{"id":"https://openalex.org/W1997372741","doi":"https://doi.org/10.1111/jam.12500","title":"A functional analysis of the formyl-coenzyme A (frc) gene fromLactobacillus reuteri100-23C","display_name":"A functional analysis of the formyl-coenzyme A (frc) gene fromLactobacillus reuteri100-23C","publication_year":2014,"publication_date":"2014-03-21","ids":{"openalex":"https://openalex.org/W1997372741","doi":"https://doi.org/10.1111/jam.12500","mag":"1997372741","pmid":"https://pubmed.ncbi.nlm.nih.gov/24655128"},"language":"en","primary_location":{"id":"doi:10.1111/jam.12500","doi":"https://doi.org/10.1111/jam.12500","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jam.12500","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002284726","display_name":"Brian Kullin","orcid":"https://orcid.org/0000-0001-5460-1977","observed_orcids":["https://orcid.org/0000-0001-5460-1977"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"B. Kullin","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079098463","display_name":"Gerald W. Tannock","orcid":"https://orcid.org/0000-0002-9197-733X","observed_orcids":["https://orcid.org/0000-0002-9197-733X"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"G.W. Tannock","raw_affiliation_strings":["Department of Microbiology and Immunology; University of Otago; Dunedin New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology; University of Otago; Dunedin New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021990378","display_name":"Diane M. Loach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"D.M. Loach","raw_affiliation_strings":["Department of Microbiology and Immunology; University of Otago; Dunedin New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology; University of Otago; Dunedin New Zealand","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073384803","display_name":"Katsunori Kimura","orcid":"https://orcid.org/0000-0002-7106-2650","observed_orcids":["https://orcid.org/0000-0002-7106-2650"]},"institutions":[{"id":"https://openalex.org/I4210114911","display_name":"Meiji (Japan)","ror":"https://ror.org/027tjex48","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210114911"]},{"id":"https://openalex.org/I4405273579","display_name":"Meiji Co., Ltd. (Japan)","ror":"https://ror.org/002q6h737","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405273579"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Kimura","raw_affiliation_strings":["Division of Research and Development, Food Functionality Research Institute, Meiji Corporation, Odawara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Research and Development, Food Functionality Research Institute, Meiji Corporation, Odawara, Kanagawa, Japan","institution_ids":["https://openalex.org/I4210114911","https://openalex.org/I4405273579"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039891269","display_name":"Valerie R. Abratt","orcid":"https://orcid.org/0000-0003-4631-3355","observed_orcids":["https://orcid.org/0000-0003-4631-3355"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"V.R. Abratt","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":null,"display_name":"S.J. Reid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"S.J. Reid","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I157614274"],"apc_list":{"value":2864,"currency":"GBP","value_usd":3777},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.14257938,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"116","issue":"6","first_page":"1657","last_page":"1667"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.00930000003427267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limosilactobacillus-reuteri","display_name":"Lactobacillus reuteri","score":0.9869999885559082},{"id":"https://openalex.org/keywords/oxalate-metabolism","display_name":"oxalate metabolism","score":0.9139999747276306},{"id":"https://openalex.org/keywords/oxalate-degradation","display_name":"oxalate degradation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/host-colonization","display_name":"host colonization","score":0.7409999966621399},{"id":"https://openalex.org/keywords/acid-stress-response","display_name":"acid stress response","score":0.9229999780654907},{"id":"https://openalex.org/keywords/insertional-mutants","display_name":"insertion mutants","score":0.5950000286102295},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7490000128746033},{"id":"https://openalex.org/keywords/urolithiasis-prevention","display_name":"urolithiasis prevention","score":0.953000009059906},{"id":"https://openalex.org/keywords/gastrointestinal-colonization","display_name":"intestinal colonization","score":0.5849999785423279}],"concepts":[{"id":"https://openalex.org/C2775898472","wikidata":"https://www.wikidata.org/wiki/Q597078","display_name":"Lactobacillus reuteri","level":4,"score":0.7733633518218994},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5919402241706848},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5825209617614746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47658631205558777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4704631268978119},{"id":"https://openalex.org/C2776351790","wikidata":"https://www.wikidata.org/wiki/Q417351","display_name":"Oxalate","level":2,"score":0.46016380190849304},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4422857165336609},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38508400321006775},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.2223406434059143},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.2149161398410797},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006851","descriptor_name":"Hydrochloric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007422","descriptor_name":"Intestines","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010070","descriptor_name":"Oxalates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010070","descriptor_name":"Oxalates","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D015256","descriptor_name":"Coenzyme A-Transferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052200","descriptor_name":"Limosilactobacillus reuteri","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D052200","descriptor_name":"Limosilactobacillus reuteri","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jam.12500","doi":"https://doi.org/10.1111/jam.12500","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jam.12500","pdf_url":null,"source":{"id":"https://openalex.org/S39794811","display_name":"Journal of Applied Microbiology","issn_l":"1364-5072","issn":["1364-5072","1365-2672"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Microbiology","raw_type":"journal-article"},{"id":"pmid:24655128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24655128","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied microbiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W170361755","https://openalex.org/W564736466","https://openalex.org/W1485645868","https://openalex.org/W1506141487","https://openalex.org/W1509401562","https://openalex.org/W1548162677","https://openalex.org/W1549539765","https://openalex.org/W1557137732","https://openalex.org/W1592527426","https://openalex.org/W1598858252","https://openalex.org/W1933029013","https://openalex.org/W1985307671","https://openalex.org/W1995230120","https://openalex.org/W2027876801","https://openalex.org/W2029877225","https://openalex.org/W2038167843","https://openalex.org/W2054317616","https://openalex.org/W2054872632","https://openalex.org/W2056561712","https://openalex.org/W2076477732","https://openalex.org/W2090900171","https://openalex.org/W2090925778","https://openalex.org/W2096325254","https://openalex.org/W2100581167","https://openalex.org/W2101646692","https://openalex.org/W2105879426","https://openalex.org/W2112326638","https://openalex.org/W2114209806","https://openalex.org/W2114910106","https://openalex.org/W2116560054","https://openalex.org/W2117736614","https://openalex.org/W2117799296","https://openalex.org/W2119255453","https://openalex.org/W2120491169","https://openalex.org/W2122694037","https://openalex.org/W2123637046","https://openalex.org/W2125121305","https://openalex.org/W2126252319","https://openalex.org/W2154886088","https://openalex.org/W2156319674","https://openalex.org/W2158024736","https://openalex.org/W2158714788","https://openalex.org/W2159435025","https://openalex.org/W2161717286","https://openalex.org/W2163076569","https://openalex.org/W2163743930","https://openalex.org/W2170363648","https://openalex.org/W2314225431","https://openalex.org/W6678540175"],"related_works":["https://openalex.org/W2114209806","https://openalex.org/W7096742495","https://openalex.org/W4390839685","https://openalex.org/W1707001945","https://openalex.org/W2101646692","https://openalex.org/W2154886088","https://openalex.org/W2186150242","https://openalex.org/W3114788510","https://openalex.org/W3211611627","https://openalex.org/W2975614847"],"abstract_inverted_index":{"AIM:":[0],"To":[1,222],"examine":[2],"the":[3,6,19,40,58,69,101,118,134,137,141,147,156,173,217,232],"role":[4],"of":[5,43,68,73,80,94,110,120,158,187,219,231,235,245],"Lactobacillus":[7],"reuteri":[8,45,96,192],"100-23C":[9,97],"frc":[10,59,70,86,165,177],"gene":[11,178],"product":[12,179],"in":[13,39,57,77,117,128,131,140,155,210],"oxalate":[14,107,127,170,237],"metabolism,":[15],"host":[16,113,183],"colonization":[17,109,184],"and":[18,32,61,87,115,146,164,185,213,225],"acid":[20,188],"stress":[21,189],"response.":[22],"METHODS":[23],"AND":[24,195],"RESULTS:":[25],"Genes":[26],"encoding":[27],"putative":[28],"formyl-CoA":[29],"transferase":[30],"(frc)":[31],"oxalyl-CoA":[33],"decarboxylase":[34],"(oxc)":[35],"enzymes":[36],"are":[37],"present":[38],"genome":[41],"sequences":[42],"Lact.":[44,95,191],"strains.":[46],"Two":[47],"strains":[48,79,206],"isolated":[49],"from":[50],"humans":[51],"harboured":[52],"an":[53,111,229],"IS200":[54],"insertion":[55],"sequence":[56],"ORF":[60],"a":[62,151],"group":[63],"2":[64],"intron-associated":[65],"transposase":[66],"downstream":[67],"gene,":[71],"both":[72],"which":[74,83],"were":[75],"lacking":[76],"two":[78],"animal":[81],"origin,":[82],"contained":[84],"intact":[85],"oxc":[88,163],"genes.":[89],"An":[90],"frc(-)":[91,138,148],"insertional":[92],"mutant":[93,125,139,149],"was":[98],"compared":[99],"with":[100,104,243],"parent":[102,123,135],"strain":[103],"respect":[105],"to":[106,216],"degradation,":[108],"RLF-mouse":[112],"model":[114],"growth":[116,153],"presence":[119,157],"acids.":[121],"Neither":[122],"nor":[124],"degraded":[126],"vitro":[129],"or":[130],"vivo.":[132],"However,":[133],"outcompeted":[136],"mouse":[142],"intestine":[143],"during":[144,182],"co-colonization":[145],"showed":[150],"reduced":[152],"rate":[154],"hydrochloric":[159],"acid.":[160],"CONCLUSIONS:":[161],"Intact":[162],"genes":[166],"do":[167],"not":[168],"ensure":[169],"degradation":[171],"under":[172],"conditions":[174],"tested.":[175],"The":[176],"is":[180],"important":[181,209],"survival":[186],"by":[190,202],"100-23C.":[193],"SIGNIFICANCE":[194],"IMPACT":[196],"OF":[197],"THE":[198],"STUDY:":[199],"Oxalate":[200],"metabolism":[201],"oxalate-degrading":[203],"intestinal":[204],"bacterial":[205],"may":[207],"be":[208,240],"preventing":[211],"urolithiasis":[212],"might":[214],"lead":[215],"derivation":[218],"probiotic":[220],"products.":[221],"produce":[223],"safe":[224],"efficacious":[226],"probiotics,":[227],"however,":[228],"understanding":[230],"genetic":[233],"characteristics":[234],"potential":[236],"degraders":[238],"must":[239],"obtained,":[241],"together":[242],"knowledge":[244],"their":[246],"functional":[247],"ramifications.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
