 20814","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064390918"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"],"apc_list":null,"apc_paid":null,"fwci":1.5442,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.8292963,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":"3","first_page":"204","last_page":"211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesoderm-induction","display_name":"mesoderm induction","score":0.9449999928474426},{"id":"https://openalex.org/keywords/activin","display_name":"activin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/goosecoid","display_name":"goosecoid","score":0.972000002861023},{"id":"https://openalex.org/keywords/xbra","display_name":"Xbra","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dorsalization","display_name":"dorsalization","score":0.8690000176429749},{"id":"https://openalex.org/keywords/lithium-chloride","display_name":"lithium chloride","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.8489999771118164},{"id":"https://openalex.org/keywords/superinduction","display_name":"superinduction","score":0.8019999861717224},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/amphibian-embryonic-development","display_name":"amphibian embryonic development","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.8345412611961365},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8176077604293823},{"id":"https://openalex.org/C2778128677","wikidata":"https://www.wikidata.org/wiki/Q412895","display_name":"Cycloheximide","level":3,"score":0.766502857208252},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.7250155210494995},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5731726884841919},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5663918852806091},{"id":"https://openalex.org/C2909761498","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Embryonic Induction","level":5,"score":0.5045217275619507},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.47659438848495483},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.46291500329971313},{"id":"https://openalex.org/C66332042","wikidata":"https://www.wikidata.org/wiki/Q5425488","display_name":"FGF and mesoderm formation","level":5,"score":0.4466203451156616},{"id":"https://openalex.org/C38643226","wikidata":"https://www.wikidata.org/wiki/Q4677604","display_name":"Activin type 2 receptors","level":4,"score":0.42250531911849976},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3957575261592865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39290767908096313},{"id":"https://openalex.org/C111001777","wikidata":"https://www.wikidata.org/wiki/Q3562192","display_name":"TGF beta signaling pathway","level":3,"score":0.31861764192581177},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.3173901438713074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2964624762535095},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.2111583650112152},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.1926182508468628},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.18881762027740479}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002712","descriptor_name":"Chlorides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005809","descriptor_name":"Genes, Regulator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007265","descriptor_name":"Inhibins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008094","descriptor_name":"Lithium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D016762","descriptor_name":"Genes, fos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018021","descriptor_name":"Lithium Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/dvg.1020140307","doi":"https://doi.org/10.1002/dvg.1020140307","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dvg.1020140307","pdf_url":null,"source":{"id":"https://openalex.org/S138282212","display_name":"Developmental Genetics","issn_l":"0192-253X","issn":["0192-253X","1520-6408"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Genetics","raw_type":"journal-article"},{"id":"pmid:8395366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8395366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W216009453","https://openalex.org/W969282383","https://openalex.org/W983135388","https://openalex.org/W1486396879","https://openalex.org/W1642229908","https://openalex.org/W1917097318","https://openalex.org/W1928260425","https://openalex.org/W1943352952","https://openalex.org/W1963624673","https://openalex.org/W1973921994","https://openalex.org/W1977509897","https://openalex.org/W1978411854","https://openalex.org/W1979142194","https://openalex.org/W1981163994","https://openalex.org/W1981213410","https://openalex.org/W1983086133","https://openalex.org/W1989721036","https://openalex.org/W1990938412","https://openalex.org/W2001199318","https://openalex.org/W2001642012","https://openalex.org/W2008999766","https://openalex.org/W2010041789","https://openalex.org/W2012477673","https://openalex.org/W2019340213","https://openalex.org/W2021253208","https://openalex.org/W2023772121","https://openalex.org/W2025853097","https://openalex.org/W2026962630","https://openalex.org/W2028323670","https://openalex.org/W2037994773","https://openalex.org/W2042902747","https://openalex.org/W2047488088","https://openalex.org/W2049827442","https://openalex.org/W2053093350","https://openalex.org/W2055830220","https://openalex.org/W2064185923","https://openalex.org/W2067513896","https://openalex.org/W2071135527","https://openalex.org/W2072179135","https://openalex.org/W2073910994","https://openalex.org/W2077492124","https://openalex.org/W2079200533","https://openalex.org/W2083741176","https://openalex.org/W2087193784","https://openalex.org/W2091630371","https://openalex.org/W2091637225","https://openalex.org/W2107332774","https://openalex.org/W2135314961","https://openalex.org/W2147631014","https://openalex.org/W2165080402","https://openalex.org/W2165200226","https://openalex.org/W2202773161","https://openalex.org/W2204701853","https://openalex.org/W2265750209","https://openalex.org/W2399009859","https://openalex.org/W4321429191"],"related_works":["https://openalex.org/W2338231722","https://openalex.org/W2087222774","https://openalex.org/W2316887429","https://openalex.org/W2018485286","https://openalex.org/W2102681982","https://openalex.org/W2294929520","https://openalex.org/W2114108282","https://openalex.org/W2199748934","https://openalex.org/W1978411854","https://openalex.org/W1975301960"],"abstract_inverted_index":{"Mesoderm":[0],"development":[1,23],"in":[2,47,114,125,144,164],"Xenopus":[3],"laevis":[4],"depends":[5],"on":[6,58],"inductive":[7],"cell":[8],"interactions":[9],"mediated":[10],"by":[11,50,68,73,128,134,156],"diffusible":[12],"molecules.":[13],"The":[14,85],"mesoderm":[15],"inducer":[16],"activin":[17,118],"is":[18,65,81,105],"capable":[19],"of":[20,24,36,55,63,70,77,95,100,117,147,153],"redirecting":[21],"the":[22,34,53,71,78,92,115,151],"animal":[25,126],"explants":[26,49,127],"both":[27],"morphologically":[28],"and":[29,45,52,103,119,121,132],"biochemically.":[30],"We":[31],"have":[32,136,160],"studied":[33],"induction":[35,62,94,99],"four":[37],"regulatory":[38],"genes,":[39],"Mix.":[40,101],"1,":[41],"goosecoid":[42],"(gsc),":[43],"Xlim-1,":[44],"Xbra":[46,96],"such":[48],"activin,":[51],"influence":[54],"other":[56,79],"factors":[57],"this":[59],"induction.":[60],"Activin":[61],"gsc":[64,110],"strongly":[66],"enhanced":[67],"dorsalization":[69],"embryo":[72],"LiCl,":[74],"while":[75,98],"expression":[76,155],"genes":[80,143],"only":[82],"slightly":[83],"enhanced.":[84],"protein":[86],"synthesis":[87],"inhibitor":[88],"cycloheximide":[89],"(CHX)":[90],"inhibits":[91],"activin-dependent":[93],"partially,":[97],"1":[102],"Xlim-1":[104],"essentially":[106],"unaffected.":[107],"In":[108],"contrast,":[109],"shows":[111],"strong":[112],"superinduction":[113,133],"presence":[116],"CHX,":[120],"can":[122],"be":[123],"induced":[124],"CHX":[129,135],"alone.":[130],"Induction":[131],"previously":[137],"been":[138,162],"observed":[139],"for":[140,150],"immediate":[141],"early":[142,165],"a":[145],"variety":[146],"systems,":[148],"notably":[149],"activation":[152],"c-fos":[154],"serum":[157],"stimulation,":[158],"but":[159],"not":[161],"reported":[163],"amphibian":[166],"embryos.":[167]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}